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This study involves a whole-day visit to the LUMC for each participant and includes the following procedures: a 3 T brain MRI scan of 60 minutes, a 7 T brain MRI scan of 60 minutes, a neuropsychological assessment, and questionnaires on demographics and vascular risk factors. An overview of the study procedures can be found in Figure 1.
JMIR Res Protoc 2025;14:e77681
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Upon categorization of states by these parameters, we chose a selection of at least 1‐3 dashboards per region and territory, based on the inclusion of all categories and upon the dashboard being (1) available for public viewing and (2) fitting the definition of a dashboard, “a visual display of the most important information needed to achieve one or more objectives, consolidated and arranged on a single screen so the information can be monitored at a glance” [5].
JMIR Public Health Surveill 2025;11:e71094
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The DSM-5 explicitly states that for a diagnosis of bipolar mania, there must be an increase in energy or activity in addition to mood changes, marking a significant shift from previous editions where mood changes alone sufficed for diagnosis [10,11].
JMIR Ment Health 2025;12:e78163
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Additionally, a custom dataset allows for the identification of domain-specific challenges, leading to more effective implementations and improvements in real-world applications. By adhering to these principles, we aim to provide a more robust and meaningful evaluation of LLMs in the medical domain, avoiding the pitfalls highlighted by the Goodhart law: “When a measure becomes a target, it ceases to be a good measure” [14].
JMIR AI 2025;4:e72153
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A new urine collection technique (midstream urine collection) for males has been applied since November 21, 2019.
JMIR Form Res 2025;9:e75929
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First, many digital clinical trials fail to enroll participants from a broad range of demographic groups, limiting the generalizability of the effects [45]. This is a common problem across clinical trials [46], and certain trial designs, such as decentralized trials, may help address participation barriers by relying on remote data collection methods [47].
Second, few trials have enrolled participants with a confirmed insomnia diagnosis established through structured clinical interviews.
JMIR Ment Health 2025;12:e84323
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The Perceived Roles of AI in Clinical Practice: National Survey of 941 Academic Physicians
Artificial intelligence (AI) is a topic of significant interest in recent literature. It has garnered considerable attention as a potential tool to aid in detecting, diagnosing, and managing diseases and demonstrated efficacy in detecting diabetic retinopathy, diagnosing skin cancers, and even predicting patients’ surgical candidacy [1-5].
JMIR AI 2025;4:e72535
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A Pitta-dominant individual is more susceptible to diseases like peptic ulcers, hypertension, and skin disorders [14]. However, a Vata-dominant individual is more prone to musculoskeletal issues like back pain and joint degeneration, and a Kapha-dominant individual faces a higher risk of developing metabolic conditions such as obesity, diabetes, and atherosclerosis [14].
JMIR Res Protoc 2025;14:e81329
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In classification problems involving input (x) and output (y) variables, a dataset shift occurs when the joint probability distribution of the data differs between training and test datasets. This can happen, for instance, when translating a model to a different site or during the AI’s use or adaptation over time (equation 1).
In this work, we considered 3 primary sources of dataset shift: covariate shift, prior probability shift, and concept shift [11], as described next.
JMIR Med Inform 2025;13:e78309
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Talkspace [33] is a telemedicine platform of over 5000 licensed therapists across the United States. Clients access the platform through the internet and complete a brief intake with a consulting clinician to identify their presenting problems and treatment history.
JMIR Form Res 2025;9:e75290
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