<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Form Res</journal-id><journal-id journal-id-type="publisher-id">formative</journal-id><journal-id journal-id-type="index">27</journal-id><journal-title>JMIR Formative Research</journal-title><abbrev-journal-title>JMIR Form Res</abbrev-journal-title><issn pub-type="epub">2561-326X</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v9i1e66889</article-id><article-id pub-id-type="doi">10.2196/66889</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Paper</subject></subj-group></article-categories><title-group><article-title>Effect of a Digital Health Exercise Program on the Intention for Spinal Surgery in Adult Spinal Deformity: Exploratory Cross-Sectional Survey</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" equal-contrib="yes"><name name-style="western"><surname>Brown</surname><given-names>Marsalis Christian</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Lin</surname><given-names>Christopher Quincy</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Jin</surname><given-names>Christopher</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Rohde</surname><given-names>Matthew</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff4">4</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Rocos</surname><given-names>Brett</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Belding</surname><given-names>Jonathan</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Woods</surname><given-names>Barrett I</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff6">6</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name name-style="western"><surname>Ackerman</surname><given-names>Stacey J</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff7">7</xref><xref ref-type="fn" rid="equal-contrib1">*</xref></contrib></contrib-group><aff id="aff1"><institution>Department of Orthopaedic Surgery, MetroHealth Medical Center</institution><addr-line>2500 MetroHealth Dr</addr-line><addr-line>Cleveland</addr-line><addr-line>OH</addr-line><country>United States</country></aff><aff id="aff2"><institution>Department of Medicine, The Larner College of Medicine, The University of Vermont</institution><addr-line>Burlington</addr-line><addr-line>VT</addr-line><country>United States</country></aff><aff id="aff3"><institution>Department of Medical, Medical College of Wisconsin</institution><addr-line>Milwaukee</addr-line><addr-line>WI</addr-line><country>United States</country></aff><aff id="aff4"><institution>The Department of Orthopaedics, Zucker School of Medicine at Hofstra/Northwell</institution><addr-line>Hempstead</addr-line><addr-line>NY</addr-line><country>United States</country></aff><aff id="aff5"><institution>Duke Spine Center, Duke University Health System</institution><addr-line>Durham</addr-line><addr-line>NC</addr-line><country>United States</country></aff><aff id="aff6"><institution>Department of Spine Surgery, Rothman Orthopaedic Institute, Thomas Jefferson University Rothman Institute</institution><addr-line>Philadelphia</addr-line><addr-line>PA</addr-line><country>United States</country></aff><aff id="aff7"><institution>Department of Biomedical Engineering, Johns Hopkins University</institution><addr-line>San Diego</addr-line><addr-line>CA</addr-line><country>United States</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Mavragani</surname><given-names>Amaryllis</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Punekar</surname><given-names>Rajeshwari S</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Marsalis Christian Brown, MD, Department of Orthopaedic Surgery, MetroHealth Medical Center, 2500 MetroHealth Dr, Cleveland, OH, 44109, United States, 1 614-441-3703; <email>brown.marsalis@gmail.com</email></corresp><fn fn-type="equal" id="equal-contrib1"><label>*</label><p>these authors contributed equally</p></fn></author-notes><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>29</day><month>4</month><year>2025</year></pub-date><volume>9</volume><elocation-id>e66889</elocation-id><history><date date-type="received"><day>25</day><month>09</month><year>2024</year></date><date date-type="rev-recd"><day>08</day><month>04</month><year>2025</year></date><date date-type="accepted"><day>10</day><month>04</month><year>2025</year></date></history><copyright-statement>&#x00A9; Marsalis Christian Brown, Christopher Quincy Lin, Christopher Jin, Matthew Rohde, Brett Rocos, Jonathan Belding, Barrett I Woods, Stacey J Ackerman. Originally published in JMIR Formative Research (<ext-link ext-link-type="uri" xlink:href="https://formative.jmir.org">https://formative.jmir.org</ext-link>), 29.4.2025. </copyright-statement><copyright-year>2025</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Formative Research, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://formative.jmir.org">https://formative.jmir.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://formative.jmir.org/2025/1/e66889"/><abstract><sec><title>Background</title><p>Adult spinal deformity (ASD) is a prevalent condition estimated at 38%. Symptomatic ASD is associated with substantial health care costs. The role of nonoperative interventions in the management of ASD remains elusive. The National Scoliosis Clinic&#x2019;s (NSC) scoliosis realignment therapy (SRT) is a personalized digital health exercise program for the nonoperative management of ASD.</p></sec><sec><title>Objective</title><p>This exploratory study had two objectives: (1) to evaluate the effect of the SRT program on users&#x2019; intention of having spinal fusion; and (2) from a US payer perspective, to estimate the annual cost savings per 100,000 beneficiaries by averting spinal surgery.</p></sec><sec sec-type="methods"><title>Methods</title><p>Individuals were enrolled in the SRT study from October 1, 2023 to September 1, 2024. Participants completed a web-based, cross-sectional survey about their history of prior scoliosis surgery and intent of having surgery before and after use of SRT (on a 4-point Likert scale, where 1 = &#x201C;No Intent for Surgery&#x201D; and 4 = &#x201C;High Intent for Surgery&#x201D;). Intent for surgery before and after participation in SRT was compared using a nonparametric Wilcoxon signed-rank test for paired data. Annual cost savings per 100,000 beneficiaries by averting spinal fusions were estimated separately for commercial payers and Medicare using published literature and public data sources. Payer expenditures were inflation-adjusted to 2024 US dollars using the Hospital Services component of the Consumer Price Index.</p></sec><sec sec-type="results"><title>Results</title><p>A total of 62 NSC members (38.8%) responded to the survey and were enrolled in the SRT program for an average (SD) of 17 (12) weeks. The mean (SD) age was 65.3 (13.5) years, and the majority were female (47/48, 98%) and White (45/46, 98%). Among the SRT users who did not have prior scoliosis surgery (n=56), 14% (8/56) reported a decrease in intent for surgery (that is, a lower Likert score) with the use of SRT. The mean (SD) intent for surgery scores before compared to after SRT were 1.29 (0.53) and 1.14 (0.35), respectively (mean difference 0.15 [<italic>P</italic>=.006]). Participants with &#x201C;No Intent for Surgery&#x201D; pre- versus postuse of SRT (42/56 versus 48/56, respectively) corresponded to an absolute risk reduction of 11% and a number needed to treat of 9 to avert one spinal fusion. Among the 6 participants who transitioned to &#x201C;No Intent&#x201D; for spinal surgery with the use of SRT, 3 were aged &#x003C;65 years and 3 were &#x2265;65 years of age. The annual cost savings from averted spinal surgeries were estimated at US $415,000 per 100,000 commercially-insured beneficiaries and US $617,000 per 100,000 Medicare beneficiaries.</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>SRT is a personalized, scoliosis-specific digital health exercise program with the potential for averting 1 spinal surgery for every 9 participants, resulting in a substantial reduction in payer expenditures while improving the quality of care for commercial payers and Medicare beneficiaries.</p></sec></abstract><kwd-group><kwd>adult spinal deformity</kwd><kwd>scoliosis</kwd><kwd>nonoperative management</kwd><kwd>spinal realignment therapy</kwd><kwd>digital health</kwd><kwd>program evaluation</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>Adult spinal deformity (ASD) is a common condition with an estimated prevalence of 38% for primary (de novo) degenerative scoliosis [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref2">2</xref>]. ASD is a 3-dimensional deformity of the spine defined by a major curve magnitude angle of &#x2265;10&#x00B0;, and women are more likely to have the diagnosis [<xref ref-type="bibr" rid="ref1">1</xref>-<xref ref-type="bibr" rid="ref4">4</xref>]. Patients with symptomatic ASD report increased back pain as well as lower health-related quality of life as demonstrated by worse SF-36 (36-Item Short Form Health Survey) scores compared to the general population [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>].</p><p>As the US population continues to age, there is growing interest in understanding the most effective means to manage ASD. While nonoperative modalities are typically the first-line treatment for patients with symptomatic ASD, the role of nonoperative management has been questioned, with some studies reporting 2-year costs ranging from US $2041 to US $14,022 without improvements in patient outcomes [<xref ref-type="bibr" rid="ref7">7</xref>-<xref ref-type="bibr" rid="ref9">9</xref>]. In contrast, several studies have reported that patients who receive operative interventions for ASD have significantly reduced disability and pain and better improvement in clinical outcomes compared to nonoperative treatment [<xref ref-type="bibr" rid="ref9">9</xref>-<xref ref-type="bibr" rid="ref12">12</xref>]. However, spinal fusion is costly (Medicare reimbursement of $60,269 [<xref ref-type="bibr" rid="ref13">13</xref>]) and carries significant risks; a multicenter database study of nearly 1000 adult surgical patients with ASD with 2-year follow-up reported an overall complication rate of 67.4% [<xref ref-type="bibr" rid="ref14">14</xref>], and a separate meta-analysis demonstrated complication rates ranging from 17.0% to 71.5% [<xref ref-type="bibr" rid="ref12">12</xref>]. Considering the substantial economic burden and complication rate associated with operative interventions for ASD&#x2014;and noting that, other digital care programs in orthopedics (low back pain and chronic knee pain) have demonstrated significant reductions in surgical intent [<xref ref-type="bibr" rid="ref15">15</xref>-<xref ref-type="bibr" rid="ref17">17</xref>]&#x2014;this study sought to further elucidate the role of a digital health program in the nonoperative management of ASD.</p><p>The National Scoliosis Clinic&#x2019;s (NSC) Scoliosis Realignment Therapy (SRT) is a remote, exercise-based, ScolioPilates&#x00AE; therapy specifically designed for individuals with scoliosis. ScolioPilates&#x00AE; is a scoliosis-specific exercise program using elongation, corrective breathing, strengthening, and activities of daily living to address pain associated with scoliosis. Additionally, members of SRT are enrolled in a supportive community with virtual group sessions, education, and AI-driven technology to assess spinal curvature with personalized therapy. While Clohisy et al [<xref ref-type="bibr" rid="ref18">18</xref>] reported that the majority of patients crossover from nonoperative to operative treatment due to perceived worsening of symptoms, Rhode et al [<xref ref-type="bibr" rid="ref19">19</xref>] recently reported that the use of SRT for 6 weeks resulted in significant improvement in pain as measured using the Scoliosis Research Society Health-Related Quality of Life Questionnaire (SRS-22r).</p><p>This exploratory study had two objectives: (1) to evaluate the effect of the SRT program on users&#x2019; intention of having spinal fusion; and (2) from a US payer perspective, to estimate the annual cost savings per 100,000 beneficiaries by averting spinal surgery.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Recruitment</title><p>Individuals with scoliosis were recruited to the NSC through multiple mechanisms, including social media and the NSC website. NSC members were enrolled nationwide in the SRT study between October 1, 2023 and September 1, 2024. All NSC members using SRT during the aforementioned time period were invited by email to participate in the closed, web-based, cross-sectional survey about surgical intention. A formal sample size calculation was not performed, given that this was an exploratory study. In addition to demographics and clinical characteristics, the survey asked, &#x201C;Has a surgeon ever told you you need scoliosis surgery, or offered you surgery?&#x201D;, &#x201C;Have you ever intended to have scoliosis surgery?&#x201D; and &#x201C;Since you have started working with the NSC SRT, what is your current intention to have scoliosis surgery?&#x201D; Responses to the questions about surgical intent were graded on a 4-point Likert scale, where 1=No Intent for Surgery, 2=Low Intent, 3=Moderate Intent, and 4=High Intent for Surgery. Given that this was an exploratory web-based survey, radiographic parameters were not collected.</p></sec><sec id="s2-2"><title>Statistical Analysis</title><p>The primary outcome measure was the intent to pursue surgical correction of scoliosis pain. A nonparametric Wilcoxon signed-rank test for paired data was conducted to evaluate the difference in intention scores before and after SRT. The Wilcoxon test is appropriate for small samples that are not normally distributed. All analyses were performed using R software (version 4.4.1; R Foundation for Statistical Computing).</p><p>For potentially averted spinal surgeries, annual cost savings per 100,000 beneficiaries were estimated separately for US commercial payers and Medicare using published literature and multiple public data sources (<xref ref-type="table" rid="table1">Table 1</xref>). Payer expenditures were inflation-adjusted to US dollars in 2024 by using the Hospital Services component of the Consumer Price Index.</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Parameter values, data sources, and estimated cost savings from potentially averted spinal fusions among individuals with adult spinal deformity in the United States (2024, $US) [<xref ref-type="bibr" rid="ref20">20</xref>].</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Parameter</td><td align="left" valign="bottom">Value</td><td align="left" valign="bottom"/><td align="left" valign="bottom">Source</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top">Commercial</td><td align="left" valign="top">Medicare</td><td align="left" valign="top"/></tr></thead><tbody><tr><td align="left" valign="top">Medical resource use for scoliosis by adults, %</td><td align="left" valign="top">0.502</td><td align="left" valign="top">1.531</td><td align="left" valign="top">[<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref21">21</xref>]</td></tr><tr><td align="left" valign="top">Adult scoliosis patients per 100,000 beneficiaries, n</td><td align="left" valign="top">502</td><td align="left" valign="top">1531</td><td align="left" valign="top">Derived</td></tr><tr><td align="left" valign="top">Convert from nonoperative care to spinal fusion (annual), %</td><td align="left" valign="top">21.7</td><td align="left" valign="top">21.7</td><td align="left" valign="top">[<xref ref-type="bibr" rid="ref22">22</xref>]</td></tr><tr><td align="left" valign="top">Conversions to spinal fusion (annual), n</td><td align="left" valign="top">109</td><td align="left" valign="top">332</td><td align="left" valign="top">Derived</td></tr><tr><td align="left" valign="top">Absolute risk reduction in intent for surgery, %</td><td align="left" valign="top">11</td><td align="left" valign="top">11</td><td align="left" valign="top">SRT survey</td></tr><tr><td align="left" valign="top">SRT<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup> participation rate (users), %</td><td align="left" valign="top">28</td><td align="left" valign="top">28</td><td align="left" valign="top">[<xref ref-type="bibr" rid="ref23">23</xref>]</td></tr><tr><td align="left" valign="top">Spinal fusions averted annually per 100,000 beneficiaries, n</td><td align="left" valign="top">3.4</td><td align="left" valign="top">10.2</td><td align="left" valign="top">Derived</td></tr><tr><td align="left" valign="top">Spinal fusion insurer payment, US $<sup><xref ref-type="table-fn" rid="table1fn2">b</xref></sup><sup><xref ref-type="table-fn" rid="table1fn3">c</xref></sup></td><td align="left" valign="top">123,551<sup><xref ref-type="table-fn" rid="table1fn4">d</xref></sup></td><td align="left" valign="top">60,269</td><td align="left" valign="top">[<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]</td></tr><tr><td align="left" valign="top">Annual cost savings per 100,000 beneficiaries, $</td><td align="left" valign="top">414,534</td><td align="left" valign="top">616,504</td><td align="left" valign="top">Derived</td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>SRT: scoliosis realignment therapy.</p></fn><fn id="table1fn2"><p><sup>b</sup>Weighted average of diagnosis-related group (DRG) 456 (spinal fusion with spinal curvature with major complication, 25%), DRG 457 (spinal fusion with spinal curvature with complication, 59%), and DRG 458 (spinal fusion with spinal curvature without complication or major complication, 16%).</p></fn><fn id="table1fn3"><p><sup>c</sup>Inflated from 2022 to 2024 (half) US $ using the Consumer Price Index for hospital services; multiplier 1.097.</p></fn><fn id="table1fn4"><p><sup>d</sup>Calculated using a Medicare-to-commercial payment multiplier of 2.05 for hospital inpatient services.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s2-3"><title>Data Exclusion</title><p>Users with prior spinal fusion surgery were excluded from the surgical intent analysis. Participants were given 2 weeks to respond to the survey, with subsequent reminders. Users who failed to respond to the surgical intent questions were excluded.</p></sec><sec id="s2-4"><title>Ethical Considerations</title><p>This web-based survey evaluated a wellness program, not a medical treatment, and study data were deidentified for privacy and confidentiality protection. The datasets generated and analyzed during this study were restricted to the researchers conducting the analysis. NSC members who participated in the web-based survey study were provided US $50 gift cards for the completion of the survey.</p><p>Per the Office of Human Research Protections, under the US Department of Health and Human Services, research that (1) involves only survey procedures of adults and (2) is collected in a deidentified fashion is exempt from institutional review board (IRB) review and informed consent can be waived [<xref ref-type="bibr" rid="ref26">26</xref>]. A retrospective IRB exemption was obtained for this study, confirming that both conditions are met, and therefore, this study was IRB exempt, and informed consent was not indicated.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>User Statistics</title><p>In total, 160 NSC members were invited to participate in the survey; 62 (38.8%) individuals nationwide voluntarily completed the survey. Six participants were excluded from the intention to pursue surgery analysis: 5 who had prior fusion surgery and 1 who did not respond. Among survey respondents who reported age (N=47), the mean (SD) age was 65.3 (13.5) years (age &#x003C;65 years, 40%; age &#x2265;65 years, 60%). The mean (SD) SRT duration of use was 118 (86.6 days); the majority were female (47/48, 98%) and White (45/46, 98%; <xref ref-type="table" rid="table2">Table 2</xref>).</p><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Demographics and clinical characteristics of scoliosis realignment therapy (SRT) cross-sectional survey participants with adult spinal deformity (n=62).</p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Characteristic</td><td align="left" valign="bottom">Value</td></tr></thead><tbody><tr><td align="left" valign="top">Age in years, mean (SD)</td><td align="char" char="." valign="top">65.3 (13.5)</td></tr><tr><td align="left" valign="top">Age &#x003C;65 years, n (%)</td><td align="char" char="." valign="top">19 (30.6)</td></tr><tr><td align="left" valign="top">Age &#x2265;65 years, n (%)</td><td align="char" char="." valign="top">28 (45.2)</td></tr><tr><td align="left" valign="top">Did not respond</td><td align="char" char="." valign="top">15 (24.2)</td></tr><tr><td align="left" valign="top">Gender, n (%)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Female</td><td align="char" char="." valign="top">47 (75.8)</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Male</td><td align="char" char="." valign="top">1 (1.6)</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Did not respond</td><td align="char" char="." valign="top">14 (22.6)</td></tr><tr><td align="left" valign="top">Race, n (%)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>White</td><td align="left" valign="top">45 (72.6)</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>American Indian and Caucasian</td><td align="left" valign="top">1 (1.6)</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Did not respond</td><td align="left" valign="top">16 (25.8)</td></tr><tr><td align="left" valign="top">SRT Duration of Use in days, mean (SD)</td><td align="char" char="." valign="top">118 (86.6)</td></tr><tr><td align="left" valign="top">Offered scoliosis surgery in the past, n (%)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Yes</td><td align="left" valign="top">15 (24.2)</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>No</td><td align="char" char="." valign="top">26 (41.9)</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Did not respond</td><td align="char" char="." valign="top">21 (33.9)</td></tr><tr><td align="left" valign="top">Prior fusion surgery for scoliosis, n (%)<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></td><td align="char" char="." valign="top"/></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Yes</td><td align="char" char="." valign="top">5 (8.1)</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>No</td><td align="char" char="." valign="top">56 (90.3)</td></tr><tr><td align="left" valign="top"><named-content content-type="indent">&#x00A0;&#x00A0;&#x00A0;&#x00A0;</named-content>Did not respond</td><td align="char" char="." valign="top">1 (1.6)</td></tr></tbody></table><table-wrap-foot><fn id="table2fn1"><p><sup>a</sup>Individuals with either prior fusion surgery or no response excluded from surgical intent analysis.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-2"><title>Evaluation Outcomes</title><sec id="s3-2-1"><title>Surgical Intent</title><p>Overall, 14% of participants (8/56) reported a decrease in intent for scoliosis surgery (ie, a lower Likert score) with the use of SRT, and no participants reported an increase in surgical intent. The mean (SD) intent for surgery scores before compared to after SRT were 1.29 (0.53) and 1.14 (0.35), respectively (mean difference 0.15 [<italic>P</italic>=.006]; <xref ref-type="table" rid="table3">Table 3</xref>). Participants with &#x201C;No Intent&#x201D; for spinal surgery pre- versus postuse of SRT (42/56 versus 48/56, respectively) corresponded to an absolute risk reduction of 11% and a number needed to treat of 9 to potentially avert 1 spinal fusion (1 divided by 0.11). Among the 6 participants who transitioned to &#x201C;No Intent&#x201D; for spinal surgery with the use of SRT, 3 were aged &#x003C;65 years (ages 30, 62, and 64 years, respectively) and 3 were aged &#x2265;65 years (ages 73, 73, and 82 years, respectively).</p><table-wrap id="t3" position="float"><label>Table 3.</label><caption><p>Intentions for surgical intervention for adult spinal deformity prior to and after using scoliosis realignment therapy (SRT; cross-sectional survey; n=56).</p></caption><table id="table3" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Statement</td><td align="left" valign="bottom" colspan="4">Percentage of respondents</td><td align="left" valign="bottom" colspan="2">Mean (SD)<sup><xref ref-type="table-fn" rid="table3fn1">a</xref></sup></td></tr><tr><td align="left" valign="bottom"/><td align="left" valign="bottom">No intent</td><td align="left" valign="bottom">Low</td><td align="left" valign="bottom">Moderate</td><td align="left" valign="bottom">High</td><td align="left" valign="bottom" colspan="2"/></tr></thead><tbody><tr><td align="left" valign="top">Have you ever intended to have scoliosis surgery?</td><td align="left" valign="top">75.0</td><td align="left" valign="top">21.4</td><td align="left" valign="top">3.6</td><td align="left" valign="top">0.0</td><td align="left" valign="top" colspan="2">1.29 (0.530)</td></tr><tr><td align="left" valign="top">Since you have started working with the NSC<sup><xref ref-type="table-fn" rid="table3fn2">b</xref></sup> SRT, what is your current intention to have scoliosis surgery?</td><td align="left" valign="top">85.7</td><td align="left" valign="top">14.3</td><td align="left" valign="top">0.0</td><td align="left" valign="top">0.0</td><td align="left" valign="top" colspan="2">1.14 (0.353)</td></tr></tbody></table><table-wrap-foot><fn id="table3fn1"><p><sup>a</sup>Four-point Likert scale, where 1=No Intent for Surgery, 2=Low Intent, 3=Moderate Intent, and 4=High Intent. <italic>P</italic>=0.006, Wilcoxon signed-rank test.</p></fn><fn id="table3fn2"><p><sup>b</sup>NSC: National Scoliosis Clinic.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-2-2"><title>Estimated Cost Savings by Averting Spinal Fusion</title><p>The percentage of adult patients using medical services for scoliosis was 0.502% (age 18&#x2010;64 years) and 1.531% (age &#x2265;65 years) for commercial and Medicare beneficiaries, respectively, or, 502 and 1531 per 100,000 beneficiaries, respectively (<xref ref-type="table" rid="table1">Table 1</xref>). An estimated 21.7% (41/189) of these patients converted from nonoperative care to spinal fusion annually. Applying the SRT-related 11% absolute risk reduction and an assumed 28% SRT participation rate based on digital health wellness intervention programs without incentives, a total of 3.4 fusions would potentially be averted annually per 100,000 commercially insured beneficiaries and 10.2 fusions potentially avoided annually per 100,000 Medicare beneficiaries. Applying a Medicare payment of US $60,269 for hospital inpatient spinal fusion (weighted average of diagnosis-related groups [DRGs] 456&#x2010;458 in 2024 in US $) and multiplier for Medicare-to-commercial payment of 2.05 (ie, commercial payment of US $123,551), the annual cost savings from averted surgeries were estimated at US $415,000 per 100,000 commercially insured beneficiaries, and US $617,000 per 100,000 Medicare beneficiaries (<xref ref-type="table" rid="table1">Table 1</xref>).</p></sec></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>This web-based, cross-sectional survey study explored whether the use of SRT, a personalized digital therapy program for adults with scoliosis, resulted in a reduction in intent for spinal surgery. After using SRT for an average of 17 weeks, an 11% absolute risk reduction in intent for surgery was observed, which corresponds to a number needed to treat of 9, suggesting that one spine surgery could potentially be averted for every 9 individuals using SRT. Hence, SRT offers a promising nonoperative therapy that may decrease spinal fusions with its associated risks and economic burden.</p></sec><sec id="s4-2"><title>Comparison With Prior Work</title><p>The reduced intent in pursuing surgery with the use of SRT is consistent with other digital care programs in orthopedics, recognizing that scoliosis is a unique condition with its own clinical challenges. For a 12-week digital care program in low back pain, Shebib et al [<xref ref-type="bibr" rid="ref15">15</xref>] demonstrated a significant reduction in surgical interest (<italic>P</italic>=.01). Similarly, Smittenaar and colleagues [<xref ref-type="bibr" rid="ref16">16</xref>] reported a decrease in surgery intent at 3 months (<italic>P</italic>&#x003C;.001) with a 12-week digital care program for chronic knee pain. Mecklenburg et al [<xref ref-type="bibr" rid="ref17">17</xref>] also found that the self-reported likelihood of having surgery decreased over 1 year with the use of a digital care program for chronic knee pain (<italic>P</italic>=.01).</p><p>Investigators have reported conversion rates from nonoperative to operative treatment ranging from 12.7% (24/189) within 1 year to 31% (42/135) after 6 months [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref22">22</xref>]. Clohisy et al [<xref ref-type="bibr" rid="ref18">18</xref>] further noted that the majority (90%) of patients crossed over from nonoperative to operative treatment due to perceived worsening of symptoms, and the remainder because the patients believed that the nonsurgical therapies were ineffective. Rhode et al [<xref ref-type="bibr" rid="ref19">19</xref>] recently reported outcomes following 6 weeks of SRT using SRS-22r. Specifically, a significant improvement was observed in the pain (<italic>P</italic>&#x003C;.001), self-image (<italic>P</italic>=.05), and mental health (<italic>P</italic>&#x003C;.001) subdomains of the SRS-22r, with the improvement in the pain subdomain exceeding the minimal clinically important difference threshold. In addition, these investigators reported high satisfaction with the SRT program (9.5 out of 10, where 1=Extremely Dissatisfied and 10=Extremely Satisfied) [<xref ref-type="bibr" rid="ref19">19</xref>]. Given that the SRT cohort reported in the study by Rhode et al (n=23) [<xref ref-type="bibr" rid="ref19">19</xref>] is a subset of those reported herein (n=62), the statistically significant decrease in intent for surgery is consistent with the previously reported perceivable improvement in pain with the use of SRT. These consistent findings across SRT studies support the validity of using the question on surgical intent to extrapolate to the estimated cost savings.</p><p>In light of the aging population among other factors, Wadhwa and colleagues [<xref ref-type="bibr" rid="ref27">27</xref>] reported that, among both commercial and Medicare beneficiaries, the rate of fusion for adult spinal deformity surgery doubled from 2007 to 2015. In addition, Passias et al [<xref ref-type="bibr" rid="ref9">9</xref>] reported that the mean 2-year cost of nonoperative treatment was US $2041, and the mean 2-year cost for operative treatment was US $66,860 based on Medicare reimbursements. As such, the estimated cost savings for averted surgeries reported in the present study are likely underestimated for multiple reasons, specifically, the percentage of beneficiaries seeking medical care for scoliosis is based on data from 2013 [<xref ref-type="bibr" rid="ref20">20</xref>], the DRG reimbursement amounts reflect only the spinal surgery hospitalization (including the global period) [<xref ref-type="bibr" rid="ref13">13</xref>], and incentives could increase the SRT participation rate [<xref ref-type="bibr" rid="ref23">23</xref>].</p><p>The cost analyses are based on the best available published data, recognizing that more recent trends in insurer reimbursement and technological advancements may not be reflected. The cost-savings estimates rely on several assumptions, including a 28% participation rate for intervention-focused digital wellness programs. Mattke et al [<xref ref-type="bibr" rid="ref23">23</xref>] described the relationship between incentive structure and participation rate, noting that the use of incentives increased wellness program participation. Our analysis assumed no incentives with an intervention-focused participation rate of 28% (versus 30% if any incentives). Others have reported a 32% participation rate for physical well-being programs [<xref ref-type="bibr" rid="ref28">28</xref>]. Hence, assuming the absence of incentives offers a conservative estimate of the participation rate.</p></sec><sec id="s4-3"><title>Limitations</title><p>There are several limitations of this formative research study. First, participants used SRT for an average of 17 weeks, which begs the question about whether the observed decrease in surgical intent would be sustained. That said, Smittenaar et al [<xref ref-type="bibr" rid="ref16">16</xref>] found that the reduction in surgery interest continued for 6 months following the initiation of a digital health program for chronic knee pain (<italic>P</italic>&#x003C;.001), and Mecklenburg et al [<xref ref-type="bibr" rid="ref17">17</xref>] reported that the decreased likelihood of knee surgery with the use of a digital care program was sustained over 5 years (<italic>P</italic>=.002). Second, the self-reported survey data are subjective and participants completed both the pre- and post-SRT questions about surgical intention after initiating SRT, which potentially may be subject to recall bias. Third, the pre-post study design may be subject to confounding because it lacks an independent control or comparison group and is less rigorous than a randomized control trial; notwithstanding, each participant served as their own control. Furthermore, study participants were not blinded in that they were aware of using SRT, which may have introduced the possibility of performance bias. Lastly, although participants represented a nationwide sample of adults with scoliosis, the study included a relatively small cohort that did not permit the exploration of nuanced effects and was not ethnically diverse; therefore, the results may not be generalizable. Future studies will explore the durability of SRT use on surgical intent with a larger, more diverse cohort.</p></sec><sec id="s4-4"><title>Conclusions</title><p>SRT is a personalized, scoliosis-specific digital health exercise program with the potential for averting 1 spinal fusion for every 9 participants, resulting in a substantial reduction in payer expenditures while improving the quality of care for commercial payer and Medicare beneficiaries. The SRT remote, digital care program holds promise as a feasible strategy to transform the nonoperative paradigm in adult spinal deformity. Digital care delivery is becoming more common with currently available health technology, and can increase patient agency and engagement, while improving overall outcomes and decreasing health care spending.</p></sec></sec></body><back><ack><p>Generative AI was not used in any portion of the manuscript writing.</p></ack><notes><sec><title>Data Availability</title><p>The datasets generated and analyzed during this study are available from the corresponding author on reasonable request.</p></sec></notes><fn-group><fn fn-type="con"><p>MCB was involved in the conceptualization, data analysis, interpretation of findings, and manuscript preparation. CQL was involved in the conceptualization, interpretation of findings, and manuscript preparation. CJ was involved in the conceptualization, data acquisition, data analysis, and manuscript preparation. MR was involved in the conceptualization and manuscript preparation. BR, JB, and BIW were involved in the conceptualization, manuscript preparation, and critical manuscript review. SJA was involved in the conceptualization, data analysis, interpretation of findings, manuscript preparation, and critical manuscript review.</p></fn><fn fn-type="conflict"><p>SJA declares to have an advisory contract with NSite Medical.</p><p>MCB declares consulting for NSite Medical.</p><p>All other authors have no conflicts of interest to disclose.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">ASD</term><def><p>adult spinal deformity</p></def></def-item><def-item><term id="abb2">DRG</term><def><p>diagnosis-related group</p></def></def-item><def-item><term id="abb3">IRB</term><def><p>institutional review board</p></def></def-item><def-item><term id="abb4">NSC</term><def><p>National Scoliosis Clinic</p></def></def-item><def-item><term id="abb5">SF-36</term><def><p>36-Item Short Form Health Survey</p></def></def-item><def-item><term id="abb6">SRT</term><def><p>scoliosis realignment therapy</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Bunnell</surname><given-names>WP</given-names> </name></person-group><article-title>The natural history of idiopathic scoliosis before skeletal maturity</article-title><source>Spine (Phila Pa 1986)</source><year>1986</year><month>10</month><volume>11</volume><issue>8</issue><fpage>773</fpage><lpage>776</lpage><pub-id pub-id-type="doi">10.1097/00007632-198610000-00003</pub-id></nlm-citation></ref><ref id="ref2"><label>2</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>McAviney</surname><given-names>J</given-names> </name><name name-style="western"><surname>Roberts</surname><given-names>C</given-names> </name><name name-style="western"><surname>Sullivan</surname><given-names>B</given-names> </name><name name-style="western"><surname>Alevras</surname><given-names>AJ</given-names> </name><name name-style="western"><surname>Graham</surname><given-names>PL</given-names> </name><name name-style="western"><surname>Brown</surname><given-names>BT</given-names> </name></person-group><article-title>The prevalence of adult de novo scoliosis: a systematic review and meta-analysis</article-title><source>Eur Spine J</source><year>2020</year><month>12</month><volume>29</volume><issue>12</issue><fpage>2960</fpage><lpage>2969</lpage><pub-id pub-id-type="doi">10.1007/s00586-020-06453-0</pub-id><pub-id pub-id-type="medline">32440771</pub-id></nlm-citation></ref><ref id="ref3"><label>3</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Schwab</surname><given-names>F</given-names> </name><name name-style="western"><surname>Dubey</surname><given-names>A</given-names> </name><name name-style="western"><surname>Gamez</surname><given-names>L</given-names> </name><etal/></person-group><article-title>Adult scoliosis: prevalence, SF-36, and nutritional parameters in an elderly volunteer population</article-title><source>Spine (Phila Pa 1986)</source><year>2005</year><month>05</month><volume>30</volume><issue>9</issue><fpage>1082</fpage><lpage>1085</lpage><pub-id pub-id-type="doi">10.1097/01.brs.0000160842.43482.cd</pub-id></nlm-citation></ref><ref id="ref4"><label>4</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Francis</surname><given-names>RS</given-names> </name></person-group><article-title>Scoliosis screening of 3,000 college-aged women. The Utah study--phase 2</article-title><source>Phys Ther</source><year>1988</year><month>10</month><volume>68</volume><issue>10</issue><fpage>1513</fpage><lpage>1516</lpage><pub-id pub-id-type="medline">3174833</pub-id></nlm-citation></ref><ref id="ref5"><label>5</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Jackson</surname><given-names>RP</given-names> </name><name name-style="western"><surname>Simmons</surname><given-names>EH</given-names> </name><name name-style="western"><surname>Stripinis</surname><given-names>D</given-names> </name></person-group><article-title>Incidence and severity of back pain in adult idiopathic scoliosis</article-title><source>Spine (Phila Pa 1976)</source><year>1983</year><month>10</month><volume>8</volume><issue>7</issue><fpage>749</fpage><lpage>756</lpage><pub-id pub-id-type="doi">10.1097/00007632-198310000-00011</pub-id><pub-id pub-id-type="medline">6229884</pub-id></nlm-citation></ref><ref id="ref6"><label>6</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Bess</surname><given-names>S</given-names> </name><name name-style="western"><surname>Line</surname><given-names>B</given-names> </name><name name-style="western"><surname>Fu</surname><given-names>KM</given-names> </name><etal/></person-group><article-title>The health impact of symptomatic adult spinal deformity: comparison of deformity types to United States population norms and chronic diseases</article-title><source>Spine (Phila Pa 1976)</source><year>2016</year><month>02</month><volume>41</volume><issue>3</issue><fpage>224</fpage><lpage>233</lpage><pub-id pub-id-type="doi">10.1097/BRS.0000000000001202</pub-id><pub-id pub-id-type="medline">26571174</pub-id></nlm-citation></ref><ref id="ref7"><label>7</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Glassman</surname><given-names>SD</given-names> </name><name name-style="western"><surname>Carreon</surname><given-names>LY</given-names> </name><name name-style="western"><surname>Shaffrey</surname><given-names>CI</given-names> </name><etal/></person-group><article-title>The costs and benefits of nonoperative management for adult scoliosis</article-title><source>Spine (Phila Pa 1986)</source><year>2010</year><month>03</month><volume>35</volume><issue>5</issue><fpage>578</fpage><lpage>582</lpage><pub-id pub-id-type="doi">10.1097/BRS.0b013e3181b0f2f8</pub-id></nlm-citation></ref><ref id="ref8"><label>8</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Teles</surname><given-names>AR</given-names> </name><name name-style="western"><surname>Mattei</surname><given-names>TA</given-names> </name><name name-style="western"><surname>Righesso</surname><given-names>O</given-names> </name><name name-style="western"><surname>Falavigna</surname><given-names>A</given-names> </name></person-group><article-title>Effectiveness of operative and nonoperative care for adult spinal deformity: systematic review of the literature</article-title><source>Global Spine J</source><year>2017</year><month>04</month><volume>7</volume><issue>2</issue><fpage>170</fpage><lpage>178</lpage><pub-id pub-id-type="doi">10.1177/2192568217699182</pub-id><pub-id pub-id-type="medline">28507887</pub-id></nlm-citation></ref><ref id="ref9"><label>9</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Passias</surname><given-names>PG</given-names> </name><name name-style="western"><surname>Ahmad</surname><given-names>W</given-names> </name><name name-style="western"><surname>Dave</surname><given-names>P</given-names> </name><etal/></person-group><article-title>Economic burden of nonoperative treatment of adult spinal deformity</article-title><source>J Neurosurg Spine</source><year>2023</year><month>12</month><day>1</day><volume>39</volume><issue>6</issue><fpage>751</fpage><lpage>756</lpage><pub-id pub-id-type="doi">10.3171/2023.7.SPINE23195</pub-id><pub-id pub-id-type="medline">37728175</pub-id></nlm-citation></ref><ref id="ref10"><label>10</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Bridwell</surname><given-names>KH</given-names> </name><name name-style="western"><surname>Glassman</surname><given-names>S</given-names> </name><name name-style="western"><surname>Horton</surname><given-names>W</given-names> </name><etal/></person-group><article-title>Does treatment (nonoperative and operative) improve the two-year quality of life in patients with adult symptomatic lumbar scoliosis</article-title><source>Spine (Phila Pa 1986)</source><year>2009</year><month>09</month><volume>34</volume><issue>20</issue><fpage>2171</fpage><lpage>2178</lpage><pub-id pub-id-type="doi">10.1097/BRS.0b013e3181a8fdc8</pub-id></nlm-citation></ref><ref id="ref11"><label>11</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Liu</surname><given-names>S</given-names> </name><name name-style="western"><surname>Schwab</surname><given-names>F</given-names> </name><name name-style="western"><surname>Smith</surname><given-names>JS</given-names> </name><etal/></person-group><article-title>Likelihood of reaching minimal clinically important difference in adult spinal deformity: a comparison of operative and nonoperative treatment</article-title><source>Ochsner J</source><year>2014</year><volume>14</volume><issue>1</issue><fpage>67</fpage><lpage>77</lpage><pub-id pub-id-type="medline">24688336</pub-id></nlm-citation></ref><ref id="ref12"><label>12</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Choi</surname><given-names>SH</given-names> </name><name name-style="western"><surname>Son</surname><given-names>SM</given-names> </name><name name-style="western"><surname>Goh</surname><given-names>TS</given-names> </name><name name-style="western"><surname>Park</surname><given-names>W</given-names> </name><name name-style="western"><surname>Lee</surname><given-names>JS</given-names> </name></person-group><article-title>Outcomes of operative and nonoperative treatment in patients with adult spinal deformity with a minimum 2-year follow-up: a meta-analysis</article-title><source>World Neurosurg</source><year>2018</year><month>12</month><volume>120</volume><fpage>e870</fpage><lpage>e876</lpage><pub-id pub-id-type="doi">10.1016/j.wneu.2018.08.179</pub-id><pub-id pub-id-type="medline">30189313</pub-id></nlm-citation></ref><ref id="ref13"><label>13</label><nlm-citation citation-type="web"><article-title>Data.CMS.gov centers for medicare and medicaid services</article-title><source>Medicare Inpatient Hospitals - by Geography and Service Data Dictionary | CMS Data</source><access-date>2024-09-17</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://data.cms.gov/resources/medicare-inpatient-hospitals-by-geography-and-service-data-dictionary-0">https://data.cms.gov/resources/medicare-inpatient-hospitals-by-geography-and-service-data-dictionary-0</ext-link></comment></nlm-citation></ref><ref id="ref14"><label>14</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Lafage</surname><given-names>R</given-names> </name><name name-style="western"><surname>Bass</surname><given-names>RD</given-names> </name><name name-style="western"><surname>Klineberg</surname><given-names>E</given-names> </name><etal/></person-group><article-title>Complication rates following adult spinal deformity surgery: evaluation of the category of complication and chronology</article-title><source>Spine (Phila Pa 1976)</source><year>2024</year><volume>49</volume><issue>12</issue><fpage>829</fpage><lpage>839</lpage><pub-id pub-id-type="doi">10.1097/BRS.0000000000004969</pub-id></nlm-citation></ref><ref id="ref15"><label>15</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Shebib</surname><given-names>R</given-names> </name><name name-style="western"><surname>Bailey</surname><given-names>JF</given-names> </name><name name-style="western"><surname>Smittenaar</surname><given-names>P</given-names> </name><name name-style="western"><surname>Perez</surname><given-names>DA</given-names> </name><name name-style="western"><surname>Mecklenburg</surname><given-names>G</given-names> </name><name name-style="western"><surname>Hunter</surname><given-names>S</given-names> </name></person-group><article-title>Randomized controlled trial of a 12-week digital care program in improving low back pain</article-title><source>NPJ Digit Med</source><year>2019</year><volume>2</volume><issue>1</issue><fpage>1</fpage><pub-id pub-id-type="doi">10.1038/s41746-018-0076-7</pub-id><pub-id pub-id-type="medline">31304351</pub-id></nlm-citation></ref><ref id="ref16"><label>16</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Smittenaar</surname><given-names>P</given-names> </name><name name-style="western"><surname>Erhart-Hledik</surname><given-names>JC</given-names> </name><name name-style="western"><surname>Kinsella</surname><given-names>R</given-names> </name><name name-style="western"><surname>Hunter</surname><given-names>S</given-names> </name><name name-style="western"><surname>Mecklenburg</surname><given-names>G</given-names> </name><name name-style="western"><surname>Perez</surname><given-names>D</given-names> </name></person-group><article-title>Translating comprehensive conservative care for chronic knee pain into a digital care pathway: 12-week and 6-month outcomes for the hinge health program</article-title><source>JMIR Rehabil Assist Technol</source><year>2017</year><month>04</month><day>5</day><volume>4</volume><issue>1</issue><fpage>e4</fpage><pub-id pub-id-type="doi">10.2196/rehab.7258</pub-id><pub-id pub-id-type="medline">28582253</pub-id></nlm-citation></ref><ref id="ref17"><label>17</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Mecklenburg</surname><given-names>G</given-names> </name><name name-style="western"><surname>Smittenaar</surname><given-names>P</given-names> </name><name name-style="western"><surname>Erhart-Hledik</surname><given-names>JC</given-names> </name><name name-style="western"><surname>Perez</surname><given-names>DA</given-names> </name><name name-style="western"><surname>Hunter</surname><given-names>S</given-names> </name></person-group><article-title>Effects of a 12-week digital care program for chronic knee pain on pain, mobility, and surgery risk: randomized controlled trial</article-title><source>J Med Internet Res</source><year>2018</year><month>04</month><day>25</day><volume>20</volume><issue>4</issue><fpage>e156</fpage><pub-id pub-id-type="doi">10.2196/jmir.9667</pub-id><pub-id pub-id-type="medline">29695370</pub-id></nlm-citation></ref><ref id="ref18"><label>18</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Clohisy</surname><given-names>JCF</given-names> </name><name name-style="western"><surname>Smith</surname><given-names>JS</given-names> </name><name name-style="western"><surname>Kelly</surname><given-names>MP</given-names> </name><etal/></person-group><article-title>Failure of nonoperative care in adult symptomatic lumbar scoliosis: incidence, timing, and risk factors for conversion from nonoperative to operative treatment</article-title><source>J Neurosurg Spine</source><year>2023</year><month>10</month><day>1</day><volume>39</volume><issue>4</issue><fpage>498</fpage><lpage>508</lpage><pub-id pub-id-type="doi">10.3171/2023.5.SPINE2326</pub-id><pub-id pub-id-type="medline">37327144</pub-id></nlm-citation></ref><ref id="ref19"><label>19</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Rhode</surname><given-names>M</given-names> </name><name name-style="western"><surname>Lin</surname><given-names>C</given-names> </name><name name-style="western"><surname>Jin</surname><given-names>C</given-names> </name><etal/></person-group><article-title>Does a digital care program for adult scoliosis improve outcomes? A pilot study</article-title><source>J Spine</source><year>2024</year><volume>13</volume><issue>4</issue><pub-id pub-id-type="doi">10.2196/preprints.66889</pub-id></nlm-citation></ref><ref id="ref20"><label>20</label><nlm-citation citation-type="web"><article-title>Daubs MD, Watkins-Castillo SI. Orthopedics research society (ORS), United States bone &#x0026; joint initiative</article-title><source>Table 2B22: Healthcare visits for conditions contributing to curvature of spine disorders by age, United States</source><year>2013</year><access-date>2024-09-08</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://www.bmus-ors.org/docs/bmus_e4_T2B.2.2.pdf">https://www.bmus-ors.org/docs/bmus_e4_T2B.2.2.pdf</ext-link></comment></nlm-citation></ref><ref id="ref21"><label>21</label><nlm-citation citation-type="report"><article-title>Projected population by five-year age group and sex for the united states</article-title><year>2023</year><month>11</month><access-date>2024-09-08</access-date><publisher-name>U.S. Census Bureau, Population Division</publisher-name><comment><ext-link ext-link-type="uri" xlink:href="https://www.census.gov/data/tables/2023/demo/popproj/2023-summary-tables.html">https://www.census.gov/data/tables/2023/demo/popproj/2023-summary-tables.html</ext-link></comment></nlm-citation></ref><ref id="ref22"><label>22</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Passias</surname><given-names>PG</given-names> </name><name name-style="western"><surname>Jalai</surname><given-names>CM</given-names> </name><name name-style="western"><surname>Line</surname><given-names>BG</given-names> </name><etal/></person-group><article-title>Patient profiling can identify patients with adult spinal deformity (ASD) at risk for conversion from nonoperative to surgical treatment: initial steps to reduce ineffective ASD management</article-title><source>Spine J</source><year>2018</year><month>02</month><volume>18</volume><issue>2</issue><fpage>234</fpage><lpage>244</lpage><pub-id pub-id-type="doi">10.1016/j.spinee.2017.06.044</pub-id><pub-id pub-id-type="medline">28688984</pub-id></nlm-citation></ref><ref id="ref23"><label>23</label><nlm-citation citation-type="web"><person-group person-group-type="author"><name name-style="western"><surname>Mattke</surname><given-names>S</given-names> </name><name name-style="western"><surname>Kapinos</surname><given-names>KA</given-names> </name><name name-style="western"><surname>Caloyeras</surname><given-names>JP</given-names> </name><etal/></person-group><source>Workplace Wellness Programs: Services Offered, Participation, and Incentives</source><year>2015</year><access-date>2024-09-17</access-date><publisher-name>RAND Corporation</publisher-name><comment><ext-link ext-link-type="uri" xlink:href="https://www.rand.org/pubs/research_reports/RR724.html">https://www.rand.org/pubs/research_reports/RR724.html</ext-link></comment></nlm-citation></ref><ref id="ref24"><label>24</label><nlm-citation citation-type="web"><article-title>U.S. bureau of labor statistics</article-title><source>Consumer Price Index for All Urban Consumers, Hospital Services</source><access-date>2024-09-08</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://data.bls.gov/pdq/SurveyOutputServlet">https://data.bls.gov/pdq/SurveyOutputServlet</ext-link></comment></nlm-citation></ref><ref id="ref25"><label>25</label><nlm-citation citation-type="web"><source>Commercial reimbursement benchmarking: Commercial payment rates for medical services as percentage of Medicare fee-for-service rates</source><access-date>2024-09-17</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://www.milliman.com/en/insight/commercial-reimbursement-benchmarking-payment-rates-medicare-fee-for-service">https://www.milliman.com/en/insight/commercial-reimbursement-benchmarking-payment-rates-medicare-fee-for-service</ext-link></comment></nlm-citation></ref><ref id="ref26"><label>26</label><nlm-citation citation-type="web"><article-title>U.S. department of health and human services</article-title><source>Human Subject Regulations Decision Charts: 2018 Requirements</source><access-date>2025-04-22</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://www.hhs.gov/ohrp/regulations-and-policy/decision-charts-2018/index.html#c1">https://www.hhs.gov/ohrp/regulations-and-policy/decision-charts-2018/index.html#c1</ext-link></comment></nlm-citation></ref><ref id="ref27"><label>27</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name name-style="western"><surname>Wadhwa</surname><given-names>H</given-names> </name><name name-style="western"><surname>Leung</surname><given-names>C</given-names> </name><name name-style="western"><surname>Sklar</surname><given-names>M</given-names> </name><etal/></person-group><article-title>Utilization trends, cost, and payments for adult spinal deformity surgery in commercial and medicare-insured populations</article-title><source>Neurosurgery</source><year>2022</year><month>12</month><day>1</day><volume>91</volume><issue>6</issue><fpage>961</fpage><lpage>968</lpage><pub-id pub-id-type="doi">10.1227/neu.0000000000002140</pub-id><pub-id pub-id-type="medline">36136402</pub-id></nlm-citation></ref><ref id="ref28"><label>28</label><nlm-citation citation-type="web"><person-group person-group-type="author"><name name-style="western"><surname>Valencia</surname><given-names>C</given-names> </name></person-group><article-title>How to get employees to (actually) participate in well-being programs</article-title><source>Harvard Business Review Published online October</source><year>2021</year><access-date>2024-11-05</access-date><comment><ext-link ext-link-type="uri" xlink:href="https://hbr.org/2021/10/how-to-get-employees-to-actually-participate-in-well-being-programs">https://hbr.org/2021/10/how-to-get-employees-to-actually-participate-in-well-being-programs</ext-link></comment></nlm-citation></ref></ref-list></back></article>