Age-related macular degeneration (AMD) is the leading cause of vision loss in patients older than 65 in the many countries [1]. Repeated intravitreal injection (IVI) of anti–vascular endothelial growth factor (VEGF) antibody is the gold standard and most common surgical treatment for AMD [2]. Clinical trials using monthly fixed doses have shown the best results, but findings are unavailable from real-world settings and are compromised owing to the use of less common strategies such as pro re nata and treat-and-extend [3,4]. Rare but serious postoperative complications leading to blindness may occur after IVI, such as endophthalmitis and retinal detachment [5,6]. The incidence of endophthalmitis after IVI is approximately 1 in 5000 patients (0.02%). Certain ocular signs and symptoms are associated with post-IVI ocular inflammation, including redness, tenderness, blurred vision, floaters, photopsia, or visual field defects. Early detection of associated symptoms and signs and prompt management could achieve better outcomes [7,8]. However, most patients receiving IVI of anti-VEGF antibody in the outpatient setting and in follow-up visits are ordinarily scheduled for assessment 1 month later to alleviate the follow-up burden resulting from a large number of injections [9]. There is a gap, which may delay treatment past the optimal window [10], especially during the COVID-19 pandemic. To support patients during this period, we developed a chatbot self-report system to provide an alternative way to monitor patients’ conditions.

In this study, we assessed the usability and feasibility of a smartphone-based postoperative care chatbot system (PCCS; Bipower Co) for assisting patients who received IVI. The PCCS periodically prompted patients to self-record and self-report post-IVI symptoms and signs and was equipped to send alerts automatically to medical staff for prompt feedback.

A total of 185 patients (87 women and 98 men) used the PCCS app after IVI. Among them, 53% (n=185) answered the app questions by themselves, 34% had their children’s respond, and 13% had others respond.

A total of 858 responses were obtained from the patients. There were 26 (3.0%) reports among 12 (6.5%) patients who chose the “Worse” option once during the 7-day follow-up. Deterioration was reported 2.16 (range 1-7; 26 divided by 12) times on average per patient, and there was no significant difference in the gender of these patients (chi-square P=.83). Six patients reported deterioration of blurred vision, 3 with increased floaters or photopsia, 2 with eye swelling or redness, and 1 with nausea or vomiting. Messages were sent to the medical staff, and the patients were contacted by phone for further OPD or ER visits. Seven of 12 patients returned to the OPD earlier after having been suggested to do so during the phone consultation. One patient with a history of diabetes mellitus reported deterioration of blurred vision and was diagnosed with endophthalmitis. Ocular inflammation and infection subsided after prompt IVI of antibiotics. Seven of the 185 (3.8%) patients had an earlier medical consultation and 1 (0.5%) had endophthalmitis.

The post–PCCS app use survey over 7 days shows that 87% (n=185) of the patients were satisfied with the use of the PCCS app to communicate their symptoms instantly; most felt that it was helpful to improve the quality of post-IVI care and were willing to use it again in the future.

In this study, the chatbot system detected 4% of patients needing earlier medical consultation without gender differences, of whom 0.5% required urgent management within 7 days post IVI. Patients reported being satisfied with the app’s enhancement of the quality of care.

Large retrospective studies have reported that around 0.6%-1.9% of patients seek urgent or unscheduled visits within 1-2 weeks after IVI, which is lower than what our study reports [8,11]. Gender differences in seeking medical consultation have been reported [12]. The chatbot system may enhance detection and eliminate gender differences.

Acute postoperative endophthalmitis frequently occurs within 1 week post surgery. Early detection and prompt management could possibly achieve better outcomes [7,13]. In contrast, a treatment delay may lead to irreversible vision loss. In this study, due to early report of deteriorated blurred vision from a patient, prompt medical intervention was provided, and the patient’s vision was salvaged after emergency treatment.

A new anti-VEGF antibody, brolucizumab, has reportedly shown adverse reactions in intraocular inflammation (IOI), such as retinal vasculitis and retinal vascular occlusion [14]. IOI occurrence should be alerted in patients treated with brolucizumab 6 mg (HAWK study: 5.3%; HARRIER study: 2.7%). Therefore, more frequent follow-up and prompt treatment are suggested for those receiving IVI of brolucizumab. The PCCS app might be a suitable choice for follow-up to promptly report the possibility of IOI after IVI of brolucizumab.

This chatbot system could thus be considered a supplementary telehealth option for postoperative ophthalmologist-delivered care to help monitor patients remotely. With the assistance of artificial intelligence and instant feedback without delay, physicians can better individualize the care of patients and treatment suggestions, and minimize clinic visits. It can also improve patient care and reduce costs after IVI, especially for those who live in rural areas. It can also be a potential solution in situations where fewer visits are possible, such as during the COVID-19 pandemic to minimize potential exposure to SARS-CoV-2. Furthermore, this PCCS app is potentially applicable in any kind of surgery to offer holistic care to patients. It could also contribute to improvement of the doctor-patient relationship.

This study has some limitations including a small sample, its retrospective nature, and the lack of a control group. Some older people or those with poor vision would be unable to use a smartphone and may need a family member’s assistance.

This smartphone-based chatbot system designed for self-reporting postoperative symptoms and providing instant bidirectional feedback could be beneficial for patients with AMD, enhancing early medical consultation without gender differences. It achieved satisfactory responses from the patients. It can potentially improve the quality of patient care after IVI and may be applicable to other surgical procedures.