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Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium Oxybate as a Potential New Treatment for Catatonia in Patients With Depression, Bipolar Disorder, or a Psychotic Disorder: Protocol for a Randomized Controlled Trial

Sodium oxybate will be titrated up to 27 g/day (4.5 g every 4 h). If, after 4 days of treatment, patients improve more than 50% on the BFCRS, they may continue sodium oxybate treatment for an additional 10 days. If no response or remission has been achieved, patients will, in general, receive ECT. However, this decision lies outside the scope of this study and is a decision made between the treating professional, the patient, and his or her legal representative, in case of incapability.

Lilian Bot, Josine G van Mill, Laetitia J C A Smarius, Adriaan W Hoogendoorn, Bram W C Storosum, Christiaan H Vinkers, Gabriel E Jacobs, Gert Jan Lammers, Hanna M Heller, Jantine C A Colen-de Koning, Joris J B van der Vlugt, Marloes S Oudijn, Martijn S van Noorden, Pierre M Bet, Rolf Fronczek, Heleen S van der Heijden, Sjors M M Lange, Ysbrand D van der Werf, Eric R van Exel

JMIR Res Protoc 2025;14:e68356

Evaluating the Effectiveness of a Mobile HIV Prevention App to Increase HIV and Sexually Transmitted Infection Testing and Pre-Exposure Prophylaxis Initiation Among Rural Men Who Have Sex With Men in the Southern United States: Protocol for a Randomized Controlled Trial

Evaluating the Effectiveness of a Mobile HIV Prevention App to Increase HIV and Sexually Transmitted Infection Testing and Pre-Exposure Prophylaxis Initiation Among Rural Men Who Have Sex With Men in the Southern United States: Protocol for a Randomized Controlled Trial

M-Cubed, an adaptation of Health Mindr that provides pop-up HIV prevention messaging, demonstrated efficacy to increase HIV testing and Pr EP uptake among urban MSM [17]. There is a need to understand which components of app-based HIV prevention are necessary to promote prevention to inform future implementation. A standard feature of most app-based HIV prevention interventions is access to free HIV and STI self-test kits [30-32].

Jeb Jones, Georgia Manley, Tiffany R Glynn, Kristin M Wall, Stefan D Baral, E Danny Harris, David Benkeser, Patrick S Sullivan

JMIR Res Protoc 2025;14:e69540