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Sodium oxybate will be titrated up to 27 g/day (4.5 g every 4 h).
If, after 4 days of treatment, patients improve more than 50% on the BFCRS, they may continue sodium oxybate treatment for an additional 10 days. If no response or remission has been achieved, patients will, in general, receive ECT. However, this decision lies outside the scope of this study and is a decision made between the treating professional, the patient, and his or her legal representative, in case of incapability.
JMIR Res Protoc 2025;14:e68356
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Audience Responses to Online Public Shaming in Online Environments: Mixed Methods Study
J Med Internet Res 2025;27:e67923
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Digital Health Portals for Individuals Living With or Beyond Cancer: Patient-Driven Scoping Review
JMIR Cancer 2025;11:e72862
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The target dose was consistent with a previous large telerehabilitation study that showed significant improvements in upper-limb impairment (42 h [29]). In contrast, training in this program was not limited to one body area [30-32] and could be achieved with multiple effectors (ie, upper-limb, hand, trunk, and lower-limb).
Training dose was delivered via synchronous telerehabilitation and asynchronous training (Table 2).
JMIR Serious Games 2025;13:e69335
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Participants received the HWC e Health program (as detailed in item 1) and participated in 3 remotely facilitated group meetings via video (each lasting 2 h). Due to the COVID-19 pandemic, these meetings were held remotely and included brief introductions to topics, such as goal setting, stress management, and self-compassion, followed by small-group discussions (Table S2 in Multimedia Appendix 1). Group meetings were held at 1, 6, and 10 months during the 12-month treatment period.
JMIR Ment Health 2025;12:e66518
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