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Approach to Design and Evaluate Digital Tools to Enhance Young Adult Participation in Clinical Trials: Co-Design and Controlled Intercept Study

Approach to Design and Evaluate Digital Tools to Enhance Young Adult Participation in Clinical Trials: Co-Design and Controlled Intercept Study

COVID-19 vaccine–related keywords “COVID-19 vaccine”, “COVID 19 vaccine”, “SARS-Co V2 vaccine”, “Coronavirus disease 2019 vaccine”, “m RNA-1273”, “Pfizer; Bio NTech”, “BNT162”, “Moderna”, “J&J” “Johnson & Johnson” Clinical trial–related keywords “Clinical trial”, “trial” Adapted inductive content coding approach of objective and subjective factors for clinical trial participation used in social listening analysis on Quora.

Tim Mackey, Raphael E Cuomo, Qing Xu, Tiana J McMann, Zhuoran Li, Mingxiang Cai, Christine Wenzel, Joshua S Yang

J Med Internet Res 2025;27:e70852

Identifying Intersecting Factors Associated With Suicidal Thoughts and Behaviors Among Transgender and Gender Diverse Adults: Preliminary Conditional Inference Tree Analysis

Identifying Intersecting Factors Associated With Suicidal Thoughts and Behaviors Among Transgender and Gender Diverse Adults: Preliminary Conditional Inference Tree Analysis

Conditional inference trees model the nonlinear relationships between a wide range of predictors and an outcome. As a data mining approach, the conditional inference tree is a data-driven analytic strategy that identifies interacting social determinants from many candidate predictors to determine which predictors are most relevant to specific outcomes.

Amelia M Stanton, Lauren A Trichtinger, Norik Kirakosian, Simon M Li, Katherine E Kabel, Kiyan Irani, Alexandra H Bettis, Conall O’Cleirigh, Richard T Liu, Qimin Liu

J Med Internet Res 2025;27:e65452

Motivation Theories and Constructs in Experimental Studies of Online Instruction: Systematic Review and Directed Content Analysis

Motivation Theories and Constructs in Experimental Studies of Online Instruction: Systematic Review and Directed Content Analysis

For example, medical students completing an online module on a basic science topic may be confident in their ability to learn but struggle to see the value in the material beyond their next examination. Conversely, students completing a virtual examination with a standardized patient may see the value in what they are learning but not feel confident in their ability to succeed.

Adam Gavarkovs, Erin Miller, Jaimie Coleman, Tharsiga Gunasegaran, Rashmi A Kusurkar, Kulamakan Kulasegaram, Melanie Anderson, Ryan Brydges

JMIR Med Educ 2025;11:e64179

A Web-Based Tool to Perform a Values Clarification for Stroke Prevention in Patients With Atrial Fibrillation: Design and Preliminary Testing Study

A Web-Based Tool to Perform a Values Clarification for Stroke Prevention in Patients With Atrial Fibrillation: Design and Preliminary Testing Study

In a wide variety of patients with AF, anticoagulation reduces the risk of ischemic stroke by 65% with a relative 2-fold increase in major extracranial bleeding compared to placebo [1-3]. Yet, medication responses vary across patients.

Michael P Dorsch, Allen J Flynn, Kaitlyn M Greer, Sabah Ganai, Geoffrey D Barnes, Brian Zikmund-Fisher

JMIR Cardio 2025;9:e67956

Development of an eHealth Mindfulness-Based Music Therapy Intervention for Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: Qualitative Study

Development of an eHealth Mindfulness-Based Music Therapy Intervention for Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: Qualitative Study

Participants (N=11; mean age 43.6, SD 17.8; range 19‐76 years) were female (55%, n=6), White (91%, n=10), Hispanic (73%, n=8), with a history of acute myeloid leukemia (100%, n=11), and a mean time of 1.64 (SD 0.81) years post-SCT at the time of the focus groups.

Sara E Fleszar-Pavlovic, Blanca Noriega Esquives, Padideh Lovan, Arianna E Brito, Ann Marie Sia, Mary Adelyn Kauffman, Maria Lopes, Patricia I Moreno, Tulay Koru-Sengul, Rui Gong, Trent Wang, Eric D Wieder, Maria Rueda-Lara, Michael Antoni, Krishna Komanduri, Teresa Lesiuk, Frank J Penedo

JMIR Form Res 2025;9:e65188

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

The aim of this study is to develop risk calculators that best predict (1) a mother’s risk of having a neonate with abnormal fetal growth (large for gestational age [LGA] or small for gestational age [SGA]); (2) a mother’s risk of having a serious adverse neonatal outcome; and (3) a mother’s risk of developing new metabolic disease after pregnancy (Figure 1).

Sarah A L Price, Digsu N Koye, Alice Lewin, Alison Nankervis, Stefan C Kane

JMIR Res Protoc 2025;14:e72542

Ethical Design of Data-Driven Decision Support Tools for Improving Cancer Care: Embedded Ethics Review of the 4D PICTURE Project

Ethical Design of Data-Driven Decision Support Tools for Improving Cancer Care: Embedded Ethics Review of the 4D PICTURE Project

Feeding into the Metro Map will be the results of two types of models developed in the project: (1) a treatment outcome prediction tool for each cancer type and (2) a conversation tool developed by analyzing patient experiences through text mining. The result of integrating these data-driven tools into the Metro Map will be a personal care path navigator for each patient that serves as a decision aid in shared decision-making.

Marieke Bak, Laura Hartman, Charlotte Graafland, Ida J Korfage, Alena Buyx, Maartje Schermer, 4D PICTURE Consortium

JMIR Cancer 2025;11:e65566

Comparison of Deep Learning Approaches Using Chest Radiographs for Predicting Clinical Deterioration: Retrospective Observational Study

Comparison of Deep Learning Approaches Using Chest Radiographs for Predicting Clinical Deterioration: Retrospective Observational Study

Furthermore, this simplifies the prediction task to a single time point, making it more feasible to compare multiple models and augmentation strategies. Patients with a chest radiograph within 48 hours before the first elevated e CART score were included in the study. Available anterior-posterior or posterior-anterior views were included in the study cohort.

Mahmudur Rahman, Jifan Gao, Kyle A Carey, Dana P Edelson, Askar Afshar, John W Garrett, Guanhua Chen, Majid Afshar, Matthew M Churpek

JMIR AI 2025;4:e67144

Provider Perspectives on Implementing an Enhanced Digital Screening for Adolescent Depression and Suicidality: Qualitative Study

Provider Perspectives on Implementing an Enhanced Digital Screening for Adolescent Depression and Suicidality: Qualitative Study

Transcripts were coded by the first author following a template analysis approach [18] with NVivo software (version 14; Lumivero), using a prespecified codebook. The codebook was created according to a hybrid approach, using a deductive approach to generate high-level codes based on the CFIR Codebook Template [15], and an inductive approach to incorporate themes that arose from the data [19].

Morgan A Coren, Oliver Lindhiem, Abby R Angus, Emma K Toevs, Ana Radovic

JMIR Form Res 2025;9:e67624

Safety and Efficacy of Modular Digital Psychotherapy for Social Anxiety: Randomized Controlled Trial

Safety and Efficacy of Modular Digital Psychotherapy for Social Anxiety: Randomized Controlled Trial

Social anxiety disorder (SAD) is a prevalent and debilitating mental health challenge that affects a substantial portion of the global population at some point in their lives [1,2]. Characterized by a persistent fear of social situations, SAD can severely limit a person’s ability to engage in everyday activities, from forming personal relationships to navigating work and educational settings.

Mona M Garvert, Jessica McFadyen, Stuart Linke, Tayla McCloud, Sofie S Meyer, Sandra Sobanska, Paul B Sharp, Alex Long, Quentin J M Huys, Mandana Ahmadi

J Med Internet Res 2025;27:e64138