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Using multiple linear regression, a sample size of 200, adjusting for one covariate that explains 20% of the variability in outcome, we have 80% power to detect an increase in R-squared of 3%.
Generalized linear mixed models will be used to examine the effects of time, risk strata, and study arm on longitudinal target and determinant data.
JMIR Res Protoc 2022;11(2):e30710
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