@Article{info:doi/10.2196/32564,
author="W{\"u}rstle, Silvia
and Erber, Johanna
and Hanselmann, Michael
and Hoffmann, Dieter
and Werfel, Stanislas
and Hering, Svenja
and Weidlich, Simon
and Schneider, Jochen
and Franke, Ralf
and Maier, Michael
and Henkel, Andreas G
and Schmid, Roland M
and Protzer, Ulrike
and Laxy, Michael
and Spinner, Christoph D",
title="A Telemedicine-Guided Self-Collection Approach for PCR-Based SARS-CoV-2 Testing: Comparative Study",
journal="JMIR Form Res",
year="2022",
month="Jan",
day="4",
volume="6",
number="1",
pages="e32564",
keywords="self-sampling; telemedicine; test strategy effectiveness; simulation model; SARS-CoV-2; COVID-19",
abstract="Background: Large-scale, polymerase chain reaction (PCR)-based SARS-CoV-2 testing is expensive, resource intensive, and time consuming. A self-collection approach is a probable alternative; however, its feasibility, cost, and ability to prevent infections need to be evaluated. Objective: This study aims to compare an innovative self-collection approach with a regular SARS-CoV-2 testing strategy in a large European industrial manufacturing site. Methods: The feasibility of a telemedicine-guided PCR-based self-collection approach was assessed for 150 employees (intervention group) and compared with a regular SARS-CoV-2 testing approach used for 143 employees (control group). Acceptance, ergonomics, and efficacy were evaluated using a software application. A simulation model was implemented to evaluate the effectiveness. An interactive R shiny app was created to enable customized simulations. Results: The test results were successfully communicated to and interpreted without uncertainty by 76{\%} (114/150) and 76.9{\%} (110/143) of the participants in the intervention and control groups, respectively (P=.96). The ratings for acceptability, ergonomics, and efficacy among intervention group participants were noninferior when compared to those among control group participants (acceptability: 71.6{\%} vs 37.6{\%}; ergonomics: 88.1{\%} vs 74.5{\%}; efficacy: 86.4{\%} vs 77.5{\%}). The self-collection approach was found to be less time consuming (23 min vs 38 min; P<.001). The simulation model indicated that both testing approaches reduce the risk of infection, and the self-collection approach tends to be slightly less effective owing to its lower sensitivity. Conclusions: The self-collection approach for SARS-CoV-2 diagnosis was found to be technically feasible and well rated in terms of acceptance, ergonomics, and efficacy. The simulation model facilitates the evaluation of test effectiveness; nonetheless, considering context specificity, appropriate adaptation by companies is required. ",
issn="2561-326X",
doi="10.2196/32564",
url="https://formative.jmir.org/2022/1/e32564",
url="https://doi.org/10.2196/32564",
url="http://www.ncbi.nlm.nih.gov/pubmed/34803022"
}