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Greater Improvements in Vaccination Outcomes Among Black Young Adults With Vaccine-Resistant Attitudes in the United States South Following a Digital Health Intervention: Latent Profile Analysis of a Randomized Control Trial

Greater Improvements in Vaccination Outcomes Among Black Young Adults With Vaccine-Resistant Attitudes in the United States South Following a Digital Health Intervention: Latent Profile Analysis of a Randomized Control Trial

The Tough Talks COVID (TT-C) study was a randomized controlled trial of a DHI designed to empower Black young adults in the United States South to make informed, autonomous decisions about COVID-19 vaccine uptake (Clinical Trials.gov NCT05490329) [30]. The TT-C intervention was cocreated using community-based participatory research methods to address structural barriers and misinformation about vaccines through interactive activities and digital storytelling [31,32].

Noah Mancuso, Jenna Michaels, Erica N Browne, Allysha C Maragh-Bass, Jacob B Stocks, Zachary R Soberano, C Lily Bond, Ibrahim Yigit, Maria Leonora G Comello, Margo Adams Larsen, Kathryn E Muessig, Audrey Pettifor, Lisa B Hightow-Weidman, Henna Budhwani, Marie C D Stoner

JMIR Public Health Surveill 2025;11:e67370

Interventions to Reduce Serum Per- and Poly-Fluoroalkyl Substances Levels, Improve Cardiovascular Risk Profiles, and Improve Epigenetic Age Acceleration in US Firefighters: Protocol for Randomized Controlled Trial

Interventions to Reduce Serum Per- and Poly-Fluoroalkyl Substances Levels, Improve Cardiovascular Risk Profiles, and Improve Epigenetic Age Acceleration in US Firefighters: Protocol for Randomized Controlled Trial

DNA methylation affects gene expression by adding a methyl group to 5’—C—phosphate—G—3’ dinucleotides. These DNA methylation patterns can be analyzed to determine epigenetic age or “biological age” through epigenetic clocks. Previous research has found that accelerated epigenetic age can be a risk factor for cancer, cardiovascular and neurological diseases, as well as death from all causes combined [12].

Reagan Conner, Cynthia Porter, Karen Lutrick, Shawn C Beitel, James Hollister, Olivia Healy, Krystal J Kern, Floris Wardenaar, John J Gulotta, Kepra Jack, Matthew Huentelman, Jefferey L Burgess, Melissa Furlong

JMIR Res Protoc 2025;14:e67120

Acceptability, Usability, and Insights Into Cybersickness Levels of a Novel Virtual Reality Environment for the Evaluation of Depressive Symptoms: Exploratory Observational Study

Acceptability, Usability, and Insights Into Cybersickness Levels of a Novel Virtual Reality Environment for the Evaluation of Depressive Symptoms: Exploratory Observational Study

Simulator Sickness Questionnaire. b DS: depressive symptom. c HC: healthy control. d Literature averages are taken from Saredakis et al [23] based on a meta-analysis of 55 studies on approximately 3000 participants. e The categorization is solely dependent on the Patient Health Questionnaire-9 score and does not indicate the presence of a clinical diagnosis. f P g P h P Boxplot of self-reported cybersickness severity scores for the HC and DS study groups—measured by the (A) SSQ, and its 3 subscales of (B) nausea, (C)

Sara Sutori, Emma Therése Eliasson, Francesca Mura, Victor Ortiz, Vincenzo Catrambonephd, Gergö Hadlaczky, Ivo Todorov, Antonio Luca Alfeo, Valentina Cardi, Mario G C A Cimino, Giovanna Mioni, Mariano Alcañiz Raya, Gaetano Valenza, Vladimir Carli, Claudio Gentili

JMIR Form Res 2025;9:e68132

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study

Summary of study activities. a Hb A1c: hemoglobin A1c. b CRP: C-reactive protein. c OGTT: oral glucose tolerance test. At the first visit, a full medical history will be taken by a trained clinician including past medical history and surgical history. Outcomes of previous pregnancies will be recorded including outcome of the pregnancy, gestation, pregnancy complications, and (if relevant) birthweight and neonatal complications. Current medications including dose, and dosing schedule will be recorded.

Sarah A L Price, Digsu N Koye, Alice Lewin, Alison Nankervis, Stefan C Kane

JMIR Res Protoc 2025;14:e72542

Decentralized Biobanking Apps for Patient Tracking of Biospecimen Research: Real-World Usability and Feasibility Study

Decentralized Biobanking Apps for Patient Tracking of Biospecimen Research: Real-World Usability and Feasibility Study

We examined all contexts along the data pipeline, from population-level breast cancer screening to diagnostic biopsies and surgical treatments, clinical pathology, and specimen accessioning through the biobanking platform, where it may be stored for future use in –80 °C freezers or distributed fresh for next-generation biobanking applications such as patient-derived organoids, multi-omics, and high-throughput testing.

William Sanchez, Ananya Dewan, Eve Budd, M Eifler, Robert C Miller, Jeffery Kahn, Mario Macis, Marielle Gross

JMIR Bioinform Biotech 2025;6:e70463