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Addressing the Chronic Pain–Early Cognitive Decline Comorbidity Among Older Adults: Protocol for the Active Brains Remote Efficacy Trial

minimum of 6 wk and willing to maintain a stable dose—changing pain or psychotropic medication introduces an additional intervention that may act as a third variable Exclusion criteria and rationale Diagnosed with dementia or another neurodegenerative disease—these individuals would require a different intervention Diagnosed with a medical illness expected to worsen in the next 6 mo (eg, malignancy)—a serious medical illness may act as a third variable Active, untreated serious mental illness or substance use

Ana-Maria Vranceanu, Nathaniel R Choukas, Elizabeth A Rochon, Brooke Duarte, Malvina O Pietrzykowski, Katherine McDermott, Julia E Hooker, Ronald Kulich, Yakeel T Quiroz, Robert A Parker, Eric A Macklin, Christine Ritchie, The Active Brains Project, Ryan A Mace

JMIR Res Protoc 2023;12:e47319

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A Live Video Mind-Body Treatment to Prevent Persistent Symptoms Following Mild Traumatic Brain Injury: Protocol for a Mixed Methods Study

Rather, symptom persistence after m TBI reflects a complex mind-body interaction, with anxiety playing a prominent role [7,8]. Anxiety may contribute to symptom persistence after m TBI by mimicking or amplifying symptoms, increasing hypervigilance and misattributions, and motivating activity avoidance [9].

Jonathan Greenberg, Tanya Singh, Grant L Iverson, Noah D Silverberg, Eric A Macklin, Robert A Parker, Joseph T Giacino, Gloria Y Yeh, Ana-Maria Vranceanu

JMIR Res Protoc 2021;10(1):e25746

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A Mind-Body Physical Activity Program for Chronic Pain With or Without a Digital Monitoring Device: Proof-of-Concept Feasibility Randomized Controlled Trial

We currently do not know whether daily monitoring of activity with a digital monitoring device such as Fitbit would aid participants in increasing step count. Our long-term goal is to conduct a fully powered RCT comparing 2 identical mind-body physical activity programs, one with a Fitbit device (Get Active-Fitbit) and the other without (Get Active), with an attention educational placebo control.

Jonathan Greenberg, Paula J Popok, Ann Lin, Ronald J Kulich, Peter James, Eric A Macklin, Rachel A Millstein, Robert R Edwards, Ana-Maria Vranceanu