<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="case-report"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Form Res</journal-id><journal-id journal-id-type="publisher-id">formative</journal-id><journal-id journal-id-type="index">27</journal-id><journal-title>JMIR Formative Research</journal-title><abbrev-journal-title>JMIR Form Res</abbrev-journal-title><issn pub-type="epub">2561-326X</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v9i1e79708</article-id><article-id pub-id-type="doi">10.2196/79708</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>A Brief Technique to Reduce Flashbacks of Sexual Trauma in an Adolescent: Proof-of-Concept Case Study Using Imagery Interference</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Lau-Zhu</surname><given-names>Alex</given-names></name><degrees>PhD, DClinPsy</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Chan</surname><given-names>Carmen</given-names></name><degrees>DClinPsy</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib></contrib-group><aff id="aff1"><institution>Department of Experimental Psychology, University of Oxford</institution><addr-line>Life and Mind Building</addr-line><addr-line>Oxford</addr-line><country>United Kingdom</country></aff><aff id="aff2"><institution>Imperial College London</institution><addr-line>London</addr-line><country>United Kingdom</country></aff><aff id="aff3"><institution>Oxford Health NHS Foundation Trust</institution><addr-line>Oxford</addr-line><country>United Kingdom</country></aff><aff id="aff4"><institution>Linacre College</institution><addr-line>Oxford</addr-line><country>United Kingdom</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Mavragani</surname><given-names>Amaryllis</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Mussap</surname><given-names>Alexander J</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Abasilim</surname><given-names>Ogochukwu</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Alex Lau-Zhu, PhD, DClinPsy, Department of Experimental Psychology, University of Oxford, Life and Mind Building, Oxford, OX1 3PS, United Kingdom, 44 1865614804; <email>alex.lauzhu@psy.ox.ac.uk</email></corresp></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>12</day><month>11</month><year>2025</year></pub-date><volume>9</volume><elocation-id>e79708</elocation-id><history><date date-type="received"><day>24</day><month>08</month><year>2025</year></date><date date-type="rev-recd"><day>27</day><month>10</month><year>2025</year></date><date date-type="accepted"><day>28</day><month>10</month><year>2025</year></date></history><copyright-statement>&#x00A9; Alex Lau-Zhu, Carmen Chan. Originally published in JMIR Formative Research (<ext-link ext-link-type="uri" xlink:href="https://formative.jmir.org">https://formative.jmir.org</ext-link>), 12.11.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Formative Research, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://formative.jmir.org">https://formative.jmir.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://formative.jmir.org/2025/1/e79708"/><abstract><sec><title>Background</title><p>Trauma exposure, including sexual harm, is prevalent in adolescents. A key resulting symptom relates to reexperiencing mental images of trauma, such as intrusive memories and flashbacks. Established treatments are used to address flashback memories but are hard to access, often leave remaining symptoms, and require extensive exposure to traumatic materials. An emerging approach with adult populations suggests intrusive imagery symptoms can be precisely targeted with simple cognitive tasks.</p></sec><sec><title>Objective</title><p>We describe a first proof-of-concept demonstration of an imagery interference technique in a 15-year-old to target residual flashback symptoms after a course of treatment for posttraumatic stress disorder (PTSD) following sexual trauma, to lay the groundwork for further evaluations.</p></sec><sec sec-type="methods"><title>Methods</title><p>A case study (Mia) was presented, drawing from routine clinical practice within the United Kingdom&#x2019;s National Health Service. After 23 sessions of trauma-focused cognitive behavioral therapy, Mia received the imagery interference technique at session 24 and returned a month later for session 25 (the final session). The technique involved playing Tetris within a wider protocol informed by the science of memory malleability (eg, including brief memory recall and working memory taxation). Memory ratings (frequency, vividness, and distress) were assessed before and immediately after training on the technique and a month later. Symptoms of PTSD, anxiety, and depression were gathered at the first and final sessions. Views from Mia and her parents were also obtained.</p></sec><sec sec-type="results"><title>Results</title><p>For the specific flashback targeted by Mia, vividness reduced within the session (40% to 15%), distress reduced within the session (40% to 15%) and a month later (then to 10%), and frequency reduced a month later (once to zero times per week; 100% reduction). Nontargeted flashbacks also reduced in frequency (from 4 times to 1 time per month; 75% reduction). Mia described the memories as more &#x201C;distant.&#x201D; Symptoms of PTSD, depression, and anxiety reduced overall.</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>Pending further rigorous testing beyond this single case, the imagery interference approach has potential as a low-intensity and early intervention for adolescents to address intrusive imagery of trauma, such as sexual harm, and also in other clinical contexts (eg, anxiety).</p></sec></abstract><kwd-group><kwd>adolescent</kwd><kwd>trauma</kwd><kwd>PTSD</kwd><kwd>flashback</kwd><kwd>intrusive memories</kwd><kwd>intrusions</kwd><kwd>imagery</kwd><kwd>posttraumatic stress disorder</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>One in 20 young people in the United Kingdom report sexual abuse, with global data confirming higher rates in girls than boys and in older than younger teens [<xref ref-type="bibr" rid="ref1">1</xref>-<xref ref-type="bibr" rid="ref3">3</xref>]. A key symptom after such traumatic events is reexperiencing in the form of intrusive memories and flashbacks&#x2014;persistent, distressing, and predominantly visual mental images of the trauma that pop back into mind [<xref ref-type="bibr" rid="ref4">4</xref>-<xref ref-type="bibr" rid="ref6">6</xref>]. They are cardinal symptoms of posttraumatic stress disorder (PTSD) and also drive distress in conditions such as anxiety and depression across the lifespan [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. The highest burden of PTSD is associated with sexual traumas in youth and adult samples [<xref ref-type="bibr" rid="ref9">9</xref>-<xref ref-type="bibr" rid="ref11">11</xref>]. Intrusive memory symptoms can bring substantial impairment even when diagnostic criteria for PTSD are not met (eg, concentration) [<xref ref-type="bibr" rid="ref7">7</xref>].</p><p>Established interventions for flashbacks and intrusive memories include trauma-focused cognitive behavioral therapies (CBT) and eye movement desensitization and reprocessing (EMDR) [<xref ref-type="bibr" rid="ref4">4</xref>]. These powerful treatments aim to treat the full constellation of PTSD symptoms, rather than just flashbacks, but they also have limitations. They require extensive exposure to traumatic materials, including talking in detail about the trauma within CBT approaches. This is a key reason adolescents are often reluctant to begin treatment after trauma [<xref ref-type="bibr" rid="ref12">12</xref>]. Residual symptoms are also common after these treatments despite meeting recovery criteria [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. Many young people struggle to access these treatments (eg, due to long waiting lists) [<xref ref-type="bibr" rid="ref15">15</xref>]. An accessible and effective intervention to specifically target intrusions may be beneficial.</p><p>A novel idea has been proposed from memory science, which can precisely address flashbacks and intrusive memories, without requiring extensive verbal recounting of trauma; for review, see [<xref ref-type="bibr" rid="ref16">16</xref>]. This involves using a brief task (such as the shape-fitting game Tetris) to tax working memory [<xref ref-type="bibr" rid="ref17">17</xref>] during memory malleability (ie, when a memory trace is thought to be labile and susceptible to update or interference), for example, upon retrieval [<xref ref-type="bibr" rid="ref18">18</xref>]. This task thus interferes with capacity-limited cognitive resources needed to maintain the image-based memory, rendering it less vivid and emotional [<xref ref-type="bibr" rid="ref19">19</xref>]. This disrupted memory is hypothesized to be re-stored [<xref ref-type="bibr" rid="ref18">18</xref>]. The predicted effects are supported by preclinical, experimental research conducted over almost 2 decades [<xref ref-type="bibr" rid="ref7">7</xref>,<xref ref-type="bibr" rid="ref20">20</xref>-<xref ref-type="bibr" rid="ref22">22</xref>]. Notably, the underpinning theory parallels a proposed explanation for the effectiveness of EMDR [<xref ref-type="bibr" rid="ref23">23</xref>].</p><p>Initial intervention development studies have demonstrated that this imagery interference protocol can reduce the incidence of intrusive memories after real-life traumas in adults [<xref ref-type="bibr" rid="ref16">16</xref>], regardless of the time since trauma. Critically, the approach appears to leave memory intact&#x2014;an ability to recall details of the traumatic event at will seems to be retained [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref22">22</xref>]. This is important because professionals are often concerned about the impact of psychological therapies on trauma memory credibility within legal investigations, which frequently follow disclosures of sexual harm [<xref ref-type="bibr" rid="ref24">24</xref>]. However, this intervention approach has yet to be translated for adolescents in experimental or clinical contexts.</p><p>Inspired by the application of this approach in adults, we present a case study as its first proof of concept for adolescents. The intervention was used predischarge to target residual flashbacks following established PTSD treatment for sexual traumas. Our aim was to gather initial information on feasibility and preliminary signal of effectiveness (ie, a reduction in the intensity and frequency of the targeted flashback) to ensure the approach is acceptable and appealing to the young person to lay the groundwork for further formal testing.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Case Presentation</title><p>Mia (pseudonym) is a 15-year-old adolescent girl referred to a specialist team supporting young people affected by sexual harm and their families. The referral was made by a community mental health team following an attempted overdose. At assessment, she no longer experienced suicidal intent, but reported recurring and distressing reexperiencing symptoms of an abusive relationship, including intrusive memories, flashbacks, and nightmares. She coped by pushing those thoughts away and avoiding reminders, such as music she listened to a lot during the relationship. The reexperiencing symptoms affected her self-confidence, as she continued to appraise the events as being her fault. She also reported occasional urges to self-harm by cutting, although these were generally fleeting. Her main therapy goal was to experience fewer intrusive memories and flashbacks, so that her concentration in school could be improved due to upcoming exams.</p></sec><sec id="s2-2"><title>Measures</title><p>For the specific flashback targeted as part of the imagery interference technique, vividness and distress ratings were obtained (&#x201C;how vivid/distressing was the flashback?&#x201D; anchored from &#x201C;not at all [0%]&#x201D; to &#x201C;extremely [100%]&#x201D;), based on prior experimental [<xref ref-type="bibr" rid="ref25">25</xref>] and intervention protocols [<xref ref-type="bibr" rid="ref26">26</xref>]; frequency estimates (for the prior week) were obtained retrospectively.</p><p>For the overall course of treatment, symptoms of PTSD were assessed using the Child PTSD Symptom Scale (CPSS; sessions 1, 12, 23, and 25) [<xref ref-type="bibr" rid="ref27">27</xref>], symptoms of anxiety and depression with the Revised Child Anxiety and Depression Scale (RCADS; sessions 1 and 25) [<xref ref-type="bibr" rid="ref28">28</xref>], and negative trauma-related appraisals were assessed with the Child Post-Traumatic Cognitions Inventory (CPTCI; sessions 1 and 25) [<xref ref-type="bibr" rid="ref29">29</xref>].</p></sec><sec id="s2-3"><title>Intervention</title><sec id="s2-3-1"><title>Overview of Full Treatment</title><p>Mia received 23 one-hour sessions of trauma-focused CBT [<xref ref-type="bibr" rid="ref30">30</xref>] over the course of 6 months. These sessions involved trauma processing by focusing on 5 key hotspots, all linked to distinct episodes of harm. She described these as highly vivid and distressing, often with strong physical sensations. She then took a 1-month break from therapy due to a busy period with exams. When she returned, she reported still experiencing some residual flashback symptoms (despite marked improvement on overall PTSD symptoms), which were the main clinical target for this report.</p></sec><sec id="s2-3-2"><title>Targeting Residual Intrusion Symptoms</title><p>The imagery interference technique (<xref ref-type="fig" rid="figure1">Figure 1</xref>) was delivered on session 24. Mia identified one specific hotspot memory (the specific key moment of the trauma that flashed back) that popped up in the last week and that in her view would make the most difference if it were to be addressed. She labeled this the &#x201C;shock memory.&#x201D; This was a mental image of a hard object approaching to hit her. She first estimated the frequency of this flashback (and others) in the last week. Then, she was instructed to gently picture this hotspot in her mind&#x2014;she was specifically told to do so just for a few seconds until she had a clear picture of it in her head, but without it needing to be as emotionally intense as done during reliving sessions of trauma-focused CBT. She provided ratings of vividness and distress for this hotspot.</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>Schematic of the imagery interference technique (key steps).</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="formative_v9i1e79708_fig01.png"/></fig><p>Afterward, the freely available game Tetris (Marathon version; Tetris Holding) was downloaded on her smartphone. The clinician (ALZ) emphasized instructions to play this by focusing on mental rotation of the upcoming shape and trying her best, rather than on performance or scores. This practice stage took around 10 minutes, and then Mia continued to play uninterrupted for another 10 minutes. Mia then provided ratings of vividness and distress again.</p><p>Mia was encouraged to use this technique on days whenever she had this flashback over the next few weeks and to apply this technique to other flashbacks she wanted to address. She could apply the technique immediately after having a flashback if it was convenient or schedule it for later within the same day, as long as the memory was briefly reactivated as part of the intervention (<xref ref-type="fig" rid="figure1">Figure 1</xref>). For the final session (session 25), Mia returned and estimated the frequency of the targeted flashbacks (and others) in the prior week. She also was instructed to gently picture the key hotspot in her mind as she did in the last session and provided ratings of vividness and distress. This intervention protocol delivered to an adolescent was based on prior work with adults [<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref32">32</xref>].</p></sec></sec><sec id="s2-4"><title>Ethical Considerations</title><p>The intervention ran as part of routine clinical care within the United Kingdom National Health Service, thus ethical approval was not needed. Parental and child consent were obtained for the study and publication. To maintain patient confidentiality, a pseudonym has been used in this report. No compensation was provided to the patient. We have abided by the Ethical Principles of Psychologists and Code of Conduct as set out by the British Association of Behavioral and Cognitive Therapies and the British Psychological Society.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>Flashback Ratings</title><p>Mia reported that the &#x201C;shock memory&#x201D; intruded once a week prior to the imagery interference intervention session (equivalent to 4 times in a 1-month period) and rated it as 40% vivid and 40% distressing when she gently brought it to mind as part of the first step of the intervention. She also reported flashbacks of other content, but these nontargeted ones were less frequent overall and together occurred about once a week (equivalent to 4 times in a 1-month period). Note these initial ratings were collected after finishing the preceding 23 sessions of trauma-focused CBT.</p><p>After the intervention, she pictured the memory in her mind again and rated it as 15% vivid (65% reduction) and 15% distressing (65% reduction).</p><p>A month later, at the follow-up, Mia explained that she managed to engage with the intervention 3 times the week immediately after the initial training. She reported the &#x201C;shock memory&#x201D; had not intruded at all in the prior week, nor in the whole period since the intervention session (100% reduction). She gently pictured the memory and rated it as 40% vivid (no reduction) and 10% distressing (75% reduction). She also reported that other flashbacks, which were not targeted in the session, intruded only once overall since the last session (75% reduction)&#x2014;when this happened, it was &#x201C;not powerful enough&#x201D; to cause her significant disruption.</p><p>Mia also reported that she had used the technique in contexts unrelated to trauma memories. She applied it to intrusive mental images of social situations, which triggered feelings of &#x201C;embarrassment.&#x201D; She found that the technique reduced the emotional intensity of the image afterward. She also said she enjoyed having it as a &#x201C;grounding&#x201D; strategy for dealing with anxiety-provoking situations in general.</p></sec><sec id="s3-2"><title>Clinical Measures</title><p>Sessions 1&#x2010;23 corresponded to the trauma-focused CBT phase, while sessions 24&#x2010;25 (final) corresponded to the imagery interference phase.</p><p>On sessions 1, 12, and 23, scores on the CPSS were 54, 32, and 23, respectively, demonstrating a progressive decline in PTSD symptoms toward under the clinical cutoff (&#x003E;31) during the CBT phase. The final score on session 25 was 22, suggesting a drop of only 1 point during the imagery interference phase.</p><p>As the imagery interference phase specifically targeted flashbacks and intrusive memories (rather than full PTSD as with the CBT phase), one relevant item was identified from the intrusion subscale of the CPSS, specific to intrusive images. Item 1 described &#x201C;Having upsetting thoughts or pictures about it that came into your head when you didn&#x2019;t want them to.&#x201D; Before the imagery interference phase, Mia&#x2019;s score on this item was 2 (referring to 2&#x2010;3 times per week or sometimes), but 1 (referring to once a week or less or a little) at the end. Although she only experienced a single flashback in the month prior (see Flashback Ratings), a score of 0 was not appropriate, as this would indicate the high threshold of &#x201C;not at all&#x201D; for the entire month.</p><p>Scores on the RCADS at session 1 were 63 for anxiety (below clinical cutoff) and 73 for depression (above cutoff); at session 25 (final), scores were 55 for anxiety and 56 for depression (both below cutoff). The score on the CPTCI declined from 69 at session 1 to 59 at session 25 (final), largely driven by Mia&#x2019;s reduced conviction that trauma had permanently damaged the self and future.</p></sec><sec id="s3-3"><title>Qualitative Feedback</title><p>Mia said she found the imagery interference technique &#x201C;helpful&#x201D; for managing her remaining intrusion symptoms. A week after practicing the technique in session, she said that the memory no longer had the sense of &#x201C;nowness.&#x201D; Instead, she experienced more sadness, like she was &#x201C;watching a TV show&#x201D; as if &#x201C;it happened to a friend; seeing someone I care about rather than myself.&#x201D; She noted how strange it felt to be able to deliberately recall the memory without feeling overwhelmed.</p><p>Mia also described feeling able to concentrate more and experiencing a renewed sense of self-confidence. She was able to enjoy her time spent with friends and to return to her hobbies, such as playing the guitar. She said &#x201C;I&#x2019;m not a broken person&#x201D; and &#x201C;if I were to have a crash, I can get out of it,&#x201D; for example, by using the technique. The gaming element of Tetris was also highlighted, as it was a &#x201C;light-hearted&#x201D; way to deal with difficult material and was easily accessible on her smartphone. She has also been free of self-harm for 87 days (which she was self-tracking), which had been her longest period in the last 2 years. Her parents also noted a change in Mia&#x2019;s self-confidence, such as observing that she talks to adults more proactively and can comfortably make jokes.</p></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Summary of Findings</title><p>We presented the first application of an imagery interference technique to address symptoms of flashbacks and intrusive memories in the adolescence context, inspired by initial clinical demonstrations in adult populations. The intervention protocol involved playing the game Tetris on a smartphone, including brief memory recall and sustained working memory engagement, informed by memory science. Thus, the intervention is not just about playing Tetris. The clinical aim was to reduce residual reexperiencing symptoms following full PTSD treatment for sexual harm.</p><p>Our findings showed that the adolescent (Mia) found the intervention appealing and was willing to try it; she reported changes in key properties of flashback memories (including frequency and distress) within the intervention session and at a 1-month follow up, with subjective accounts of perceived benefits. Overall improvements in symptoms of PTSD, depression, anxiety, trauma-related appraisals, and self-harm were also observed in relation to the full therapeutic arc, which included preceding trauma-focused CBT prior to introducing the imagery interference technique.</p></sec><sec id="s4-2"><title>Clinical Implications</title><p>These preliminary adolescent data align with emerging laboratory [<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref22">22</xref>] and clinical findings with adults [<xref ref-type="bibr" rid="ref16">16</xref>]. The brief and precise nature of the protocol meant that minimal adaptations to the adolescent context were needed, especially as it does not require detailed discussions of trauma (eg, sexual abuse). The game- and phone-based nature of the intervention made it particularly accessible to the adolescent.</p><p>As this case illustrated, the aim of the technique was not to replace an established treatment approach, which we used as first-line treatment (ie, trauma-focused CBT). A relatively simple technique could provide an additional tool for managing distressing symptoms, such as residual ones common after trauma-focused treatments [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. Given problems with access in child and adolescent mental health services [<xref ref-type="bibr" rid="ref15">15</xref>], the technique presented here holds potential as an early intervention; for example, while young people are waiting for treatment or in the form of a scalable, single-session intervention [<xref ref-type="bibr" rid="ref33">33</xref>]. Many adolescents are often reluctant to initiate trauma-focused therapies [<xref ref-type="bibr" rid="ref12">12</xref>]; thus, this technique may also facilitate a gentler initial engagement with trauma memory.</p><p>Although clinical guidelines recommend CBT&#x2014;often delivered by highly-trained therapists&#x2014;within the first 3 months after trauma [<xref ref-type="bibr" rid="ref34">34</xref>], many young people&#x2019;s first professional contact after disclosures of sexual harm is with nonspecialists, such as teachers and social workers. Interventions that can be more easily deployed have potential for scalability, including for high-risk and low-resource contexts. However, despite the seemingly simple nature of the technique, appropriate training and supervision may still be important as with other low-intensity interventions [<xref ref-type="bibr" rid="ref35">35</xref>]. A game-based technique like this may also be harnessed as an adjunct within established treatment for out-of-session practice, given the frequent challenges with therapy homework with adolescents [<xref ref-type="bibr" rid="ref36">36</xref>].</p></sec><sec id="s4-3"><title>Limitations</title><p>The changes observed may not be solely attributed to the imagery interference technique. Other explanations for the observed effects on intrusive memories should be considered (eg, a continuation of improvement after 23 sessions of CBT). The single case design was limited by the routine setup, in collaboration with the adolescent, rather than designed as a research study. Building on these initial data supporting acceptability, stronger designs for causal inference should be used in the future, such as single-case experimental designs, which can better account for time trends prior to introducing the intervention.</p><p>The reduction in intrusive memory indices was not easily captured by the CPSS, an established questionnaire for PTSD symptoms. However, this only captured intrusive memories with a single item, which may not be sufficiently sensitive. Novel measurement approaches to capture changes in intrusive memories could be considered, such as diary methods and validated scales.</p></sec><sec id="s4-4"><title>Conclusions</title><p>Early intrusive symptoms are important to ameliorate to support key developmental tasks, such as school learning. Our preliminary data lay the groundwork to evaluate the use of this imagery interference technique in adolescents, so we can better attribute any observed benefits to the technique itself rather than other therapeutic elements. Beyond sexual harm, the benefits on flashbacks and intrusions are predicted to extend to other types of trauma experienced by young people, as the focus is on shared memory mechanisms. Finally, as Mia used the technique for addressing anxiety, where intrusive imagery is also prominent [<xref ref-type="bibr" rid="ref8">8</xref>], the technique merits additional explorations in a range of clinical contexts relevant to youth mental health.</p></sec></sec></body><back><ack><p>We are grateful for Mia for her bravery in sharing her story with us and her generosity in allowing us to share these findings.</p></ack><notes><sec><title>Funding</title><p>ALZ is funded by a Medical Research Council Clinician Scientist Fellowship (MR/Y009460/1).</p></sec><sec><title>Data Availability</title><p>The data are available from the corresponding author on reasonable request.</p></sec></notes><fn-group><fn fn-type="con"><p>ALZ: conceptualization, formal analysis, investigation, writing &#x2013; original draft; CC: supervision, writing &#x2013; reviewing &#x0026; editing.</p></fn><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">CBT</term><def><p>cognitive behavioral therapy</p></def></def-item><def-item><term id="abb2">CPSS</term><def><p>Child PTSD Symptom Scale</p></def></def-item><def-item><term id="abb3">CPTCI</term><def><p>Child Post-Traumatic Cognitions Inventory</p></def></def-item><def-item><term id="abb4">EMDR</term><def><p>eye movement desensitization and reprocessing</p></def></def-item><def-item><term id="abb5">PTSD</term><def><p>posttraumatic stress disorder</p></def></def-item><def-item><term id="abb6">RCADS</term><def><p>Revised Children's Anxiety and Depression Scale</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="web"><person-group person-group-type="author"><name name-style="western"><surname>Radford</surname><given-names>L</given-names> </name><name 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