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Use of Large Language Models to Classify Epidemiological Characteristics in Synthetic and Real-World Social Media Posts About Conjunctivitis Outbreaks: Infodemiology Study

Use of Large Language Models to Classify Epidemiological Characteristics in Synthetic and Real-World Social Media Posts About Conjunctivitis Outbreaks: Infodemiology Study

For some APIs that allowed them, we also included a system prompt [59] to convey a public health analyst role to the LLM (Textbox 2). Such a system prompt may reduce the chance that the LLM will respond with helpful advice (such as telling the user to seek medical attention), respond with disclaimers, or refuse to answer the query. System prompt: “You are a health analyst for a Department of Public Health.

Michael S Deiner, Russell Y Deiner, Cherie Fathy, Natalie A Deiner, Vagelis Hristidis, Stephen D McLeod, Thomas J Bukowski, Thuy Doan, Gerami D Seitzman, Thomas M Lietman, Travis C Porco

J Med Internet Res 2025;27:e65226

Enhancing the Predictions of Cytomegalovirus Infection in Severe Ulcerative Colitis Using a Deep Learning Ensemble Model: Development and Validation Study

Enhancing the Predictions of Cytomegalovirus Infection in Severe Ulcerative Colitis Using a Deep Learning Ensemble Model: Development and Validation Study

This transfer-learning approach, where a model is pretrained on a large dataset and subsequently fine-tuned for a specific task, is a well-established strategy in medical imaging and has demonstrated substantial efficacy.

Jeong Heon Kim, A Reum Choe, Ju Ran Byeon, Yehyun Park, Eun Mi Song, Seong-Eun Kim, Eui Sun Jeong, Rena Lee, Jin Sung Kim, So Hyun Ahn, Sung Ae Jung

JMIR Med Inform 2025;13:e64987

Proposal for Using AI to Assess Clinical Data Integrity and Generate Metadata: Algorithm Development and Validation

Proposal for Using AI to Assess Clinical Data Integrity and Generate Metadata: Algorithm Development and Validation

Therefore, providing a precise and detailed description of data through metadata when merging heterogeneous sources enables a valid and meaningful integration aimed at ensuring traceable reuse. Metadata assists researchers and users in searching, categorizing, and interpreting data from a data warehouse. In addition, metadata ensures data consistency and facilitates data management [8,9].

Caroline Bönisch, Christian Schmidt, Dorothea Kesztyüs, Hans A Kestler, Tibor Kesztyüs

JMIR Med Inform 2025;13:e60204

Assessing the Psychosocial Impact of Expressive Writing on Adults With Spinal Cord Injury: Qualitative Study

Assessing the Psychosocial Impact of Expressive Writing on Adults With Spinal Cord Injury: Qualitative Study

Once participants understood a prompt, they were given at least 20 minutes to write. After a short break, they were asked to read what they wrote with a spirit of wonder and curiosity as though they were reading a good friend’s writing. They could use the Zoom mute button to read their writing aloud to themselves if they chose. The intent was not to fix, edit, or alter their writing but simply to absorb what they wrote.

Shelly M Xie, Molly McKenna, Kendall Veach, Sydney Williams, Mary Grace Jones, Elizabeth Vander Kamp, Salaam Green, Lauren Edwards, Kimberly Kirklin, Benjamin A Jones, Hon K Yuen

JMIR Form Res 2025;9:e71162

In Vitro Characterization of the Immune Response to an Epitope Ensemble Vaccine Against Rhinovirus in Pediatric Asthma and Adults With Chronic Obstructive Pulmonary Disease: Protocol for an Observational and Exploratory Study

In Vitro Characterization of the Immune Response to an Epitope Ensemble Vaccine Against Rhinovirus in Pediatric Asthma and Adults With Chronic Obstructive Pulmonary Disease: Protocol for an Observational and Exploratory Study

HRV is a small, nonenveloped virus belonging to the Picornaviridae family and the Enterovirus genus. It has a positive-strand RNA genome of approximately 7.2 kb [1,2]. The viral genome is translated into a single polyprotein, which undergoes proteolytic processing to generate 11 distinct viral proteins (Figure 1 A). The HRV capsid is composed of 4 viral proteins (VPs): VP1, VP2, VP3, and VP4 (Figure 1 B).

Sara Alonso Fernandez, Raquel Reyes-Manzanas, Susana Camara, Juan Mozas-Gutierrez, Myriam Calle-Rubio, Juan Rodriguez-Hermosa, Andres Bodas-Pinedo, Santiago Rueda Esteban, Esther M Lafuente, Jesús Reiné, Pedro A Reche

JMIR Res Protoc 2025;14:e73383

ChatGPT-4–Driven Liver Ultrasound Radiomics Analysis: Diagnostic Value and Drawbacks in a Comparative Study

ChatGPT-4–Driven Liver Ultrasound Radiomics Analysis: Diagnostic Value and Drawbacks in a Comparative Study

Beyond radiomics analysis, we evaluated Chat GPT-4 as a tool for distinguishing normal from abnormal cases based on imaging findings. We aimed to demonstrate its capability as a supportive tool in clinical settings. Such a tool could significantly reduce the workload of radiologists by efficiently filtering out normal cases, allowing them to focus their expertise on more complex and abnormal cases.

Laith R Sultan, Shyam Sunder B Venkatakrishna, Sudha A Anupindi, Savvas Andronikou, Michael R Acord, Hansel J Otero, Kassa Darge, Chandra M Sehgal, John H Holmes

JMIR AI 2025;4:e68144

A Virtual Self-Management Intervention for Adolescents With Juvenile Idiopathic Arthritis: Protocol for the VISTA-JIA Randomized Controlled Trial

A Virtual Self-Management Intervention for Adolescents With Juvenile Idiopathic Arthritis: Protocol for the VISTA-JIA Randomized Controlled Trial

Previous needs assessments [12-14] have identified the need for virtual self-management interventions incorporating peer support and for standards of technology delivery and guidance for effective virtual communications in a group setting [20,21]. Our aim is to conduct a pilot multicenter randomized controlled trial (RCT) to evaluate the feasibility and preliminary effectiveness of a virtual group-based SMP for adolescents with JIA in comparison to a waitlist control group.

Jessica Booth, Kathryn A Birnie, Kelsey Chomistek, Maria Santana, Jennifer N Stinson, Babatope O Adebiyi, Julia Brooks, Jaime Guzman, Robin Hellweg, Lily SH Lim, Dax Rumsey, Brian M Feldman, Jamie Tagseth, Jennifer Wilson, Heinrike Schmeling

JMIR Res Protoc 2025;14:e69539

Influence of Virtual Reality Illusions on Balance Performance and Immersive User Experience in Young Adults: A Within-Subject Experimental Study

Influence of Virtual Reality Illusions on Balance Performance and Immersive User Experience in Young Adults: A Within-Subject Experimental Study

It consisted of immersive VR system based on a Head Mounted Display (HMD) (Quest 2; Meta, formerly Oculus), instrumented split belt treadmill (FIT5; Bertec), a safety harness, a personal computer, and a mobile phone camera (i Phone 14; Apple Inc) to record the participants’ gameplay on the monitor of the personal computer. Furthermore, the treadmill has force plates to measure ground reaction forces.

R Achintha M Abayasiri, Antonio Padilha Lanari Bo, Taylor J M Dick, Nilufar Baghaei

JMIR Serious Games 2025;13:e70376

Associations Among Minority Stress, Allostatic Load, and Drug and Alcohol Use in Sexual Minorities: Protocol for the Queer Health Study—a Longitudinal Feasibility Evaluation

Associations Among Minority Stress, Allostatic Load, and Drug and Alcohol Use in Sexual Minorities: Protocol for the Queer Health Study—a Longitudinal Feasibility Evaluation

Another study found that SM young adults who were raised in highly stigmatizing environments demonstrated a blunted cortisol response to a social stressor [12]. In addition to limited studies linking minority stress processes to individual markers of stress physiology, research has revealed that SMs, compared to heterosexuals, demonstrate different stress physiology patterns. For example, Juster et al [13] showed that SM men had a lower allostatic load (AL) than heterosexual men.

Nathan Grant Smith, Tzuan A Chen, Robert-Paul Juster, Ezemenari M Obasi, Jacob S Crocker

JMIR Res Protoc 2025;14:e73070