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Temporal Dynamics of Subtle Cognitive Change: Validation of a User-Friendly Multidomain Digital Assessment Using an Alcohol Challenge

Temporal Dynamics of Subtle Cognitive Change: Validation of a User-Friendly Multidomain Digital Assessment Using an Alcohol Challenge

Respondents are asked to place a mark on the line representing their current feeling of intoxication, and its position is later measured using a ruler to extract a value. The experiment follows a repeated-measures, placebo-controlled (single-blind) crossover within-participant design (see Figure 3). The order of treatment was counterbalanced, such that half of the participants (n=15) received alcohol in their first session and a placebo in their second.

John Frederick Dyer, Florentine Marie Barbey, Ayan Ghoshal, Ann Marie Hake, Bryan J Hansen, Md Nurul Islam, Judith Jaeger, Rouba Kozak, Hugh Marston, Mark Moss, Viet Nguyen, Rebecca Louise Quinn, Leslie A Shinobu, Elizabeth Tunbridge, Brian Murphy, Niamh Kennedy

J Med Internet Res 2025;27:e55469

Effect of an Online Mobility Self-Management Program on Walking Speed in Older Adults With Preclinical Mobility Limitation: Protocol for a Randomized Controlled Trial

Effect of an Online Mobility Self-Management Program on Walking Speed in Older Adults With Preclinical Mobility Limitation: Protocol for a Randomized Controlled Trial

The instructions will describe the setup required for the assessment and a list of equipment needed (measuring tape, chair, and masking tape to mark distances). If the participant is unable to secure these items independently, they will be mailed to them before their baseline assessment. The same physiotherapist blinded to group assignment will perform baseline and follow-up assessments for a given participant. All trial assessments will be conducted virtually using the Zoom platform.

Julie Richardson, Ayse Kuspinar, Susanne Sinclair, Marla Beauchamp, Sinead Dufour, Ada Tang, Joy MacDermid, Evelyne Durocher, Lehana Thabane, Feng Xie, Andrew Costa

JMIR Res Protoc 2025;14:e72585