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The findability, accessibility, interoperability, and reusability (FAIR) principles [15] provide high-level guidance for data management and sharing, ensuring that research data are well documented, discoverable, and reusable. While FAIR does not directly address study reproducibility, its principles support transparency and consistency in data handling, which are critical for reproducibility efforts.
J Med Internet Res 2025;27:e63343
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Despite wide acceptance in medical research, implementation of the FAIR (findability, accessibility, interoperability, and reusability) data principles in certain health domains and interoperability across data sources remain a challenge [1].
JMIR Med Inform 2025;13:e63906
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Responding to the need to make digital data assets and their associated metadata more usable by machines and reusable by humans, Wilkinson et al [33], developed a set of 15 guiding principles for scientific data management and stewardship, which are grouped into the four higher principles of Findability, Accessibility, Interoperability, and Reusability (FAIR). Implementing the FAIR Principles is relevant to improving efficiency and access to research and health care data.
JMIR Med Inform 2025;13:e64099
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Exploring Metadata Catalogs in Health Care Data Ecosystems: Taxonomy Development Study
To define the meta-dimensions, the FAIR framework was used [7]. These well-known data principles postulate an accepted approach to the discoverability and usability of RWD [19]. While FAIR emphasizes making data interoperable and reusable, it inherently involves considerations related to data governance and harmonization [40].
In step 2 in Figure 1, ending conditions for the iterative part of the process are defined, determining its termination criteria.
JMIR Form Res 2025;9:e63396
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Toward Better Semantic Interoperability of Data Element Repositories in Medicine: Analysis Study
Practice of FAIR principles: finally, analyzing the repository’s adherence to the FAIR principles as a supplementary assessment.
Data resources and services dimensions are primarily determined by repository and portal characteristics, while resource organization, quality control, and semantics leverage insights from relevant literature and the ISO/IEC 11179 standard. Practice of FAIR adheres to the FAIR principle and its 15 subprinciples.
JMIR Med Inform 2024;12:e60293
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