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Developing an Online Community Advisory Board (CAB) of Parents From Social Media to Co-Design an Human Papillomavirus Vaccine Intervention: Participatory Research Study

Developing an Online Community Advisory Board (CAB) of Parents From Social Media to Co-Design an Human Papillomavirus Vaccine Intervention: Participatory Research Study

Community advisory boards (CABs) are a widely integrated methodology in participatory health research to understand community needs, advise research, and ultimately improve health behaviors or health outcomes [1]. Comprising community members, leaders, stakeholders, and others, CABs are united by a common health interest, identity, status, or experience [2].

Regan M Murray, Shawn C Chiang, Ann C Klassen, Jennifer A Manganello, Amy E Leader, Wen-Juo Lo, Philip M Massey

JMIR Form Res 2025;9:e65986

Digital, Personalized Clinical Trials Among Older Adults, Lessons Learned From the COVID-19 Pandemic, and Directions for the Future: Aggregated Feasibility Data From Three Trials Among Older Adults

Digital, Personalized Clinical Trials Among Older Adults, Lessons Learned From the COVID-19 Pandemic, and Directions for the Future: Aggregated Feasibility Data From Three Trials Among Older Adults

Despite the presumed barriers to enrolling older adults in digital, remote clinical research, several trials conducted during the COVID-19 pandemic have succeeded in this pursuit, including a longitudinal brain aging study [20], a telemedicine initiative in a primary care setting [21], telehealth delivery of music therapy services [22], and a digital group intervention addressing worry and social isolation [23].

Lindsay Arader, Danielle Miller, Alexandra Perrin, Frank Vicari, Ciaran P Friel, Elizabeth A Vrany, Ashley M Goodwin, Mark Butler

J Med Internet Res 2025;27:e54629

Testing a Machine Learning–Based Adaptive Motivational System for Socioeconomically Disadvantaged Smokers (Adapt2Quit): Protocol for a Randomized Controlled Trial

Testing a Machine Learning–Based Adaptive Motivational System for Socioeconomically Disadvantaged Smokers (Adapt2Quit): Protocol for a Randomized Controlled Trial

Thus, when a participant is sent a text message, it will be accompanied by a question (see definition in the Data Elements, Statistical Analysis, and Power Calculation for Specific Aims section) asking the participant to rate the text message using the influence ratings question. The participant can choose how frequently they wish to rate the text messages.

Ariana Kamberi, Benjamin Weitz, Julie Flahive, Julianna Eve, Reem Najjar, Tara Liaghat, Daniel Ford, Peter Lindenauer, Sharina Person, Thomas K Houston, Megan E Gauvey-Kern, Jackie Lobien, Rajani S Sadasivam

JMIR Res Protoc 2025;14:e63693

A Digital Photo Activity Intervention for Nursing Home Residents With Dementia and Their Carers: Mixed Methods Process Evaluation

A Digital Photo Activity Intervention for Nursing Home Residents With Dementia and Their Carers: Mixed Methods Process Evaluation

Using the app, informal and formal carers can easily conduct the digital photo activity with residents by accessing a database of artistic, black-and-white, generic photos and making a person-centered selection of digital photos to view with the residents [13], as opposed to having a limited collection of printed photos.

Josephine Rose Orejana Tan, David P Neal, Maria Vilmen, Petra Boersma, Teake P Ettema, Robbert J J Gobbens, Sietske A M Sikkes, Rose-Marie Dröes

JMIR Form Res 2025;9:e56586

Acceptability, Usability, and Insights Into Cybersickness Levels of a Novel Virtual Reality Environment for the Evaluation of Depressive Symptoms: Exploratory Observational Study

Acceptability, Usability, and Insights Into Cybersickness Levels of a Novel Virtual Reality Environment for the Evaluation of Depressive Symptoms: Exploratory Observational Study

The VR system was developed using the HP Reverb G2 Omnicept Edition headset, which includes a variety of biometric sensors such as eye tracking, a facial camera (lower), a heart rate sensor, and sensors for brain activity while maintaining the core features of the standard version. These features include a resolution of 2160 × 2160 px per eye, a 114° field of view, a 90 Hz refresh rate, and integrated audio.

Sara Sutori, Emma Therése Eliasson, Francesca Mura, Victor Ortiz, Vincenzo Catrambonephd, Gergö Hadlaczky, Ivo Todorov, Antonio Luca Alfeo, Valentina Cardi, Mario G C A Cimino, Giovanna Mioni, Mariano Alcañiz Raya, Gaetano Valenza, Vladimir Carli, Claudio Gentili

JMIR Form Res 2025;9:e68132

Methadone Patient Access to Collaborative Treatment: Protocol for a Pilot and a Randomized Controlled Trial to Establish Feasibility of Adoption and Impact on Methadone Treatment Delivery and Patient Outcomes

Methadone Patient Access to Collaborative Treatment: Protocol for a Pilot and a Randomized Controlled Trial to Establish Feasibility of Adoption and Impact on Methadone Treatment Delivery and Patient Outcomes

The creation of a trauma-informed codevelopment space was crucial to facilitate safer and more open discussions. To accomplish this, we established a parallel, intervention refinement process using a helical structure developed by this team and based on our prior research with structural indicators for community-based participatory action research [33]. As shown in Figure 2, the “hand off” of work drives an iterative (helical) thinking process.

Beth E Meyerson, Alissa Davis, Richard A Crosby, Linnea B Linde-Krieger, Benjamin R Brady, Gregory A Carter, Arlene N Mahoney, David Frank, Janet Rothers, Zhanette Coffee, Elana Deuble, Jonathon Ebert, Mary F Jablonsky, Marlena Juarez, Barbara Lee, Heather M Lorenz, Michael D Pava, Kristen Tinsely, Sana Yousaf

JMIR Res Protoc 2025;14:e69829

Impact of an Alert-Based Inpatient Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome: Large-Scale, System-Wide Observational Study

Impact of an Alert-Based Inpatient Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome: Large-Scale, System-Wide Observational Study

The index visit was defined as the first order of a culprit medication for a given patient on a given hospitalization (encounter), with only one medication used to define each hospitalization for each patient. As such, a given individual patient could be included more than once, although each encounter (hospitalization) was only used once for each patient under a given culprit medication. The earliest date of enrollment was July 6, 2011, and the latest was April 16, 2024.

Katy E Trinkley, Steven T Simon, Michael A Rosenberg

J Med Internet Res 2025;27:e68256

Designing eHealth Interventions for Pediatric Emergency Departments: Protocol for a Usability Testing Study With Youth, Parent, and Clinician Participants

Designing eHealth Interventions for Pediatric Emergency Departments: Protocol for a Usability Testing Study With Youth, Parent, and Clinician Participants

The International Organization for Standardization describes usability as “the extent to which a system, product or service can be used by specified users to achieve specified goals with effectiveness, efficiency and satisfaction in a specified context of use” [1]. Usability testing is a method in which a product is evaluated by users as they perform tasks, and may include formative or summative testing [2].

Mari Somerville, Lori Wozney, Allyson Gallant, Janet A Curran

JMIR Res Protoc 2025;14:e64350

Early Detection of Type 1 Diabetes in First-Degree Relatives in Saudi Arabia (VISION-T1D): Protocol for a Pilot Implementation Study

Early Detection of Type 1 Diabetes in First-Degree Relatives in Saudi Arabia (VISION-T1D): Protocol for a Pilot Implementation Study

To enhance recruitment, a home testing option is provided, allowing families to conveniently perform finger-prick testing and data collection at home. After screening results are available, a research physician reviews the findings. Participants who test positive for islet autoantibodies are invited to a follow-up visit that includes personalized counseling, targeted educational interventions, and additional metabolic staging to determine their T1 D stage.

Iman S Algadi, Yazed AlRuthia, Muhammad H Mujammami, Khaled Hani Aburisheh, Metib Alotaibi, Sharifah Al Issa, Amal A Al-Saif, David Seftel, Cheng-Ting Tsai, Reem A Al Khalifah

JMIR Res Protoc 2025;14:e70575