In its fifth decade, HIV continues to disproportionately impact gay, bisexual, and other men who have sex with men (GBM) in the United States, particularly those belonging to racial and ethnic minority subgroups [1,2]. The approval of pre-exposure prophylaxis (PrEP) to prevent HIV, the development of clinical guidelines for those at high risk, and the strategic investments in scaling up PrEP represent critical milestones in slowing the HIV epidemic. Currently, 2 oral PrEP formulations (Truvada and Descovy) are approved by the Food and Drug Administration for daily use among GBM. If used as recommended, daily oral PrEP can reduce the risk of acquiring HIV from sex by up to 99% [3] and from injection drug use by at least 74% [4]. Although PrEP use among GBM has been increasing [5], individual, social, and structural barriers have impeded its widespread adoption. These include a lack of information about PrEP’s purpose and effectiveness, concerns about potential side effects and long-term safety, low HIV risk perception, stigma, and limited access to health care [6-8].

To address the heavy burden of HIV among Black or African American and Hispanic or Latino GBM in the United States [2], concerted efforts have been made by public health agencies to engage them in prevention and care services [9-11]. Several community-informed interventions have also been developed to improve the uptake of PrEP [12-14]. One subgroup that has consistently been neglected in HIV prevention programming and research is South Asian American GBM, individuals who trace their heritage to countries such as India, Pakistan, and Sri Lanka. South Asian Americans are ethnically, linguistically, and culturally diverse and represent a rapidly expanding segment of the overall population [15]. The majority of South Asian Americans are immigrants, with foreign-born individuals comprising 66%, 62%, and 75% of the total Indian, Pakistani, and Sri Lankan populations, respectively, in 2023 [16].

Research from Australia [17,18], Canada [19,20], and the United Kingdom [21,22] has found that South Asian GBM experience multiple minority stressors stemming from their intersectional identities, such as internalized homophobia, racial prejudice, and homonegative discrimination. These stressors have been associated with increased participation in sexual risk behaviors among Black or African American and Hispanic or Latino GBM in the United States [23-25] and may similarly affect South Asian American GBM. Another stressor that could heighten this subgroup’s vulnerability to HIV is immigration [26]. Structural stigma toward sexual minorities and foreign-born individuals has been linked to insufficient HIV prevention knowledge, limited engagement in protective behaviors, and inadequate receipt of health care services among GBM [27,28]. Collectively, these studies underscore the importance of engaging South Asian American GBM in HIV prevention efforts.

Information-motivation-behavioral (IMB) skills model, by Fisher and Fisher, provides a useful framework for conceptualizing and promoting HIV preventive behaviors [29]. Over the years, it has been used to develop interventions promoting consistent condom use [30], to guide content creation for smartphone apps [31], and to evaluate PrEP adherence among racial and ethnic minority GBM [32]. In the context of PrEP use, information refers to the knowledge and understanding an individual has about this HIV prevention tool, including its safety, efficacy, and potential contraindications. Motivation involves an individual’s desire and willingness to use PrEP, shaped by elements such as attitudes, stigma, and social norms. The latter are often categorized into subjective norms (ie, perceived expectations and opinions of others regarding a behavior) and descriptive norms (ie, actual behavior of others). Behavioral skills encompass an individual’s self-efficacy to use PrEP as recommended (ie, belief in their ability to perform the behavior successfully). These constructs are interconnected and reciprocally interact to determine whether an individual will initiate and sustain PrEP use [33].

Due to the scarcity of HIV scientific literature focusing on South Asian American GBM, little is known about their use of PrEP or the upstream factors influencing its uptake. This study seeks to address this gap by describing PrEP use history among South Asian American GBM and comparing PrEP users and nonusers with respect to their demographic and behavioral characteristics, as well as PrEP knowledge, attitudes, stigma, social norms, and self-efficacy, elements that reflect key constructs of the IMB model [33]. Our results could help lay a strong foundation for designing and evaluating novel, culturally relevant PrEP-related interventions for South Asian American GBM at elevated risk of HIV.

Data for these analyses were derived from “Ujala,” a pilot web-based survey study conducted from April to July 2022 among South Asian American GBM residing in different regions of the country. The study’s name, which means “light,” “radiant,” or “bright” in multiple South Asian languages, was chosen to pique curiosity and bolster engagement among potential participants. “Ujala” was designed as a preliminary investigation of HIV-related risk and preventive behaviors among South Asian American GBM. Pilot studies are well suited for exploratory research to identify recruitment avenues, estimate parameters, and inform subsequent larger-scale studies, with recommended sample sizes ranging from 50 to 150 participants [34-36]. Accordingly, we aimed to recruit approximately 100 participants, corresponding to the midpoint of the recommended range for pilot studies.

Participants were recruited by requesting administrators of web-based South Asian American LGBTQ+ (lesbian, gay, bisexual, transgender/transsexual, queer, and other minority sexual orientations and gender identities) groups (eg, MASALA Boston, Trikone Bay Area, and Khush ATX) to post study advertisements on their social media channels. Individuals who clicked through to the study’s landing page, programmed in Qualtrics, were requested to provide electronic informed consent and were screened for eligibility. Only those who identified as male, were at least 18 years of age, resided in the United States, were of legal age to provide consent in their state or territory of residence, identified as South Asian, had at least 1 male sex partner in the past 6 months, had never been diagnosed with HIV, and were willing to provide their name and email address to receive a US $25 Amazon e-gift card were eligible to participate. Eligible individuals were directed to a Qualtrics survey that collected information on demographic and behavioral characteristics as well as on several PrEP-related variables (Multimedia Appendix 1). The final page of the survey included a link to the study’s landing page that could be shared with potential participants in their networks.

Specifics regarding participant recruitment, including the number of individuals at each stage (ie, click-throughs to the study’s landing page, provision of informed consent, and eligibility screening), have been described elsewhere [37]. Of the 140 individuals who began the survey, 103 (74%) provided complete data on all PrEP-related variables of interest and were included in the analytic sample. Missing data were handled using complete-case analysis, ensuring that all reported results are based solely on observed participant responses. No differences in demographic or behavioral characteristics were observed between individuals included in the analytic sample and those excluded.

Statistical analyses were conducted using SAS. Descriptive statistics were calculated to summarize the demographic and behavioral characteristics of the participants, overall and stratified by current PrEP use. Fisher exact tests, which are useful when dealing with small sample sizes, were conducted to compare PrEP users and nonusers with respect to each characteristic. Reasons indicated by the participants for never using or discontinuing PrEP were also summarized.

Responses to items on the PrEP knowledge, attitudes, stigma, subjective norms, descriptive norms, and self-efficacy scales were summed to generate a score for each scale for each participant. Medians and IQRs were calculated for each score to characterize their distribution, overall and stratified by current PrEP use. Mann-Whitney U tests were conducted to compare PrEP users and nonusers with respect to each scale score.

Study materials and procedures were reviewed and approved by the institutional review board at the University of Michigan (HUM00209310). Electronic informed consent was obtained from all individual participants included in the study. Survey responses were deidentified, as names and email addresses used for incentive distribution were collected through a separate Qualtrics form and were not linked to survey responses. Participant data were stored and analyzed on secure, password-protected platforms at the University of Michigan approved for sensitive human-subjects research data, with access restricted to institutional review board–approved study team members. Participants who completed at least 80% of the survey were thanked for their contribution via email and sent a US $25 Amazon e-gift card.

Table 1 summarizes the demographic and behavioral characteristics of the 103 participants, overall and stratified by current PrEP use. Regarding ethnic origin, the majority were Indian (94, 91%), followed by Pakistani (7, 7%), Sri Lankan (1, 1%), and Sindhi (1, 1%). Ages ranged from 22 to 57 years, with a median of 34 (IQR 31-42) years. The majority held a master’s or doctoral degree, were employed full time or part time, were born outside the United States, had been residing in the United States for more than 10 years, and identified as gay. Of those who were partnered, almost half were in an open relationship, and almost one-quarter were in a relationship wherein no sexual agreement had been formulated. In the past 6 months, almost two-thirds had at least 2 male sex partners, and almost one-third had condomless anal sex with at least 2 male partners. Additionally, almost one-third had not been tested for HIV in the past year.

Regarding PrEP use among the 103 participants, 34 (33%) were currently using it, 52 (50%) had never used it, and 17 (17%) had discontinued its use. Greater proportions of PrEP users were in open relationships, had at least 2 male sex partners in the past 6 months, and had condomless anal sex with at least 2 male partners in the past 6 months compared to nonusers. The most frequently cited reasons for never using PrEP included being in a relationship (17/52, 33%), low HIV risk perception (15/52, 29%), and concern about its long-term safety (7/52, 13%). The most frequently cited reasons for discontinuing PrEP included starting a relationship (7/17, 41%), limited coverage under one’s health insurance plan (3/17, 18%), and concern about its long-term safety (2/17, 12%). Subgroup analyses among 63 participants who likely met clinical indications for PrEP (ie, had condomless anal sex in the past 6 months or had anal sex with a partner living with HIV in the past 6 months) revealed that 29 (46%) were currently using it, 22 (35%) had never used it, and 12 (19%) had discontinued its use.

Figure 1 depicts the proportions of each item on the PrEP knowledge scale that were answered correctly and those answered incorrectly or marked as “Don’t know” by the 103 participants. The majority answered each question correctly, except for the ones asking if PrEP has serious side effects and if the PrEP pill contains a combination of medications also used to treat HIV.

Figure 2 summarizes the proportions of each item on the PrEP attitudes, stigma, subjective norms, and descriptive norms scales that were strongly agreed or agreed with, marked as neutral, and disagreed or strongly disagreed with by the 103 participants. The majority strongly agreed or agreed with each item on the PrEP attitudes scale, disagreed or strongly disagreed with each item on the PrEP stigma scale (except for the one about disclosure of PrEP use to family members), and strongly agreed or agreed with each item on the subjective and descriptive norms scales.

Figure 3 depicts the proportions of each item on the PrEP self-efficacy scale that were deemed very hard or somewhat hard to perform and somewhat easy or very easy to perform by the 103 participants. The majority indicated that each task was somewhat easy or very easy to perform.

Table 2 summarizes the distributions of scores on the PrEP knowledge, attitudes, stigma, subjective norms, descriptive norms, and self-efficacy scales completed by the 103 participants, overall and stratified by current PrEP use. The distribution of scores on the PrEP knowledge scale was skewed to the left, indicating generally high knowledge. Greater knowledge was noted among PrEP users versus nonusers. The distribution of scores on the PrEP attitudes scale was skewed to the left, indicating generally positive attitudes. More positive attitudes were noted among PrEP users versus nonusers. The distribution of scores on the PrEP stigma scale was skewed to the right, indicating generally low stigma. No differences in stigma were noted between PrEP users and nonusers. The distribution of scores on the PrEP subjective norms scale was skewed to the left, indicating generally positive subjective norms. More positive subjective norms were noted among PrEP users versus nonusers. The distribution of scores on the PrEP descriptive norms scale was skewed to the left, indicating generally positive descriptive norms. No differences in descriptive norms were noted between PrEP users and nonusers. The distribution of scores on the PrEP self-efficacy scale was skewed to the left, indicating generally high self-efficacy. Greater self-efficacy was noted among PrEP users versus nonusers.

Our study addresses an important gap in the HIV scientific literature by examining PrEP utilization among South Asian American GBM and the potential role of theory-based behavioral antecedents, specifically information, motivation, and behavioral skills, in shaping its uptake. Consistent with the IMB model, greater knowledge, more positive attitudes and subjective norms, and greater self-efficacy were noted among PrEP users compared to nonusers, paralleling studies with other racial and ethnic minority GBM in the United States [38-42], and providing empirical support for the IMB model in explaining PrEP use behavior in this subgroup. Our results indicate suboptimal PrEP use, with only one-third of all participants and less than half of those who likely met clinical indications for PrEP reporting use at the time of the survey. Notably, the underuse of PrEP in our sample occurred despite high PrEP knowledge, positive attitudes, low stigma, positive social norms, and high PrEP self-efficacy, suggesting a disconnect between individual readiness and uptake. Theoretically, these findings suggest that within the IMB framework, favorable levels of information, motivation, and behavioral skills may not fully translate into PrEP uptake in the absence of enabling contextual factors. Our study underscores the need for targeted strategies that address personal, cultural, and structural barriers that may be limiting access to, initiation of, and sustained use of PrEP among South Asian American GBM.

Although PrEP uptake among GBM in the United States has been on the rise, racial and ethnic disparities persist. In 2023, 38% of 1125 non-Hispanic Black or African American GBM and 43% of 1477 Hispanic or Latino GBM participating in the National HIV Behavioral Surveillance were using PrEP, compared to 51% of 1709 non-Hispanic White GBM [43]. Interestingly, 60% of 187 non-Hispanic Asian GBM were using PrEP, higher than any other racial or ethnic category [43]. Disaggregated data for South Asian American GBM were not reported, a disconcerting and recurring issue in the HIV surveillance literature, as it precludes our understanding of their unmet HIV prevention needs. Our current PrEP use estimates of 33% among all participants and 46% among those who likely met clinical indications for PrEP offer preliminary evidence to fill this gap. They also shed light on the progress made thus far and the need to promote equitable PrEP implementation to ensure that South Asian American GBM are not underserved in HIV prevention efforts.

Regarding variations in characteristics between PrEP users and nonusers, no differences were observed across any demographic characteristic, except for relationship type. Although similar proportions of GBM in each category were single, more PrEP users were in open relationships, and more nonusers were in closed relationships or did not have mutually formulated sexual agreements. This suggests that PrEP uptake may be influenced by relationship dynamics and communication, with GBM in open relationships potentially engaging in explicit conversations about sexual boundaries and HIV risk with their partners [44,45]. South Asian American GBM in relationships that are not strictly monogamous or include periods of nonmonogamy, whether consensual or not, remain susceptible to HIV and warrant attention in HIV prevention research and programming.

Exploring the reasons indicated by our participants for never using PrEP and discontinuing its use, the most frequently reported were being in a relationship and starting a relationship, respectively. Racial and ethnic minority GBM in the United States frequently cite these as normative justifications for avoiding or stopping PrEP [46,47]. Modeling suggests that a significant proportion of new HIV infections among partnered GBM occur within relationships [48,49], often due to reduced risk perception stemming from assumptions of exclusivity, leading to decreased condom use [50,51] and less frequent testing [52,53]. Decisions regarding PrEP use among partnered GBM should ideally be based on actual risk behaviors, open and honest communication, and clarity around sexual agreements. Our findings have practical implications for PrEP programming within couple-based and relationship-focused interventions. Empowering partnered South Asian American GBM to make informed, realistic, and mutually agreed-upon decisions about using PrEP, for example, through couples counseling, peer-led discussions, and digital resources, is important for safeguarding their sexual health.

Another frequently cited reason for never using or discontinuing PrEP was a concern about its long-term safety, which also parallels findings from other studies with GBM [54,55]. Although both FDA-approved oral formulations for PrEP are generally regarded to be safe and well tolerated [56], especially with regular monitoring, the possibility of long-term side effects from extended use exists. Truvada has been linked to decreased kidney function [57] and small reductions in bone mineral density [58], whereas Descovy has been associated with weight gain and elevated lipid levels [59]. However, these adverse events are rare, as confirmed by multiple clinical trials [60,61]. South Asian Americans have a strong cultural connection to traditional medicinal systems, such as Ayurveda, Siddha, and Unani, and may be reluctant to embrace the long-term use of allopathic drugs [62,63]. Our results highlight the need for clear, culturally informed PrEP communication strategies and suggest that tailored messaging emphasizing the safety of PrEP, possibly comparing it to other common long-term medications such as those for diabetes and hypertension, might help alleviate such concerns.

Shifting focus to the information construct of the IMB model, our sample demonstrated generally high PrEP knowledge, indicating a strong baseline understanding of this HIV prevention tool. Notably, most of our participants were highly educated, with more than three-fourths holding a master’s or doctoral degree. Yet, more than half responded incorrectly or indicated uncertainty on questions about whether PrEP has serious side effects and whether the PrEP pill contains a combination of medications also used to treat HIV, highlighting deficits in specific knowledge areas. Many GBM have reported receiving PrEP information from their peers, who, while accessible, sometimes provide incomplete or inaccurate details [64]. Others have identified their health care providers as initial sources of PrEP information, acknowledging them as trusted authorities who dispel misconceptions while reinforcing its safety and effectiveness [64]. South Asian GBM residing in Western countries are often reluctant to disclose their sexual orientation to medical professionals due to familial, cultural, and social pressures [17,19,21], limiting their opportunities to learn about HIV prevention options, including PrEP. Our findings underscore the importance of strengthening accurate, provider-delivered PrEP education and improving access to affirming health care environments. Future studies could explore how perceived and experienced stigmas influence clinical interactions and identify practical strategies to further enhance PrEP knowledge.

Focusing on the motivation construct of the IMB model, our participants harbored generally positive attitudes, low stigma, and generally positive subjective and descriptive norms regarding PrEP, suggesting favorable perceptions and adequate social support to consider or initiate its use. The only exception was that more than two-fifths were concerned about their families finding out if they were using PrEP. This may reflect fears of being questioned about their sexual orientation, being judged as promiscuous, or being perceived to already have HIV. Family plays a pivotal role in South Asian culture, and for GBM, relationships often exist in a delicate balance between personal identity, cultural expectations, and societal conformity [18,20,22]. Given the potential for conflict between individual autonomy in health-related decisions and familial influences on those decisions, creating supportive spaces for open dialogue could help mitigate concerns about the inadvertent disclosure of PrEP use.

Regarding the behavioral skills construct of the IMB model, our sample exhibited generally high PrEP self-efficacy, indicating a strong sense of confidence in navigating behaviors related to accessing, initiating, and sustaining PrEP use. However, almost a quarter reported that finding a way to pay for PrEP, taking a pill every day, and visiting a health care provider every 3 months for routine screenings would be arduous. Cost, adherence, and ongoing clinic visits are practical barriers, but they are not insurmountable. The first could be addressed by investigating insurance coverage options and public health initiatives that offer PrEP at reduced or no cost [65,66]. The second could be mitigated through considering medication adherence programs that provide support in the form of counseling and reminders [67,68] or by exploring long-acting injectable PrEP formulations (Apretude and Yeztugo) [69]. The third could be addressed by using telehealth delivery models to reduce structural and logistical impediments [70,71].

Despite our understanding that “Ujala” is among the few studies focusing on the sexual health of South Asian American GBM, it is not without limitations. Participants were recruited from web-based South Asian American LGBTQ+ groups and via peer referral, thereby excluding individuals with limited engagement in web-based LGBTQ+ communities and social networks. Individuals self-selected into the study and were required to provide their name and email address in a separate Qualtrics form to receive the incentive, resulting in the study not being fully anonymous and potentially introducing selection bias. More than three-fourths of the participants were born outside the United States and had a postgraduate degree, which may limit the generalizability of our findings. However, these characteristics should be interpreted in the context of the broader South Asian American population, which is predominantly composed of immigrants [16] and has been consistently reported to have high levels of educational attainment [72]. Social desirability bias may have resulted in an underreporting of sexual risk behaviors and overreporting of HIV prevention behaviors, but we do not anticipate substantial misreporting, as our participants self-completed the survey and could skip questions that made them uncomfortable. The cross-sectional design of this study precludes us from commenting on temporal associations between the IMB model constructs and PrEP use. Additionally, the scope of the data collected in the study and the sample size limited our ability to conduct additional subgroup analyses. Future studies with larger samples of South Asian American GBM could examine potential variations in PrEP use as well as PrEP knowledge, attitudes, stigma, social norms, and self-efficacy across different subgroups. Finally, the previously validated scales that we used to measure IMB model constructs were developed before the availability of long-acting injectable PrEP formulations and therefore did not capture knowledge, motivation, or self-efficacy related to this option. Nonetheless, they provided reliable information on these constructs with respect to daily oral PrEP in our sample.

Our study makes a noteworthy contribution by describing PrEP use among sexually active South Asian American GBM, exploring differences in demographic and behavioral characteristics between PrEP users and nonusers, and illuminating reasons for avoiding or stopping PrEP, issues that have not been well characterized in the HIV scientific literature. It also highlights the use of the IMB model in explaining PrEP use behavior in this historically understudied subgroup and underscores the importance of addressing informational, motivational, and behavioral skills-related barriers to improve PrEP uptake. As a pilot study with a relatively small, convenience-based sample, these findings provide preliminary evidence and should be interpreted as an initial exploration. Nonetheless, they offer a foundation for future larger-scale research examining PrEP use and its behavioral determinants among South Asian American GBM across diverse settings in the United States. Subsequent work to better understand the underlying causes of suboptimal PrEP use in this subgroup conducted through an intersectional lens could help identify possible points for intervention.