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Challenges and Approaches to Recruitment for and Retention in a Dyad-Focused eHealth Intervention During COVID-19: Randomized Controlled Trial

Challenges and Approaches to Recruitment for and Retention in a Dyad-Focused eHealth Intervention During COVID-19: Randomized Controlled Trial

Although providing flexibility and convenience, contacting prospective participants through telephone, email, and mail without face-to-face meetings could jeopardize participant accrual and retention, because cold-calling and remote contacts reduced trust. The sensitive nature of prostate cancer could exacerbate these concerns for patients and partners.

Chunxuan Ma, Rachel H Adler, Daria B Neidre, Ronald C Chen, Laurel L Northouse, Christine Rini, Xianming Tan, Lixin Song

J Med Internet Res 2024;26:e51877

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Creating and Implementing a Principal Investigator Tool Kit for Enhancing Accrual to Late Phase Clinical Trials: Development and Usability Study

Creating and Implementing a Principal Investigator Tool Kit for Enhancing Accrual to Late Phase Clinical Trials: Development and Usability Study

NCTN trials are critical to advancing cancer care, but many trials take years to complete accrual owing to lower-than-projected accrual rates. To facilitate the goal of meeting projected clinical trial accrual, the NRG Oncology Protocol Operations Management (POM) Committee sought to develop, with input from the NRG Communications Committee, a tool kit for study principal investigators of newly activated NRG Oncology trials.

Kristin A Higgins, Alexandra Thomas, Nancy Soto, Rebecca Paulus, Thomas J George, Thomas B Julian, Sharon Hartson Stine, Merry Jennifer Markham, Maria Werner-Wasik

JMIR Cancer 2022;8(3):e38514

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The Successful Synchronized Orchestration of an Investigator-Initiated Multicenter Trial Using a Clinical Trial Management System and Team Approach: Design and Utility Study

The Successful Synchronized Orchestration of an Investigator-Initiated Multicenter Trial Using a Clinical Trial Management System and Team Approach: Design and Utility Study

Haidich et al [16] proposed that a Gini coefficient for accrual distribution in multisite trials could provide a standardized approach to assessing accrual disparities. They identified a Gini coefficient of less than 0.2 as suggesting low accrual inequality and calculated a mean Gini coefficient of 0.33 among multisite trials. The KUMC granted approval under a central institutional review board with reliance by the other institutions (STUDY00003455).

Dinesh Pal Mudaranthakam, Alexandra Brown, Elizabeth Kerling, Susan E Carlson, Christina J Valentine, Byron Gajewski

JMIR Form Res 2021;5(12):e30368

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