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Applying the Human-Centered Innovation Biodesign Framework to the Development and Piloting of a Program to Mitigate Risk for Cognitive Decline Among Historically Underrepresented Individuals: Case Study

Applying the Human-Centered Innovation Biodesign Framework to the Development and Piloting of a Program to Mitigate Risk for Cognitive Decline Among Historically Underrepresented Individuals: Case Study

A longitudinal study of 404 community-dwelling older adults who were free from dementia at baseline found that despite having high levels of physical activity, individuals with high sedentary behavior had neurodegeneration and worse cognition over 7 years [2].

Rebecca Lassell, Ada Metaxas, Katherine Wang, Sara Hantgan, Prabhat Gottipati, Sarah Zwerling, Triana Pena, Chava Pollak, Laura Gitlin, Sunit Jariwala

JMIR Form Res 2025;9:e64930


Detection of Vascular Mild Cognitive Impairment in Southeast Asia Using the Visual Cognitive Assessment Test: Machine Learning Analysis From the BIOCIS (Biomarkers and Cognition Study, Singapore)

Detection of Vascular Mild Cognitive Impairment in Southeast Asia Using the Visual Cognitive Assessment Test: Machine Learning Analysis From the BIOCIS (Biomarkers and Cognition Study, Singapore)

Although it is designed to be a global cognition test, it potentially offers a comprehensive method for detecting VMCI by assessing key cognitive domains, such as processing speed and executive function. These domains are closely linked to visual skills, as visual information is processed in the brain to guide accurate actions and judgments [17].

Pricilia Tanoto, Hannah En Ye, Seyed Ehsan Saffari, Yi Jin Leow, Ashwati Vipin, Faith Phemie Hui En Lee, Smriti Ghildiyal, Shan Yao Liew, Adnan Azam Mohammed, Gurveen Kaur Sandhu, Kiirtaara Aravindhan, Gursimar Bhalla, Rasyiqah Binte Shaik Mohamed Salim, Nagaendran Kandiah

JMIR Aging 2025;8:e76847


Effectiveness of Tocotrienol-Rich Fraction in Older Adults: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial

Effectiveness of Tocotrienol-Rich Fraction in Older Adults: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial

TRF supplement with a complete spectrum of tocotrienol isomers has been found to alleviate inflammatory symptoms of allergic rhinitis [72], enhance mental health and cognition [73], reduce inflammation and oxidative stress in ulcerative colitis [31], and mitigate UV-induced skin inflammation [38]. A previous study reported that TRF can improve antioxidant enzyme activities and glutathione levels in women aged between 50 years and 55 years [74].

Nor Amira Nabila Amir Razak, Jo Aan Goon, Wan Zurinah Wan Ngah, Suzana Makpol, Mohd Hanafi Ahmad Damanhuri, Nor Faeizah Ibrahim, Nur Fathiah Abdul Sani, Nuraqila Mohd Murshid, Anis Faqihah Mohd Azizan, Kok Yong Chin, Amilia Aminuddin, Mohd Heikal Mohd Yunus, Munirah Md Mansor, Juvenia Rui En Neo, Wei Ney Yap, Hsieu Yen Loong, Yee Wei Ung

JMIR Res Protoc 2025;14:e73039


Dynamic Interactions Among Sleep Duration, Cognitive Function, and Depressive Symptoms in Middle-Aged and Older Chinese Adults: Temporal Network Analysis From CHARLS

Dynamic Interactions Among Sleep Duration, Cognitive Function, and Depressive Symptoms in Middle-Aged and Older Chinese Adults: Temporal Network Analysis From CHARLS

Impaired cognition and sleep disturbances are prevalent in aging populations, and accumulating evidence suggests that sleep deficits may mediate up to 15% of cognitive decline [7-9]. In addition, depression is a common comorbidity in older adults, which further exacerbates cognitive risks [10].

Furong Chen, Jiaying Li, Junchen Guo, Ying Xiong, Zengjie Ye

JMIR Aging 2025;8:e76210


Impacts of Environmental Distractions and Interruptions on Unsupervised Digital Cognitive Assessments in Older Adults: Cognitive Ecological Momentary Assessment Study

Impacts of Environmental Distractions and Interruptions on Unsupervised Digital Cognitive Assessments in Older Adults: Cognitive Ecological Momentary Assessment Study

Depending on study goals, environmental distractions may be considered confounds that need to be controlled for in EMA studies of cognition. In studies of aging and neurodegenerative disease, researchers are interested in capturing subtle changes in cognition related to changes in neurological functioning, so understanding the effects of different sources of distraction is critical.

Matthew Welhaf, Hannah Wilks, Andrew J Aschenbrenner, Samhita Katteri, John C Morris, Jason J Hassenstab

JMIR Mhealth Uhealth 2025;13:e71578


A Teleneuropsychological Battery for Assessing Older Panamanian Adults: Protocol for a Cross-Sectional Pilot Feasibility Study

A Teleneuropsychological Battery for Assessing Older Panamanian Adults: Protocol for a Cross-Sectional Pilot Feasibility Study

These assessments help identify any underlying neurological diseases or uncontrolled medical conditions that may impact cognition, such as depression or bipolar disorder. The screening aims to (1) confirm that the participant does not have cognitive impairment (eg, mild cognitive impairment or dementia) and (2) ensure that they have the cognitive capacity to provide informed consent. Participants scoring ≤31 points in TICS-M, indicating mild cognitive impairment or dementia, are excluded from the study.

Luis Guillermo Santos Mejía, Diana C Oviedo, Ambar Perez-Lao, Gabrielle B Britton, Glenn Smith

JMIR Res Protoc 2025;14:e68520


Finnish Registry-Based Protocol for Screening and Management of Fatigue and Cognitive Problems in Multiple Sclerosis: Observational Study

Finnish Registry-Based Protocol for Screening and Management of Fatigue and Cognitive Problems in Multiple Sclerosis: Observational Study

Results on the Symbol Digit Modalities Test (SDMT) and the patient-reported measures of disability, quality of life, fatigue, cognition, and mood (n=430). a PREDSS 0‐9 where 0 stands for no disability and 9 for bedridden most of the time. b VAS: Visual Analog Scale. VAS scores where 0 stands for no problems and 100 for worst possible problems. c EQ-5 D: Euro Quality of Life–5 Dimension. Higher scores refer to better quality of life in EQ-5 D (range 0‐1). d FSMC: Fatigue Scale for Motor and Cognitive Functions.

Päivi Hämäläinen, Elina Lämsä, Matias Viitala, Hanna Kuusisto, Marja Niiranen, Sari Avikainen, Juha Puustinen, Mervi Ryytty, Juhani Ruutiainen, Merja Soilu-Hänninen

JMIR Hum Factors 2025;12:e67990


Machine Learning–Based Cognitive Assessment With The Autonomous Cognitive Examination: Randomized Controlled Trial

Machine Learning–Based Cognitive Assessment With The Autonomous Cognitive Examination: Randomized Controlled Trial

First, we compare the reliability of the ACo E to phenotype overall cognition and cognitive symptoms compared to the ACE-3. We then evaluate the ability of the ACo E’s phenotypic output to achieve similar screening results as the ACE-3 and Mo CA. A 2-period double crossover randomized controlled study was used. The double-crossover study design mitigates learning bias and has been previously shown to improve statistical power [43].

Calvin Howard, Amy Johnson, Sheena Baratono, Katharina Faust, Joseph Peedicail, Marcus Ng

J Med Internet Res 2025;27:e67446


Cognitive and Spontaneous Brain Activity in Nonaddictive Smartphone Users Among Older Adults in China: Cross-Sectional Study

Cognitive and Spontaneous Brain Activity in Nonaddictive Smartphone Users Among Older Adults in China: Cross-Sectional Study

Several other similar studies have also reported similar findings, highlighting the positive effects of smartphone use on cognition in older adults [32,36,37]. Using smartphones could be regarded as a mentally stimulating activity.

Zhenyu Wan, Xucong Qin, Qirong Wan, Baohua Xu, Hong Lin, Fangcheng Ouyang, Gaohua Wang

J Med Internet Res 2025;27:e63485


The Effect of Maternal Choline Intake on Offspring Cognition in Adolescence: Protocol for a 14-year Follow-Up of a Randomized Controlled Feeding Trial

The Effect of Maternal Choline Intake on Offspring Cognition in Adolescence: Protocol for a 14-year Follow-Up of a Randomized Controlled Feeding Trial

In contrast to the robust literature in rodents, relatively few studies have assessed the impact of varied maternal choline intakes on offspring cognition in humans. The available observational and experimental studies are discussed next. Most of the human studies evaluating the impact of maternal choline intake on offspring cognition have been observational.

Sophie A Roth, Angie E Lam, Barbara J Strupp, Richard L Canfield, Elisabeth Anne Larson

JMIR Res Protoc 2025;14:e73508