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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JFR</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Form Res</journal-id>
      <journal-title>JMIR Formative Research</journal-title>
      <issn pub-type="epub">2561-326X</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v6i6e35118</article-id>
      <article-id pub-id-type="pmid">35687409</article-id>
      <article-id pub-id-type="doi">10.2196/35118</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Paper</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Original Paper</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>A Theory-Informed, Personalized mHealth Intervention for Adolescents (Mobile App for Physical Activity): Development and Pilot Study</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Mavragani</surname>
            <given-names>Amaryllis</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Middelweerd</surname>
            <given-names>Anouk</given-names>
          </name>
        </contrib>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Wang</surname>
            <given-names>Liyuan</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Domin</surname>
            <given-names>Alex</given-names>
          </name>
          <degrees>BA, MPhil, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Research Group: Self-Regulation and Health</institution>
            <institution>Department of Behavioural and Cognitive Sciences</institution>
            <institution>University of Luxembourg</institution>
            <addr-line>Maison des Sciences Humaines</addr-line>
            <addr-line>11, Porte des Sciences</addr-line>
            <addr-line>Esch-sur-Alzette, 4366</addr-line>
            <country>Luxembourg</country>
            <fax>352 46 66 44 39389</fax>
            <phone>352 46 66 44 93</phone>
            <email>alex.domin@uni.lu</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0003-1417-7387</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author">
          <name name-style="western">
            <surname>Uslu</surname>
            <given-names>Arif</given-names>
          </name>
          <degrees>BSc, MSc</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-8310-1098</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author">
          <name name-style="western">
            <surname>Schulz</surname>
            <given-names>André</given-names>
          </name>
          <degrees>BSc, MSc, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-9381-2651</ext-link>
        </contrib>
        <contrib id="contrib4" contrib-type="author">
          <name name-style="western">
            <surname>Ouzzahra</surname>
            <given-names>Yacine</given-names>
          </name>
          <degrees>BSc, MSc, PhD</degrees>
          <xref rid="aff2" ref-type="aff">2</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-9684-0757</ext-link>
        </contrib>
        <contrib id="contrib5" contrib-type="author">
          <name name-style="western">
            <surname>Vögele</surname>
            <given-names>Claus</given-names>
          </name>
          <degrees>BSc, MSc, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0001-8086-0788</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Research Group: Self-Regulation and Health</institution>
        <institution>Department of Behavioural and Cognitive Sciences</institution>
        <institution>University of Luxembourg</institution>
        <addr-line>Esch-sur-Alzette</addr-line>
        <country>Luxembourg</country>
      </aff>
      <aff id="aff2">
        <label>2</label>
        <institution>Research Support Department</institution>
        <institution>University of Luxembourg</institution>
        <addr-line>Esch-sur-Alzette</addr-line>
        <country>Luxembourg</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Alex Domin <email>alex.domin@uni.lu</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>6</month>
        <year>2022</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>10</day>
        <month>6</month>
        <year>2022</year>
      </pub-date>
      <volume>6</volume>
      <issue>6</issue>
      <elocation-id>e35118</elocation-id>
      <history>
        <date date-type="received">
          <day>22</day>
          <month>11</month>
          <year>2021</year>
        </date>
        <date date-type="rev-request">
          <day>2</day>
          <month>2</month>
          <year>2022</year>
        </date>
        <date date-type="rev-recd">
          <day>13</day>
          <month>3</month>
          <year>2022</year>
        </date>
        <date date-type="accepted">
          <day>11</day>
          <month>4</month>
          <year>2022</year>
        </date>
      </history>
      <copyright-statement>©Alex Domin, Arif Uslu, André Schulz, Yacine Ouzzahra, Claus Vögele. Originally published in JMIR Formative Research (https://formative.jmir.org), 10.06.2022.</copyright-statement>
      <copyright-year>2022</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Formative Research, is properly cited. The complete bibliographic information, a link to the original publication on https://formative.jmir.org, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://formative.jmir.org/2022/6/e35118" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Evidence suggests that physical activity (PA) during childhood and adolescence is crucial as it usually results in adequate PA levels in adulthood. Given the ubiquitous use of smartphones by adolescents, these devices may offer feasible means to reach young populations and deliver interventions aiming to increase PA participation and decrease sedentary time. To date, very few studies have reported smartphone-based interventions promoting PA for adolescents. In addition, most available fitness apps do not include the latest evidence-based content.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This paper described the systematic development of a behavior change, theory-informed Mobile App for Physical Activity intervention with personalized prompts for adolescents aged 16 to 18 years. The within-subject trial results provided the first evidence of the general effectiveness of the intervention based on the outcomes step count, sedentary time, and moderate to vigorous PA (MVPA) minutes. The effectiveness of the intervention component <italic>personalized PA prompt</italic> was also assessed.</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>A 4-week within-subject trial with 18 healthy adolescents aged 16 to 18 years was conducted (mean age 16.33, SD 0.57 years). After the baseline week, the participants used the Mobile App for Physical Activity intervention (Fitbit fitness tracker+app), which included a daily personalized PA prompt delivered via a pop-up notification. A paired 1-tailed <italic>t</italic> test was performed to assess the effectiveness of the intervention. Change-point analysis was performed to assess the effectiveness of a personalized PA prompt 30 and 60 minutes after prompt delivery.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>The results showed that the intervention significantly reduced sedentary time in adolescents during the first week of the trial (<italic>t</italic><sub>17</sub>=−1.79; <italic>P</italic>=.04; bootstrapped <italic>P</italic>=.02). This trend, although remaining positive, diminished over time. Our findings indicate that the intervention had no effect on metabolic equivalent of task–based MVPA minutes, although the descriptive increase may give reason for further investigation. Although the results suggested no overall change in heart rate–based MVPA minutes, the results from the change-point analyses suggest that the personalized PA prompts significantly increased heart rate per minute during the second week of the study (<italic>t</italic><sub>16</sub>=1.84; <italic>P</italic>=.04; bootstrapped <italic>P</italic>=.04). There were no significant increases in participants’ overall step count; however, the personalized PA prompts resulted in a marginally significant increase in step counts per minute in the second week of the study (<italic>t</italic><sub>17</sub>=1.35; <italic>P</italic>=.09; bootstrapped <italic>P</italic>=.05).</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>The results of the trial provide preliminary evidence of the benefit of the Mobile App for Physical Activity intervention for modest yet significant reductions in participants’ sedentary time and the beneficial role of personalized PA prompts. These results also provide further evidence of the benefits and relative efficacy of personalized activity suggestions for inclusion in smartphone-based PA interventions. This study provides an example of how to guide the development of smartphone-based mobile health PA interventions for adolescents.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>mobile health</kwd>
        <kwd>physical activity</kwd>
        <kwd>app</kwd>
        <kwd>adolescents</kwd>
        <kwd>within-subject</kwd>
        <kwd>mHealth</kwd>
        <kwd>sedentary behavior</kwd>
        <kwd>behavior change techniques</kwd>
        <kwd>BCTs</kwd>
        <kwd>Fitbit</kwd>
        <kwd>mobile phone</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>The beneficial impact of physical activity (PA) has been extensively documented, showing improved physical and mental health across the life span together with increased life expectancy [<xref ref-type="bibr" rid="ref1">1</xref>]. In contrast, lack of PA and increased sedentary time continue to represent a serious public health burden. Low PA levels are associated with a higher prevalence of chronic diseases (eg, coronary heart disease, type 2 diabetes, breast cancer, and colon cancer) and an increased risk of morbidity and mortality, accounting for &#62;5.3 million premature deaths annually [<xref ref-type="bibr" rid="ref2">2</xref>]. In European Union countries, alarming levels of physical inactivity have been observed in adolescents [<xref ref-type="bibr" rid="ref1">1</xref>]. As indicated by the Organisation for Economic Co-operation and Development report <italic>Health at a Glance: Europe 2020</italic>, less than 25% of boys and 20% of girls show sufficient levels of self-reported PA at the age of 15 years [<xref ref-type="bibr" rid="ref3">3</xref>].</p>
        <p>There is evidence that PA during childhood and adolescence is crucial as it usually results in adequate PA levels in adulthood [<xref ref-type="bibr" rid="ref1">1</xref>]. Therefore, it is an essential research and public health priority to increase PA participation and decrease sedentary time in adolescents. Specific attention should be devoted to adolescents aged 16 to 18 years as they show the lowest absolute PA levels among children and young people aged 5 to 19 years [<xref ref-type="bibr" rid="ref4">4</xref>]. Recent advances in digital technology have the potential to be successfully used in interventions aiming to improve PA-related outcomes in adolescents. In this study, we used the rationale that mobile devices have the potential to help their users engage in and adhere to different types of PA in several contexts (eg, school, leisure time, and transportation). In addition, mobile health (mHealth) interventions have the potential to adaptively respond to individuals’ actions and states and deliver intervention options <italic>just in time</italic> (ie, when and where they are most appropriate [<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref6">6</xref>]). Such just-in-time adaptive interventions (JITAIs) can facilitate health behavior change at times of both need for behavior support and receptivity [<xref ref-type="bibr" rid="ref7">7</xref>]. Given the ubiquitous use of smartphones by adolescents, these devices may offer feasible means to reach young populations and deliver interventions aiming to increase PA participation and decrease sedentary time. Previous research suggests that an automated advice system may be as productive as or even preferable to a human advisor for increasing PA participation [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. Preliminary evidence suggests that cardiorespiratory fitness gains can be sustained using a dedicated smartphone app [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref12">12</xref>]. The literature on JITAIs in particular shows mixed yet promising evidence. Specifically, a review found mixed evidence for JITAI effects on behavior, but no study was sufficiently powered to detect any effects. Another study reported that the JITAI condition demonstrated a significant improvement in health over the wait-list control condition [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>]. In addition to interventions based on smartphone apps potentially being efficacious, they may also come with reduced costs in comparison with interventions involving face-to-face interviewing and guidance.</p>
        <p>Although numerous fitness apps for smartphones address PA participation and sedentary behavior, most of them do not include the latest evidence-based content [<xref ref-type="bibr" rid="ref15">15</xref>]. A recent review concluded that, despite not being grounded in theory, some interventions contain one or more behavior change components or behavior change techniques (BCTs) [<xref ref-type="bibr" rid="ref16">16</xref>]. However, the systematic implementation of BCTs in dedicated apps has rarely been achieved. Michie et al [<xref ref-type="bibr" rid="ref17">17</xref>] argue that many interventions applying recommended BCTs are not designed systematically and are theory-inspired rather than theory-based. This may result in low participant engagement with the intervention and a lack of longitudinal effects. Therefore, it is crucial to implement BCTs systematically while evaluating not only the effectiveness of the complete intervention but also the effectiveness of its smallest components. In a recent scoping review, we argued that the efficacy of smartphone-based mHealth PA interventions can be considerably improved through a more systematic approach of developing, reporting, and coding the interventions [<xref ref-type="bibr" rid="ref18">18</xref>]. Therefore, in this study, we try to build on the previous theoretical findings systematically to maximize the impact of our intervention.</p>
        <p>Smartphone-based behavior change interventions are typically tested using randomized controlled trials (RCTs) [<xref ref-type="bibr" rid="ref19">19</xref>]. Although RCTs provide the highest level of scientific evidence, they evaluate the effect of an intervention as a whole. Therefore, RCTs would typically not provide information regarding which components work best and what factors modulate their efficacy. Considering the critical role of factors such as the timing of administration and the context in which components are implemented [<xref ref-type="bibr" rid="ref6">6</xref>], an RCT may not provide the level of detail required to appropriately assess the efficacy of smartphone-based interventions. Finally, RCTs are quite long, averaging 5.5 years from recruitment to publication date [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref21">21</xref>]. Therefore, it was suggested to implement alternative designs that may provide prompter and more relevant answers while being more suitable to the research question. Trial designs where participants serve as their own controls, also known as within-subject designs, can reduce the number of study participants needed to detect outcomes and accelerate the research process while also simplifying the study procedures [<xref ref-type="bibr" rid="ref22">22</xref>]. In addition, such designs have a much shorter duration and allow for the testing of the efficacy of individual components [<xref ref-type="bibr" rid="ref6">6</xref>]. Therefore, an mHealth PA intervention for adolescents may benefit from the implementation of such an evaluation design.</p>
        <p>Personalization of intervention components has been shown to be important for their overall success as it may significantly affect the to date unresolved challenge of mHealth intervention engagement of the participants and, as a result, the outcomes of the intervention [<xref ref-type="bibr" rid="ref23">23</xref>]. However, most current mHealth apps do not often offer personalized features although they could be important in increasing motivation and engagement. Examples of personalization include but are not limited to differentiation between habitual and unforeseen behaviors, collection of information about preferred PA, and activity suggestions depending on the current location or daily schedule [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref24">24</xref>]. Therefore, to maximize the potential of the intervention, it is important that the intervention components are personalized for its participants.</p>
        <p>Previous studies mainly centered on the adult population have demonstrated that tackling the aforementioned gaps might be beneficial. Bond et al [<xref ref-type="bibr" rid="ref25">25</xref>] developed and tested a smartphone-based intervention with a dedicated smartphone app, which significantly reduced sedentary behavior time over 4 weeks. Rabbi et al [<xref ref-type="bibr" rid="ref23">23</xref>] and Klasnja et al [<xref ref-type="bibr" rid="ref24">24</xref>] designed smartphone-based interventions that demonstrated preliminary evidence of the efficacy of personalized PA suggestions that are contextualized to the user’s previous behavior and environment. Kramer et al [<xref ref-type="bibr" rid="ref26">26</xref>] conducted a microrandomized trial (MRT) reporting a significant step goal increase triggered by cash incentive components. Finally, Gaudet et al [<xref ref-type="bibr" rid="ref27">27</xref>] used a minimalist PA Fitbit tracker–based intervention with adolescents aged 13 to 14 years, which resulted in increased PA.</p>
      </sec>
      <sec>
        <title>Objectives</title>
        <p>This project aimed to further the findings from previously conducted studies while concentrating on the adolescent population. The Mobile App for Physical Activity intervention uses a personalization feature through setting individualized PA goals and delivering tailored feedback based on the individual’s performance not limited solely to step count. The Mobile App for Physical Activity intervention was developed based on the Behaviour Change Wheel framework [<xref ref-type="bibr" rid="ref28">28</xref>] by applying an approach that incorporates findings from qualitative studies and recommended and efficacious BCTs based on systematic reviews and meta-analyses. Finally, the research available to date tends to focus on the development of apps for adults rather than adolescents. Although adolescents aged 16 to 18 years represent a highly relevant target group for improving PA participation, only very few studies have addressed this particular age group [<xref ref-type="bibr" rid="ref18">18</xref>]. To the best of our knowledge, this is the first study to develop a behavior change PA mHealth intervention with personalized prompts for adolescents aged 16 to 18 years evaluated using a within-subject experimental design.</p>
        <p>The Mobile App for Physical Activity within-subject trial was conducted with the objective to provide the first evidence of the general effectiveness of the Mobile App for Physical Activity intervention among adolescents based on the outcomes of step count, sedentary time, and moderate to vigorous PA (MVPA) minutes. The effectiveness of the intervention component <italic>personalized PA prompt</italic> was also assessed using change-point analyses to determine whether similar PA smartphone-based interventions could benefit from the implementation of such a component.</p>
        <p>We hypothesized that (1) the Mobile App for Physical Activity intervention would decrease the daily sedentary time of adolescents during the intervention in weeks 1, 2, and 3 compared with baseline measurements (primary variable of interest). We also hypothesized that (2) there would be an increase in the time spent in MVPA minutes and the number of daily steps in weeks 1, 2, and 3 compared with baseline measurements (secondary variables of interest). Finally, we hypothesized that (3) the participants’ step count and heart rate (HR) would show an increase after the delivery of a personalized PA prompt.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>The Mobile App for Physical Activity Intervention</title>
        <p>Mobile App for Physical Activity is an intervention developed to promote PA among adolescents aged 16 to 18 years. It was aimed at adolescents who showed insufficient PA levels according to the World Health Organization (WHO) recommendations (ie, &#60;60 minutes of moderate or vigorous PA each day, associated with 11,700 steps daily [<xref ref-type="bibr" rid="ref29">29</xref>]) but were interested in increasing it. This minimalist, multicomponent mHealth PA intervention combines a Fitbit smartphone app [<xref ref-type="bibr" rid="ref30">30</xref>], personalized assistance, and a wrist-worn activity tracker (Fitbit Charge 4) [<xref ref-type="bibr" rid="ref31">31</xref>] that collects HR-based Active Zone Minutes or MVPA minutes, active minutes based on the metabolic equivalent of task (MET) or MVPA minutes, step count, and sedentary minutes based on MET data. The Mobile App for Physical Activity intervention includes basic features of the Fitbit app and tracker as well as additional personalized assistance features—daily personalized PA prompts, weekly goal adjustment, and interactive assistance realized via the chat messaging feature—to help participants resolve any problems concerning achieving daily goals or using the intervention components. All additional components were implemented just in time by AD using the back-end features of the intervention (the Fitabase platform and Fitbit web interface). In total, 4 different outcome measures were controlled for following the recommendations of Thompson et al [<xref ref-type="bibr" rid="ref32">32</xref>] suggesting the consideration of a multidimensional PA user profile. This device was selected for several reasons. We were interested in a device that would be, on the one hand, attractive yet unnoticeable and the least burdensome (to support user engagement) yet, by contrast, able to collect HR data (for MVPA minute calculation based on HR data in addition to MET values) and that would track and automatically recognize various types of PA performed by users. The triaxial accelerometer produced by ActiGraph is considered the gold standard in PA measurement, currently proposing several wrist-worn activity trackers [<xref ref-type="bibr" rid="ref33">33</xref>]. However, the proposed HR measurement method would have necessitated additional wireless devices, which may be considered burdensome by users. In addition, activity recognition was not automated. The latest reviews have reported satisfactory validity, reliability, and feasibility of consumer-grade activity trackers produced by Fitbit and other companies [<xref ref-type="bibr" rid="ref34">34</xref>,<xref ref-type="bibr" rid="ref35">35</xref>]. After analyzing the market of commercial activity trackers, we identified the device that matched most of our requirements—Fitbit Charge 4, a small, wrist-worn, waterproof activity tracker with an inbuilt photoplethysmographic sensor to assess HR and automatic recognition of 7 types of PA. Similar Fitbit devices have already been used in mHealth PA interventions for data collection [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref36">36</xref>-<xref ref-type="bibr" rid="ref40">40</xref>]. The limitation that we encountered with this device related to data received from the Fitbit server—MVPA minutes or, according to Fitbit, <italic>activity minutes</italic> (calculated based on MET values) and <italic>Active Zone Minutes</italic> (calculated based on HR values) were provided <italic>as is</italic> (ie, without providing an algorithm based on which MVPA minutes were calculated). To date, the literature presents mixed evidence on the validity of HR (–3% to +3% error rates), maximal aerobic capacity (VO<sub>2max</sub>), and energy expenditure measurements [<xref ref-type="bibr" rid="ref41">41</xref>] yet confirms the relative validity of the Fitbit MVPA minute calculation [<xref ref-type="bibr" rid="ref42">42</xref>], accurate recognition of the PA type [<xref ref-type="bibr" rid="ref43">43</xref>], excellent interinstrument reliability, and good levels of agreement between devices [<xref ref-type="bibr" rid="ref44">44</xref>]. On the basis of these considerations, we decided to use the Fitbit Charge 4 as a primary data collection device taking into account the limitations described.</p>
        <p>The Fitbit app presents the user with a large set of features and tools that can be displayed in a selective manner. To use this software as a part of the Mobile App for Physical Activity intervention, the functionality of the Fitbit app was used as a toolkit and was tweaked to only make use of the features selected below. Therefore, the next constituent of the Mobile App for Physical Activity intervention included a combination of the Fitbit smartphone app and personalized assistance, which included both <italic>push</italic> and <italic>pull</italic> intervention components.</p>
        <p>The first pull component was <italic>graphs and stats</italic>. This component, delivered via the home page of the Fitbit app, presents users with graphical feedback on their daily goals with the potential for personalization. Specifically, users can compare the results attained thus far with their personalized goals. Each participant was assigned 2 personalized daily goals: a step count goal and an <italic>Active Zone Minutes</italic> goal. These goals were set individually via remote Fitbit account access at the end of every week based on a 5% increase from the average daily step or Active Zone Minute count achieved during the previous week. A 5% increase mark was chosen to provide a substantial yet feasible increase goal based on the findings from the study by Degroote et al [<xref ref-type="bibr" rid="ref45">45</xref>]. If a participant underperformed, the daily step or Active Zone Minute goals remained the same.</p>
        <p>The second pull component was <italic>interactive assistance</italic>. Through a dedicated message tab, the participants received advice or could communicate with AD in case they encountered any problems in either achieving their daily goals or using the intervention components. Web-based support was initially intended as an automated advisor providing personalized support and problem-solving strategies and answering inquiries based on a strategy grounded in artificial intelligence research. However, because of the prolonged development period, for this first version of the Mobile App for Physical Activity intervention, AD substituted an automated advice system. There is recent evidence that, while providing solutions for identified obstacles, the implementation of an automated advisor is considered promising in increasing PA even compared with human advisors. Therefore, this component should be further developed and tested in future trials [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>]. This component also has the potential to reinforce coping planning (by providing coping responses for dealing with potential barriers and difficult situations) [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref48">48</xref>].</p>
        <p>The first push component was a <italic>personalized PA prompt</italic>. According to the results of the 2 most recent MRTs, tailored push suggestions in a PA context were associated with greater engagement with an mHealth app and increased PA participation [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref49">49</xref>]. In the Mobile App for Physical Activity, the users received 1 tailored suggestion (delivered as a pop-up notification). Every day after school classes had finished (5 PM-7 PM), the participants received a personalized PA prompt via a Fitbit pop-up notification. Each message was prepared by AD considering the daily step count performance so far and its percentage correlation with the daily goal. Depending on the participant’s achievements, the message could be framed in 5 different ways according to the percentage reached compared with the personalized goal: &#60;40%, ≥40%, ≥60%, ≥80%, and ≥100%. The message also included different PA health benefits that the participants could potentially achieve by following their activity goals based on WHO recommendations [<xref ref-type="bibr" rid="ref50">50</xref>]. Additional attention was paid to the positive framing of the PA suggestions [<xref ref-type="bibr" rid="ref47">47</xref>]. The Mobile App for Physical Activity intervention included &#62;25 PA suggestion templates developed by the research team using data collected during focus group discussions. All generated suggestion templates were reviewed and edited, and additional suggestions were created to provide a sufficient number of prompts for each condition, including the personalization to such events as an exam period. An example of such a suggestion would be the following: <italic>Hi, Bob! You did around xxxxx steps so far and reached 80% of your goal for today—good job, can you do even better? Interesting fact: physical activity benefits improved concentration, so if you are active, you may get better study results! Keep up the effort!</italic> Therefore, depending on the participants and their performance level as well as their daily goal, messages could differ in relation to five variables: (1) participant name, (2) number of steps so far, (3) step count percentage correlation with the daily goal, (4) PA health benefits based on WHO recommendations, and (5) general message framing. This resulted in a personalized message that could potentially be followed by interactive assistance, which is a qualitatively different combination compared with the generic messages currently provided by most commercial apps. In further iterations of the Mobile App for Physical Activity intervention, this process is planned to be more automated and personalized considering contextual factors.</p>
        <p>The second push component was <italic>reminders to move</italic>. Every day after classes (4 PM-9 PM), if the participants’ behavior was identified as sedentary (no steps or any other HR-increasing activity were performed), they would receive a pop-up reminder motivating them to take ≥250 steps by the end of each hour.</p>
        <p>These approaches were designed to support the users’ self-regulation, which is recognized as a principal factor in health behavior change [<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref52">52</xref>]. The self-monitoring and feedback strategies implemented in this intervention component are characterized as “especially helpful” and recommended for inclusion in PA promotion interventions [<xref ref-type="bibr" rid="ref47">47</xref>].</p>
        <p>The last intervention component was <italic>rewards</italic>. This component was introduced to reinforce the self-monitoring strategies used in the Mobile App for Physical Activity intervention. The strategy of providing users with rewards was recently reported to be especially helpful in increasing PA [<xref ref-type="bibr" rid="ref47">47</xref>]. In the preliminary-held focus group discussions, adolescents identified the sports-related rewards as the most attractive. At intake, the participants were informed that rewards could be obtained based on the number of consecutively accumulated days in line with or above the personalized goals. The rewards consisted of a digital gift voucher from a local sporting goods store. The value of the voucher depended on the number of consecutively accumulated days in line with or above the personalized goals (ie, 3, 5, or 7 days of the week resulted in a €15 [US $15.97], €30 [US $31.94], or €40 [US $42.58] voucher reward, respectively). Rewards or gift vouchers were time-contingent (ie, they were delivered via email directly at the end of the week). The reward scenario aimed to reinforce users’ self-monitoring and the consequent regular performance of sufficient PA. As the Mobile App for Physical Activity intervention was intended to be available to users over a longer period (ie, after the completion of the study), incentives were projected to be effective at early stages and further gradually substituted by habitually formed self-monitoring strategies [<xref ref-type="bibr" rid="ref53">53</xref>]. Finally, the participants were allowed to keep the activity trackers after the end of the study.</p>
      </sec>
      <sec>
        <title>Selection of the Intervention Components</title>
        <p>The selection of the Mobile App for Physical Activity intervention components was guided by 2 combined approaches. The first approach included an analysis of qualitative studies (survey, interview, and focus group discussion as methods of data collection) that explored user preferences in terms of the technological functionality of PA promotion apps [<xref ref-type="bibr" rid="ref54">54</xref>-<xref ref-type="bibr" rid="ref61">61</xref>]. We also conducted a focus group discussion to explore the app feature preferences of adolescents. After identification of potentially advantageous and attractive features for the PA promotion app, we aligned the results with our second approach (ie, the identification and implementation of recommended, effective, and efficacious BCTs).</p>
        <p>To identify and select such BCTs, we used the approach described by Lyons et al [<xref ref-type="bibr" rid="ref62">62</xref>], compiling recommended BCTs from several sources in 1 list [<xref ref-type="bibr" rid="ref62">62</xref>]. Our selection was based on the following steps: (1) successful BCTs for increasing PA in adolescents based on the meta-analysis by Brannon and Cushing for adolescents [<xref ref-type="bibr" rid="ref63">63</xref>], (2) BCTs that predicted PA as reported in meta-analyses on PA interventions for adults [<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref63">63</xref>-<xref ref-type="bibr" rid="ref67">67</xref>], (3) recommendations from the systematic review by Sullivan et al [<xref ref-type="bibr" rid="ref47">47</xref>], and (4) BCTs identified by applying the Behaviour Change Wheel framework [<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]. We used the Acceptability, Practicability, Effectiveness, Affordability, Side-effects, and Equity criteria (worksheet 7 of the Behaviour Change Wheel manual) to identify the appropriate BCTs based on the Mobile App for Physical Activity intervention functions. As an example, the BCT <italic>Credible source</italic> was identified as appropriate and applied within 2 intervention components: interactive assistance and personalized PA prompt. In the Mobile App for Physical Activity intervention, for both cases, a communication from a credible source in favor of the active behavior was presented. In a final step, the selection was reviewed and confirmed by a panel of 4 senior researchers (<xref ref-type="boxed-text" rid="box1">Textbox 1</xref>).</p>
        <p>It is important to note the limitations of the current literature in which the presented BCTs were identified. First, the Mobile App for Physical Activity intervention was developed for adolescents, although data from meta-analyses and reviews for adults were used as there is a gap concerning studies on mHealth PA promotion in younger populations [<xref ref-type="bibr" rid="ref18">18</xref>]. Second, although the review by Brannon and Cushing [<xref ref-type="bibr" rid="ref63">63</xref>] concentrates on apps, the meta-analysis they performed was based on <italic>classic</italic> PA interventions rather than apps. Third, the identified meta-analyses (also based on <italic>classic</italic> PA interventions) presented a mix of results in terms of BCTs. Therefore, we included BCTs in our list only if they were associated with PA in at least two of the 6 meta-analyses. Finally, yet importantly, there are several reviews on the topic published to date that can inform the reader on BCTs identified in efficacious interventions [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref69">69</xref>,<xref ref-type="bibr" rid="ref70">70</xref>]; however, only 1 review (Sullivan et al [<xref ref-type="bibr" rid="ref47">47</xref>]) provides specific recommendations on helpful strategies [<xref ref-type="bibr" rid="ref47">47</xref>]. Therefore, we implemented the recommendations from these reviews and meta-analyses in that we coded all the BCTs presented according to previous versions of BCT taxonomies (26 and 40 BCTs) into the latest taxonomy (93 BCTs) [<xref ref-type="bibr" rid="ref71">71</xref>-<xref ref-type="bibr" rid="ref73">73</xref>].</p>
        <p>The combination of potentially advantageous and attractive PA app features and the selection of BCTs associated with PA change supported a novel approach in developing the Mobile App for Physical Activity intervention. The selection of BCT components was based on two factors: (1) components were selected if considered attractive to adolescents and (2) components were selected if they were considered the most appropriate to reflect a certain BCT (eg, components such as <italic>graphical representation of performed PA</italic> would naturally include the BCT <italic>Feedback on behavior</italic>). The result (ie, the components of the app and the BCTs implemented in them) is presented in <xref ref-type="table" rid="table1">Table 1</xref>.</p>
        <boxed-text id="box1" position="float">
          <title>Recommended, effective, and efficacious behavior change techniques (BCTs).</title>
          <p>
            <bold>BCTs associated with physical activity (PA) identified in at least two of the 6 meta-analyses [<xref ref-type="bibr" rid="ref51">51</xref>,<xref ref-type="bibr" rid="ref63">63</xref>-<xref ref-type="bibr" rid="ref67">67</xref>]</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Self-monitoring of behaviour (2.3), self-monitoring of outcome(s) of behaviour (2.4)</p>
            </list-item>
            <list-item>
              <p>Goal setting (behaviour; 1.1), goal setting (outcome; 1.3)</p>
            </list-item>
            <list-item>
              <p>Feedback on behaviour (2.2), feedback on outcome(s) of behaviour (2.7)</p>
            </list-item>
            <list-item>
              <p>Information about health consequences (5.1)</p>
            </list-item>
          </list>
          <p>
            <bold>BCTs associated with PA according to the meta-analysis by Brannon and Cushing [<xref ref-type="bibr" rid="ref63">63</xref>]</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Information about health consequences (5.1)</p>
            </list-item>
            <list-item>
              <p>Information about others’ approval (6.3)</p>
            </list-item>
            <list-item>
              <p>Goal setting (behaviour; 1.1), goal setting (outcome; 1.3)</p>
            </list-item>
            <list-item>
              <p>Self-monitoring of behaviour (2.3), self-monitoring of outcome(s) of behaviour (2.4)</p>
            </list-item>
            <list-item>
              <p>Behavioural contract (1.8)</p>
            </list-item>
          </list>
          <p>
            <bold>BCTs recommended for implementation by Sullivan et al [<xref ref-type="bibr" rid="ref47">47</xref>]</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Goal setting: goal setting (behaviour; 1.1), goal setting (outcome; 1.3)</p>
            </list-item>
            <list-item>
              <p>Self-monitoring: self-monitoring of behaviour (2.3), self-monitoring of outcome(s) of behaviour (2.4)</p>
            </list-item>
            <list-item>
              <p>Feedback: feedback on behaviour (2.2), feedback on outcome(s) of behaviour (2.7)</p>
            </list-item>
            <list-item>
              <p>Rewards: reward (outcome; 10.10), nonspecific reward (10.3)</p>
            </list-item>
            <list-item>
              <p>Social support: social support (unspecified; 3.1), social support (practical; 3.2), social support (emotional; 3.3)</p>
            </list-item>
            <list-item>
              <p>Coaching: instruction on how to perform the behaviour (4.1)</p>
            </list-item>
            <list-item>
              <p>Identifying obstacles: problem solving (1.2)</p>
            </list-item>
            <list-item>
              <p>Restructuring negative attitudes: framing/reframing (13.2)</p>
            </list-item>
            <list-item>
              <p>Action planning: action planning (1.4)</p>
            </list-item>
            <list-item>
              <p>Modifying environmental factors: restructuring the physical environment (12.1)</p>
            </list-item>
          </list>
          <p>
            <bold>BCTs selected through the Behaviour Change Wheel framework</bold>
            <bold>[<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref68">68</xref>]</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Credible source (9.1)</p>
            </list-item>
            <list-item>
              <p>Monitoring of behaviour by others without feedback (2.1), monitoring of outcome(s) of behaviour without feedback (2.5)</p>
            </list-item>
            <list-item>
              <p>Adding objects to the environment (12.5)</p>
            </list-item>
            <list-item>
              <p>Review behaviour goal(s) (1.5), review outcome goal(s) (1.7)</p>
            </list-item>
          </list>
        </boxed-text>
        <table-wrap position="float" id="table1">
          <label>Table 1</label>
          <caption>
            <p>Behavior change techniques (BCTs) included in the Mobile App for Physical Activity intervention components.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="120"/>
            <col width="210"/>
            <col width="670"/>
            <thead>
              <tr valign="top">
                <td>Push or pull</td>
                <td>Component</td>
                <td>BCTs</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Push</td>
                <td>Personalized PA<sup>a</sup> prompt</td>
                <td>Feedback on behavior, prompts/cues, discrepancy between current behavior and goal, information about health consequences, credible source</td>
              </tr>
              <tr valign="top">
                <td>Push</td>
                <td>Reminders to move</td>
                <td>Feedback on behavior, prompts/cues, discrepancy between current behavior and goal</td>
              </tr>
              <tr valign="top">
                <td>Push</td>
                <td>Rewards</td>
                <td>Reward (outcome), self-monitoring of behavior</td>
              </tr>
              <tr valign="top">
                <td>Pull</td>
                <td>Interactive assistance</td>
                <td>Problem solving, restructuring the physical environment, credible source</td>
              </tr>
              <tr valign="top">
                <td>Pull</td>
                <td>Graphs and stats</td>
                <td>Goal setting (outcome), feedback on behavior, information about health consequences, monitoring of outcome(s) of behavior without feedback</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table1fn1">
              <p><sup>a</sup>PA: physical activity.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
      </sec>
      <sec>
        <title>Theoretical Background</title>
        <p>A meta-regression by Michie et al [<xref ref-type="bibr" rid="ref51">51</xref>] has demonstrated that including such BCTs as self-monitoring combined with at least one other BCT from control theory (ie, prompt intention formation, prompt specific goal setting, providing feedback on performance, prompt self-monitoring of behavior, and prompt review of behavioral goals) in PA interventions is effective [<xref ref-type="bibr" rid="ref51">51</xref>]. Three of these BCTs—namely, self-monitoring, goal setting, and feedback—correspond to the process of self-regulation or, more specifically, control theory [<xref ref-type="bibr" rid="ref74">74</xref>]. This theory suggests that self-monitoring behavior, receiving feedback, setting goals, and reviewing goals following feedback are central to behavioral self-management. Thus, the Mobile App for Physical Activity intervention components were centered on behavioral self-regulation (<xref rid="figure1" ref-type="fig">Figure 1</xref>). This, in addition to the aforementioned rigorous selection approach, enabled the selection and sequencing of the central BCTs [<xref ref-type="bibr" rid="ref75">75</xref>].</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Components of adjusted self-regulation control theory, which informed the Mobile App for Physical Activity intervention. PA: physical activity.</p>
          </caption>
          <graphic xlink:href="formative_v6i6e35118_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Participants</title>
        <p>The selection criteria were similar to the ones applied in our focus group discussion study. A local international school was chosen to recruit healthy adolescents aged 16 to 18 years. The advertisement with study details was disseminated via the school’s email service, seeking to attract adolescents who were insufficiently active yet, on principle, willing to increase their PA participation. In addition, several adolescent students of local Luxembourgish schools were recruited from the participant list of the focus group discussion, which took place earlier and has been described elsewhere [<xref ref-type="bibr" rid="ref76">76</xref>]. The advertisement contained general information about the study and informed potential participants that they would be remunerated for taking part. Remuneration was provided by letting the participants keep the activity tracker implemented in the study (Fitbit Charge 4) and the possibility to win sporting goods store vouchers. The participants needed to be fluent in English and possess a smartphone. Participants were excluded if they had any constraints toward performing PA and if they owned and actively used an activity tracker (eg, Fitbit, Garmin, or Apple Watch) as additional devices provided within the Mobile App for Physical Activity trial could be perceived as burdensome. The study participants were provided with an informed consent form, which had to be signed by the participants themselves (when aged 18 years) or their legal representative (when aged &#60;18 years) before participation.</p>
      </sec>
      <sec>
        <title>Ethics Approval</title>
        <p>This study was approved by the Ethics Review Panel of the University of Luxembourg (19-046A2 Mobile App for Physical Activity).</p>
      </sec>
      <sec>
        <title>Study Design and Procedure</title>
        <p>The Mobile App for Physical Activity intervention was carried out as a 4-week within-subject trial (baseline week+3 intervention weeks). At the selection stage, the PA profile of the interested participants was evaluated using the Physical Activity Questionnaire for Adolescents (PAQ-A) [<xref ref-type="bibr" rid="ref77">77</xref>]. This questionnaire was selected based on an expert panel ranking that evaluated the PAQ-A as one of the very few self-report instruments with acceptable reliability, practicality, and validity [<xref ref-type="bibr" rid="ref78">78</xref>]. The PAQ-A is a 7-day-recall self-administered questionnaire designed to provide a general estimate of PA levels in healthy adolescents aged between 8 and 20 years derived from a series of questionnaire items on activity during and after school, sports participation, and activity in the evenings and weekends [<xref ref-type="bibr" rid="ref77">77</xref>]. Participants were included if they had a PAQ-A score of ≤3 out of 5 (low to moderate levels of weekly PA). An introduction session was organized for the participants at intake to provide them with general information; create Fitbit accounts; link the fitness trackers to them; and analyze their PA habits, basic sociodemographic information, and previous experiences with PA and fitness apps. The participants were then given activity trackers and instructed to wear them at all times (including bathing, sleeping, and swimming). The participants were also instructed to install the Fitbit app and create a Fitbit account while all the notifications for the Fitbit app (and activity tracker) were disabled during the baseline week, and users were encouraged to ignore any notifications that might appear erroneously. Credentials for the Fitbit account were shared with AD to further turn on certain notifications and features during the treatment weeks. The participants were also asked not to use the Fitbit app during the baseline week. AD also connected with all the participants via the Fitbit app (<italic>Add friends</italic> feature) to send them later the personalized PA prompt via the dedicated <italic>Messages</italic> chat tab in the Fitbit app. After the initial week (a baseline period), notifications were turned on remotely via Fitbit account manipulation for proper functioning of components, and personalized step and Active Zone Minute goals were set. Users were informed that the Fitbit app could be assessed at any time without a prerequired frequency. Adherence to both the Fitbit app and the activity tracker and data collection was monitored through the Fitabase platform [<xref ref-type="bibr" rid="ref79">79</xref>]. Emails were sent to the participants when tracker data were missing for &#62;24 hours or when the participants forgot to synchronize data. If data were not received after 48 hours, the participant was contacted by the study supervisor via SMS text message or a phone call. Normally, this situation did not occur more often than 4 to 6 times per week.</p>
      </sec>
      <sec>
        <title>Statistical Analysis</title>
        <p>The aggregated data set was downloaded in CSV format from the Fitbit application programming interface via the Fitabase platform. Fitbit provides data of a different resolution (days or minutes) and, for the primary analysis, we aggregated daily into weekly records.</p>
        <p>To test the first and second hypotheses, we [<xref ref-type="bibr" rid="ref80">80</xref>] performed paired 1-tailed <italic>t</italic> tests to reveal within-subject differences in the primary and secondary outcome measures between measurement occasions (baseline, week 1, week 2, and week 3). We tested for the outcome measures outlined in <xref ref-type="boxed-text" rid="box2">Textbox 2</xref>.</p>
        <boxed-text id="box2" position="float">
          <title>Primary and secondary outcome measures.</title>
          <p>
            <bold>Primary outcome</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Sedentary minutes based on the metabolic equivalent of task (MET)</p>
            </list-item>
          </list>
          <p>
            <bold>Secondary outcomes</bold>
          </p>
          <list list-type="bullet">
            <list-item>
              <p>Active Minutes based on MET or moderate to vigorous physical activity (MVPA) minutes</p>
            </list-item>
            <list-item>
              <p>Active Zone Minutes based on heart rate or MVPA minutes</p>
            </list-item>
            <list-item>
              <p>Step count</p>
            </list-item>
          </list>
        </boxed-text>
        <p>As the 2 recruitment sources (international school and local schools) had different holiday schedules, we plotted for differences in outcomes between participants from these 2 groups. Owing to the small sample size, we computed a bootstrapped paired 1-tailed <italic>t</italic> test in addition to the classic paired 1-tailed <italic>t</italic> test. The measurement occasions were 7-day periods, further referred to as <italic>baseline</italic>, <italic>week 1</italic>, <italic>week 2</italic>, and <italic>week 3</italic>. Each week 1 to week 3 value was compared with the baseline. The α level was set to .05 for all tests. While α inflation is an issue with multiple testing, we decided not to use the Bonferroni correction as it is considered overly conservative and, therefore, increases the risk of type 2 error. Given the early stage of development and research in this area, we would argue that reporting the uncorrected results contributes to the literature by stimulating studies with larger samples in which hypotheses can then be tested more rigorously.</p>
        <p>To test the third hypothesis, we performed change-point detection analysis to identify change points in the means of the step count and the HR time series in the minute-to-minute resolution. As personalized PA prompts were given every day between 5 PM and 7 PM, we used a time frame of 3 PM to 7 PM to estimate change points. Once estimated, we chose the best-fitting change point after 5 PM per participant and day. We then subtracted the averaged step counts and HR of the 30-minute period before from the 30-minute period after the change point to calculate the magnitude of physiological change at that time. The 30-minute period was chosen based on the approach by Klasnja et al [<xref ref-type="bibr" rid="ref24">24</xref>]. As a 30-minute period value was rather theory-inspired, we used an empirical approach and tested for the magnitude of physiological change also within a 60-minute period. To analyze the differences between weeks, we aggregated the magnitude of HR changes per participant and week. Although we did not provide a personalized PA prompt during the baseline, we nevertheless controlled for the random variations from 5 PM to 7 PM, which resulted in a comparison value for the treatment weeks. All statistical analyses were carried out using RStudio (version 4.1.1; R Foundation for Statistical Computing) [<xref ref-type="bibr" rid="ref80">80</xref>].</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Sample</title>
        <p>We recruited 18 participants, of whom 6 (33%) were women. Most participants (11/18, 61%) were recruited from an international school, whereas the other 39% (7/18) were recruited from Luxembourgish schools. The participants had different levels of motivation to improve their PA behavior, varying from very low to moderate. For most of the participants (11/18, 61%)), English was their primary language. Nevertheless, plain English was used within the Mobile App for Physical Activity intervention to make it more attractive to all the participants. The participant mean age was 16.33 (SD 0.57) years. All participants (18/18, 100%) filled in the PAQ-A questionnaire, ranging from a score of 1, which indicates a low PA level, to a score of 5, which indicates a high PA level, with a mean score of 2.72 (SD 0.48). Most participants (16/18, 89%) owned an iOS-powered smartphone, with 11% (2/18) of the participants owning an Android-powered smartphone. We conducted the analysis while differentiating (color coding) between participants from the international school and Luxembourgish schools. However, the recruitment site was not introduced as a between-subject factor owing to the small sample size; therefore, we did not further report data on the differences between recruitment sites, describing rather our general observations of the differences between the 2 sites. Although showing similar trends in sedentary behavior, the step count and MVPA minute trends were generally divergent; students from local schools tended to increase their step count and MVPA minutes, whereas students from the international school tended to decrease their step count and MVPA minutes over the trial period.</p>
      </sec>
      <sec>
        <title>Primary Outcome Analysis: Change in Daily Time Spent in Sedentary Behavior Based on MET</title>
        <p>Sedentary minute counts decreased significantly during the first week of the trial compared with the baseline (<italic>t</italic><sub>17</sub>=−1.79; <italic>P</italic>=.04; bootstrapped <italic>P</italic>=.02; <xref ref-type="table" rid="table2">Table 2</xref>). This effect diminished over time and was no longer significant at week 2 (<italic>t</italic><sub>17</sub>=−0.51; <italic>P</italic>=.30; bootstrapped <italic>P</italic>=.30) and week 3 (<italic>t</italic><sub>17</sub>=−0.94; <italic>P</italic>=.17; bootstrapped <italic>P</italic>=.21). <xref rid="figure2" ref-type="fig">Figure 2</xref> depicts the time course of sedentary minutes over the entire duration of the intervention. The error area in this and the other figures represents the SE of the mean.</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Outcome measures during the baseline and intervention periods.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="580"/>
            <col width="0"/>
            <col width="390"/>
            <thead>
              <tr valign="top">
                <td colspan="3">Outcome and measurement occasion</td>
                <td>Values per day, mean (SD)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="4">
                  <bold>Sedentary behavior (minutes per week)</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Baseline</td>
                <td colspan="2">789.34 (176.71)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Week 1</td>
                <td colspan="2">718.30 (177.58)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Week 2</td>
                <td colspan="2">764.09 (209.89)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Week 3</td>
                <td colspan="2">749.13 (209.80)</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>MVPA</bold>
                  <sup>a</sup>
                  <bold>based on MET<sup>b</sup> (minutes per week)</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Baseline</td>
                <td colspan="2">90.37 (47.94)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Week 1</td>
                <td colspan="2">100.85 (46.24)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Week 2</td>
                <td colspan="2">95.50 (55.08)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Week 3</td>
                <td colspan="2">91.57 (49.10)</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>MVPA based on HR</bold>
                  <sup>c</sup>
                  <bold>(minutes per week)</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Baseline</td>
                <td colspan="2">42.88 (27.41)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Week 1</td>
                <td colspan="2">45.88 (27.15)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Week 2</td>
                <td colspan="2">37.81 (24.51)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Week 3</td>
                <td colspan="2">39.94 (32.66)</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>Step count (steps per week)</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Baseline</td>
                <td colspan="2">14,134.56 (4980.45)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Week 1</td>
                <td colspan="2">14,298.28 (4523.17)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Week 2</td>
                <td colspan="2">13,581.28 (5529.25)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Week 3</td>
                <td colspan="2">14,126.29 (5413.41)</td>
              </tr>
            </tbody>
          </table>
          <table-wrap-foot>
            <fn id="table2fn1">
              <p><sup>a</sup>MVPA: moderate to vigorous physical activity.</p>
            </fn>
            <fn id="table2fn2">
              <p><sup>b</sup>MET: metabolic equivalent of task.</p>
            </fn>
            <fn id="table2fn3">
              <p><sup>c</sup>HR: heart rate.</p>
            </fn>
          </table-wrap-foot>
        </table-wrap>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>Averaged sedentary minutes (mean+SE of the mean).</p>
          </caption>
          <graphic xlink:href="formative_v6i6e35118_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Secondary Outcome Analyses</title>
        <sec>
          <title>Change in MVPA Minutes Based on MET</title>
          <p>In total, 2 outliers with &#62;500 MVPA minutes a day were excluded. With MET-based MVPA minutes, we observed a reversed nonsignificant trend in comparison with sedentary minute count (<xref ref-type="table" rid="table2">Table 2</xref>)—in the first week, the descriptive values of MET-based MVPA minutes increased compared with the baseline (<italic>t</italic><sub>17</sub>=1.23; <italic>P</italic>=.11; bootstrapped <italic>P</italic>=.12). This effect diminished over time and, although it was still positive in week 2 (<italic>t</italic><sub>17</sub>=0.41; <italic>P</italic>=.34; bootstrapped <italic>P</italic>=.34), it was smaller in week 3 (<italic>t</italic><sub>17</sub>=0.12; <italic>P</italic>=.45; bootstrapped <italic>P</italic>=.45). None of these changes reached significance levels (see <xref rid="figure3" ref-type="fig">Figure 3</xref> for the complete time course).</p>
          <fig id="figure3" position="float">
            <label>Figure 3</label>
            <caption>
              <p>Averaged moderate to vigorous physical activity (MVPA) minutes based on the metabolic equivalent of task (mean+SE of the mean).</p>
            </caption>
            <graphic xlink:href="formative_v6i6e35118_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
        <sec>
          <title>Change in MVPA Minutes Based on HR</title>
          <p>Although we observed an initial nonsignificant increase in the first week (<italic>t</italic><sub>17</sub>=0.50; <italic>P</italic>=.31; bootstrapped <italic>P</italic>=.29), we observed a nonsignificant decline compared with the baseline for weeks 2 (<italic>t</italic><sub>17</sub>=−0.57; <italic>P</italic>=.71; bootstrapped <italic>P</italic>=.72) and 3 (<italic>t</italic><sub>17</sub>=−0.39; <italic>P</italic>=.65; bootstrapped <italic>P</italic>=.63). See <xref rid="figure4" ref-type="fig">Figure 4</xref> for the complete time course.</p>
          <fig id="figure4" position="float">
            <label>Figure 4</label>
            <caption>
              <p>Averaged moderate to vigorous physical activity (MVPA) minutes based on heart rate (mean+SE of the mean).</p>
            </caption>
            <graphic xlink:href="formative_v6i6e35118_fig4.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
        <sec>
          <title>Change in Step Count</title>
          <p>The analysis of step count revealed a descriptive course similar to the results of the MVPA minutes based on HR (<xref ref-type="table" rid="table2">Table 2</xref>)—although we observed a slight nonsignificant increase in the first week (<italic>t</italic><sub>17</sub>=0.20; <italic>P</italic>=.41; bootstrapped <italic>P</italic>=.43), there was no clear linear trend over the following weeks. In weeks 2 (<italic>t</italic><sub>17</sub>=−0.33; <italic>P</italic>=.62; bootstrapped <italic>P</italic>=.63) and 3 (<italic>t</italic><sub>17</sub>=−0.006; <italic>P</italic>=.50; bootstrapped <italic>P</italic>=.50), we observed a nonsignificant decline compared with the baseline (<xref rid="figure5" ref-type="fig">Figure 5</xref>).</p>
          <fig id="figure5" position="float">
            <label>Figure 5</label>
            <caption>
              <p>Averaged steps (mean+SE of the mean).</p>
            </caption>
            <graphic xlink:href="formative_v6i6e35118_fig5.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
      </sec>
      <sec>
        <title>Estimation of the Effect After the Delivery of a Personalized PA Prompt: Change-Point Analyses</title>
        <sec>
          <title>HR at 60 Minutes</title>
          <p>We linearly interpolated some missing data (up to 5 minutes per day) to be able to perform the change-point analysis. If &#62;5 minutes per day were missing, data from that day were excluded before running the change-point analysis. As shown in <xref ref-type="table" rid="table3">Table 3</xref>, the intervention resulted in a nonsignificant increase in HR compared with the baseline in the first week (<italic>t</italic><sub>16</sub>=1.28; <italic>P</italic>=.10; bootstrapped <italic>P</italic>=.09) and a significant increase in the second week (<italic>t</italic><sub>16</sub>=1.84; <italic>P</italic>=.04; bootstrapped <italic>P</italic>=.04). However, this effect diminished during week 3 (<italic>t</italic><sub>16</sub>=−0.07; <italic>P</italic>=.52; bootstrapped <italic>P</italic>=.52), where we observed a nonsignificant decline compared with the baseline (see <xref rid="figure6" ref-type="fig">Figure 6</xref> for the complete time course).</p>
          <table-wrap position="float" id="table3">
            <label>Table 3</label>
            <caption>
              <p>Change-point analysis results.</p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="30"/>
              <col width="330"/>
              <col width="0"/>
              <col width="190"/>
              <col width="0"/>
              <col width="190"/>
              <col width="0"/>
              <col width="260"/>
              <thead>
                <tr valign="top">
                  <td colspan="3">Outcome and measurement occasion</td>
                  <td colspan="2">Minutes before</td>
                  <td colspan="2">Minutes after</td>
                  <td>Increase per minute, mean (SD)</td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td colspan="8">
                    <bold>Change-point analysis: heart rate at 60 minutes (bpm)</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Baseline</td>
                  <td colspan="2">80.637</td>
                  <td colspan="2">81.762</td>
                  <td colspan="2">1.12 (11.09)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Week 1</td>
                  <td colspan="2">77.617</td>
                  <td colspan="2">84.211</td>
                  <td colspan="2">6.59 (11.73)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Week 2</td>
                  <td colspan="2">78.877</td>
                  <td colspan="2">89.024</td>
                  <td colspan="2">10.14 (16.23)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Week 3</td>
                  <td colspan="2">83.183</td>
                  <td colspan="2">80.831</td>
                  <td colspan="2">−2.35 (17.29)</td>
                </tr>
                <tr valign="top">
                  <td colspan="8">
                    <bold>Change-point analysis: heart rate at 30 minutes (bpm)</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Baseline</td>
                  <td colspan="2">81.256</td>
                  <td colspan="2">81.893</td>
                  <td colspan="2">0.63 (13.28)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Week 1</td>
                  <td colspan="2">78.656</td>
                  <td colspan="2">84.534</td>
                  <td colspan="2">5.87 (10.36)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Week 2</td>
                  <td colspan="2">79.496</td>
                  <td colspan="2">90.772</td>
                  <td colspan="2">11.27 (15.88)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Week 3</td>
                  <td colspan="2">83.647</td>
                  <td colspan="2">81.865</td>
                  <td colspan="2">−1.78 (15.74)</td>
                </tr>
                <tr valign="top">
                  <td colspan="8">
                    <bold>Change-point analysis: step count at 60 minutes (steps)</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Baseline</td>
                  <td colspan="2">16.955</td>
                  <td colspan="2">23.604</td>
                  <td colspan="2">6.64 (13.10)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Week 1</td>
                  <td colspan="2">19.813</td>
                  <td colspan="2">25.510</td>
                  <td colspan="2">5.69 (17.28)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Week 2</td>
                  <td colspan="2">13.912</td>
                  <td colspan="2">27.997</td>
                  <td colspan="2">14.08 (21.92)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Week 3</td>
                  <td colspan="2">17.826</td>
                  <td colspan="2">23.755</td>
                  <td colspan="2">5.92 (12.70)</td>
                </tr>
                <tr valign="top">
                  <td colspan="8">
                    <bold>Change-point analysis: step count at 30 minutes (steps)</bold>
                  </td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Baseline</td>
                  <td colspan="2">19.732</td>
                  <td colspan="2">27.038</td>
                  <td colspan="2">7.30 (16.18)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Week 1</td>
                  <td colspan="2">20.191</td>
                  <td colspan="2">29.808</td>
                  <td colspan="2">9.61 (16.50)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Week 2</td>
                  <td colspan="2">15.036</td>
                  <td colspan="2">30.855</td>
                  <td colspan="2">15.81 (22.52)</td>
                </tr>
                <tr valign="top">
                  <td>
                    <break/>
                  </td>
                  <td>Week 3</td>
                  <td colspan="2">19.794</td>
                  <td colspan="2">26.224</td>
                  <td colspan="2">6.42 (13.33)</td>
                </tr>
              </tbody>
            </table>
          </table-wrap>
          <fig id="figure6" position="float">
            <label>Figure 6</label>
            <caption>
              <p>Change-point analysis: heart rate (mean+SE of the mean). bpm: beats per minute.</p>
            </caption>
            <graphic xlink:href="formative_v6i6e35118_fig6.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
        <sec>
          <title>HR at 30 Minutes</title>
          <p>The intervention resulted in a nonsignificant increase in HR compared with the baseline in the first week (<italic>t</italic><sub>16</sub>=1.15; <italic>P</italic>=.13; bootstrapped <italic>P</italic>=.13) and a significant increase in the second week (<italic>t</italic><sub>16</sub>=1.95; <italic>P</italic>=.03; bootstrapped <italic>P</italic>=.03). However, this effect diminished during week 3 (<italic>t</italic><sub>16</sub>=0.07; <italic>P</italic>=.47; bootstrapped <italic>P</italic>=.46), where we observed a nonsignificant decline compared with the baseline (<xref rid="figure6" ref-type="fig">Figure 6</xref>).</p>
        </sec>
        <sec>
          <title>Step Count at 60 Minutes</title>
          <p>Change-point analysis of step count revealed no clear linear trend (<xref ref-type="table" rid="table3">Table 3</xref>)—although we observed an insignificant decrease in the first week (<italic>t</italic><sub>17</sub>=−0.23; <italic>P</italic>=.59; bootstrapped <italic>P</italic>=.58), there was a significant increase in the second week (<italic>t</italic><sub>17</sub>=1.35; <italic>P</italic>=.09; bootstrapped <italic>P</italic>=.05). In week 3 (<italic>t</italic><sub>17</sub>=−0.21; <italic>P</italic>=.58; bootstrapped <italic>P</italic>=.56), we observed a nonsignificant decline compared with the baseline (see <xref rid="figure7" ref-type="fig">Figure 7</xref> for the complete time course).</p>
          <fig id="figure7" position="float">
            <label>Figure 7</label>
            <caption>
              <p>Change-point analysis: steps (mean+SE of the mean).</p>
            </caption>
            <graphic xlink:href="formative_v6i6e35118_fig7.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
          </fig>
        </sec>
        <sec>
          <title>Step Count at 30 Minutes</title>
          <p>As shown in <xref ref-type="table" rid="table3">Table 3</xref>, the change-point analysis of step count revealed a trend similar to the 60-minute measurement period—although we observed an insignificant increase in the first week (<italic>t</italic><sub>17</sub>=0.50; <italic>P</italic>=.30; bootstrapped <italic>P</italic>=.29), there was an increase in the second week, which was significant (<italic>t</italic><sub>17</sub>=1.34; <italic>P</italic>=.09; bootstrapped <italic>P</italic>=.05). In week 3 (<italic>t</italic><sub>17</sub>=−0.22; <italic>P</italic>=.58; bootstrapped <italic>P</italic>=.58), we observed a nonsignificant decline compared with the baseline (<xref rid="figure7" ref-type="fig">Figure 7</xref>).</p>
        </sec>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <p>This study, to our knowledge, is the first to develop a behavior change, theory-informed PA mHealth intervention with personalized prompts for adolescents aged 16 to 18 years evaluated using a within-subject experimental design. In contrast to the widespread 1D approach (eg, step count only [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref38">38</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]), this study involved the inclusion of 4 outcome measures to assess the multidimensional PA user profiles.</p>
        <p>Overall, the results showed that the Mobile App for Physical Activity smartphone-based intervention produced significant reductions in sedentary time among adolescents during the first week of the trial. This trend, although it remained positive, diminished over time. This may be related to several reasons, including the holiday period, or certain aspects of the intervention being perceived as burdensome. This suggests that the implementation of the Mobile App for Physical Activity intervention may result in better health outcomes for adolescents, although there is currently insufficient evidence available to determine a specific dose-response relationship between sedentary time and health outcomes in adolescents [<xref ref-type="bibr" rid="ref81">81</xref>]. Our findings indicate that the intervention had no effect on MET-based MVPA minutes, although the descriptive increase may give reason for further investigation. Although the results suggested no overall change in HR-based MVPA minutes, the results from the change-point analyses suggest that the personalized PA prompts significantly increased HR per minute (bpm) during the second week of the study. There were no significant increases in the participants’ overall step count; however, the personalized PA prompts resulted in a marginally significant increase in step counts per minute in the second week of the study. The results also revealed that the participants’ engagement, based on the amount of missing data and responses to app suggestions, although initially high, decreased over the study period. These results may suggest that the intervention was successful in giving adolescents a nudge strong enough to interrupt and decrease their sedentary behavior but insufficient for a more high-effort increase in MVPA minutes. Personalized PA prompts, although moderately successful in promoting a light activity increase, did not result in a more intense MVPA minute increase.</p>
        <p>As noted in the <italic>Results</italic> section, there were noticeable differences between participants from the 2 recruitment sites. This study was carried out between the summer term and the vacation period; therefore, this divergence may be explained by the fact that the 2 schools differed in their holiday calendars. Specifically, although the holiday period for students from Luxembourgish schools started at week 3 of the study, students from the international school were in the holiday period earlier, from week 1 onward. This may have resulted in an earlier decrease in PA for students from the international school compared with students from Luxembourgish schools. The descriptive lack of correlation between step count levels and MVPA levels confirmed the importance of accounting for various outcome measures while tracking the participants’ PA in several dimensions.</p>
        <p>Our study supports the results of a previous study by Bond et al [<xref ref-type="bibr" rid="ref25">25</xref>], where a smartphone-based intervention yielded significant decreases in MET-based sedentary behavior in adults, which may confirm that smartphone-based PA interventions also have a high potential among adolescent populations. These results are also in line with some of the previous findings of the studies by Rabbi et al [<xref ref-type="bibr" rid="ref23">23</xref>] and Klasnja et al [<xref ref-type="bibr" rid="ref24">24</xref>] supporting the beneficial impact of personalized PA suggestions for adolescents. These results partially confirm the findings of the study by Kramer et al [<xref ref-type="bibr" rid="ref82">82</xref>] supporting the use of financial incentives to initiate increased PA. However, future interventions should consider the exit strategy where, in time, participants would sustain increased PA levels based on intrinsic rather than extrinsic motivation. Challenges concerning the limited engagement of adolescents (based on the amount of missing data and decreased response to app suggestions over time) were similar to problems encountered by Lubans et al [<xref ref-type="bibr" rid="ref83">83</xref>]. Engagement with mHealth PA interventions remains an important challenge to overcome for behavior change experts and developers in future interventions. Finally, our findings partially confirm the findings of the study by Gaudet et al [<xref ref-type="bibr" rid="ref27">27</xref>], in which a minimalistic intervention based on the Fitbit activity tracker resulted in MVPA minute increases in adolescents, which may suggest that interventions including commercial fitness trackers may be advantageous for interventions among adolescent populations. Most published smartphone-based intervention studies such as ours include a relatively small participant sample. Therefore, it is important for future studies to replicate these findings and extend them to larger samples to further investigate approaches to increase adolescents’ PA.</p>
        <p>This study used a set of devices and a data platform that are designed to improve sedentary behavior and PA levels among adolescents and are currently commercially available. With their accessibility and relatively low price, compact and waterproof HR- and GPS-powered wrist-worn devices [<xref ref-type="bibr" rid="ref31">31</xref>] in combination with research-grade data collection platforms provide researchers with attractive solutions for data collection and analysis, mitigating burdensomeness and intervention development time span.</p>
        <p>A small number of studies on adolescents in the domain of mHealth PA and even fewer studies using theory-informed interventions call for future research in this area to further knowledge accumulation, both qualitative and quantitative. Systematic methods of intervention development with the help of tools such as the Behaviour Change Wheel and the BCT Taxonomy should be applied further by researchers to allow for the identification of effective intervention components and BCTs for the adolescent age group. Further sustainability of PA and sedentary behavior changes should be investigated via longitudinal studies. Finally, future research should implement alternative designs such as a within-subject design or MRT, which may investigate the efficacy of the intervention’s individual components within a relatively short study duration.</p>
        <p>These results suggest the feasibility and promise of smartphone-based PA interventions with personalized PA suggestions for adolescents. Although minimalist in nature, the introduction of such an intervention may represent a sufficient trigger for adolescents to decrease their sedentary behavior and increase their PA levels.</p>
      </sec>
      <sec>
        <title>Strengths and Limitations</title>
        <p>This study has several strengths. It is one of the few studies to develop and test an mHealth PA intervention for adolescents. Key methodological strengths include (1) the multidimensional PA profile assessment, specifically using versatile outcome measures; (2) the rigorous multistage theoretical development of the intervention guided by intervention development frameworks, taxonomies, and the latest research findings; and (3) the use of the latest wearable device and data collection platform, which presented inherent advantages and features, including undemanding data collection, quick device acceptance by participants, and prompt feedback time between participants and researchers.</p>
        <p>This study also has important limitations. First, probably aggravated by restrictions imposed by the COVID-19 pandemic, we managed to enroll only a relatively small participant sample. Second, some participants did not wear the device for the entire duration of the study, taking it off during sleep or certain activities as wearing a watch or a fitness tracker was considered dangerous; for instance, in martial arts classes. The participants also forgot to wear the device on several occasions after sleep or forgot to charge the device in a timely manner, which resulted in missing data. Another important limitation is the short-term and small-scale nature of this study, which reduces the possibility to come to exhaustive conclusions. It is also important to note that the participants took part in the study during the summer holiday period, which may have affected their PA patterns. In line with previous studies, during the baseline week of the study, we turned all the notifications off. However, we could not fully ensure that the participants would not use a Fitbit app or check the data provided by the fitness tracker either; similarly, we could not ascertain that the notifications during the treatment weeks would be read at once. The participants’ second-language proficiency may have affected their overall engagement with the intervention. Finally, as the proprietary algorithms used to calculate HR- and MET-based MVPA minutes are not publicly available, caution must be taken when interpreting PA data collected by such trackers.</p>
        <p>Despite these limitations, this study provides preliminary evidence of the usefulness of an mHealth PA smartphone intervention while shedding light on potential directions for future mHealth PA smartphone intervention developments.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This study provides preliminary evidence of the benefits of the Mobile App for Physical Activity intervention for modest yet significant reductions in the participants’ sedentary time and the beneficial role of personalized PA prompts. These results also provide further evidence of the benefits and relative efficacy of personalized activity suggestions for inclusion in smartphone-based PA interventions. This study also provides an example of how to guide the development of subsequent smartphone-based mHealth PA interventions for adolescents. Future investigations should focus on replicating these findings and testing the potential for scalability of such an intervention in larger population samples.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group/>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">BCT</term>
          <def>
            <p>behavior change technique</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">HR</term>
          <def>
            <p>heart rate</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">JITAI</term>
          <def>
            <p>just-in-time adaptive intervention</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">MET</term>
          <def>
            <p>metabolic equivalent of task</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">mHealth</term>
          <def>
            <p>mobile health</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">MRT</term>
          <def>
            <p>microrandomized trial</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">MVPA</term>
          <def>
            <p>moderate to vigorous physical activity</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">PA</term>
          <def>
            <p>physical activity</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb9">PAQ-A</term>
          <def>
            <p>Physical Activity Questionnaire for Adolescents</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb10">RCT</term>
          <def>
            <p>randomized controlled trial</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb11">WHO</term>
          <def>
            <p>World Health Organization</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>AD was supported by an Industrial Fellowship from the Luxembourg National Research Fund (reference 12674722) and by Actimage Luxembourg SA. The authors would like to gratefully acknowledge their colleague and one of the coauthors of this paper, ASU, who helped immensely with the statistical analysis.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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