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The existing literature lacks a systematic pipeline for producing high-quality, label-efficient imputations, along with calibrated causal modeling methods that can generate reliable RWE to complement RCT data.
To advance the use of RWE as a complement to RCTs, we present a tutorial on a pipeline designed to produce reproducible and generalizable RWE on disease outcomes, specifically for evaluating therapies in chronic diseases, using multiple sclerosis (MS) as a demonstration case.
J Med Internet Res 2025;27:e71873
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Moreover, research suggests that more contemporary generations of adults have a greater MCC burden and are diagnosed with MCC at earlier ages than previous generations [6]. Estimation of the prevalence of MCC throughout all stages of adulthood is a critical reflection of the MCC burden; it is important to examine the prevalence of MCC broadly using regularly updated data sources to inform targeted prevention and management strategies and resource prioritization.
JMIR Form Res 2025;9:e69138
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(computer, smartphone, internet, and text message) outside of the traditional F2 F therapy setting; and (4) the article was written in English as a peer-reviewed journal article.
JMIR Ment Health 2025;12:e67670
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However, a key challenge that has impacted the ability to develop strong recommendations on approaches to address EHR-related issues has been limited insight into the impact of these initiatives [9,14,15]. In particular, most of these evaluations have been limited to a single-site pilot with a limited duration and small participant size.
JMIR Hum Factors 2025;12:e65656
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Note-taking during learning has long been a mainstay of educational practice and data over the last 60 years, demonstrating its contribution to improved learning and test scores [1,2]. In 1995, a study on effective note-taking among students reported that free note-taking by learners was a particularly effective process [3]. A 2002 report noted that the most effective way for medical students to perform well was to take written notes on materials prepared in advance by the teachers [4].
JMIR Form Res 2025;9:e55087
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This led to the creation of 2 different scenarios for postpartum hemorrhage, a scenario for eclampsia, a scenario involving fetal distress with a ventouse delivery, and a breech delivery scenario. Both medical-technical and teamwork skills were included in the training, with the difficulty level increasing throughout the day. Every SHO participated in at least 2 scenarios during the 1-day training, while having an observer role in the nonparticipating scenarios.
JMIR Med Educ 2025;11:e54911
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A pilot study with a quasi-experimental pre- and postintervention design will be implemented. As we will try to explore the participants’ characteristics, we want to conduct a pilot study to see the feasibility of this project among these participants. We plan to conduct quasi-experimental pre- and postintervention design, as we found in this setting randomization; case-control is rather difficult.
JMIR Res Protoc 2025;14:e71849
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Sociocentric study designs collect information about a “complete” network among members of a population or cohort of interest, whereas egocentric studies focus on the network of contacts that immediately surround a focal individual (ego) and often collect information from subgroups sampled from a larger population [1,9].
JMIR Public Health Surveill 2025;11:e64497
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Next, we launched a nationwide Google Ad campaign. Advertisement-derived interest surveys identified potential participants who were then contacted by phone. Interest surveys reported the mode of recruitment through a single-choice answer of “a website,” “Facebook,” “Instagram,” “Google,” “referral,” or “other.” More detailed responses for choices like “other” were obtained through free response options. Referrals are defined as participants referred to the study by family, friends, or a physician.
J Med Internet Res 2025;27:e63712
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Because if you say, “Well, I’m a woman, a teenager, a girl,” it would give you more tailored options, right?
Participants emphasized the importance of being heard, suggesting the platform should offer options for discussing MH with professionals via videoconference, call, or chat while also highlighting the need for both crisis support and follow-up care (annotations: 33/504, CF=6.5%).
JMIR Hum Factors 2025;12:e66558
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