<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="letter"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Form Res</journal-id><journal-id journal-id-type="publisher-id">formative</journal-id><journal-id journal-id-type="index">27</journal-id><journal-title>JMIR Formative Research</journal-title><abbrev-journal-title>JMIR Form Res</abbrev-journal-title><issn pub-type="epub">2561-326X</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v9i1e74218</article-id><article-id pub-id-type="doi">10.2196/74218</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Letter</subject></subj-group></article-categories><title-group><article-title>How Medical Students Manage Depression, Anxiety, and Stress: A Cross-Sectional Study</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" equal-contrib="yes"><name name-style="western"><surname>Shaw</surname><given-names>Jonathan</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Lai</surname><given-names>Ashley</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Singh</surname><given-names>Sasha</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Yoo</surname><given-names>Seung Rim</given-names></name><degrees>BA</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Fathali</surname><given-names>Maha</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Stuck</surname><given-names>Laura</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Hagerty</surname><given-names>James</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Le</surname><given-names>Van</given-names></name><degrees>BA</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Shin</surname><given-names>Jisu</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Lai</surname><given-names>Charles</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Bota</surname><given-names>Peter</given-names></name><degrees>BA</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Jacobs</surname><given-names>Aaron</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib></contrib-group><aff id="aff1"><institution>School of Medicine, California University of Science and Medicine</institution><addr-line>1501 Violet St</addr-line><addr-line>Colton</addr-line><addr-line>CA</addr-line><country>United States</country></aff><aff id="aff2"><institution>Medical Education, California University of Science and Medicine</institution><addr-line>Colton</addr-line><addr-line>CA</addr-line><country>United States</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Mavragani</surname><given-names>Amaryllis</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Andricioaei</surname><given-names>Anton</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Adnan</surname><given-names>Muhammad</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Jonathan Shaw, BS, School of Medicine, California University of Science and Medicine, 1501 Violet St, Colton, CA, 92324, United States, 1 909498003; <email>jonathan.shaw@md.cusm.edu</email></corresp><fn fn-type="equal" id="equal-contrib1"><label>*</label><p>these authors contributed equally</p></fn></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>7</day><month>7</month><year>2025</year></pub-date><volume>9</volume><elocation-id>e74218</elocation-id><history><date date-type="received"><day>19</day><month>03</month><year>2025</year></date><date date-type="rev-recd"><day>15</day><month>05</month><year>2025</year></date><date date-type="accepted"><day>03</day><month>06</month><year>2025</year></date></history><copyright-statement>&#x00A9; Jonathan Shaw, Ashley Lai, Sasha Singh, Seung Rim Yoo, Maha Fathali, Laura Stuck, James Hagerty, Van Le, Jisu Shin, Charles Lai, Peter Bota, Aaron Jacobs. Originally published in JMIR Formative Research (<ext-link ext-link-type="uri" xlink:href="https://formative.jmir.org">https://formative.jmir.org</ext-link>), 7.7.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Formative Research, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://formative.jmir.org">https://formative.jmir.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://formative.jmir.org/2025/1/e74218"/><abstract><p>Given the established challenging nature of medical school, first- and second-year medical students were surveyed on their feelings of stress alongside their coping mechanisms; the study found a higher level of stress among second-year medical students, indicating a need for support during difficult transition periods.</p></abstract><kwd-group><kwd>medical student</kwd><kwd>stress</kwd><kwd>depression</kwd><kwd>anxiety</kwd><kwd>coping</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>Due to the intense pressure and stress of the training process, medical students face a higher risk of burnout and depression than the general US population [<xref ref-type="bibr" rid="ref1">1</xref>]. They must pursue extracurriculars, like research, to be competitive for residency applications. Common stressors include academics, peer-to-peer relationships, and finances [<xref ref-type="bibr" rid="ref2">2</xref>], which can impact sleep quality, physical and mental health, and academic performance [<xref ref-type="bibr" rid="ref3">3</xref>]. Stress can lead to burnout, with some even considering leaving medicine [<xref ref-type="bibr" rid="ref4">4</xref>]. Medical students may cope with stress through healthy habits like exercise or harmful ones like alcohol abuse [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>].</p><p>This study explores how first- and second-year medical students manage and reduce stress, to improve medical student wellness efforts.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Participants and Recruitment</title><p>Overall, 120 first-year and 126 second-year students at a California allopathic medical school were contacted via institutional email to complete an anonymous survey. One survey round was sent, with 27 responses collected.</p></sec><sec id="s2-2"><title>Measures</title><p>The survey comprised 2 demographic questions (school year and gender); 24 multiple-choice questions on stress management; 1 free-response question for any unlisted stress management activities and their frequency; and 21 randomly shuffled questions from the Depression, Anxiety and Stress Scale&#x2013;21 Items (DASS-21) [<xref ref-type="bibr" rid="ref7">7</xref>]. The hobbies listed were based on community observation.</p></sec><sec id="s2-3"><title>Statistical Analysis</title><p>Data were analyzed using IBM SPSS Statistics (version 28.0.1.0). Normality was assessed via the Kolmogorov-Smirnov test. For nonnormally distributed data, a Kruskal-Wallis test (via <italic>k</italic> independent samples) was conducted, with gender and school year as the grouping variables and the range being 1-2. Additionally, Spearman correlations were obtained through SPSS&#x2019;s bivariate correlation function.</p></sec><sec id="s2-4"><title>Ethical Considerations</title><p>This study received ethical approval from the California University of Science and Medicine Institutional Review Board (HS-2023&#x2010;56) on November 27, 2023. Informed consent was obtained from all participants included in the study for data collection and analyses. Identifying information was not collected. Participants were not compensated.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><p>The Kolmogorov-Smirnov test found that neither the questions nor the DASS-21 subscores were normally distributed. The Kruskal-Wallis results are presented in <xref ref-type="table" rid="table1">Table 1</xref>. Spearman correlations showed that school year was positively and moderately correlated with stress (<italic>r</italic><sub>27</sub>=.699; <italic>P</italic>&#x003C;.001), anxiety (<italic>r</italic><sub>27</sub>=.585; <italic>P</italic>&#x003C;.001), and depression (<italic>r</italic><sub>27</sub>=.408; <italic>P</italic>=.03).</p><p>Second-year medical students had mild depression (13.67), with moderate anxiety (11.17) and stress (20.50; <xref ref-type="fig" rid="figure1">Figure 1</xref>). In contrast, first-year medical students were in the &#x201C;normal&#x201D; range across all categories. This demonstrates that second-year medical students experience higher levels of distress.</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>The Kruskal-Wallis results. DASS-21<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup> scoring was conducted by summing the Likert-scale responses (0=did not apply to me at all, 3=applied to me very much or most of the time) for each subscale (Depression, Anxiety, and Stress) and multiplying this sum by 2 to determine the participant severity per subscale. Depression thresholds included normal (0&#x2010;9), mild (10-13), moderate (14-20), severe (21-27), and extremely severe (28+). Anxiety thresholds included normal (0&#x2010;7), mild (8-9), moderate (10-14), severe (15-19), and extremely severe (20+). Stress thresholds included normal (0&#x2010;14), mild (15-18), moderate (19-25), severe (26-33), and extremely severe (34+). All other questions used a Likert scale (0=not at all, 3=nearly every day), asking participants if they had partaken in a stress management behavior within the last 2 weeks. This included a free-response question, which asks participants to fill in any unlisted activities and self-report the frequency of the activity in the same manner as the Likert scale.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="top">Question or topic</td><td align="left" valign="top">Kruskal-Wallis <italic>H</italic> (<italic>df</italic>=1)</td><td align="left" valign="top"><italic>P</italic> value</td><td align="left" valign="top">Group 1, mean (SD)</td><td align="left" valign="top">Group 2, mean (SD)</td></tr></thead><tbody><tr><td align="left" valign="top">Read books to relax</td><td align="left" valign="top">4.994</td><td align="left" valign="top">.02</td><td align="left" valign="top">.67 (.900)<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td><td align="left" valign="top">.00 (.000)<sup><xref ref-type="table-fn" rid="table1fn3">c</xref></sup></td></tr><tr><td align="left" valign="top">Talk with friends</td><td align="left" valign="top">5.888</td><td align="left" valign="top">.02</td><td align="left" valign="top">2.28 (.895)<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup></td><td align="left" valign="top">1.44 (.726)<sup><xref ref-type="table-fn" rid="table1fn3">c</xref></sup></td></tr><tr><td align="left" valign="top">Go out with friends in person</td><td align="left" valign="top">5.081</td><td align="left" valign="top">.02</td><td align="left" valign="top">1.14 (.910)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">.20 (.447)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Painting</td><td align="left" valign="top">4.000</td><td align="left" valign="top">.046</td><td align="left" valign="top">.00 (.000)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">.75 (1.500)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Find it harder to wind down</td><td align="left" valign="top">12.222</td><td align="left" valign="top">.001</td><td align="left" valign="top">.62 (.590)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">2.50 (.837)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Aware of having a dry mouth</td><td align="left" valign="top">10.300</td><td align="left" valign="top">.001</td><td align="left" valign="top">.10 (.301)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">1.50 (1.225)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Could not experience positive feelings</td><td align="left" valign="top">7.502</td><td align="left" valign="top">.006</td><td align="left" valign="top">.14 (.359)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">1.33 (1.366)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Difficulty breathing</td><td align="left" valign="top">5.234</td><td align="left" valign="top">.02</td><td align="left" valign="top">.10 (.301)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">.67 (.816)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Overreacting to situations</td><td align="left" valign="top">6.131</td><td align="left" valign="top">.01</td><td align="left" valign="top">.19 (.402)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">1.17 (1.169)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Using a lot of nervous energy</td><td align="left" valign="top">13.211</td><td align="left" valign="top">.001</td><td align="left" valign="top">.57 (.676)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">2.33 (.516)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Getting more agitated</td><td align="left" valign="top">6.911</td><td align="left" valign="top">.009</td><td align="left" valign="top">.57 (.870)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">2.00 (1.095)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Difficult to relax</td><td align="left" valign="top">9.453</td><td align="left" valign="top">.002</td><td align="left" valign="top">.81 (.873)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">2.50 (.837)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Felt downhearted and blue</td><td align="left" valign="top">4.374</td><td align="left" valign="top">.04</td><td align="left" valign="top">.48 (.602)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">1.33 (1.033)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Felt close to panic</td><td align="left" valign="top">8.576</td><td align="left" valign="top">.003</td><td align="left" valign="top">.14 (.478)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">1.17 (1.169)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Feeling scared without any good reason</td><td align="left" valign="top">5.565</td><td align="left" valign="top">.02</td><td align="left" valign="top">.24 (.539)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">1.17 (1.169)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Stress levels (DASS-21)</td><td align="left" valign="top">12.715</td><td align="left" valign="top">.001</td><td align="left" valign="top">5.48 (4.665)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">20.50 (4.416)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Anxiety levels (DASS-21)</td><td align="left" valign="top">8.894</td><td align="left" valign="top">.003</td><td align="left" valign="top">2.43 (3.091)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">11.17 (7.139)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">Depression levels (DASS-21)</td><td align="left" valign="top">4.336</td><td align="left" valign="top">.04</td><td align="left" valign="top">4.67 (5.677)<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">13.67 (11.535)<sup><xref ref-type="table-fn" rid="table1fn5">e</xref></sup></td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>DASS-21: Depression, Anxiety and Stress Scale&#x2013;21 Items.</p></fn><fn id="table1fn2"><p><sup>b</sup>Female group.</p></fn><fn id="table1fn3"><p><sup>c</sup>Male group.</p></fn><fn id="table1fn4"><p><sup>d</sup>First-year group.</p></fn><fn id="table1fn5"><p><sup>e</sup>Second-year group.</p></fn></table-wrap-foot></table-wrap><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>DASS-21 scoring differences across the Depression, Anxiety, and Stress sections between first- and second-year medical students. The DASS-21 can be divided into 3 subsections: Depression, Anxiety, and Stress. Depression thresholds included normal (0&#x2010;9), mild (10-13), moderate (14-20), severe (21-27), and extremely severe (28+). Anxiety thresholds included normal (0&#x2010;7), mild (8-9), moderate (10-14), severe (15-19), and extremely severe (20+). Stress thresholds included normal (0&#x2010;14), mild (15-18), moderate (19-25), severe (26-33), and extremely severe (34+). Averaged DASS-21 scores are displayed, with the bars representing the SD. DASS-21: Depression, Anxiety and Stress Scale&#x2013;21 Items.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="formative_v9i1e74218_fig01.png"/></fig></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><p>Female participants were more likely to read (<italic>H</italic><sub>1</sub>=4.994; <italic>P</italic>=.02) and talk with friends (<italic>H</italic><sub>1</sub>=5.888; <italic>P</italic>=.02). This aligns with the existing literature, as women have been shown to read more than men, but this could also be due to our limited sample size [<xref ref-type="bibr" rid="ref8">8</xref>]. Exercise habits did not significantly differ by school year (<italic>P</italic>=.09) or gender (<italic>P</italic>=.71). Prior studies have shown that exercise reduces burnout and improves quality of life [<xref ref-type="bibr" rid="ref6">6</xref>], suggesting that medical schools should encourage physical activity, especially for students studying remotely.</p><p>First-year medical students were more likely to go out with friends (<italic>H</italic><sub>1</sub>=5.081; <italic>P</italic>=.02). Second-year medical students had varied schedules, due to rotations or professional development semesters, which at this institution are a dedicated 6-month period for self-directed activities such as research projects or studying for the United States Medical Licensing Examination (USMLE) Step exams. This may limit socialization opportunities compared to first-year medical students, who remain on a shared schedule. On the DASS-21, second-year medical students had moderate stress levels compared to first-year medical students&#x2014;who had &#x201C;normal&#x201D; stress levels (a 15-point difference)&#x2014;potentially due to clinical rotations, professional development semesters, or Step 1 exam preparation. The 6&#x2010; to 8-week &#x201C;dedicated&#x201D; study period is highly stressful, and despite Step 1&#x2019;s transition to a pass-or-fail grade, concerns remain about its impact on mental health. However, it is important to acknowledge that due to the limited sample size (n=27), it would be difficult to make broad generalizations. Similarly, this raises the question of validity, as students at other medical schools may have different experiences.</p><p>These findings highlight the need to focus on increasing social support through events such as mug painting, potlucks, or board game nights. This will help students build a network, better cope with stress, and reduce the negative feelings they experience [<xref ref-type="bibr" rid="ref9">9</xref>]. Future research should focus on optimizing such interventions not only for second-year medical students but also for third- and fourth-year medical students, who were not included in this study. Future studies should also measure stress management and stress levels longitudinally across cohorts of various institutions so that standardized approaches can be developed, which can further be adjusted to fit the cultures of individual institutions.</p></sec></body><back><ack><p>The authors declare that they did not use generative artificial intelligence in the writing of this research letter.</p></ack><notes><sec><title>Data Availability</title><p>The data used to support the conclusions were not acquired from a public repository. The raw data and statistical analyses can be accessed on the web [<xref ref-type="bibr" rid="ref10">10</xref>].</p></sec></notes><fn-group><fn fn-type="con"><p>Conceptualization: J Shaw, PB, CL</p><p>Data curation: J Shaw, MF</p><p>Formal analysis: J Shaw</p><p>Supervision: AJ</p><p>Visualization: J Shaw, CL</p><p>Writing - original draft: AL, SS, SRY, LS, MF, JH, VL, J Shin</p><p>Writing - reviewing &#x0026; editing: J Shaw, SS, AL, MF, SRY</p></fn><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">DASS-21</term><def><p>Depression, Anxiety and Stress Scale&#x2013;21 Items</p></def></def-item><def-item><term id="abb2">USMLE</term><def><p>United States Medical Licensing Examination</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name 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