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Leveraging Cognitive and Speech Ecological Momentary Assessment in Individuals With Phenylketonuria: Development and Usability Study of Cognitive Fluctuations in a Rare Disease Population

Leveraging Cognitive and Speech Ecological Momentary Assessment in Individuals With Phenylketonuria: Development and Usability Study of Cognitive Fluctuations in a Rare Disease Population

A brief description of the tests used are below, with further detailed information and psychometric characteristics described in Germine et al [38] and Singh et al [28]. In digit symbol matching (DSM) [22,26,39], participants are presented with 6 symbols, each of which are paired with a single digit between 1 and 3 (ie, 2 symbols were paired with each digit). These pairings remain visible throughout the duration of the test.

Shifali Singh, Lisa Kluen, Katelin Curtis, Raquel Norel, Carla Agurto, Elizabeth Grinspoon, Zoe Hawks, Shawn Christ, Susan Waisbren, Guillermo Cecchi, Laura Germine

JMIR Form Res 2025;9:e63644

Glycemic Variability and Fluctuations in Cognitive Status in Adults With Type 1 Diabetes (GluCog): Observational Study Using Ecological Momentary Assessment of Cognition

Glycemic Variability and Fluctuations in Cognitive Status in Adults With Type 1 Diabetes (GluCog): Observational Study Using Ecological Momentary Assessment of Cognition

The study, led by principal investigators Dr Laura Germine of Mc Lean Hospital and Dr Naomi Chaytor of Washington State University, uses the EMA of cognitive performance and self-report data, coupled with blinded CGM. Four endocrinology centers (SUNY Upstate Medical University, University of Pennsylvania, Mayo Clinic, and Advent Health Diabetes Institute), with central clinical site coordination by the Jaeb Center for Health Research, are currently recruiting participants for this study.

Luciana Mascarenhas Fonseca, Roger W Strong, Shifali Singh, Jane D Bulger, Michael Cleveland, Elizabeth Grinspoon, Kamille Janess, Lanee Jung, Kellee Miller, Eliza Passell, Kerry Ressler, Martin John Sliwinski, Alandra Verdejo, Ruth S Weinstock, Laura Germine, Naomi S Chaytor

JMIR Diabetes 2023;8:e39750