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Clinical Prediction Models Incorporating Blood Test Trend for Cancer Detection: Systematic Review, Meta-Analysis, and Critical Appraisal

Clinical Prediction Models Incorporating Blood Test Trend for Cancer Detection: Systematic Review, Meta-Analysis, and Critical Appraisal

We included any in-human primary research article reporting the development or validation of a diagnostic clinical risk prediction model using a prediagnostic trend over repeat measurements of at least one blood test parameter (Table 1) for subsequent diagnosis of cancer. A prediction model was defined as any multivariable model designed to predict the presence of undiagnosed cancer (outcome), where at least one predictor in the model was a blood test trend.

Pradeep S Virdee, Kiana K Collins, Claire Friedemann Smith, Xin Yang, Sufen Zhu, Nia Roberts, Jason L Oke, Clare Bankhead, Rafael Perera, FD Richard Hobbs, Brian D Nicholson

JMIR Cancer 2025;11:e70275

Validation of the Perceived Barriers to Antiretroviral Therapy Adherence (PEDIA) Scale Among Gay, Bisexual, and Other Men Who Have Sex With Men and Transgender and Nonbinary Persons: Cross-Sectional Study

Validation of the Perceived Barriers to Antiretroviral Therapy Adherence (PEDIA) Scale Among Gay, Bisexual, and Other Men Who Have Sex With Men and Transgender and Nonbinary Persons: Cross-Sectional Study

However, ART adherence is a challenge for people living with HIV across multiple settings and populations [2]. Brazil’s HIV epidemic is characterized as a concentrated epidemic, with specific populations bearing a disproportionate burden of the disease. Among these groups, gay, bisexual, other men who have sex with men (MSM), and transgender and nonbinary (TGNB) persons are one of the most severely affected population groups.

Victor C Matos, Dyego Carlos Araújo, Thiago S Torres, Paula M Luz

JMIR Public Health Surveill 2025;11:e67005

A Virtual Self-Management Intervention for Adolescents With Juvenile Idiopathic Arthritis: Protocol for the VISTA-JIA Randomized Controlled Trial

A Virtual Self-Management Intervention for Adolescents With Juvenile Idiopathic Arthritis: Protocol for the VISTA-JIA Randomized Controlled Trial

Previous needs assessments [12-14] have identified the need for virtual self-management interventions incorporating peer support and for standards of technology delivery and guidance for effective virtual communications in a group setting [20,21]. Our aim is to conduct a pilot multicenter randomized controlled trial (RCT) to evaluate the feasibility and preliminary effectiveness of a virtual group-based SMP for adolescents with JIA in comparison to a waitlist control group.

Jessica Booth, Kathryn A Birnie, Kelsey Chomistek, Maria Santana, Jennifer N Stinson, Babatope O Adebiyi, Julia Brooks, Jaime Guzman, Robin Hellweg, Lily SH Lim, Dax Rumsey, Brian M Feldman, Jamie Tagseth, Jennifer Wilson, Heinrike Schmeling

JMIR Res Protoc 2025;14:e69539

Validation and Comparison of Pediatric Appendicitis Scores and Management Strategies (Project SPASMS): Protocol for a Prospective Multicenter Observational Study

Validation and Comparison of Pediatric Appendicitis Scores and Management Strategies (Project SPASMS): Protocol for a Prospective Multicenter Observational Study

If the study participant is transferred from a nonstudy site to a study site, the data collection form will be completed by the initial treating physician at the study site; if the study participant is transferred from a study site to a second study site, this will ideally be completed by the initial treating physician at the first study site.

Wei Hao Lee, Sharon O'Brien, Elizabeth J Mckinnon, Simon Craig, Stuart Dalziel, Michael Collin, Natalie Phillips, Franz E Babl, Sarah Julia Davidson, Shane George, Shefali Jani, Doris Tham, Viet Tran, Meredith L Borland

JMIR Res Protoc 2025;14:e67941

Influence of Virtual Reality Illusions on Balance Performance and Immersive User Experience in Young Adults: A Within-Subject Experimental Study

Influence of Virtual Reality Illusions on Balance Performance and Immersive User Experience in Young Adults: A Within-Subject Experimental Study

A total of 15 healthy young adults (8 male and 7 female participants; mean age 27.7, SD 3.8 years; mean height 1.7, SD 0.1 m; mean weight 73.62, SD 16.9 kg) were recruited through advertisements posted on university notice boards, social media, and by word of mouth. Once participants expressed their interest, the research team contacted them via email to provide detailed information about the study and confirm their participation. All the recruited participants were reported to be right-hand dominant.

R Achintha M Abayasiri, Antonio Padilha Lanari Bo, Taylor J M Dick, Nilufar Baghaei

JMIR Serious Games 2025;13:e70376

Associations Among Minority Stress, Allostatic Load, and Drug and Alcohol Use in Sexual Minorities: Protocol for the Queer Health Study—a Longitudinal Feasibility Evaluation

Associations Among Minority Stress, Allostatic Load, and Drug and Alcohol Use in Sexual Minorities: Protocol for the Queer Health Study—a Longitudinal Feasibility Evaluation

Another study found that SM young adults who were raised in highly stigmatizing environments demonstrated a blunted cortisol response to a social stressor [12]. In addition to limited studies linking minority stress processes to individual markers of stress physiology, research has revealed that SMs, compared to heterosexuals, demonstrate different stress physiology patterns. For example, Juster et al [13] showed that SM men had a lower allostatic load (AL) than heterosexual men.

Nathan Grant Smith, Tzuan A Chen, Robert-Paul Juster, Ezemenari M Obasi, Jacob S Crocker

JMIR Res Protoc 2025;14:e73070

Public Perception of the Brain-Computer Interface Based on a Decade of Data on X: Mixed Methods Study

Public Perception of the Brain-Computer Interface Based on a Decade of Data on X: Mixed Methods Study

Words that are more opinion-based (eg, scary and amazing) have a higher subjectivity score, whereas words that are fact-based (eg, data and communication) have a lower subjectivity score. The threshold used in our study is a subjectivity score of 0.5. If the score is greater than or equal to 0.5, the post is labeled as “subjective,” otherwise the post is labeled as “objective.”

Mohammed A Almanna, Lior M Elkaim, Mohammed A Alvi, Jordan J Levett, Ben Li, Muhammad Mamdani, Mohammed Al‑Omran, Naif M Alotaibi

JMIR Form Res 2025;9:e60859

Impact of a Novel Electronic Medical Record–Integrated Electronic Form (Provider Asthma Assessment Form) and Severe Asthma Algorithm in Primary Care: Single-Center, Pre- and Postobservational Study

Impact of a Novel Electronic Medical Record–Integrated Electronic Form (Provider Asthma Assessment Form) and Severe Asthma Algorithm in Primary Care: Single-Center, Pre- and Postobservational Study

Initial implementation was conducted by a site champion, a first-year family medicine resident at the FHT. The PAAF was initially introduced by the site champion to attending and resident physicians through a presentation and via email. Subsequent implementation efforts throughout the course of the study period included a reminder poster in the FHT clinic team rooms about the PAAF and how to access it in OSCAR.

Matheson L McFarlane, Alison Morra, Delanya Podgers, David Barber, M Diane Lougheed

JMIR Form Res 2025;9:e74043