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In addition to significant and large (r>0.90) positive associations between fat mass and circulating leptin levels [21], weight loss impacts leptin levels independently of BMI [21,22]. Our previous work supported a significant association between greater WS and lower leptin levels, controlling for BMI [23,24] and body fat percentage [23].
JMIR Res Protoc 2025;14:e66554
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The PMIS (Pearson r=−0.76; P
As we examined the sensitivity and specificity data to choose cut scores, we chose to favor sensitivity to minimize missing individuals with true disease in this sample of patients considered high risk because of their cognitive concerns. The cut scores for a positive result on the 5-Cog components were as follows: PMIS ≤6 (range 0-8), Symbol Match ≤25 (range 0-65), and s MCR >5 (range 0-7).
JMIR Res Protoc 2025;14:e60471
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The application of this mapping to the data was performed using R version 4.3.2 (R Foundation for Statistical Computing). The full list of diagnosis names corresponding to ADRD diagnosis categories is provided in Multimedia Appendix 1.
To assess associations between clusters and sex, as well as ADRD diagnoses, we used the chi-square test.
JMIR Aging 2025;8:e65178
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