JMIR Formative Research

Oral anticancer therapy enables convenient, home-based cancer care but can introduce adherence challenges, particularly with complex dosing schedules. Capecitabine is commonly used in breast cancer, often as adjuvant therapy or in advanced disease, and typically requires twice-daily dosing on cyclical schedules, increasing the risk of missed or incorrect doses. Low health literacy may exacerbate these difficulties, and emerging remote monitoring tools may help close this gap.

Baduanjin qigong is a traditional mind-body exercise used to support balance and physical health in older adults. Age-related changes in proprioception may make accurate self-directed performance difficult without external guidance.

The availability of dedicated image analysis scripts for adaptive optics (AO)–flood illumination ophthalmoscopy (FIO) is limited, especially for large-scale measurements and analyses of nonhealthy images. This limitation highlights the need for alternative approaches to facilitate automated and scalable analysis. Large language models may help develop such scripts.

Respiratory infectious disease surveillance increasingly requires timely integration of routine case reporting, laboratory pathogen surveillance, and digital behavioral signals. However, the incremental predictive value of spatially stratified regional pathogen activity and internet search data for short-term urban respiratory disease prediction remains unclear.

Tech testing panels (TTPs) can assess the usability of patient-facing health technology and provide critical feedback; TTPs should draw upon diverse patient populations by language preference and with a range of technology usage and literacy to ensure that digital health interventions are equitably designed.

Global dementia cases, currently exceeding 55 million, are projected to triple by 2050. In the absence of disease-modifying therapies, identifying modifiable risk factors is critical. Preclinical studies show that herpes simplex virus type-1 (HSV-1) is neurotropic and can drive amyloid-beta accumulation and tau hyperphosphorylation. Epidemiologic findings remain inconsistent, partly because many studies lack standardized designs for real-world data.

Emerging adults (aged 18‐29 years) experience a high burden of mental health (MH) concerns during a developmental period marked by increasing autonomy and vulnerability to symptom onset. Many emerging adults face challenges in accessing and sustaining engagement with developmentally appropriate care. Digital measurement-based care (dMBC), which involves the routine use of patient-reported outcome measures (PROMs), has been introduced as an approach to support emerging adult engagement and improve responsiveness of care through ongoing monitoring and informed clinical decision-making. However, its integration into routine care remains variable, and there is limited understanding of how emerging adults experience and engage with dMBC in practice.

Mental health care is undergoing rapid digital transformation, with continued development and implementation of digitally delivered interventions. Despite growing evidence for digital mental health interventions, implementation in routine practice has often lagged technological advances. Although teletherapy became more widely accepted during the COVID-19 pandemic, little is known about the psychological processes through which clinicians adapt to disruptive changes in treatment delivery when required to work within a novel medium.

Over 600,000 student veterans use military benefits to pursue higher education annually, with 75% enrolled as full-time students. Advancing their education is an important step toward improving their employment, financial, and social opportunities. However, student veterans also experience high rates of co-occurring psychiatric concerns like substance use disorder (SUD), posttraumatic stress disorder (PTSD), or depression. For these students, additional psychoeducation, support, and guidance may be required. To support their goals, a mobile app with targeted content for student veterans managing common psychiatric concerns could be particularly helpful.

Training visual processing skills, a domain implicated in sport performance and injury risk, could reduce injuries among youth athletes. The useful field of view (UFOV) cognitive training program improves visual processing efficiency. While UFOV training has been extensively studied in aging populations and yields significant cognitive and functional benefits, it has yet to be examined in adolescents.

Advances in hardware and software have transformed how users perform activities across various domains by integrating technology in ways that enhance task execution. In education, these processes facilitate pedagogical innovation and learning through diverse interaction models, such as web systems, augmented or virtual reality, and mobile devices. An example of these approaches occurs in the context of cytopathology. Digitization and slide visualization technologies allow the use of real images in a computational environment, enabling an alternative model of interaction between the professional and the samples.

Young and middle-aged patients with hypertension often show poor self-management due to limited cognitive bandwidth. Mobile health apps using behavioral economics may be helpful for these patients.