<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="letter"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Form Res</journal-id><journal-id journal-id-type="publisher-id">formative</journal-id><journal-id journal-id-type="index">27</journal-id><journal-title>JMIR Formative Research</journal-title><abbrev-journal-title>JMIR Form Res</abbrev-journal-title><issn pub-type="epub">2561-326X</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v9i1e70613</article-id><article-id pub-id-type="doi">10.2196/70613</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Letter</subject></subj-group></article-categories><title-group><article-title>Expressions of &#x201C;Ikizurasa&#x201D; in Posts on X (Formerly Twitter) in Japan in 2023: Descriptive Analysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Tsuno</surname><given-names>Kanami</given-names></name><degrees>MPH, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Arimoto</surname><given-names>Azusa</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Imamatsu</surname><given-names>Yuki</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kobayashi</surname><given-names>Yumiko</given-names></name><degrees>MPH, PhD</degrees><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Satoh</surname><given-names>Miho</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Miyazaki</surname><given-names>Tomoyuki</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib></contrib-group><aff id="aff1"><institution>School of Health Innovation, Kanagawa University of Human Services</institution><addr-line>Yokosuka</addr-line><country>Japan</country></aff><aff id="aff2"><institution>Department of Community Health Nursing, Graduate School of Medicine, Yokohama City University</institution><addr-line>3-9 Fukura Kanazawa-ku</addr-line><addr-line>Yokohama</addr-line><country>Japan</country></aff><aff id="aff3"><institution>Center for Promotion of Research and Industry-Academic Collaboration, Yokohama City University</institution><addr-line>Yokohama</addr-line><country>Japan</country></aff><aff id="aff4"><institution>Department of Fundamental Nursing, Graduate School of Medicine, Yokohama City University</institution><addr-line>Yokohama</addr-line><country>Japan</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Mavragani</surname><given-names>Amaryllis</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Minoura</surname><given-names>Akira</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Arce-Garcia</surname><given-names>Sergio</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Azusa Arimoto, PhD, Department of Community Health Nursing, Graduate School of Medicine, Yokohama City University, 3-9 Fukura Kanazawa-ku, Yokohama, 236&#x2010;0004, Japan, 81 45-787-2756; <email>arimotoa@yokohama-cu.ac.jp</email></corresp></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>22</day><month>8</month><year>2025</year></pub-date><volume>9</volume><elocation-id>e70613</elocation-id><history><date date-type="received"><day>27</day><month>12</month><year>2024</year></date><date date-type="rev-recd"><day>10</day><month>07</month><year>2025</year></date><date date-type="accepted"><day>11</day><month>07</month><year>2025</year></date></history><copyright-statement>&#x00A9; Kanami Tsuno, Azusa Arimoto, Yuki Imamatsu, Yumiko Kobayashi, Miho Satoh, Tomoyuki Miyazaki. Originally published in JMIR Formative Research (<ext-link ext-link-type="uri" xlink:href="https://formative.jmir.org">https://formative.jmir.org</ext-link>), 22.8.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Formative Research, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://formative.jmir.org">https://formative.jmir.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://formative.jmir.org/2025/1/e70613"/><abstract><p>This study analyzed all public X (formerly Twitter) posts in Japan in 2023 and identified a substantial number mentioning <italic>ikizurasa</italic> (pain of living), with notable fluctuations over time. The findings suggest a link between <italic>ikizurasa</italic> and stress in minority groups, particularly minority ethnic and gender groups.</p></abstract><kwd-group><kwd>Japan</kwd><kwd>social media</kwd><kwd>social networking</kwd><kwd>suicide</kwd><kwd>young adult</kwd><kwd>youth</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>In Japan, deaths from suicide declined during the early phase of the COVID-19 pandemic but later increased, especially among women and people younger than 40 years [<xref ref-type="bibr" rid="ref1">1</xref>]. Depression and hopelessness are key predictors of suicidal ideation and behavior [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>].</p><p>Recently, <italic>ikizurasa</italic> (&#x201C;pain of living&#x201D;) has drawn attention as a factor in adolescent mental health issues, including <italic>hikikomori</italic> (&#x201C;being confined,&#x201D; a term used to describe deep social isolation) and suicide [<xref ref-type="bibr" rid="ref4">4</xref>]. <italic>Ikizurasa</italic> was defined by the Japanese Neuropsychiatric Society as &#x201C;impairment and suppression of independent social relationship formation.&#x201D; It has also been described as involving solitude, anxiety, low self-esteem, hopelessness, and anger [<xref ref-type="bibr" rid="ref5">5</xref>]. However, quantitative research focusing on <italic>ikizurasa</italic> remains scarce.</p><p>Social media behavior has been linked to mental health, particularly among youth. A cross-sectional study in Japan found that posting phrases like &#x201C;want to die&#x201D; on X (formerly Twitter) was significantly associated with suicidal thoughts and behaviors [<xref ref-type="bibr" rid="ref6">6</xref>]. A meta-analysis also reported that frequent social media and smartphone use correlates with suicidal tendencies [<xref ref-type="bibr" rid="ref7">7</xref>].</p><p>This study aimed to examine how often <italic>ikizurasa</italic> was expressed and when these expressions peaked on X in Japan, which has the second-largest X user base after the United States. In 2023, X was used by 65.7% of teenagers, and 81.6% of people in their 20s&#x2014;much higher rates than among older generations or on other platforms [<xref ref-type="bibr" rid="ref8">8</xref>]. As X allows anonymous, text-based posting, it offers a space where users may express their emotional distress openly.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Overview</title><p>All X public account data from January 1, 2023, through December 31, 2023, were obtained using the official X application programming interface (version 2). The search query was &#x751F;&#x304D;&#x3065;&#x3089; (<italic>ikizura</italic>) or &#x751F;&#x304D;&#x306B;&#x304F;&#x3044; (<italic>ikinikui</italic>; both mean &#x201C;pain of living&#x201D; or "hard to live"). The analysis was performed in Python.</p></sec><sec id="s2-2"><title>Ethical Considerations</title><p>This study used only secondary data without identifiable individuals.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><p>In 2023, 1,399,746 posts mentioned <italic>ikizurasa</italic>; 397,517 were organic (ie, excluding reposts or quotes). <xref ref-type="fig" rid="figure1">Figure 1</xref> shows the daily number of posts. The overall average was 3835, with a peak of 26,063 on April 29. Organic posts averaged 1089, peaking at 3414 on July 13, with another peak in late February.</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>Time series of X posts. The blue line shows the total number of posts (including original posts and reposts), and the green line shows the number of original posts.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="formative_v9i1e70613_fig01.png"/></fig><p>On April 28, an interview article titled &#x201C;Difficulties in Life as a Minority&#x201D; [<xref ref-type="bibr" rid="ref9">9</xref>] was published, reporting on the experiences of discrimination of an ethnically Uyghur member of the House of Representatives, Eri Arfiya, and many X users mentioned the article. On July 12, the news of the death (by presumed suicide) of a well-known transgender celebrity, Ryuchell, was shared with the X community. Many mentioned the news by discussing <italic>ikizurasa</italic> as a transgender person and expressing their shock at Ryuchell&#x2019;s sudden death that day.</p><p>The late February peak was triggered by a post from a US celebrity in Japan, who noted that the lack of English on train tickets may cause foreigners to feel <italic>ikizurasa</italic>.</p><p><xref ref-type="table" rid="table1">Table 1</xref> shows the age distribution of the X users who posted using the term <italic>ikizurasa</italic>. Most users who posted <italic>ikizurasa</italic> were in their 20s and 30s.</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Age distribution of X users who posted using the terms <italic>ikizura</italic> or <italic>ikinikui</italic>.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="top">Age (years)</td><td align="left" valign="top">Men, %</td><td align="left" valign="top">Women, %</td></tr></thead><tbody><tr><td align="left" valign="top">&#x2264;19</td><td align="left" valign="top">1.19</td><td align="left" valign="top">9.66</td></tr><tr><td align="left" valign="top">20&#x2010;29</td><td align="left" valign="top">28.57</td><td align="left" valign="top">39.20</td></tr><tr><td align="left" valign="top">30&#x2010;39</td><td align="left" valign="top">33.33</td><td align="left" valign="top">32.95</td></tr><tr><td align="left" valign="top">40&#x2010;49</td><td align="left" valign="top">22.62</td><td align="left" valign="top">15.34</td></tr><tr><td align="left" valign="top">&#x2265;50</td><td align="left" valign="top">10.71</td><td align="left" valign="top">2.84</td></tr></tbody></table></table-wrap></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><p>This study aimed to examine the frequency and timing of posts using the term <italic>ikizurasa</italic> on X in Japan, where the platform is particularly popular among younger generations. Our results showed that over 1.3 million posts containing the term <italic>ikizurasa</italic> were recorded in 2023, with notable peaks in late April and mid-July. These peaks appeared to coincide with news events involving ethnic and gender minorities, suggesting that expressions of <italic>ikizurasa</italic> may be linked to the stress of being part of a minority group.</p><p>Previous studies have documented strong associations between minority status&#x2014;such as ethnicity or gender&#x2014;and poor mental health outcomes [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref11">11</xref>]. Consistent with this literature, our findings indicate that individuals from minority backgrounds may be more likely to experience and publicly express feelings of <italic>ikizurasa</italic>, reflecting psychological distress tied to discrimination and marginalization.</p><p>This study has limitations. It focused only on posts using specific Japanese terms, possibly excluding other expressions of distress. As the analysis relied on public social media data, user authenticity, intent, and demographics could not be verified, limiting interpretation.</p><p>Even so, the findings suggest that social media can serve as a real-time indicator of psychological distress, especially among younger and marginalized groups. Integrating such monitoring into public health strategies may help detect emerging mental health issues and support timely, targeted responses.</p></sec></body><back><ack><p>This work was supported by the Japan Science and Technology Agency (JST; grant JPMJPF2203) and YCU Future Co-Creation Project. We also thank D4DR Inc and Missile Inc for supporting the scraping and analyzing of X posts for this study.</p></ack><notes><sec><title>Data Availability</title><p>The datasets generated and analyzed during the current study were obtained via the public X API. In accordance with X&#x2019;s Developer Policy, raw tweet content cannot be redistributed. However, tweet IDs used in this study are available from the corresponding author upon reasonable request.</p></sec></notes><fn-group><fn fn-type="con"><p>AA, YI, and YK conceived and planned the study. KT took the lead in writing the manuscript. AA and TM supervised the entire study project. 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