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Toward an Extended Definition of Major Depressive Disorder Symptomatology: Digital Assessment and Cross-validation Study

This finding is in line with a recent study by Han et al [61], whose findings revealed that leaden paralysis was a robust and important predictor of first-onset MDD. Critically, although leaden paralysis is included in the DSM-5 specifier for atypical depression, it is not deemed a core feature of the disorder [20]. In fact, even fatigue or loss of energy and tiredness are not considered essential symptoms according to the DSM-5 [20].

Nayra A Martin-Key, Dan-Mircea Mirea, Tony Olmert, Jason Cooper, Sung Yeon Sarah Han, Giles Barton-Owen, Lynn Farrag, Emily Bell, Pawel Eljasz, Daniel Cowell, Jakub Tomasik, Sabine Bahn