JMIR Formative Research

Digital phenotyping—the use of continuous data streams from digital devices such as smartphones to assess behavioral, psychological, and physiological states—holds transformative potential for health monitoring and personalized care. However, real-time analysis of large multimodal data often exceeds mobile devices’ computational resources, leading most platforms to rely on sequential processing and cloud-based computation.

Lack of diversity in clinical trials reduces the generalizability of treatment efficacy across different demographic groups, thereby diminishing the relevance, quality, and equity of research findings.

Continuous ambulatory HF-HRV (high-frequency heart rate variability) monitoring using a chest-worn ECG (electrocardiogram) device met a priori feasibility benchmarks (≥75% compliance and data quality) in adolescents at high risk for suicide over approximately two to three weeks, including during school days and sleep.

Digital media literacy (DML) may help adolescents to handle online risks, misinformation, digital violence, and problematic media use more reflectively. However, structured interventions for adolescents in child and adolescent psychiatry (CAP), particularly in inpatient and day-treatment settings, remain scarce.

Systematic collection of social determinants of health (SDoH) data remains inconsistent across health care settings, despite its critical impact on patient outcomes. Large language model–powered chatbots offer promise for scalable SDoH data collection, but rigorous, feasible evaluation methods for patient-facing applications are lacking.

The development of robust medical AI for knowledge discovery and decision support commonly necessitates large-scale datasets from multiple institutions. However, such data aggregation is severely constrained by privacy regulations and the inherent risk of sensitive information leakage, making it difficult to navigate the utility-privacy trade-off.

As information technology becomes increasingly pervasive in early childhood education, the impact of digital gameplay on developmental outcomes has emerged as a critical research frontier.

Sighing has been proposed as a primary respiratory reset mechanism that is often linked to emotional regulation. However, evidence linking sighing to anxiety relies heavily on laboratory studies, which lack ecological validity. It remains unclear whether ambulatory sighing dynamics in free-living settings reflect momentary (state) symptom fluctuations or enduring (trait) pathology. Evidence from daily-life monitoring is needed to evaluate sighing dynamics as a candidate digital biomarker for anxiety disorders (ADs).

Gambling consumers show low uptake and engagement with tools designed to support safer gambling practices and reduce the risk of experiencing gambling-related harms. We used co-design principles to design and develop a digital tool for safer gambling (BetWell) to overcome known barriers to tool uptake, including a focus on gambling problems. BetWell aims to increase awareness of personal gambling expenditure and knowledge of how gambling products function to support informed decision-making about gambling. It was designed based on behavioral change theories and presents a personalized amalgamation of gambling expenditure relative to alternative spend options, and psychoeducational information via a quiz.

Measurement-based care (MBC) and shared decision-making can improve clinical outcomes for patients with major depressive disorder (MDD) in primary care. However, primary care providers often have limited time to administer patient-reported outcome measures recommended for MBC. Digital health tools like the Pathway Platform can help facilitate MBC and patient-provider engagement, aiding enhanced shared decision-making.

Obesity is a chronic disease requiring long-term treatment, yet current treatment models do not align with the chronicity of obesity. Current guidelines provide limited direction on how to adapt treatment to support weight loss maintenance as adolescents transition into emerging adulthood, a distinct developmental period from the late teens to the mid-to-late twenties.

Older adults living with dementia often have limited tolerance for intraoral procedures, which can restrict access to even basic oral health assessment in clinical care. Procedural burden—characterized by sustained intraoral manipulation, sensory overload, and limited opportunities for interruption—may represent a key barrier to equitable oral care. Intraoral scanning (IOS) enables stepwise, interruptible acquisition of oral data and may reduce this burden, but feasibility and tolerability in people living with dementia have not been systematically evaluated.