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Greater Improvements in Vaccination Outcomes Among Black Young Adults With Vaccine-Resistant Attitudes in the United States South Following a Digital Health Intervention: Latent Profile Analysis of a Randomized Control Trial

Greater Improvements in Vaccination Outcomes Among Black Young Adults With Vaccine-Resistant Attitudes in the United States South Following a Digital Health Intervention: Latent Profile Analysis of a Randomized Control Trial

The Tough Talks COVID (TT-C) study was a randomized controlled trial of a DHI designed to empower Black young adults in the United States South to make informed, autonomous decisions about COVID-19 vaccine uptake (Clinical Trials.gov NCT05490329) [30]. The TT-C intervention was cocreated using community-based participatory research methods to address structural barriers and misinformation about vaccines through interactive activities and digital storytelling [31,32].

Noah Mancuso, Jenna Michaels, Erica N Browne, Allysha C Maragh-Bass, Jacob B Stocks, Zachary R Soberano, C Lily Bond, Ibrahim Yigit, Maria Leonora G Comello, Margo Adams Larsen, Kathryn E Muessig, Audrey Pettifor, Lisa B Hightow-Weidman, Henna Budhwani, Marie C D Stoner

JMIR Public Health Surveill 2025;11:e67370

Tough Talks COVID-19 Digital Health Intervention for Vaccine Hesitancy Among Black Young Adults: Protocol for a Hybrid Type 1 Effectiveness Implementation Randomized Controlled Trial

Tough Talks COVID-19 Digital Health Intervention for Vaccine Hesitancy Among Black Young Adults: Protocol for a Hybrid Type 1 Effectiveness Implementation Randomized Controlled Trial

Considering these factors, we developed this protocol to adapt a previously developed DHI in the domain of HIV status disclosure (Tough Talks) to a COVID-19 vaccine decision-making context (Tough Talks for COVID-19 [TT-C]) [25]. The TT-C intervention aims to enable Black young adults in the southern United States to make informed, autonomous decisions about COVID-19 vaccine receipt via nonstigmatizing and tailored messaging.

Henna Budhwani, Allysha C Maragh-Bass, Elizabeth E Tolley, Maria Leonora G Comello, Marie C D Stoner, Margo Adams Larsen, Donald Brambilla, Kathryn E Muessig, Audrey Pettifor, Christyenne L Bond, Christina Toval, Lisa B Hightow-Weidman

JMIR Res Protoc 2023;12:e41240