<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Form Res</journal-id><journal-id journal-id-type="publisher-id">formative</journal-id><journal-id journal-id-type="index">27</journal-id><journal-title>JMIR Formative Research</journal-title><abbrev-journal-title>JMIR Form Res</abbrev-journal-title><issn pub-type="epub">2561-326X</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v10i1e74167</article-id><article-id pub-id-type="doi">10.2196/74167</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Paper</subject></subj-group></article-categories><title-group><article-title>Exploring the Preferences and Behavioral Trends of e-Patients in Psychosomatics Towards Telemedicine During and Post COVID-19 Pandemic: Cross-Sectional Analysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Mahling</surname><given-names>Moritz</given-names></name><degrees>MD, MHBA</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>McQueeney</surname><given-names>Alexander</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Festl-Wietek</surname><given-names>Teresa</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Masters</surname><given-names>Ken</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Zipfel</surname><given-names>Stephan</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Herrmann-Werner</surname><given-names>Anne</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Rometsch</surname><given-names>Caroline</given-names></name><degrees>PhD, MHBA</degrees><xref ref-type="aff" rid="aff5">5</xref><xref ref-type="aff" rid="aff6">6</xref></contrib></contrib-group><aff id="aff1"><institution>Deanery of Students&#x2019; Affairs, University of T&#x00FC;bingen</institution><addr-line>T&#x00FC;bingen</addr-line><country>Germany</country></aff><aff id="aff2"><institution>Department of Diabetology, Endocrinology, Nephrology, Section of Nephrology and Hypertension, University Hospital T&#x00FC;bingen</institution><addr-line>T&#x00FC;bingen</addr-line><country>Germany</country></aff><aff id="aff3"><institution>T&#x00FC;bingen Institute for Medical Education (TIME), Faculty of Medicine</institution><addr-line>T&#x00FC;bingen</addr-line><country>Germany</country></aff><aff id="aff4"><institution>Medical Education and Informatics Department, College of Medicine and Health Sciences, Sultan Qaboos University</institution><addr-line>Muscat</addr-line><country>Sultanate of Oman</country></aff><aff id="aff5"><institution>Department of Psychosomatic Medicine and Psychotherapy, University Hospital T&#x00FC;bingen</institution><addr-line>Osianderstr. 5</addr-line><addr-line>T&#x00FC;bingen</addr-line><country>Germany</country></aff><aff id="aff6"><institution>Department of Psychosomatic Medicine and Psychotherapy, Otto-von-Guericke University of Magdeburg</institution><addr-line>Magdeburg</addr-line><country>Germany</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Mavragani</surname><given-names>Amaryllis</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Coloma</surname><given-names>Emmanuel</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Caroline Rometsch, PhD, MHBA, Department of Psychosomatic Medicine and Psychotherapy, University Hospital T&#x00FC;bingen, Osianderstr. 5, T&#x00FC;bingen, 72074, Germany, 49 7071 29-86719; <email>caroline.rometsch@med.uni-tuebingen.de</email></corresp></author-notes><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>16</day><month>1</month><year>2026</year></pub-date><volume>10</volume><elocation-id>e74167</elocation-id><history><date date-type="received"><day>19</day><month>03</month><year>2025</year></date><date date-type="rev-recd"><day>30</day><month>07</month><year>2025</year></date><date date-type="accepted"><day>06</day><month>08</month><year>2025</year></date></history><copyright-statement>&#x00A9; Moritz Mahling, Alexander McQueeney, Teresa Festl-Wietek, Ken Masters, Stephan Zipfel, Anne Herrmann-Werner, Caroline Rometsch. Originally published in JMIR Formative Research (<ext-link ext-link-type="uri" xlink:href="https://formative.jmir.org">https://formative.jmir.org</ext-link>), 16.1.2026. </copyright-statement><copyright-year>2026</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Formative Research, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://formative.jmir.org">https://formative.jmir.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://formative.jmir.org/2026/1/e74167"/><abstract><sec><title>Background</title><p>COVID-19 accelerated the adoption of health services, with a growing number of psychosomatic patients turning to the internet for health-related decisions. This study explored changes in communication behavior, information-seeking habits, and post-pandemic consultation preferences among psychosomatic patients during and after COVID-19.</p></sec><sec><title>Objective</title><p>This study explored changes in communication behavior, information-seeking habits, and post-pandemic consultation preferences among psychosomatic patients during and after COVID-19.</p></sec><sec sec-type="methods"><title>Methods</title><p>In a cross-sectional study, 150 adult patients (&#x003E;18 y) from the psychosomatic outpatient department in T&#x00FC;bingen, Germany, were invited to complete an ad hoc questionnaire to identify e-patients&#x2019; preferences related to communication, information-seeking behavior, subjective explanations, and postpandemic preferences. Group comparisons and multiple linear regression analyses were conducted.</p></sec><sec sec-type="results"><title>Results</title><p>The study revealed a slight increase in online-based communication between patients and caregivers (eg, caregivers&#x2019; system use +10.8%; live video consultations +30.8%), as well as in patient&#x2013;patient interactions (eg, online correspondence +16.9%). Significant group differences were observed for social media correspondence by patient age (<italic>&#x03C7;</italic><sup>2</sup>&#x00AC;=17.44, <italic>P</italic>&#x003C;.001) and for live video consultations by gender (<italic>&#x03C7;</italic><sup>2</sup>&#x00AC;=70.17, <italic>P</italic>&#x003C;.001). For both age and gender, significant group differences were found in the use of medical videos (age <italic>&#x03C7;</italic><sup>2</sup>&#x00AC;=6.36, <italic>P</italic>=.04; gender <italic>&#x03C7;</italic><sup>2</sup>&#x00AC;=76.70, <italic>P</italic>&#x003C;.001). Age, gender, and preferences for live video consultations were identified as significant predictors (<italic>F</italic><sub>1,11</sub>=14.195, <italic>P</italic>&#x003C;.001, <italic>R</italic><sup>&#x00B2;</sup>=0.299) of patients&#x2019; future preferences for on-site versus online consultations.</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>Although a slight increase in online-based communication was observed, resilience in patient&#x2013;caregiver and patient&#x2013;patient communication indicated relative stability under challenging circumstances. Older adults and female patients expressed a preference for on-site consultations, emphasizing the significance of in-person care. Male patients demonstrated greater openness towards online consultations, indicating potential for expansion of eHealth services. Identifying preferences is a core essential for providing future eHealth implementations that account for diverse patient needs and for designing care offerings. Incorporating these findings may enhance patient engagement and satisfaction in the evolving landscape of eHealth services for better health care outcomes.</p></sec></abstract><kwd-group><kwd>COVID-19</kwd><kwd>pandemic</kwd><kwd>eHealth</kwd><kwd>e-patient</kwd><kwd>preferences</kwd><kwd>gender differences</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>eHealth refers to the delivery of health services and information via the internet or other electronic technologies [<xref ref-type="bibr" rid="ref1">1</xref>]. During the COVID-19 pandemic, the role of eHealth in medicine achieved its highest level of importance while combating the deadly virus [<xref ref-type="bibr" rid="ref2">2</xref>]. The accompanying social distancing norms further expedited digital developments in this field [<xref ref-type="bibr" rid="ref3">3</xref>]. eHealth has presented promising evidence for its effectiveness [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>], improving care quality, while reducing health care costs [<xref ref-type="bibr" rid="ref6">6</xref>]. During the pandemic, eHealth services facilitated communication between caregivers and patients while maintaining distancing policies, thereby reducing hospital visits and direct contact [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. During the COVID-19 pandemic, patient&#x2013;caregiver communication was conducted via webcam-enabled computers, smartphones, and telephone conferencing [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>]. This assisted caregivers in making patient-centered clinical decisions [<xref ref-type="bibr" rid="ref11">11</xref>].</p><p>Reflecting the growing emphasis on patient involvement in decision-making, eHealth has enabled patients to use the internet as a source of empowerment. Consequently, patients are able to play a more active role in their own medical care, for example, by presenting information during consultations [<xref ref-type="bibr" rid="ref12">12</xref>] and making informed decisions [<xref ref-type="bibr" rid="ref13">13</xref>]. Patients who use the internet to inform themselves about health are termed &#x201C;e-patients&#x201D; [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>]. In this study, e-patients refer to patients who actively use digital technologies to seek health information, which distinguishes them from broader digital health users who may passively use online health services without engaging in informed decision-making.</p><p>As nonmedical experts, e-patients often seek practical advice on social media [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]. The use of these platforms is influenced by patients&#x2019; awareness of health problems and their attempts to reduce the risk of illness [<xref ref-type="bibr" rid="ref3">3</xref>]. Apart from social media, e-patients use general search engines (eg, Google), medical sites (eg, UpToDate, WebMD), and medical journals (eg, BMJ, Lancet) for information [<xref ref-type="bibr" rid="ref18">18</xref>-<xref ref-type="bibr" rid="ref20">20</xref>]. Moreover, health apps and wearables provide relevant health-related information (eg, tracking COVID-19 infection) that has been incorporated into medical treatments [<xref ref-type="bibr" rid="ref21">21</xref>]. This shift has resulted in a more informed e-patient population than in previous decades, as is evident in patient&#x2013;physician interactions [<xref ref-type="bibr" rid="ref22">22</xref>].</p><p>The growing literature on patients&#x2019; experiences with eHealth during COVID-19 indicates high satisfaction rates, including such factors as dealing with concerns, communication, usefulness, reliability, time savings, access, and cost-efficiency [<xref ref-type="bibr" rid="ref23">23</xref>]. In managed care, eHealth is pivotal in promoting patient-focused care. However, challenges remain [<xref ref-type="bibr" rid="ref24">24</xref>], particularly the technical demands of using eHealth [<xref ref-type="bibr" rid="ref25">25</xref>]. To ensure that patient involvement remains a core element in the future implementation of eHealth after the COVID-19 pandemic [<xref ref-type="bibr" rid="ref26">26</xref>], further investigation into patients&#x2019; preferences and behaviors is required.</p><p>Thus, this study aims to examine patient adoption of eHealth, changes in patients&#x2019; behavior, and patients&#x2019; explanations for those changes during and after the COVID-19 pandemic. Specifically, it focuses on the dimensions of preferences and experiences in communication, information acquisition and the use of health apps and wearables in a German psychosomatic outpatient clinic.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Study Design</title><p>This cross-sectional study was conducted from October 1, 2020, to March 31, 2021, at the Outpatient Department of Psychosomatic Medicine and Psychotherapy in T&#x00FC;bingen, Germany. A total of 175 patients aged 18 years and older were invited to voluntary participate and were asked to complete a specially-designed questionnaire. It took approximately 15 to 20 minutes for patients to complete the written questionnaire.</p><p>Patients were seen by a medical doctor or psychologist in the outpatient department for diagnostic consultations, including clinical interviews and psychometric assessments. Admission to the outpatient service was voluntary, and most patients had been referred by general practitioners, psychiatrists, or psychologists because of mental health complaints. Participation in the study was entirely voluntary. Patients with insufficient German language proficiency or severe psychiatric disorders were excluded, and no responses were excluded during data analysis.</p></sec><sec id="s2-2"><title>Ethical Considerations</title><p>This study was conducted in accordance with the ethical standards of the Declaration of Helsinki [<xref ref-type="bibr" rid="ref27">27</xref>], and was approved by the Ethics Committee of T&#x00FC;bingen Medical Faculty (no. 243/2022BO2). Patients provided written, informed consent prior to participation, after being informed about the study&#x2019;s aim, the voluntary nature of participation, their right to withdraw without consequences, and the measures taken to ensure data security. For analysis, data were anonymized to ensure that patients could not be identified. The authors did not have access to information that could identify individual participants during or after data collection. No incentives were provided. No images of individual participants or users are included in the manuscript or supplementary material.</p></sec><sec id="s2-3"><title>Assessment Instruments</title><p>Drawing from the literature on current e-patient activities and changes in physician&#x2013;patient interactions during the COVID-19 pandemic [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref29">29</xref>], an ad hoc questionnaire was created to examine e-patients&#x2019; activities and the impact that COVID-19 had on them. The think-aloud technique was used in the development of the ad hoc questionnaire items, as no validated questionnaire on e-patients&#x2019; activities existed [<xref ref-type="bibr" rid="ref30">30</xref>]. The questionnaire assessed four main domains: (1) changes in communication compared to 2019, (2) changes in patients&#x2019; use of eHealth compared to 2019, (3) patients&#x2019; interpretations of changes attributable to COVID-19, and (4) patients&#x2019; preferences post-COVID-19 pandemic. Items regarding communication and changes in patients&#x2019; use of eHealth explored whether patients&#x2019; health-related electronic activity had changed (eg, decreased, increased, no change) since December 2019 in terms of communication with caregivers or other patients, specifying the medium used (eg, video calls, emails, medical websites, wearable devices, apps) or the method of information acquisition (eg, medical books, videos, medical journals, networking). Changes were quantified on a 3-point Likert scale (1=&#x2018;not at all&#x2019;, 2=&#x2018;somewhat&#x2019;, 3=&#x2018;very&#x2019;) to evaluate subjective explanations linked to COVID-19. Patients&#x2019; preferences for future interactions (face-to-face vs eHealth) were assessed using their reaction to the following statement: &#x201C;After things return to normal, I would like to interact with my doctors in the following way: only face-to-face; mostly face-to-face; face-to-face and online equally; mostly online; or only online.&#x201D;</p></sec><sec id="s2-4"><title>Statistical Analysis</title><p>Statistical analyses were run using SPSS software (version 28; IBM Corp) [<xref ref-type="bibr" rid="ref31">31</xref>]. Sociodemographic data and responses to the ad hoc questionnaire were evaluated descriptively. Respondents were categorized into two age groups based on the mean age (&#x003C;37 y and &#x2265;37 y). Group differences were determined using <italic>&#x03C7;</italic><sup>2</sup> tests. The statistically significance was set at <italic>P</italic>&#x003C;.05. A multiple linear regression analysis was performed with the consultation format preference (on-site vs online) as the dependent variable, assessed on a 5-point ordinal scale (only face-to-face, mostly face-to-face, face-to-face and online equally, mostly online, and only online). For analysis, this variable was treated as continuous to approximate the linear trend across levels, enabling the use of multiple linear regression. This approach was chosen because the preference scale reflects a spectrum of consultation preferences rather than discrete categories. The potential predictors incorporated in the model included age, gender, communication preferences, and modes of medication and information acquisition. These predictors were selected based on their theoretical relevance from prior studies [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref32">32</xref>]. Multicollinearity was assessed using variance inflation factors (VIF), and no issues were identified (all VIF &#x003C;2). Model fit was evaluated using <italic>R</italic>&#x00B2; and the Durbin&#x2013;Watson statistic to prove autocorrelation in residuals.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>Sociodemographic Data</title><p>A total of 150 patients participated in the study, yielding a response rate of 85.7%. The mean age of the participants was 37.06 (SD 12.4) years, with the majority being female (n=88, 58.7%; unspecified n=41, 27.3%). Most patients (92/125, 73.6%) reported undergoing an in-person examination in the department, while 33/150 patients (22.0%) reported an online consultation. In-person examinations were cited as the preferred consultation type by 70.9% of patients (61/86), with no significant differences observed regarding age or gender.</p></sec><sec id="s3-2"><title>Changes in Patients&#x2019; Communication in Relation to the Timeframe of 2019</title><p>The results indicate an increase in online-based communication methods since 2019, including both written communication (eg, email, social media) and direct consultations (eg, via electronic systems, video calls). However, there was a noted decrease in live video consultations among 51/133 patients (38.3%). Patient-to-patient communication did not show significant changes. Significant group differences were observed for social media correspondence by age (<italic>&#x03C7;</italic><sup>2</sup>=17.44, <italic>P</italic>&#x003C;.001). Regarding gender, significant group differences were found for live video consultations (<italic>&#x03C7;</italic><sup>2</sup>=70.17, <italic>P</italic>&#x003C;.001) (see <xref ref-type="table" rid="table1">Table 1</xref>).</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Changes in communication behaviors among patients with mental health complaints attending the outpatient department of psychosomatic medicine and psychotherapy at T&#x00FC;bingen University Hospital, Germany (cross-sectional study, October 2020 to March 2021), compared with the prepandemic year 2019.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Communication partner, eHealth type, and changes in use</td><td align="left" valign="bottom">Total responses, n (%)</td></tr></thead><tbody><tr><td align="left" valign="top" colspan="2">Correspondence with physicians</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Changes in email correspondence (n=90)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="left" valign="top">51 (56.7)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="left" valign="top">37 (41.1)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="left" valign="top">2 (2.2)</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Social media correspondence (n=83)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="char" char="." valign="top">71 (85.5)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="char" char="." valign="top">5 (6.0)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="char" char="." valign="top">7 (8.4)</td></tr><tr><td align="left" valign="top" colspan="2">Patient&#x2013;physician communication</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Caregivers&#x2019; system (n=102)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="left" valign="top">67 (65.7)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="char" char="." valign="top">11 (10.8)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="char" char="." valign="top">24 (23.5)</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Live video consultation (n=133)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="left" valign="top">41 (30.8)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="char" char="." valign="top">41 (30.8)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="left" valign="top">51 (38.3)</td></tr><tr><td align="left" valign="top" colspan="2">Patient&#x2013;patient correspondence</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Internet use (n=83)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="left" valign="top">60 (72.3)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="char" char="." valign="top">14 (16.9)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="char" char="." valign="top">9 (10.8)</td></tr></tbody></table></table-wrap></sec><sec id="s3-3"><title>Changes in Patients&#x2019; E-Health Use in Relation to the Timeframe of 2019</title><p>Aligned with the results on communication, an increase was observed for wearables and eHealth apps. However, no significant changes were observed regarding the purchase of medication and obtaining medical information via the internet. However, when closely examining the increase in obtaining online medical information, the greatest growth is observed for online medical books and videos compared to the others.</p><p>Significant group differences were detected concerning online purchase of medication (<italic>&#x03C7;</italic><sup>2</sup>=6.94, <italic>P</italic>=.03), medical books (<italic>&#x03C7;</italic><sup>2</sup>=9.43, <italic>P</italic>=.009), medical videos (<italic>&#x03C7;</italic><sup>2</sup>=6.36, <italic>P</italic>=.04), medical journals (<italic>&#x03C7;</italic><sup>2</sup>=9.53, <italic>P</italic>&#x003C;.05), and wearables (<italic>&#x03C7;</italic><sup>2</sup>=8.92, <italic>P</italic>&#x003C;.05), in regard to the patient&#x2019;s age. Regarding gender, significant group differences were found for medical videos (<italic>&#x03C7;</italic><sup>2</sup>=76.70, <italic>P</italic>&#x003C;.001), medical websites (<italic>&#x03C7;</italic><sup>2</sup>=43.67, <italic>P</italic>&#x003C;.001) (see <xref ref-type="table" rid="table2">Table 2</xref>).</p><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Changes in behavior regarding e-health activities by patients with mental health complaints attending the outpatient Department of Psychosomatic Medicine and Psychotherapy at T&#x00FC;bingen University Hospital, Germany (October 2020 to March 2021), compared to the pre-pandemic year 2019).</p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Category, specification, and changes in use</td><td align="left" valign="bottom">Total , n (%)</td></tr></thead><tbody><tr><td align="left" valign="top" colspan="2">Medication</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Online purchase (n=87)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="left" valign="top">54 (62.1)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="char" char="." valign="top">30 (20)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="char" char="." valign="top">3 (3.4)</td></tr><tr><td align="left" valign="top" colspan="2">Obtaining medical information</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Medical books (n=87)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="left" valign="top">62 (71.3)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="char" char="." valign="top">20 (23.0)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="char" char="." valign="top">5 (5.7)</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Medical videos (n=132)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="left" valign="top">58 (43.9)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="left" valign="top">27 (18.0)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="left" valign="top">47 (35.6)</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Medical websites (n=107)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="left" valign="top">61 (57.0)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="char" char="." valign="top">22 (20.6)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="char" char="." valign="top">24 (22.4)</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Medical journals (n=87)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="left" valign="top">71 (81.6)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="left" valign="top">7 (8.0)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="char" char="." valign="top">9 (6.0)</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Networking sites (n=88)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="char" char="." valign="top">65 (73.9)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="left" valign="top">13 (14.8)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="left" valign="top">10 (11.4)</td></tr><tr><td align="left" valign="top" colspan="2">eHealth technology</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Wearables (n=133)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="left" valign="top">100 (75.2)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="char" char="." valign="top">21 (15.8)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="char" char="." valign="top">12 (9.0)</td></tr><tr><td align="left" valign="top" colspan="2">&#x2003;Health applications (n=104)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Indifferent</td><td align="char" char="." valign="top">53 (51.0)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Increase</td><td align="left" valign="top">46 (44.2)</td></tr><tr><td align="left" valign="top">&#x2003;&#x2003;Decrease</td><td align="left" valign="top">5 (3.3)</td></tr></tbody></table></table-wrap></sec><sec id="s3-4"><title>Changes Due to COVID-19</title><p>Patients&#x2019; communication was moderately affected by the COVID-19 pandemic, with a mean score of 1.69 (SD 0.53). A similar impact was observed in their search for online information (mean 1.24, SD 0.47). However, a more significant change due to the pandemic was observed in two aspects: the online acquisition of medication (mean 1.70, SD 0.68) and the use of eHealth technology (mean 2.23, SD 0.45). For a detailed analysis of the changes caused by COVID-19, see <xref ref-type="fig" rid="figure1">Figure 1</xref>.</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>Changes in patient communication, information acquisition, online purchase of medication, and wearables and eHealth apps among patients attending the outpatient department of psychosomatic medicine and psychotherapy at T&#x00FC;bingen University Hospital, Germany (cross-sectional study, October 2020 to March 2021) caused by the COVID-19 pandemic.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="formative_v10i1e74167_fig01.png"/></fig></sec><sec id="s3-5"><title>Explanation of Changes Due to COVID-19</title><p>In terms of patient communication, changes in email correspondence were attributed to COVID-19 by 16/90 patients. Social media correspondence was reported to have changed due to COVID-19 by 3/83 patients. A total of 8/102 indicated that the caregivers&#x2019; system had changed, while 27/102 patients reported alterations in live video consultations.</p><p>With respect to eHealth use, the online purchase of medication was identified as having changed due to COVID-19 by 7/87 patients. A total of 5/87 patients reported informing themselves more via medical books. Changes in the use of medical videos were reported by 4/132 patients , while 3/107 patients reported changes in the use of medical websites. A total of 3/87 patients indicated changes in the use of medical journals. Lastly, the use of wearable technology was reported to have subjectively increased due to COVID-19 by 5/130 patients.</p></sec><sec id="s3-6"><title>Patients&#x2019; Post-COVID-19 Pandemic Preferences</title><p>After most restrictions due to COVID-19 were lifted, most patients (n=120/147, 81.7%) stated a preference for seeing a medical caregiver on-site. Correspondingly, patients preferred patient&#x2013;patient interactions to be on-site (n=88/145, 60.7%). Approximately, one-third of patients (n=48/145, 32.0%) were open to ordering medication both on-site and online, although most patients (n=81/145, 55.1%) chose the on-site option. Finally, when obtaining medical information, patients regarded on-site and online channels as equal (n=66/146, 45.2%).</p></sec><sec id="s3-7"><title>Predictors of Preference for on-Site vs Online Consultations</title><p>The results of the multiple linear regression analysis revealed a statistically significant model (<italic>F</italic><sub>1,11</sub>=14.195, <italic>P</italic>&#x003C;.001) that explained patients&#x2019; future preferences regarding on-site versus online consultations. Significant predictors included age (B=&#x2212;0.011, SE=0.005, <italic>t</italic>=&#x2212;2.29; <italic>P</italic>=.02), gender (B=0.491, SE=0.113, <italic>t</italic>=4.35; <italic>P</italic>&#x003C;.001), and changes in live video consultation use during COVID-19 (B=0.270, SE=0.084, <italic>t</italic>=3.20; <italic>P</italic>=.002). This finding suggests that patients of older age are more inclined towards on-site consultations. Furthermore, the data indicates that males prefer online consultations, while female patients show a tendency towards on-site consultations. An increase in the preference for live video consultations due to COVID-19 was positively correlated with a willingness to engage in online consultations. However, online communication via email (<italic>P</italic>=.95), online searches for medical information (books (<italic>P</italic>=.70) or videos (<italic>P</italic>=.12)) and online medication purchases (<italic>P</italic>=.11) were not found to be statistically significant predictors (see <xref ref-type="table" rid="table3">Table 3</xref>).</p><table-wrap id="t3" position="float"><label>Table 3.</label><caption><p>Multiple linear regression analysis identifying predictors of patients&#x2019; preferences for on-site versus online consultations in a cross-sectional study of patients with mental health complaints at the outpatient department of psychosomatic medicine and psychotherapy, T&#x00FC;bingen University Hospital, Germany (October 2020&#x2013;March 2021).</p></caption><table id="table3" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Variables</td><td align="left" valign="bottom"><italic>R</italic><sup>&#x00B2;</sup><sup><xref ref-type="table-fn" rid="table3fn1">a</xref></sup></td><td align="left" valign="bottom">SE<sup><xref ref-type="table-fn" rid="table3fn2">b</xref></sup></td><td align="left" valign="bottom">B<sup><xref ref-type="table-fn" rid="table3fn3">c</xref></sup></td><td align="left" valign="bottom">t test<sup><xref ref-type="table-fn" rid="table3fn4">d</xref></sup></td><td align="left" valign="bottom">95% CI</td><td align="left" valign="bottom"><italic>P</italic> value</td></tr></thead><tbody><tr><td align="left" valign="top">Constant</td><td align="left" valign="top">&#x2003;1781</td><td align="left" valign="top">&#x2003;0.344</td><td align="left" valign="top">&#x2014;</td><td align="left" valign="top">&#x2003;5181</td><td align="left" valign="top">&#x2003;1101 to 2461</td><td align="left" valign="top">&#x2003;&#x003C;,001<sup><xref ref-type="table-fn" rid="table3fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Age</td><td align="left" valign="top">&#x2003;&#x2212;.011</td><td align="left" valign="top">&#x2003;0.005</td><td align="left" valign="top">&#x2003;&#x2212;0.169</td><td align="left" valign="top">&#x2003;&#x2212;2289</td><td align="left" valign="top">&#x2003;&#x2212;0.020 to &#x2212;0.001</td><td align="left" valign="top">&#x2003;.02</td></tr><tr><td align="left" valign="top">Gender</td><td align="left" valign="top">&#x2003;0.491</td><td align="left" valign="top">&#x2003;0.113</td><td align="left" valign="top">&#x2003;0.389</td><td align="left" valign="top">&#x2003;4347</td><td align="left" valign="top">&#x2003;0.268 to 0.715</td><td align="left" valign="top">&#x2003;&#x003C;.001<sup><xref ref-type="table-fn" rid="table3fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Online purchase of medication</td><td align="left" valign="top">&#x2003;&#x2212;0.159</td><td align="left" valign="top">&#x2003;0.099</td><td align="left" valign="top">&#x2003;&#x2212;0.136</td><td align="left" valign="top">&#x2003;&#x2212;1599</td><td align="left" valign="top">&#x2003;&#x2013;0.356 to &#x2013;0.038</td><td align="left" valign="top">&#x2003;.11</td></tr><tr><td align="left" valign="top">Correspondence via mail</td><td align="left" valign="top">&#x2003;&#x2212;0.006</td><td align="left" valign="top">&#x2003;0.094</td><td align="left" valign="top">&#x2003;&#x2212;,006</td><td align="left" valign="top">&#x2003;&#x2212;0.069</td><td align="left" valign="top">&#x2003;&#x2013;0.192 to 0.179</td><td align="left" valign="top">&#x2003;.95</td></tr><tr><td align="left" valign="top">Live-video consultations</td><td align="left" valign="top">&#x2003;0.270</td><td align="left" valign="top">&#x2003;0.084</td><td align="left" valign="top">&#x2003;0.262</td><td align="left" valign="top">&#x2003;3204</td><td align="left" valign="top">&#x2003;0.104 to 0.437</td><td align="left" valign="top">&#x2003;.002<sup><xref ref-type="table-fn" rid="table3fn6">f</xref></sup></td></tr><tr><td align="left" valign="top">Information via medical books</td><td align="left" valign="top">&#x2003;0.059</td><td align="left" valign="top">&#x2003;0.151</td><td align="left" valign="top">&#x2003;0.048</td><td align="left" valign="top">&#x2003;0.391</td><td align="left" valign="top">&#x2003;&#x2212;0.240 to 0.358</td><td align="left" valign="top">&#x2003;.67</td></tr><tr><td align="left" valign="top">Information via medical videos</td><td align="left" valign="top">&#x2003;&#x2212;0.245</td><td align="left" valign="top">&#x2003;0.156</td><td align="left" valign="top">&#x2003;&#x2212;0.196</td><td align="left" valign="top">&#x2003;&#x2212;1573</td><td align="left" valign="top">&#x2003;&#x2013;0.553 to 0.063</td><td align="left" valign="top">&#x2003;.12</td></tr></tbody></table><table-wrap-foot><fn id="table3fn1"><p><sup>a</sup><italic>R</italic><sup>&#x00B2;</sup>: coefficient of determination.</p></fn><fn id="table3fn2"><p><sup>b</sup>SE: standard error.</p></fn><fn id="table3fn3"><p><sup>c</sup>B: unstandardized regression coefficient.</p></fn><fn id="table3fn4"><p><sup>d</sup>T: t statistic.</p></fn><fn id="table3fn5"><p><sup>e</sup><italic>P</italic>&#x003C;.001.</p></fn><fn id="table3fn6"><p><sup>f</sup><italic>P</italic>&#x003C;.05.</p></fn></table-wrap-foot></table-wrap><p>The model demonstrates a sufficient fit with an <italic>R</italic>&#x00B2; of 0.299, indicating that 29.9% of the variation can be explained by the independent variables. The Durbin&#x2013;Watson test statistic 1.354, suggests no evidence of autocorrelation in the residuals. Additionally, the collinearity diagnostics did not indicate any multicollinearity.</p></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><p>This study explored alterations in eHealth patients&#x2019; behavior and their inclinations towards eHealth throughout and following the COVID-19 pandemic. This investigation demonstrated slight variations in how patients and caregivers communicated, as well as the interactions between patients themselves. Two notable shifts due to the pandemic were evident: an increase in online obtaining of medication and an increasing deployment of eHealth technology. This study determined that age and gender were key factors influencing patients&#x2019; future decisions for in-person or virtual consultations. Older adults and female patients leaned towards on-site consultations, while male patients preferred online consultations. Furthermore, a preference for live video consultations predicted patients&#x2019; openness towards online consultations.</p><p>&#x2003;eHealth reduces disease transmission and is especially suitable for self-isolating or high-risk patients [<xref ref-type="bibr" rid="ref33">33</xref>]. Its growth, accelerated not only by the COVID-19 pandemic, presents several advantages, such as protection, time-saving, and cost reduction, yet it also carries disadvantages, such as difficulties in building a stable relationship between caregivers and patients, assessment challenges, technological issues, and data protection concerns [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>].</p><p>This study&#x2019;s findings underlined, on the one hand, a significant increase in using online-based communication but also showed no remarkable changes in its overall utilization. This resilience of communication indicated that patients made only minimal changes to their communication behavior even though social distancing was strongly regulated by the German government. This is in line with international discrete choice experiments indicating a top preference for in-person consultations for most clinical scenarios [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>]. To sustain the eHealth revolution in health care delivery [<xref ref-type="bibr" rid="ref38">38</xref>], an in-depth understanding of communication, currently lacking, is necessary.</p><p>The research identified crucial points for a successful implementation of eHealth. First, a clear differentiation in e-health applications is needed, as some authors suggest (eg, specific diseases, specialties, technologies, clinical problems [<xref ref-type="bibr" rid="ref39">39</xref>]). Second, comprehensive investigations must be conducted to provide evidence (eg, chronic pain [<xref ref-type="bibr" rid="ref40">40</xref>], oncology [<xref ref-type="bibr" rid="ref41">41</xref>], palliative care [<xref ref-type="bibr" rid="ref42">42</xref>]). Third, eHealth communication necessitates best practices (eg, use of plain language, reducing information overload, application of teach-back [<xref ref-type="bibr" rid="ref43">43</xref>]), ideally provided by national or international organizations such as the World Health Organization [<xref ref-type="bibr" rid="ref44">44</xref>].</p><p>&#x2003;While adhering to best communication practices, patients&#x2019; information level must be respected. Reasons for information-seeking vary widely, from discussing specific diseases to social and emotional support through peer-to-peer interactions [<xref ref-type="bibr" rid="ref45">45</xref>]. The increasing health-related internet use by patients results in both positive and negative effects on the caregiver&#x2013;patient relationship [<xref ref-type="bibr" rid="ref46">46</xref>]. Positive effects were observed when patients openly discussed their findings with caregivers, thereby enabling active participation in decision-making, which alters traditional consultation models [<xref ref-type="bibr" rid="ref47">47</xref>].</p><p>A primary objective of eHealth may also be a central aspect in guiding patients within the framework of managed care programs [<xref ref-type="bibr" rid="ref48">48</xref>]. Conversely, misleading health information may have a serious impact on an individual&#x2019;s health or mental state [<xref ref-type="bibr" rid="ref49">49</xref>], such as the phenomenon of cyberchondria [<xref ref-type="bibr" rid="ref50">50</xref>], which involves excessive fear of symptoms resulting from reviewing of search results and references on the Web, higher medical costs [<xref ref-type="bibr" rid="ref51">51</xref>], and overall lower quality of life due to poor health care management [<xref ref-type="bibr" rid="ref52">52</xref>]. This study&#x2019;s analysis showed only a slight increase in online-based information-seeking; however, during the pandemic, most studies found an increased desire to understand the virus&#x2019;s risk situation and to cope with uncertainty [<xref ref-type="bibr" rid="ref53">53</xref>].</p><p>&#x2003;Wearables and eHealth apps played a vital role in detecting the spread of the coronavirus [<xref ref-type="bibr" rid="ref54">54</xref>], and their usage for monitoring physical activity has risen [<xref ref-type="bibr" rid="ref55">55</xref>]. This aligns with an increase in the use of wearables and e-health apps in this sample. Wearables and health-related apps are promising tools for managing long COVID [<xref ref-type="bibr" rid="ref56">56</xref>] and, in general, for empowering patients to take responsibility for their health and care [<xref ref-type="bibr" rid="ref57">57</xref>,<xref ref-type="bibr" rid="ref58">58</xref>]. In research, wearables have become essential for data collection in population-based research, experimental outcome assessment, prognostic forecasting, and explorative analysis of big data sets [<xref ref-type="bibr" rid="ref59">59</xref>].</p><p>In addition to the rise of wearables, online medication procurement also increased, in line with recent research [<xref ref-type="bibr" rid="ref60">60</xref>]. However, a large number of online pharmacies have failed to comply with regulations [<xref ref-type="bibr" rid="ref61">61</xref>], leading to deaths [<xref ref-type="bibr" rid="ref62">62</xref>] and emphasizing the need for greater awareness and stricter government laws [<xref ref-type="bibr" rid="ref63">63</xref>].</p><p>&#x2003;Despite substantial literature demonstrating high satisfaction with eHealth across all ages and genders [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref64">64</xref>], this investigation revealed a clear preference for on-site consultations, in line with recent findings [<xref ref-type="bibr" rid="ref32">32</xref>]. This may be specific to the psychosomatic sector, where comprehensive examinations of both psyche and body are part of daily practice. To elaborate on these findings, regression analysis provided more insights: older adults and female patients expressed a preference for on-site consultations, highlighting the importance of personalized, in-person care. This aligns with findings from large and international surveys that especially older people prefer in-person consultations [<xref ref-type="bibr" rid="ref65">65</xref>] and also supports the argument that e-health may not completely replace face-to-face consultations [<xref ref-type="bibr" rid="ref38">38</xref>]. Conversely, male patients demonstrated greater openness towards online consultations. Recent studies have found a correlation between male sex and satisfaction with treatment plan or follow-up via eHealth [<xref ref-type="bibr" rid="ref66">66</xref>], controversially also female sex was associated with higher satisfaction of eHealth services [<xref ref-type="bibr" rid="ref67">67</xref>]. Further influencing factors, such as positive promotion of e-health by caregivers [<xref ref-type="bibr" rid="ref68">68</xref>], as well as personality structure or cultural background, need to be further explored.</p><p>&#x2003;Limitations of this study include its cross-sectional design, which captures a retrospective snapshot of patient behavior without enabling the tracking of changes over time. Moreover, while the ad hoc questionnaire addressed context-specific topics, it was not formally validated, which restricts the reliability and generalizability of its measures. Although the think-aloud method was used during development to improve clarity and content relevance, no psychometric evaluation was conducted prior to its use. This limitation may limit the generalizability and interpretability of the findings. However, evidence suggests that data from ad hoc clinician-generated patient questionnaires can be aggregated into valid factors [<xref ref-type="bibr" rid="ref69">69</xref>] which indicates ad hoc questionnaires may still provide meaningful insights into patient behaviors and preferences.</p><p>Potential selection bias due to the voluntary participation of patients may also be a limitation. An additional limitation is missing data regarding the participants&#x2019; gender, which may have introduced bias or reduced the validity of gender-related analyses. While the regression model still identified significant associations with gender, the missing data may have affected the robustness of these results. Patients in psychosomatic medicine suffer from psychological disorders, which may have influenced their preferences and behavior. Nevertheless, recent studies have shown that eHealth services are an effective and appropriate therapeutic tool [<xref ref-type="bibr" rid="ref70">70</xref>] to reduce mental complaints [<xref ref-type="bibr" rid="ref71">71</xref>] and stress symptoms [<xref ref-type="bibr" rid="ref72">72</xref>].</p><p>In conclusion, the study indicates that recognition and accommodation of diverse preferences is critical in designing and implementing future eHealth services, which might be central in managed care programs. Although this investigation focused on the pandemic context, eHealth services can be expected to remain an integral component of health care delivery [<xref ref-type="bibr" rid="ref73">73</xref>]. By integrating these findings, especially accommodating the age and gender of patients, a potential rise in patient engagement can be anticipated within the transforming eHealth environment. These results highlight the need for a tailored approach to diverse patient requirements to improve health care outcomes as eHealth services continue to progress and evolve.</p></sec></body><back><notes><sec><title>Data Availability</title><p>The datasets generated or analyzed during this study are available from the corresponding author on reasonable request.</p></sec></notes><fn-group><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">VIF</term><def><p>variance inflation factors</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Eysenbach</surname><given-names>G</given-names> </name></person-group><article-title>What is e-health?</article-title><source>J Med Internet 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