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Currently, the only US Food and Drug Administration (FDA)–approved treatment is oral pentosan polysulfate sodium (PPS). Use of PPS has been demonstrated to improve symptoms [10], although recent studies link PPS to a unique presentation of pigmentary maculopathy [11]. Pigmentary maculopathy can produce moderate visual impairment, macular hyperpigmented spots, yellow-orange deposits, and patchy retinal pigment epithelium atrophy [12].
JMIR Form Res 2025;9:e54209
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