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Improving HIV Prevention Among Heterosexual Men Seeking Sexually Transmitted Infection Services in Malawi: Protocol for a Type I Effectiveness-Implementation Hybrid Randomized Controlled Trial of Systems Navigator–Delivered Integrated Prevention Package (HPTN 112-NJIRA Study)

Improving HIV Prevention Among Heterosexual Men Seeking Sexually Transmitted Infection Services in Malawi: Protocol for a Type I Effectiveness-Implementation Hybrid Randomized Controlled Trial of Systems Navigator–Delivered Integrated Prevention Package (HPTN 112-NJIRA Study)

A Z-test based on asymptotic normality will be used to compare persistent Pr EP use between the intervention and SOC arms. For binary end points, frequencies will be tabulated, and proportions will be calculated along with variances estimated under the binomial distribution. For continuous end points, the mean, median, SD, quantiles, and range will be reported. Secondary data analysis will tabulate the number of each end point observed during the study.

Sarah E Rutstein, Laura Limarzi-Klyn, Jane S Chen, Yaw O Agyei, Shahnaz Ahmed, Ian Bell, Myron Cohen, Jessica M Fogel, Vivian Go, Dan Haines, Erica L Hamilton, Irving F Hoffman, Mina C Hosseinipour, Mark A Marzinke, William C Miller, Mathews Mukatipa, Julie Pulerwitz, Hans M L Spiegel, Ting Ye, Mitch Matoga

JMIR Res Protoc 2025;14:e72981

Recovery of Patient-Reported Outcome Measures vs Gait Parameters Obtained by Instrumented Insoles After Tibial and Malleolar Fractures: Prospective Longitudinal Observational Study

Recovery of Patient-Reported Outcome Measures vs Gait Parameters Obtained by Instrumented Insoles After Tibial and Malleolar Fractures: Prospective Longitudinal Observational Study

Demographics and diagnoses by sex. a For continuous variables, means (SDs) and F test scores of the Wilcoxon tests are reported. For categorical variables, n (percentages) and chi-square values from Pearson tests are reported. b Not applicable. Patient-Reported Outcome Measurement Information System scores preinjury and 6 months and 1 year after surgery, separated by sex. a PROMIS: Patient-Reported Outcome Measurement Information System.

Elke Warmerdam, Marianne Huebner, Caroline Stoll, Andrey Ivanovic Lange, Bergita Ganse

JMIR Mhealth Uhealth 2025;13:e71022

The Use of AI-Powered Thermography to Detect Early Plantar Thermal Abnormalities in Patients With Diabetes: Cross-Sectional Observational Study

The Use of AI-Powered Thermography to Detect Early Plantar Thermal Abnormalities in Patients With Diabetes: Cross-Sectional Observational Study

For categorical variables, such as sex and health conditions, we used 2-proportion z tests to compare both groups. For the correlation analysis, the foot skin temperature obtained is the average for the entire plantar region. We used the independent 2-tailed t test and the effect size (Cohen d) to compare foot skin temperature in healthy participants versus participants with diabetes.

Meshari F Alwashmi, Mustafa Alghali, AlAnoud AlMogbel, Abdullah Abdulaziz Alwabel, Abdulaziz S Alhomod, Ibrahim Almaghlouth, Mohamad-Hani Temsah, Amr Jamal

JMIR Diabetes 2025;10:e65209