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Effect of Continuous Positive Airway Pressure or Positional Therapy Compared to Control for Treatment of  Obstructive Sleep Apnea on the Development of Gestational Diabetes Mellitus in Pregnancy: Protocol for Feasibility Randomized Controlled Trial

Effect of Continuous Positive Airway Pressure or Positional Therapy Compared to Control for Treatment of Obstructive Sleep Apnea on the Development of Gestational Diabetes Mellitus in Pregnancy: Protocol for Feasibility Randomized Controlled Trial

Biomarkers (s Flt-1 [soluble fms-like tyrosine kinase 1], Pl GF [placental growth factor], IL-6 [interleukin-6], TNFα [tumor necrosis factor alpha], and HIF1α [hypoxia-inducible factor 1-alpha]) will be assayed at the conclusion of the study blinded to outcomes. Urinalysis will be conducted at each study visit using SIEMENS Multistix 10 SG Test strips. A score of negative, trace, 30 mg/d L (++), 100 mg/d L (++), 300 mg/d L (++), or >2000 mg/d L (+++) will be recorded.

Frances Clements, Hima Vedam, Yewon Chung, John Smoleniec, Colin Sullivan, Renuka Shanmugalingam, Annemarie Hennessy, Angela Makris

JMIR Res Protoc 2025;14:e51434