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Greater Improvements in Vaccination Outcomes Among Black Young Adults With Vaccine-Resistant Attitudes in the United States South Following a Digital Health Intervention: Latent Profile Analysis of a Randomized Control Trial

Noah Mancuso, Jenna Michaels, Erica N Browne, Allysha C Maragh-Bass, Jacob B Stocks, Zachary R Soberano, C Lily Bond, Ibrahim Yigit, Maria Leonora G Comello, Margo Adams Larsen, Kathryn E Muessig, Audrey Pettifor, Lisa B Hightow-Weidman, Henna Budhwani, Marie C D Stoner

JMIR Public Health Surveill 2025;11:e67370

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Tough Talks COVID-19 Digital Health Intervention for Vaccine Hesitancy Among Black Young Adults: Protocol for a Hybrid Type 1 Effectiveness Implementation Randomized Controlled Trial

We will use the g-formula command in Stata (Stata Corp LLC), which uses the mediational g-formula, to estimate the controlled direct effects, natural direct effects, and natural mediated (indirect) effects [54]. In sensitivity analyses, we will also use inverse probability of treatment weights to account for missing data and potential differential retention between study arms over the study period.

Henna Budhwani, Allysha C Maragh-Bass, Elizabeth E Tolley, Maria Leonora G Comello, Marie C D Stoner, Margo Adams Larsen, Donald Brambilla, Kathryn E Muessig, Audrey Pettifor, Christyenne L Bond, Christina Toval, Lisa B Hightow-Weidman