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Integrating Ambient In-Home Sensor Data and Electronic Health Record Data for the Prediction of Outcomes in Amyotrophic Lateral Sclerosis: Protocol for an Exploratory Feasibility Study

Integrating Ambient In-Home Sensor Data and Electronic Health Record Data for the Prediction of Outcomes in Amyotrophic Lateral Sclerosis: Protocol for an Exploratory Feasibility Study

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder that usually leads to death within 3 years of symptom onset and within 2 years from diagnosis [1]. The sequence and rate of ALS progression can vary widely depending on the phenotype, age at onset, and diagnostic delay [2,3].

William E Janes, Noah Marchal, Xing Song, Mihail Popescu, Abu Saleh Mohammad Mosa, Juliana H Earwood, Vovanti Jones, Marjorie Skubic

JMIR Res Protoc 2025;14:e60437

Exploring Speech Biosignatures for Traumatic Brain Injury and Neurodegeneration: Pilot Machine Learning Study

Exploring Speech Biosignatures for Traumatic Brain Injury and Neurodegeneration: Pilot Machine Learning Study

For instance, the study by Mallela et al [23] presents an automatic voice assessment approach for separating healthy individuals from patients with amyotrophic lateral sclerosis (ALS). Although our study focuses exclusively on PD as the representative neurodegenerative condition, references to ALS studies are included to highlight the broader research landscape on neurodegenerative speech biosignatures and their diagnostic significance.

Rahmina Rubaiat, John Michael Templeton, Sandra L Schneider, Upeka De Silva, Samaneh Madanian, Christian Poellabauer

JMIR Neurotech 2025;4:e64624

Prevalence and Economic Impact of Acute Respiratory Failure in the Prehospital Emergency Medical Service of the Madrid Community: Retrospective Cohort Study

Prevalence and Economic Impact of Acute Respiratory Failure in the Prehospital Emergency Medical Service of the Madrid Community: Retrospective Cohort Study

Each emergency care is provided by a health professional team formed by an emergency physician, an emergency nurse, and 1 or 2 emergency technicians; these teams assist at home and other places and take care of the patient in the mobile intensive critical unit (ALS). The EMRs analyzed are those performed by the ALS physicians who attended the pathologies under study.

Ana María Cintora-Sanz, Cristina Horrillo-García, Víctor Quesada-Cubo, Ana María Pérez-Alonso, Alicia Gutiérrez-Misis

JMIR Public Health Surveill 2025;11:e66179

The Feasibility and Acceptability of Sharing Video Recordings of Amyotrophic Lateral Sclerosis Clinical Encounters With Patients and Their Caregivers: Pilot Randomized Clinical Trial

The Feasibility and Acceptability of Sharing Video Recordings of Amyotrophic Lateral Sclerosis Clinical Encounters With Patients and Their Caregivers: Pilot Randomized Clinical Trial

While not studied in ALS, access to visit recordings has been linked to better self-management and treatment adherence in other chronic conditions [13]. We conducted a randomized controlled pilot trial to determine the feasibility and acceptability of video recording in an ALS MDC setting. By understanding whether recordings are feasible or acceptable, the results of this pilot study will help determine whether these modalities have potential for future study.

Reed W R Bratches, Jeffrey Cohen, Elizabeth Carpenter-Song, Lisa Mistler, Paul J Barr

JMIR Form Res 2024;8:e57519

Patient-Reported Outcome of Physical Therapy in Amyotrophic Lateral Sclerosis: Observational Online Study

Patient-Reported Outcome of Physical Therapy in Amyotrophic Lateral Sclerosis: Observational Online Study

Excessive or high resistance exercises have been associated with overwork damage and thus are not recommended in ALS treatment [8]. The key focus for physical therapists is to delay the decline of muscular strength by submaximal resistance exercise, which has been shown to be safe and efficacious. Additionally, because pain and spasticity worsen the burden of ALS, physical therapy also addresses these symptoms.

Robert Meyer, Susanne Spittel, Laura Steinfurth, Andreas Funke, Dagmar Kettemann, Christoph Münch, Thomas Meyer, André Maier

JMIR Rehabil Assist Technol 2018;5(2):e10099