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Using the Healthy Native Youth Implementation Toolbox to Provide Web-Based Adolescent Health Promotion Decision Support to American Indian and Alaska Native Communities: Implementation Study

Using the Healthy Native Youth Implementation Toolbox to Provide Web-Based Adolescent Health Promotion Decision Support to American Indian and Alaska Native Communities: Implementation Study

The HNY website provides a “one-stop-shop” for Tribal health advocates to access engaging, culturally relevant, age-appropriate health curricula and programs for AI/AN youth within a single website structured to provide implementation decision support [14].

Amrita Sidhu, Ross Shegog, Stephanie Craig-Rushing, Nicole Trevino, Michelle Singer, Cornelia Jessen, Gwenda Gorman, Sean Simpson, Melissa Peskin, Belinda Hernandez, Christine Markham

JMIR Form Res 2025;9:e67885

Developing an Online Community Advisory Board (CAB) of Parents From Social Media to Co-Design an Human Papillomavirus Vaccine Intervention: Participatory Research Study

Developing an Online Community Advisory Board (CAB) of Parents From Social Media to Co-Design an Human Papillomavirus Vaccine Intervention: Participatory Research Study

Community advisory boards (CABs) are a widely integrated methodology in participatory health research to understand community needs, advise research, and ultimately improve health behaviors or health outcomes [1]. Comprising community members, leaders, stakeholders, and others, CABs are united by a common health interest, identity, status, or experience [2].

Regan M Murray, Shawn C Chiang, Ann C Klassen, Jennifer A Manganello, Amy E Leader, Wen-Juo Lo, Philip M Massey

JMIR Form Res 2025;9:e65986

Digital, Personalized Clinical Trials Among Older Adults, Lessons Learned From the COVID-19 Pandemic, and Directions for the Future: Aggregated Feasibility Data From Three Trials Among Older Adults

Digital, Personalized Clinical Trials Among Older Adults, Lessons Learned From the COVID-19 Pandemic, and Directions for the Future: Aggregated Feasibility Data From Three Trials Among Older Adults

Despite the presumed barriers to enrolling older adults in digital, remote clinical research, several trials conducted during the COVID-19 pandemic have succeeded in this pursuit, including a longitudinal brain aging study [20], a telemedicine initiative in a primary care setting [21], telehealth delivery of music therapy services [22], and a digital group intervention addressing worry and social isolation [23].

Lindsay Arader, Danielle Miller, Alexandra Perrin, Frank Vicari, Ciaran P Friel, Elizabeth A Vrany, Ashley M Goodwin, Mark Butler

J Med Internet Res 2025;27:e54629

Testing a Machine Learning–Based Adaptive Motivational System for Socioeconomically Disadvantaged Smokers (Adapt2Quit): Protocol for a Randomized Controlled Trial

Testing a Machine Learning–Based Adaptive Motivational System for Socioeconomically Disadvantaged Smokers (Adapt2Quit): Protocol for a Randomized Controlled Trial

Thus, when a participant is sent a text message, it will be accompanied by a question (see definition in the Data Elements, Statistical Analysis, and Power Calculation for Specific Aims section) asking the participant to rate the text message using the influence ratings question. The participant can choose how frequently they wish to rate the text messages.

Ariana Kamberi, Benjamin Weitz, Julie Flahive, Julianna Eve, Reem Najjar, Tara Liaghat, Daniel Ford, Peter Lindenauer, Sharina Person, Thomas K Houston, Megan E Gauvey-Kern, Jackie Lobien, Rajani S Sadasivam

JMIR Res Protoc 2025;14:e63693

A Digital Photo Activity Intervention for Nursing Home Residents With Dementia and Their Carers: Mixed Methods Process Evaluation

A Digital Photo Activity Intervention for Nursing Home Residents With Dementia and Their Carers: Mixed Methods Process Evaluation

Using the app, informal and formal carers can easily conduct the digital photo activity with residents by accessing a database of artistic, black-and-white, generic photos and making a person-centered selection of digital photos to view with the residents [13], as opposed to having a limited collection of printed photos.

Josephine Rose Orejana Tan, David P Neal, Maria Vilmen, Petra Boersma, Teake P Ettema, Robbert J J Gobbens, Sietske A M Sikkes, Rose-Marie Dröes

JMIR Form Res 2025;9:e56586

Acceptability, Usability, and Insights Into Cybersickness Levels of a Novel Virtual Reality Environment for the Evaluation of Depressive Symptoms: Exploratory Observational Study

Acceptability, Usability, and Insights Into Cybersickness Levels of a Novel Virtual Reality Environment for the Evaluation of Depressive Symptoms: Exploratory Observational Study

: Depression Anxiety Stress Scale-Depression. i DASS-A: Depression Anxiety Stress Scale-Anxiety. j DASS-S: Depression Anxiety Stress Scale-Stress. kj PANAS-Pos: Positive and Negative Affect Schedule – Positive affect l VR: virtual reality. m P n PANAS-Neg: Positive and Negative Affect Schedule – Negative affect o P A post hoc power analysis was conducted to assess the statistical power of the study based on the observed sample size of 100 participants (50 per group).

Sara Sutori, Emma Therése Eliasson, Francesca Mura, Victor Ortiz, Vincenzo Catrambonephd, Gergö Hadlaczky, Ivo Todorov, Antonio Luca Alfeo, Valentina Cardi, Mario G C A Cimino, Giovanna Mioni, Mariano Alcañiz Raya, Gaetano Valenza, Vladimir Carli, Claudio Gentili

JMIR Form Res 2025;9:e68132

iCogCA to Promote Cognitive Health Through Digital Group Interventions for Individuals Living With a Schizophrenia Spectrum Disorder: Protocol for a Nonrandomized Concurrent Controlled Trial

iCogCA to Promote Cognitive Health Through Digital Group Interventions for Individuals Living With a Schizophrenia Spectrum Disorder: Protocol for a Nonrandomized Concurrent Controlled Trial

To test this implementation strategy, we propose a study spanning 5 different mental health care sites across Canada. In collaboration with partners and knowledge users, we will conduct a hybrid effectiveness-implementation trial and create a bilingual digital learning platform (English and French) to ensure the long-term use of these digital interventions nationwide. The first objective of this study is to investigate the clinical effectiveness of the digital modality of ABCR and MCT.

Christy Au-Yeung, Helen Thai, Michael Best, Christopher R Bowie, Synthia Guimond, Katie M Lavigne, Mahesh Menon, Steffen Moritz, Myra Piat, Geneviève Sauvé, Ana Elisa Sousa, Elisabeth Thibaudeau, Todd S Woodward, Martin Lepage, Delphine Raucher-Chéné

JMIR Res Protoc 2025;14:e63269

Methadone Patient Access to Collaborative Treatment: Protocol for a Pilot and a Randomized Controlled Trial to Establish Feasibility of Adoption and Impact on Methadone Treatment Delivery and Patient Outcomes

Methadone Patient Access to Collaborative Treatment: Protocol for a Pilot and a Randomized Controlled Trial to Establish Feasibility of Adoption and Impact on Methadone Treatment Delivery and Patient Outcomes

Individual screening outcomes (results) trigger a curated and immediately presented message regarding self-care, referral to the VA PTSD Coach [38,39] (a downloadable, free application) and referral to the employee assistance program offered as a behavioral health benefit to employees where indicated. Employees will have access to wellness training throughout the MPACT intervention period and can use the self-screener repeatedly if desired.

Beth E Meyerson, Alissa Davis, Richard A Crosby, Linnea B Linde-Krieger, Benjamin R Brady, Gregory A Carter, Arlene N Mahoney, David Frank, Janet Rothers, Zhanette Coffee, Elana Deuble, Jonathon Ebert, Mary F Jablonsky, Marlena Juarez, Barbara Lee, Heather M Lorenz, Michael D Pava, Kristen Tinsely, Sana Yousaf

JMIR Res Protoc 2025;14:e69829

Impact of an Alert-Based Inpatient Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome: Large-Scale, System-Wide Observational Study

Impact of an Alert-Based Inpatient Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome: Large-Scale, System-Wide Observational Study

The index visit was defined as the first order of a culprit medication for a given patient on a given hospitalization (encounter), with only one medication used to define each hospitalization for each patient. As such, a given individual patient could be included more than once, although each encounter (hospitalization) was only used once for each patient under a given culprit medication. The earliest date of enrollment was July 6, 2011, and the latest was April 16, 2024.

Katy E Trinkley, Steven T Simon, Michael A Rosenberg

J Med Internet Res 2025;27:e68256