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Advancing Remote Monitoring for Patients With Alzheimer Disease and Related Dementias: Systematic Review

Advancing Remote Monitoring for Patients With Alzheimer Disease and Related Dementias: Systematic Review

Alzheimer disease (AD) is the most generic form of dementia, and significantly affects the brain cells, declines cognitive abilities, and makes it difficult to perform daily tasks [1]. The main effects of the disease are loss of memory, inability to use problem-solving and logical thinking skills, anxiety, depression, and confusion [2]. AD has remained the leading cause of death among people aged >60 years.

Mohmmad Arif Shaik, Fahim Islam Anik, Md. Mehedi Hasan, Sumit Chakravarty, Mary Dioise Ramos, Mohammad Ashiqur Rahman, Sheikh Iqbal Ahamed, Nazmus Sakib

JMIR Aging 2025;8:e69175

Assessing Social Interaction and Loneliness and Their Association With Frailty Among Older Adults With Subjective Cognitive Decline or Mild Cognitive Impairment: Ecological Momentary Assessment Approach

Assessing Social Interaction and Loneliness and Their Association With Frailty Among Older Adults With Subjective Cognitive Decline or Mild Cognitive Impairment: Ecological Momentary Assessment Approach

Additionally, Alzheimer disease pathology, hormonal changes, and chronic inflammation are potential mechanistic links between frailty and cognitive decline. While this study focuses on social interaction, physiological dimensions such as physical activity, metabolic health, and nutritional status were not assessed to minimize the participants’ measurement burden during the 2-week survey period.

Bada Kang, Dahye Hong, Seolah Yoon, Chaeeun Kang, Jennifer Ivy Kim

JMIR Mhealth Uhealth 2025;13:e64853

Identifying Unmet Needs of Informal Dementia Caregivers in Clinical Practice: User-Centered Development of a Digital Assessment Tool

Identifying Unmet Needs of Informal Dementia Caregivers in Clinical Practice: User-Centered Development of a Digital Assessment Tool

We involved individuals from 3 stakeholder groups, namely, family dementia caregivers, health care professionals (general practitioners, neurologists, psychiatrists, psychologists, and nurses), and Alzheimer Society representatives. We approached HCPs of a medical university and memory clinic staff, as well as Alzheimer Society representatives, and asked for their feedback (phase 1).

Olga A Biernetzky, Jochen René Thyrian, Melanie Boekholt, Matthias Berndt, Wolfgang Hoffmann, Stefan J Teipel, Ingo Kilimann

JMIR Aging 2025;8:e59942

A Dynamic Adaptive Ensemble Learning Framework for Noninvasive Mild Cognitive Impairment Detection: Development and Validation Study

A Dynamic Adaptive Ensemble Learning Framework for Noninvasive Mild Cognitive Impairment Detection: Development and Validation Study

Neurodegenerative conditions such as Alzheimer disease (AD) and related dementias precipitate accelerated cognitive deterioration, markedly impacting patients’ daily lives and social engagement [1]. Current estimates suggest that approximately 50 million individuals worldwide suffer from dementia, with this number expected to soar to 152 million by 2050 [2]. Generally, patients diagnosed with mild cognitive impairment (MCI) are at a much higher risk of developing dementia [3].

Aoyu Li, Jingwen Li, Yishan Hu, Yan Geng, Yan Qiang, Juanjuan Zhao

JMIR Med Inform 2025;13:e60250

The PDC30 Chatbot—Development of a Psychoeducational Resource on Dementia Caregiving Among Family Caregivers: Mixed Methods Acceptability Study

The PDC30 Chatbot—Development of a Psychoeducational Resource on Dementia Caregiving Among Family Caregivers: Mixed Methods Acceptability Study

Reference 34: Benefit-finding intervention for Alzheimer caregivers: conceptual framework, implementation Reference 35: A benefit-finding intervention for family caregivers of persons with Alzheimer disease: Reference 37: Long-term outcomes of the benefit-finding group intervention for Alzheimer family caregivers Reference 38: Benefit-finding intervention delivered individually to Alzheimer family caregivers: longer-termalzheimer

Sheung-Tak Cheng, Peter H F Ng

JMIR Aging 2025;8:e63715

A Multivariable Prediction Model for Mild Cognitive Impairment and Dementia: Algorithm Development and Validation

A Multivariable Prediction Model for Mild Cognitive Impairment and Dementia: Algorithm Development and Validation

Early detection of MCI is important for optimizing patient care, potentially enabling the timely use of disease-modifying therapies to prevent Alzheimer disease (AD) and related dementia [4]. As the life expectancy of patients with AD is approximately 8-10 years after symptom onset, preventing disease progression at an early stage is crucial [3].

Sarah Soyeon Oh, Bada Kang, Dahye Hong, Jennifer Ivy Kim, Hyewon Jeong, Jinyeop Song, Minkyu Jeon

JMIR Med Inform 2024;12:e59396

Remote Passive Sensing of Older Adults’ Activities and Function: User-Centered Design Considerations for Behavioral Interventions Conducted in the Home Setting

Remote Passive Sensing of Older Adults’ Activities and Function: User-Centered Design Considerations for Behavioral Interventions Conducted in the Home Setting

Subtle decline in everyday function occurs as part of the normal aging process and as a symptom of pathologies commonly found among older adults, such as Alzheimer disease and related disorders. Likewise, stress from caregiving for older adults with chronic health conditions impacts everyday routines and behaviors such as sleep and physical activity.

Lyndsey M Miller, Jeffrey Kaye, Allison Lindauer, Wan-Tai M Au-Yeung, Nathaniel K Rodrigues, Sara J Czaja

J Med Internet Res 2024;26:e54709

Investigating Acoustic and Psycholinguistic Predictors of Cognitive Impairment in Older Adults: Modeling Study

Investigating Acoustic and Psycholinguistic Predictors of Cognitive Impairment in Older Adults: Modeling Study

Prior studies have reported speech and language declines across disease progression from early MCI to moderate-stage Alzheimer disease [6-8]. Mueller et al [8] found that subtle declines in speech fluency and semantic content are apparent even prior to the onset of clinically diagnosed MCI. Therefore, developing techniques to identify early changes in language functioning may enhance the detection of subtle cognitive decline associated with pathological cognitive aging.

Varsha D Badal, Jenna M Reinen, Elizabeth W Twamley, Ellen E Lee, Robert P Fellows, Erhan Bilal, Colin A Depp

JMIR Aging 2024;7:e54655

The Dual Task Ball Balancing Test and Its Association With Cognitive Function: Algorithm Development and Validation

The Dual Task Ball Balancing Test and Its Association With Cognitive Function: Algorithm Development and Validation

In the presence of disease, for example, a neurodegenerative disease such as Alzheimer disease, cognitive reserve is engaged to sustain function for as long as possible and minimize symptoms and disability. Thus, individuals with more cognitive reserve manifest symptoms or disability later than those with lower cognitive reserve; symptoms are less prominent or severe than might be expected for a given amount of pathology.

Barry Greene, Sean Tobyne, Ali Jannati, Killian McManus, Joyce Gomes Osman, Russell Banks, Ranjit Kher, John Showalter, David Bates, Alvaro Pascual-Leone

J Med Internet Res 2024;26:e49794