Central ethical approval was obtained for this study from the medical ethics committee of the LUMC.

This retrospective observational study was conducted as part of the COVID-box project, which was initiated at the LUMC in May 2020 upon the first wave of the pandemic. A detailed operational description of the COVID-box project was previously reported [2]. In this study, we evaluated patients with COVID-19 and their experiences with telemonitoring by surveying patients after the completion of the telemonitoring phase and full recovery. Patients were asked to anonymously fill out questionnaires regarding the sense of reassurance and safety, experiences with teleconsultations, their appreciation for staying at home, and the instructions for the COVID-box. Health care professionals who treated patients with the COVID-box were given separate questionnaires regarding the characteristics of the COVID-box, the technical support service and general satisfaction (estimated patient satisfaction), and their expectations and support for this telemonitoring concept. All questions were multiple-choice questions on a 5-point or 10-point Likert scale. For this study, scores were interpreted as follows: on a 5-point Likert scale, scores of ≤2 were insufficient scores, scores of 3 were sufficient scores, and scores of ≥5 were good scores; on a 10-point scale, scores of ≤5 were marked as insufficient, scores of 6 to 7 were marked as sufficient, and scores of ≥8 were marked as good. Unvalidated questionnaires were developed by members of the Department of the Directorate of Quality and Patient Safety and clinicians from the Department of Internal Medicine. The questionnaires were web-based and anonymous.

Descriptive statistics were used to summarize the results. The scores given by patients and health care professionals are presented as medians with IQRs, and the number of patients and health care professionals are presented as absolute numbers and percentages. We used IBM SPSS Statistics Version 25 (IBM Corporation).

Of the first 300 patients who were monitored in the COVID-box project from June 2020 to March 2021, a total of 117 (39%) responded to a web-based survey (Multimedia Appendix 1). All of these patients underwent actual telemonitoring with at least 1 contact with a health care professional by using the COVID-box as a home monitoring tool. The results are summarized in Figure 1.

The median score for the sense of reassurance and for the instructions of the COVID-box was 4 (IQR 3-5), with good scores from 67.6% (75/111) and 70% (80/115) of patients, respectively. For the sense of safety, experiences with teleconsultations, the appreciation for staying at home, and the ability to ask questions about the disease and disease course, the median score was 4 (IQR 4-5); good scores were given by 76.5% (88/115), 83.6% (92/110), 86% (56/65), and 91.2% (104/114) of patients, respectively. Overall, 74.4% (87/117) of patients scored the home monitoring program with the COVID-box as good, with a score of 8 or higher.

Our study demonstrates that the home monitoring of patients with COVID-19 is well appreciated by patients as well as health care professionals. Previous observational studies have shown the safety of the remote telemonitoring of patients with (suspected) COVID-19 and its efficacy in reducing hospitalization. Few studies have addressed user experience and patients’ and health care professionals’ satisfaction with telemonitoring. It is well established that the successful implementation of novel eHealth solutions is critically dependent on the positive experiences and satisfaction of involved users.

During the extraordinary situation of the COVID-19 pandemic, remote telemonitoring has been quickly implemented in different ways [5-7,10-13]. In general, many patients and health care professionals are very positive about this concept. Remote telemonitoring is used for conducting disease triage; reducing hospital admissions; and providing reassurance, disease and disease course information, and psychological support to clinically stable patients at home. Several studies have reported that patients appreciate all forms of remote telemonitoring (eg, the measuring of vital parameters, symptom recording, and daily teleconsultations) in various settings (eg, in primary care and after an emergency department visit or hospital admission) [5-7,10-13]. The important aspects are easy access to the program, good information provision, and the good quality of the service for the onboarding process. Importantly, older age does not seem to be a problem, as different studies have successfully included patients aged >50 years [5,7,11]. Patients have pointed out that video consultations are also highly appreciated. Self-evidently, the adherence of patients to telemonitoring is critical to its success. Nonadherence to telemonitoring among patients with COVID-19 has been reported when they feel too sick, forget to measure vital parameters, feel insufficiently informed, or experience quick improvements in disease symptoms [13]. Health care professionals are largely convinced of the benefits of remote telemonitoring, as long as a program is easy to use and it is possible to receive patient data correctly.

Given the observational and retrospective nature of our study, which was conducted during the COVID-19 pandemic, our study has several limitations that are noteworthy. First, the patient-reported experience measure questionnaires on telemonitoring a new disease, such as COVID-19, were not validated, and a formal validation of these questionnaires was out of the scope of this study. Second, the questionnaires were completed anonymously; therefore, internal consistency could not be reliably assessed. Lastly, the relatively low response rates (patients: 117/300, 39%; health care professionals: 25/60, 42%) could have introduced unwanted bias to the results of this study.

In conclusion, the home monitoring of patients with COVID-19 is well appreciated by patients as well as health care professionals. This study demonstrated that patients felt safe and reassured with the home monitoring and daily teleconsultations in the COVID-box project. Additionally, health care professionals were satisfied with the safety and user-friendliness of the COVID-box. The acceptation of the COVID-box is critical for the successful implementation and expansion of home monitoring for patients with COVID-19 to relieve the burden on health care systems. Our findings could be especially relevant to the current perspectives on oral antiviral agents for the out-of-hospital treatment of patients with COVID-19.