JMIR Formative Research

Periodontitis is a chronic gum disease affecting approximately 42% of adults aged 30 years and older in the United States. Training dental students to accurately diagnose and manage periodontitis is a critical component of dental education and clinical care. Recent advances in large language models offer new opportunities to support both domains, yet their performance in periodontal diagnosis remains largely unexplored, particularly for newer models such as GPT-5.

In recent years, large language models (LLMs) have undergone swift cycles of refinement and iteration. However, in the realm of clinical medicine, different LLMs' capability of logical reasoning and disease diagnosis needs further investigation.

Increasing life expectancy has increased focus on the health-related consequences of aging, such as sarcopenia and frailty. Given the prevalence of these conditions among older individuals and the frequent resulting long-term care needs, early detection and intervention are crucial.

Men face a substantially higher risk of suicide. Effective suicide prevention strategies for men should specifically target gender-related risk factors, such as their lower likelihood of seeking professional help.

After breast cancer, cervical cancer (CC) is one of the leading causes of female mortality. CC accounts for more than 7.5% of female cancer deaths worldwide. Human papillomavirus (HPV) is the most common sexually transmitted disease in women and the leading cause of CC in almost 99% of all CC cases. HPV vaccination could prevent up to 70% of HPV-related CC and 90% of genital warts. HPV vaccination is the bedrock of primary prevention and helps reduce the incidence and death rates of HPV-associated CC.

Digitalization in geriatric rehabilitation presents unique challenges, making it essential to align eHealth solutions with patients’ digital skills. The Quickscan Digital Skills (QDS) is a tool designed to help health care professionals match eHealth interventions to individual skill levels.

Practice-based research networks (PBRNs) rely on sustainable and interoperable IT infrastructures to support coordination, data management, and long-term collaboration across geographically distributed primary care practices. Large federated initiatives, such as the German DESAM-ForNet (Initiative of German Practice-Based Research Networks) program, face substantial sociotechnical challenges, as diverse user groups, heterogeneous local systems, and multiple governance levels must align around shared digital solutions.

Individuals with one or more socially stigmatized identities experience extensive health disparities, resulting in poorer health outcomes. However, most studies consider the effects of only individual stigmatized identities.

Achieving optimal adherence to anticoagulation therapy is a major challenge in the management of venous thromboembolism (VTE). Mobile health (mHealth) technologies may offer a scalable approach to supporting medication adherence and self-management.

Nipah virus (NiV) infection is considered one of the deadliest infectious diseases, with a case fatality rate of approximately 71%. In Bangladesh, the primary risk factor for NiV infection is the consumption of raw date palm sap (DPS) contaminated with excreta from fruit bats (ie, members of the family). Recently, the increasing use of social media among Bangladeshi youth has enabled business groups to widely advertise and sell raw DPS. This increased access, combined with young people perceiving consumption of raw DPS as an “adventurous event,” may facilitate an increase in incidences of NiV infection.

US overdose deaths continue to exceed 77,000 per year, the majority of which involve opioids. One evidence-based response to this crisis is overdose education and naloxone distribution (OEND). There is a large national (US) network of citizens and first response agencies connected through an app called , who are engaged in facilitating rapid layperson cardiopulmonary resuscitation administration in cases of public emergencies. Our goal is to recruit these first response agencies to provide targeted messaging about OEND to this large subpopulation of motivated layperson responders. This study focuses on the first step: the feasibility of our national efforts to recruit first response agencies to participate in our project.

Social media platforms have become integral to daily life, particularly among younger users. While they offer opportunities for connection, they also introduce new psychological stressors. Prior research has often relied on simplistic metrics such as screen time, failing to capture complex emotional and behavioral dimensions of digital engagement. There is a growing need to understand how design features and user experiences contribute to problematic social media use (PSMU), especially in adult populations.