@Article{info:doi/10.2196/formative.9707,
author="C{\^o}t{\'e}, Jos{\'e}
and Fortin, Marie-Chantal
and Auger, Patricia
and Rouleau, Genevi{\`e}ve
and Dubois, Sylvie
and Boudreau, Nathalie
and Vaillant, Isabelle
and G{\'e}linas-Lemay, {\'E}lisabeth",
title="Web-Based Tailored Intervention to Support Optimal Medication Adherence Among Kidney Transplant Recipients: Pilot Parallel-Group Randomized Controlled Trial",
journal="JMIR Formativ Res",
year="2018",
month="Jul",
day="19",
volume="2",
number="2",
pages="e14",
keywords="medication adherence; transplant recipient; self-management; nursing; Web-based tailored intervention; randomized controlled trial",
abstract="Background: Optimal immunosuppressive medication adherence is essential to graft survival. Transplant-TAVIE is a Web-based tailored intervention developed to promote this adherence. Objective: The objective of our study was to evaluate the Transplant-TAVIE intervention's acceptability, feasibility, and preliminary efficacy. Methods: In a pilot, parallel-group, randomized controlled trial, we randomly assigned a convenience sample of 70 kidney transplant patients on immunosuppressive medication either to an experimental group (Transplant-TAVIE) or to a control group (existing websites). Kidney transplant recipients had to be older than 18 years, be taking immunosuppressant medication, and have access to the internet to participate in this study. Transplant-TAVIE was composed of three interactive Web-based sessions hosted by a virtual nurse. We documented user appreciation of and exposure to the intervention. Furthermore, we assessed medication adherence, medication self-efficacy, intake-related skills, and medication side effects at baseline and 3 and 6 months later. Analyses of variance were used to assess intergroup differences over time. Results: After baseline questionnaire completion, participants were randomly assigned either to Transplant-TAVIE (n=35) or to the websites (n=35) group. All participants had received their kidney graft <1 year to 32 years earlier (mean 6.8 years). Of the experimental group, 54{\%} (19/35) completed the sessions of Transplant-TAVIE. Users found the intervention to be acceptable---33{\%} were extremely satisfied (6/18), 39{\%} were very satisfied (7/18), and 28{\%} were satisfied (5/18). At baseline and over time, both experimental and control groups reported high medication adherence, high medication self-efficacy, and frequent use of skills related to medication intake. No intergroup differences emerged over time. Conclusions: The results of this study support the feasibility and acceptability of Transplant-TAVIE. It could constitute an accessible adjunct in support of existing specialized services. ",
issn="2561-326X",
doi="10.2196/formative.9707",
url="http://formative.jmir.org/2018/2/e14/",
url="https://doi.org/10.2196/formative.9707",
url="http://www.ncbi.nlm.nih.gov/pubmed/30684400"
}