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Advancing the Use of Longitudinal Electronic Health Records: Tutorial for Uncovering Real-World Evidence in Chronic Disease Outcomes

Advancing the Use of Longitudinal Electronic Health Records: Tutorial for Uncovering Real-World Evidence in Chronic Disease Outcomes

For instance, Hou et al [1] emulated the Clinical Outcomes of Surgical Therapy Study Group Trial by integrating both EHR data and unstructured textual information from clinical notes. They found that with appropriate adjustment of temporal shift, RWE can supplement RCTs in the assessment of treatment outcomes over time. Patorno et al [2] further augmented EHR and insurance claims data with wearable devices and patient-reported outcomes in their treatment outcome analysis.

Feiqing Huang, Jue Hou, Ningxuan Zhou, Kimberly Greco, Chenyu Lin, Sara Morini Sweet, Jun Wen, Lechen Shen, Nicolas Gonzalez, Sinian Zhang, Katherine P Liao, Tianrun Cai, Zongqi Xia, Florence T Bourgeois, Tianxi Cai

J Med Internet Res 2025;27:e71873

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