Through Twitter streaming application programming interface, we collected Twitter posts (tweets) related to tobacco or nicotine between April 28th, 2022, and May 27th, 2022, using a set of keywords, including “smok*,” “cig*,” “nicotine,” and “tobacco” [27,28]. After we removed duplicate tweets and retweets, there were 323,444 tweets related to tobacco and nicotine in the data set.

Using the hashtag “mentholban,” some sample tweets related to the FDA’s proposed menthol cigarette rules can be directly identified on Twitter. After finding some common keywords among the sample tweets, our final keyword list includes the following: “ban & menthol,” “ban & mentholcigarette,” “prohibit & menthol,” “prohibit & mentholcigarette,” “get rid of & menthol,” “get rid of & mentholcigarette,” “fda & ban,” “fda &prohibit,” “fda & get rid of,” “fda & prohibit,” “fda & rule,” and “fda & policy.” The tense of the verbs, the plural form of the nouns, and the different names of the FDA were all considered. Through further filtering with the keywords from the keyword list, 1989 tweets that could be related to the FDA’s proposed menthol cigarette rules were identified.

From 1989 tweets that were potentially related to the FDA’s proposed menthol cigarette rules, 300 samples were randomly selected and manually coded individually by 2 researchers. Firstly, each tweet was manually determined if it was relevant to the FDA’s proposed menthol cigarette rules. Then, each relevant tweet was checked for the attitude toward the FDA’s proposed menthol cigarette rules as either positive, negative, or neutral. A positive attitude means that the corresponding tweets generally supported the FDA’s proposed menthol cigarette rules, a negative attitude means that the corresponding tweets generally disagreed with the FDA’s proposed menthol cigarette rules, and a neutral attitude means that the tweets did not show any clear attitude. Lastly, each tweet was grouped into different topics based on its content. Tweets that had a positive sentiment toward the FDA’s proposed menthol cigarette rules were categorized into the positive attitude category. Normally, those tweets contained the keywords “support,” “agree,” and “like.” On the other hand, tweets that had negative sentiments toward the FDA’s proposed menthol cigarette rules were categorized into the negative attitude category. Keywords such as “dislike,” “disagree,” and “shouldn’t” helped identify those tweets that conveyed negative attitudes. Tweets in which it was hard to identify the sentiments toward the FDA’s proposed menthol cigarette rules were categorized into the neutral attitude category. Those tweets, such as “The U.S. government on Thursday will lay out its long-awaited plan to ban menthol cigarettes…,” were typically about news articles or other information not directly related to the FDA’s proposed menthol cigarette rules. Tweets with a positive attitude were further categorized into 6 different topics, primarily “preventing smoking-related diseases” (discussions of how the proposed menthol regulations can be beneficial to smokers with physical health conditions) and “reducing disproportionate tobacco use among minorities” (discussions of how African American communities have been disproportionately targeted by the advertisement of menthol cigarettes), and other topics including “preventing youth addiction” and “preventing nicotine addiction.” Tweets with a negative attitude were categorized into 7 topics, primarily “ignoring alternative tobacco/nicotine products” (discussions of the futility of the proposed regulation due to the existence of many other alternative products with nicotine) and “discriminating minority groups” (discussions of the proposed regulation discriminating against African American smokers who are the major users of menthol cigarettes). Other topics included “impeding the freedom to smoke,” “having potential enforcement problems,” and “hindering needed nicotine intake.” For the rest of the tweets that displayed either positive or negative attitudes, they were classified into “others” if their topics were not representative enough to become a separate category, and they were classified into “no reasons” if they only expressed attitudes toward the proposed regulation but did not mention any specific reason. A more detailed description of different topics in positive and negative attitudes with sample tweets for each topic is shown in Table S1 in Multimedia Appendix 1. The Kappa statistic for interrater reliabilities between the 2 researchers was 0.91 based on the selected 300 samples. Any discrepancy was resolved by a group of 4 members.

With the development of a codebook for hand coding, the rest of the tweets related to the FDA’s proposed menthol cigarette rules were coded individually by the 2 researchers. Each tweet was assigned only to 1 topic.

This study was reviewed and approved by the Office for Human Subject Protection Research Subjects Review Board at the University of Rochester (Study00006570).

In this study, we investigated the public perceptions and discussions of the FDA’s proposed menthol cigarette rules using collected Twitter data from April 28, 2022, to May 27, 2022. Overall, we identified a more positive attitude toward the FDA’s proposed menthol cigarette rules during our study period. This result indicated that there was more support in the public for the FDA’s proposed menthol cigarette rules. The main topics for tweets with a positive attitude included “reducing disproportionate tobacco use among minorities” and “preventing smoking-related diseases.” Among tweets with a negative attitude, “ignoring alternative tobacco/nicotine products” and “discriminating minority groups” were the top two topics. Prohibiting menthol cigarettes could benefit the African American community by potentially reducing their smoking prevalence and improving their health, while the availability of many other tobacco or nicotine products on the market could diminish the potential benefits from the FDA’s proposed menthol cigarette rules. In addition, the high prevalence of menthol cigarette usage in the African American community also led to potential racial discrimination issues. Our study results provided important information on the public perceptions and discussions about the FDA’s proposed menthol cigarette rules, which will be valuable for FDA’s future actions on menthol cigarettes.

Although the regulation was proposed in April 2022, the discussions of the restriction of menthol cigarettes have appeared since the FDA banned other characterizing flavors in cigarettes under the 2009 Family Smoking Prevention and Tobacco Control Act [29]. A previous study has analyzed the impact of either hypothetical or implemented menthol cigarette regulations, and one previous study has summarized these analyses and concluded that banning menthol cigarettes could assist with smoking cessation and lower smoking initiation [30]. Nevertheless, these studies analyzed the behaviors of individual smokers and did not consider the reactions of the public. Our study instead focused on the reactions of the public to the FDA’s proposed menthol cigarette rules on Twitter after the proposition of the rules. The support and concerns of the public would be helpful to the FDA if the proposed menthol cigarette rules will be implemented in the future.

In our study, slightly more users showed positive attitudes toward the FDA’s proposed menthol cigarette rules. “Reducing disproportionate tobacco use among minorities” was the most frequently discussed topic among the supporters. One previous publication has also argued that both the disproportionate menthol cigarette advertisement and the exemption of menthol flavor from the 2009 Family Smoking Prevention and Tobacco Control Act are the results of social injustice experienced by minority communities [31]. Another similar publication has discussed how a menthol cigarette ban can protect African American communities [32]. In the real world, many community-based organizations in African American communities were also taking action to educate members of their communities about the risks of smoking menthol cigarettes and engaging community members to reduce the use of menthol cigarette [33]. The proposed menthol cigarette rules will further support community-based organizations’ efforts in reducing menthol cigarette smoking among African Americans.

Two other popular reasons supporting the proposed menthol cigarette rules on Twitter are the concerns over the overall health effect of menthol cigarettes and the potential of such rules to prevent youth from nicotine addiction. Although menthol cigarette is not generally more harmful than nonmenthol cigarettes, being biomedically active, menthol may interact with nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, which can damage cells and reduce the feelings of respiratory discomfort [34]. In addition, menthol cigarettes contribute to both the initiation and the addiction of smoking cigarettes among youth [35]. The FDA’s Tobacco Products Scientific Advisory Committee also concluded that more children began smoking menthol cigarettes, and they were more likely to be addicted and become long-term users [36]. As a result, a regulation on menthol cigarette products seems to be beneficial, especially for African American communities. However, other concerns over the proposed regulation should not be ignored.

Among tweets with a negative attitude, the most popular topic was “ignoring alternative tobacco/nicotine products.” These tweets argued that nicotine is the main factor that causes addiction. One of them stated that such a regulation would be futile because people would still use other nonmenthol cigarette products that contain nicotine like e-cigarettes. A study on the impact of a comprehensive tobacco product flavor ban in San Francisco found that the tobacco products flavor ban cannot immediately reduce the use of flavored tobacco products individually; although it can significantly reduce the overall e-cigarette and cigar use, it may at the same time increase cigarette use [37]. The proposed national menthol cigarette rules may have different effects in comparison to a local flavor ban; however, the potential problems, such as the existence of alternative tobacco products, might diminish the effectiveness of the menthol cigarette rules. Several studies have also examined the reaction of menthol cigarette smokers toward the FDA’s previous menthol cigarette regulations [38-40]. The impacts of those regulations seem to correlate well with the availability of e-cigarettes, which could be an alternative product to menthol cigarettes. These studies have found that around 15%-30% of the current menthol cigarette smokers would switch to e-cigarettes if menthol cigarettes were banned [38-40].

Our study has several limitations. The demographic distributions of Twitter users are slightly different from the general population in the United States. For example, a large proportion (38.5%) of Twitter users are between the ages of 25 and 34 years [41], which is much higher than the proportion of adults aged 25-34 years (13.7%) in the United States [42]. Thus, the result we obtained from this study will not fully represent the perceptions of the FDA’s proposed menthol cigarette rules in the general US population. Furthermore, the limited number of keywords used in this study could make us miss some tweets and introduce some biases. Similarly, due to the limited access to demographical information of Twitter users, we cannot determine if Twitter users with different demographics had different perceptions of the proposed rules on menthol cigarettes.

Generally, the public held a favorable view toward the FDA’s proposed menthol cigarette rules. Analyzing public perceptions of the FDA’s proposed menthol cigarette rules on Twitter provided important information for the FDA before either the enforcement or the revision of the proposed menthol cigarette rules.