%0 Journal Article
%@ 2561-326X
%I JMIR Publications
%V 5
%N 11
%P e24936
%T Role of 18F-Fluorodeoxyglucose–Positron Emission Tomography/Computed Tomography Imaging in the Prediction of Prognosis in Patients With Indolent Lymphoma: Prospective Study
%A AlShehry,Nawal Faiez
%A Shanker,Raja
%A Zaidi,Syed Ziauddin Ahmed
%A AlGhmlas,Fahad
%A Motabi,Ibraheem Hussein
%A Iqbal,Shahid
%A Butt,Ahmad Ali
%A AlShehri,Hassan
%A Tailor,Imran Khan
%A Altaf,Syed Yasir
%A AlGhamdi,Mubarak
%A Marie,Mohammed
%A AlFayez,Mansour
%A Al Zahrani,Kamal
%A Dwaimah,Mohammed
%A Al-Halouli,Tahani
%A Al-Shakweer,Wafaa
%A AlShehery,Maied Zaher
%A Zaidi,Abdul Rehman Zia
%A Gill,Atta Munawar
%A Albtoosh,Belal Mohammed
%A Ahmed,Musab
%+ Department of Adult Hematology/Bone Marrow Transplantation, King Fahad Medical City, Comprehensive Cancer Center, PO Box 59046, Riyadh, 11525, Saudi Arabia, 966 112889999 ext 23040, nalshehry@kfmc.med.sa
%K positron emission tomography
%K lymphoma
%K prognosis
%K indolent lymphoma
%K SUVmax
%K Deauville criteria
%D 2021
%7 12.11.2021
%9 Original Paper
%J JMIR Form Res
%G English
%X Background: The role of fluorodeoxyglucose–positron emission tomography/computed tomography (FDG-PET/CT) in indolent lymphoma has been minimally studied. Objective: This study aims to assess the value of FDG-PET/CT in predicting the prognosis of indolent lymphoma. Methods: We prospectively recruited 42 patients with indolent lymphoma. A total of 2 patients were excluded, and 40 underwent baseline PET/CT and follow-up at various time points. A total of 9 patients were observed only, 7 received 4 doses of rituximab alone, and 24 received chemoimmunotherapy. Metabolic response on follow-up PET/CT was assessed using the maximum standardized uptake value (SUVmax) and Deauville criteria (DC). We aimed to obtain the best SUVmax and DC to predict optimal survival rates, risk stratification, and optimize therapeutic strategies. The mean follow-up from the initial diagnosis was 33.83 months. Results: SUVmax <4.35 at interim PET/CT provided the best discrimination, with a progression-free survival (PFS) of 100% and a median survival time of 106.67 months compared with SUVmax ≥4.35 (P=.04), which had a PFS of 43.8% and a median survival time of 50.17 months. This cutoff was also valuable in predicting overall survival at baseline, that is, 100% overall survival with baseline SUVmax <4.35, versus 58.4% for SUVmax ≥4.35 (P=.13). The overall survival of patients with a baseline DC score <3.0 was 100%, with a median overall survival of 106.67 months. Conclusions: We demonstrated the utility of PET/CT in indolent lymphomas. SUVmax (<4.35 vs ≥4.35) on interim PET/CT performed best in predicting PFS. 
%M 34508363
%R 10.2196/24936
%U https://formative.jmir.org/2021/11/e24936
%U https://doi.org/10.2196/24936
%U http://www.ncbi.nlm.nih.gov/pubmed/34508363