@Article{info:doi/10.2196/12218,
author="Almonacid, Carlos
and Melero, Carlos
and L{\'o}pez Vi{\~{n}}a, Antol{\'i}n
and Cisneros, Carolina
and P{\'e}rez de Llano, Luis
and Plaza, Vicente
and Garc{\'i}a-Rivero, Juan Luis
and Romero Falc{\'o}n, Auxiliadora
and Ramos, Jacinto
and Baz{\'u}s Gonz{\'a}lez, Teresa
and Andr{\'e}s Prado, Mar{\'i}a
and Muriel, Alfonso",
title="Effectiveness of Text Message Reminders on Adherence to Inhaled Therapy in Patients With Asthma: Prospective Multicenter Randomized Clinical Trial",
journal="JMIR Form Res",
year="2021",
month="Feb",
day="9",
volume="5",
number="2",
pages="e12218",
keywords="asthma; adherence; SMS; control; cell phone; inhaler; Smartinhaler",
abstract="Background: Poor adherence to inhaled medication in asthma patients is of great concern. It is one of the main reasons for inadequate asthma control. Objective: The goal of the research was to determine if motivational messages using short message service (SMS, or text) improved adherence to inhaled medication in patients with asthma. Methods: A prospective multicenter randomized parallel-group clinical trial was conducted in 10 asthma clinics in Spain. Adherence was assessed with electronic monitors (Smartinhaler, Adherium Ltd) connected to inhalers. Patients in the SMS group received psychologist-developed motivational messages every 3 days for 6 months. Results: There were 53 patients in the SMS group and 88 patients in the control group. After 6 months, mean electronic adherence was 70{\%} (SD 17{\%}) in the intervention group and 69{\%} (SD 17{\%}) in the control group (P=.82). Significant differences between the study groups in morning and evening adherence to inhaled therapy, asthma control, exhaled nitric oxide levels, or improvement of lung functions were not observed. Conclusions: Motivational messages were not useful to improve adherence to inhaled asthma medication compared with usual care. ",
issn="2561-326X",
doi="10.2196/12218",
url="http://formative.jmir.org/2021/2/e12218/",
url="https://doi.org/10.2196/12218",
url="http://www.ncbi.nlm.nih.gov/pubmed/33560235"
}