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Development of a Cocreated Decision Aid for Patients With Depression—Combining Data-Driven Prediction With Patients’ and Clinicians’ Needs and Perspectives: Mixed Methods Study

Development of a Cocreated Decision Aid for Patients With Depression—Combining Data-Driven Prediction With Patients’ and Clinicians’ Needs and Perspectives: Mixed Methods Study

The I-SHARED dataset was used to develop a data-driven prediction algorithm to guide depression treatment decisions. To be included in the dataset, patients had to have a primary diagnosis of MDD (N=17,788). The dataset comprised routinely collected intake and outcome data, as well as mental health care usage data. Intake data included sociodemographic characteristics and medical and mental health information (for a complete list, see Section B in Multimedia Appendix 1).

Kaying Kan, Frederike Jörg, Klaas J Wardenaar, Frank J Blaauw, Maarten F Brilman, Ellen Visser, Dennis Raven, Dwayne Meijnckens, Erik Buskens, Danielle C Cath, Bennard Doornbos, Robert A Schoevers, Talitha L Feenstra

J Particip Med 2025;17:e67170

A Human-Centered Approach for a Student Mental Health and Well-Being Mobile App: Protocol for Development, Implementation, and Evaluation

A Human-Centered Approach for a Student Mental Health and Well-Being Mobile App: Protocol for Development, Implementation, and Evaluation

A recurrent theme across these sessions was the absence of a personalized, regularly updated medium through which students could effectively engage with available university resources. Although a range of services existed, participants emphasized the need for an integrated system to support continuous search, discovery, and engagement.

Maryam Gholami, David Wing, Manas Satish Bedmutha, Job Godino, Anahi Ibarra, Byron Fergerson, Nicole May, Christopher A Longhurst, Nadir Weibel, Anne Duffy, Heidi Rataj, Karandeep Singh, Kevin Patrick

JMIR Res Protoc 2025;14:e68368

Patient Interaction Phenotypes With an Automated SMS Text Message–Based Program and Use of Acute Health Care Resources After Hospital Discharge: Observational Study

Patient Interaction Phenotypes With an Automated SMS Text Message–Based Program and Use of Acute Health Care Resources After Hospital Discharge: Observational Study

the software accepted only a narrow set of responses (Y, Yes, N, or No). Despite this, patients could respond as desired without a limit on character count. Messages containing text lacking a prespecified response triggered an outbound SMS text message to patients stating, “I don’t understand that response. Valid choices are: [prespecified choices].” We undertook a process of feature engineering to describe patients’ interaction with the program.

Klea Profka, Agnes Wang, Emily Schriver, Ashley Batugo, Anna U Morgan, Danielle Mowery, Eric Bressman

J Med Internet Res 2025;27:e72875

Intervention for Justice-Involved Homeless Veterans With Co-Occurring Substance Use and Mental Health Disorders: Protocol for a Randomized Controlled Hybrid Effectiveness-Implementation Trial

Intervention for Justice-Involved Homeless Veterans With Co-Occurring Substance Use and Mental Health Disorders: Protocol for a Randomized Controlled Hybrid Effectiveness-Implementation Trial

Using a hybrid type 1 effectiveness-implementation design [55], we will test the effectiveness of the MISSION-CJ intervention in a randomized controlled trial (RCT) across 2 large VA health care systems as well as conduct a qualitative evaluation of MISSION-CJ’s implementation.

Kathryn Bruzios, Paige M Shaffer, Daniel M Blonigen, Michael A Cucciare, Michael Andre, Thomas Byrne, Jennifer Smith, David Smelson

JMIR Res Protoc 2025;14:e70750

Streamlining a Patchwork - Exploring the Challenges of Digital Transformation in Pathology: Ethnographic Study

Streamlining a Patchwork - Exploring the Challenges of Digital Transformation in Pathology: Ethnographic Study

A key analogue practice in pathology that is now being digitized via whole-slide imaging is diagnosis. This means that, instead of examining tissue samples on glass slides under a microscope, the glass slide is scanned as a high-resolution image, and the digital slide is examined on a computer screen. Digitizing this step can be seen as a paradigm shift in the digital transformation of pathology. It affects the entire pathology workflow [6].

Birte Linny Geisler, Ourania Amperidou, Sina Patricia Pauly, Sven Mattern, Christian M Schürch, Claudia Hermann, Christiane Stoffregen, Ilona Steinleitner, Natali Paigin, Claudia Lamß, Falko Fend, Monika A Rieger, Esther Rind, Christine Preiser

J Med Internet Res 2025;27:e63366

Delivering an Electronic Health Record Based Educational Intervention Promoting Peri-Operative Non-Pharmacological Pain Care as Part of a Randomized Controlled Trial: Mixed Method Evaluation of Inpatient Nurses’ Perspectives

Delivering an Electronic Health Record Based Educational Intervention Promoting Peri-Operative Non-Pharmacological Pain Care as Part of a Randomized Controlled Trial: Mixed Method Evaluation of Inpatient Nurses’ Perspectives

These 7 questions were rated on a 10-point numeric rating scale, and participants were provided the anchors, 1=not at all, 10=a great deal. Participants could also select "unable to assess" as a response. Survey items were generated by members of the study team (including nursing professionals, a researcher, and physicians), whose experience helping implement the intervention informed key questions for nursing leadership to assess how implementation was going.

Sarah A Minteer, Cindy Tofthagen, Kathy Sheffield, Susanne Cutshall, Susan Launder, Jane Hein, Mary McGough, Christy M Audeh, Jon C Tilburt, Andrea L Cheville

JMIR Nursing 2025;8:e70332

Impact of the Exposome in Type 1 Diabetes: Protocol for a Scoping Review

Impact of the Exposome in Type 1 Diabetes: Protocol for a Scoping Review

Such a comprehensive understanding is essential for the identification of new strategies for disease prevention and management. Conducting a scoping review is well-suited for this broad research question, as it allows for an exhaustive exploration, particularly for a fragmented research area. Unlike systematic reviews, scoping reviews map existing knowledge, identify research gaps, and comprehensively synthesize the available evidence [27-29].

Maurane Rollet, Gloria A Aguayo, Jean-Pierre Riveline, Emmanuel Cosson, Guy Fagherazzi

JMIR Res Protoc 2025;14:e73424

Peer Review of “Advancing Early Detection of Major Depressive Disorder Using Multisite Functional Magnetic Resonance Imaging Data: Comparative Analysis of AI Models”

Peer Review of “Advancing Early Detection of Major Depressive Disorder Using Multisite Functional Magnetic Resonance Imaging Data: Comparative Analysis of AI Models”

This is a peer-review report for “Advancing Early Detection of Major Depressive Disorder Using Multisite Functional Magnetic Resonance Imaging Data: Comparative Analysis of AI Models.” The paper [1] “Advancing Early Detection of Major Depressive Disorder: A Comparative Analysis of AI Models Using Multi-Site Functional MRI Data” examines a very relevant mental health disorder.

Reviewer N Anonymous

JMIRx Med 2025;6:e76746

Exploring the Dilemma of AI Use in Medical Research and Knowledge Synthesis: A Perspective on Deep Research Tools

Exploring the Dilemma of AI Use in Medical Research and Knowledge Synthesis: A Perspective on Deep Research Tools

“Overall, I think Deep Research does produce a good first draft that would probably be readily accepted in a mid-tier journal, but which could be significantly improved with editing and revisions. Perhaps the outputs might improve with better prompts or guidance (eg providing refined outlines and a reference list).”

Ariel Yuhan Ong, David A Merle, Siegfried K Wagner, Pearse A Keane

J Med Internet Res 2025;27:e75666

The Effect of Maternal Choline Intake on Offspring Cognition in Adolescence: Protocol for a 14-year Follow-Up of a Randomized Controlled Feeding Trial

The Effect of Maternal Choline Intake on Offspring Cognition in Adolescence: Protocol for a 14-year Follow-Up of a Randomized Controlled Feeding Trial

The original study was a double-blind, randomized controlled choline feeding study. Pregnant women entering their third trimester (N=26) were randomly assigned to consume either 480 mg choline/day (roughly the AI level) or 930 mg choline/day (roughly double the AI level) [27]. All participants consumed the same study-provided, standardized diet containing 380 mg/day of choline.

Sophie A Roth, Angie E Lam, Barbara J Strupp, Richard L Canfield, Elisabeth Anne Larson

JMIR Res Protoc 2025;14:e73508