%0 Journal Article
%@ 2561-326X
%I JMIR Publications
%V 7
%N 
%P e37269
%T An Emerging Screening Method for Interrogating Human Brain Function: Tutorial
%A Sudre,Gustavo
%A Bagić,Anto I
%A Becker,James T
%A Ford,John P
%+ Brain FIT Imaging, LLC, 141 Main Street, Unadilla, NY, 13849, United States, 1 607 435 0930, gsudre@brainfitimaging.com
%K screening
%K brain function
%K cognition
%K magnetoencephalography
%K MEG
%K neuroimaging
%K tutorial
%K tool
%K cognitive test
%K neuroimaging
%K signal
%K cognitive function
%D 2023
%7 27.4.2023
%9 Tutorial
%J JMIR Form Res
%G English
%X Cognitive decline can be observed due to a myriad of causes. Clinicians would benefit from a noninvasive quantitative tool to screen and monitor brain function based on direct measures of neural features. In this study, we used neuroimaging data from magnetoencephalography (with a whole-head Elekta Neuromag 306 sensor system) to derive a set of features that strongly correlate with brain function. We propose that simple signal characteristics related to peak variability, timing, and abundance can be used by clinicians as a screening tool to investigate cognitive function in at-risk individuals. Using a minimalistic set of features, we were able to perfectly distinguish between participants with normative and nonnormative brain function, and we were also able to successfully predict participants’ Mini-Mental Test score (r=0.99; P<.001; mean absolute error=0.413). This set of features can be easily visualized in an analog fashion, providing clinicians with several graded measurements (in comparison to a single binary diagnostic tool) that can be used for screening and monitoring cognitive decline.
%M 37103988
%R 10.2196/37269
%U https://formative.jmir.org/2023/1/e37269
%U https://doi.org/10.2196/37269
%U http://www.ncbi.nlm.nih.gov/pubmed/37103988