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A Responsible Framework for Assessing, Selecting, and Explaining Machine Learning Models in Cardiovascular Disease Outcomes Among People With Type 2 Diabetes: Methodology and Validation Study

A Responsible Framework for Assessing, Selecting, and Explaining Machine Learning Models in Cardiovascular Disease Outcomes Among People With Type 2 Diabetes: Methodology and Validation Study

Then, a sensitivity analysis of the trade-off between these performance metrics is carried out to aid model selection. Finally, for model explanation, we use a unified approach that combines multiple methods to explain the best-performing models.

Yang Yang, Che-Yi Liao, Esmaeil Keyvanshokooh, Hui Shao, Mary Beth Weber, Francisco J Pasquel, Gian-Gabriel P Garcia

JMIR Med Inform 2025;13:e66200

A Virtual Self-Management Intervention for Adolescents With Juvenile Idiopathic Arthritis: Protocol for the VISTA-JIA Randomized Controlled Trial

A Virtual Self-Management Intervention for Adolescents With Juvenile Idiopathic Arthritis: Protocol for the VISTA-JIA Randomized Controlled Trial

Previous needs assessments [12-14] have identified the need for virtual self-management interventions incorporating peer support and for standards of technology delivery and guidance for effective virtual communications in a group setting [20,21]. Our aim is to conduct a pilot multicenter randomized controlled trial (RCT) to evaluate the feasibility and preliminary effectiveness of a virtual group-based SMP for adolescents with JIA in comparison to a waitlist control group.

Jessica Booth, Kathryn A Birnie, Kelsey Chomistek, Maria Santana, Jennifer N Stinson, Babatope O Adebiyi, Julia Brooks, Jaime Guzman, Robin Hellweg, Lily SH Lim, Dax Rumsey, Brian M Feldman, Jamie Tagseth, Jennifer Wilson, Heinrike Schmeling

JMIR Res Protoc 2025;14:e69539

Validation and Comparison of Pediatric Appendicitis Scores and Management Strategies (Project SPASMS): Protocol for a Prospective Multicenter Observational Study

Validation and Comparison of Pediatric Appendicitis Scores and Management Strategies (Project SPASMS): Protocol for a Prospective Multicenter Observational Study

If the study participant is transferred from a nonstudy site to a study site, the data collection form will be completed by the initial treating physician at the study site; if the study participant is transferred from a study site to a second study site, this will ideally be completed by the initial treating physician at the first study site.

Wei Hao Lee, Sharon O'Brien, Elizabeth J Mckinnon, Simon Craig, Stuart Dalziel, Michael Collin, Natalie Phillips, Franz E Babl, Sarah Julia Davidson, Shane George, Shefali Jani, Doris Tham, Viet Tran, Meredith L Borland

JMIR Res Protoc 2025;14:e67941

Mediating Effects of Psychological Independence and Social Support on the Association Between Family Strength and Depression in Young Korean Adults: Cross-Sectional Study

Mediating Effects of Psychological Independence and Social Support on the Association Between Family Strength and Depression in Young Korean Adults: Cross-Sectional Study

A cross-sectional web-based survey was conducted among 1,000 young Korean adults aged 19‐24 years. This study adhered to the STROBE (Strengthening the Reporting of Observational Studies) guidelines, ensuring rigorous compliance with the reporting standards for cross-sectional studies. Using the G-power version 3.1.9.4 program [25], the required sample size was calculated based on a significance level of 5%, statistical power of 85%, an effect size of 0.02 (small), and 11 predictors.

Sunyoung Kim, Suin Park, Hyunlye Kim, Dabok Noh

JMIR Form Res 2025;9:e71485

Influence of Virtual Reality Illusions on Balance Performance and Immersive User Experience in Young Adults: A Within-Subject Experimental Study

Influence of Virtual Reality Illusions on Balance Performance and Immersive User Experience in Young Adults: A Within-Subject Experimental Study

It consisted of immersive VR system based on a Head Mounted Display (HMD) (Quest 2; Meta, formerly Oculus), instrumented split belt treadmill (FIT5; Bertec), a safety harness, a personal computer, and a mobile phone camera (i Phone 14; Apple Inc) to record the participants’ gameplay on the monitor of the personal computer. Furthermore, the treadmill has force plates to measure ground reaction forces.

R Achintha M Abayasiri, Antonio Padilha Lanari Bo, Taylor J M Dick, Nilufar Baghaei

JMIR Serious Games 2025;13:e70376

Empowering Capabilities of People With Chronic Conditions Supported by Digital Health Technologies: Scoping Review

Empowering Capabilities of People With Chronic Conditions Supported by Digital Health Technologies: Scoping Review

For example, if a patient’s ability to learn more about their health condition is a valued capability for their empowerment, then they need to be able to use DHTs for this purpose, which requires sufficient digital literacy (a personal conversion factor) and internet access (an external conversion factor). Figure 1 illustrates the core components of the capability approach applied to patient empowerment through DHTs based on adapted concepts from Robeyns [29].

Messaline Fomo, Liyousew G Borga, Thomas Abel, Philip S Santangelo, Sara Riggare, Jochen Klucken, Ivana Paccoud

J Med Internet Res 2025;27:e68458

Associations Among Minority Stress, Allostatic Load, and Drug and Alcohol Use in Sexual Minorities: Protocol for the Queer Health Study—a Longitudinal Feasibility Evaluation

Associations Among Minority Stress, Allostatic Load, and Drug and Alcohol Use in Sexual Minorities: Protocol for the Queer Health Study—a Longitudinal Feasibility Evaluation

Another study found that SM young adults who were raised in highly stigmatizing environments demonstrated a blunted cortisol response to a social stressor [12]. In addition to limited studies linking minority stress processes to individual markers of stress physiology, research has revealed that SMs, compared to heterosexuals, demonstrate different stress physiology patterns. For example, Juster et al [13] showed that SM men had a lower allostatic load (AL) than heterosexual men.

Nathan Grant Smith, Tzuan A Chen, Robert-Paul Juster, Ezemenari M Obasi, Jacob S Crocker

JMIR Res Protoc 2025;14:e73070

Gender-Based Susceptibility to Mental Health Issues in Adolescents During the COVID-19 Pandemic: Descriptive Study

Gender-Based Susceptibility to Mental Health Issues in Adolescents During the COVID-19 Pandemic: Descriptive Study

The shift to online learning and reduced physical and social activity has marked a drastic change in adolescents’ lifestyles, contributing to increased screen time and more sedentary behaviors [11]. In the United States, there was a 50.6% rise in emergency department visits by adolescent girls for suicide attempts in February 2021 compared to 2019 [12].

Young-Shin Lee, Minjeong Kim, Kim Moreno

Asian Pac Isl Nurs J 2025;9:e63284

Public Perception of the Brain-Computer Interface Based on a Decade of Data on X: Mixed Methods Study

Public Perception of the Brain-Computer Interface Based on a Decade of Data on X: Mixed Methods Study

Words that are more opinion-based (eg, scary and amazing) have a higher subjectivity score, whereas words that are fact-based (eg, data and communication) have a lower subjectivity score. The threshold used in our study is a subjectivity score of 0.5. If the score is greater than or equal to 0.5, the post is labeled as “subjective,” otherwise the post is labeled as “objective.”

Mohammed A Almanna, Lior M Elkaim, Mohammed A Alvi, Jordan J Levett, Ben Li, Muhammad Mamdani, Mohammed Al‑Omran, Naif M Alotaibi

JMIR Form Res 2025;9:e60859