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Clinical Efficacy and Safety of the Herbal Prescription, HH333, in Preventing Recurrent Stroke in Patients With Ischemic Stroke Induced by Small-Vessel Disease: Protocol for Multicenter, Double-Blind, Randomized, Prospective, Pilot Clinical Trial

Clinical Efficacy and Safety of the Herbal Prescription, HH333, in Preventing Recurrent Stroke in Patients With Ischemic Stroke Induced by Small-Vessel Disease: Protocol for Multicenter, Double-Blind, Randomized, Prospective, Pilot Clinical Trial

Total scores on the Fatigue Severity Scale (FSS), Fatigue Assessment Scale (FAS), Korean Patient Health Questionnaire (K-PHQ-9), and the probability of each type of Pattern Identification (fire heat, dampness-phlegm, qi deficiency or yin deficiency) will be evaluated as secondary efficacy endpoints at baseline and 90, 180, 270, 360, 450, 540, 630, and 720 days after starting medication.

Han-Gyul Lee, Seungwon Kwon, Woo-Sang Jung, Sang-Kwan Moon, Cheol-Hyun Kim, Dong-Jun Choi

JMIR Res Protoc 2025;14:e70953