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There is a high prevalence of unexplained and unexplored obstructive sleep apnea (OSA) among patients with type 2 diabetes. The daytime symptoms of OSA include severe fatigue, cognitive problems, a decreased quality of life, and the reduced motivation to perform self-care. These symptoms impair the management of both diabetes and daily life. OSA may therefore have negative implications for diabetes self-management. Continuous positive airway pressure (CPAP) therapy is used to treat OSA. This treatment improves sleep quality, insulin resistance, and glycemic control. Although the benefits of using CPAP as a treatment for OSA are clear, the noncompliance rate is high, and the evidence for the perceived effect that CPAP treatment has on patients with type 2 diabetes and OSA is poor.
The purpose of this study was to analyze the impacts that comorbid diabetes and OSA have on the daily lives of older adults and to investigate the perceived effect that CPAP treatment for OSA has on patients’ diabetes self-management.
A qualitative follow-up study that involved in-depth, semistructured dyad interviews with couples before and after CPAP treatment (N=22) was conducted. Patients were recruited from the Hilleroed Hospital in Denmark and were all diagnosed with type 2 diabetes, aged >18 years, and had an apnea-hypopnea index of ≥15. All interviews were coded and analyzed via thematic analysis.
The results showed that patients and their partners did not consider OSA to be a serious disorder, as they believed that OSA symptoms were similar to those of the process of aging. Patients experienced poor nocturnal sleep, took frequent daytime naps, exhibited reduced cognitive function, and had low levels of physical activity and a high-calorie diet. These factors negatively influenced their diabetes self-management. Despite the immediate benefit of CPAP treatment, most patients (11/12, 92%) faced technical challenges when using the CPAP device. Only the patients with severe OSA symptoms that affected their daily lives overcame the challenges of using the CPAP device and thereby improved their diabetes self-management. Patients with less severe symptoms rated CPAP-related challenges as more burdensome than their symptoms.
If used correctly, CPAP has the potential to significantly improve OSA, resulting in better sleep quality; improved physical activity; improved diet; and, in the end, better diabetes self-management. However, there are many barriers to undergoing CPAP treatment, and only few patients manage to overcome these barriers and comply with correct treatment.
Type 2 diabetes is one of the most prevalent chronic diseases worldwide and is a lifelong condition with many complications [
A high prevalence of obstructive sleep apnea (OSA) has been documented among patients with diabetes; prevalence estimates range from 23% to 60% [
OSA is characterized by recurrent episodes of apnea and hypopnea during sleep. It has varying levels of severity, which range from a few to several hundred apneic events per night [
The purpose of this study was to analyze the impacts that comorbid diabetes and OSA have on the daily lives of older adults and to investigate the perceived effect that CPAP treatment for OSA has on patients’ diabetes self-management.
This was a qualitative follow-up study in which dyad interviews with couples were conducted before and after CPAP treatment. Dyadic interviews draw on the interdependence of two informants as a source of data. Patients with diabetes and OSA and their partners were interviewed simultaneously via joint interviews before and after the intervention [
Participants were recruited from Nordsjællands Hospital, wherein they were a part of a randomized controlled trial—the DiaBOSA (Diabetes and Obstructive Sleep Apnoea) trial (ClinicalTrials.gov identifier: NCT02482584) [
The DiaBOSA trial analyzed different disease-related aspects of patients with type 2 diabetes and newly diagnosed OSA. Our qualitative study was a substudy of the DiaBOSA study, which used the same population.
The patient characteristics for this study were a diagnosis of type 2 diabetes; an age of >18 years; and OSA, which was defined as having an apnea-hypopnea index (AHI) ≥15 (measured using ResMed's ApneaLink Air). An AHI of >15 indicates moderate OSA, and an AHI of >30 indicates severe OSA, according to the American Academy of Sleep Medicine guidelines [
During patients’ enrollment in the DiaBOSA trial (N=70), the physician informed the participants about the qualitative study. The authors (DHL and GR) invited the participants, seeking to enroll as many as possibly while also seeking diversity among participants in terms of sex and age. More men than women were enrolled in the DiaBOSA trial. This reflected the proportions of men and women with OSA in general. These proportions were also represented in our qualitative study.
Participants were included until the interviews revealed no new information and the criteria for information power were met. The criteria included a high quality for all interviews and sufficient data for carrying out the analytical strategy [
All interviews took place in patients’ homes, were conducted by 1 or 2 authors, and lasted approximately 60 minutes (range 35-80 minutes). Interviews were recorded, transcribed, and coded using Nvivo version 11 (QSR International).
For the thematic analysis [
This study was approved by the Danish Data Protection Agency (journal number: 2012-58-0004). All participants provided written consent after being informed about anonymity and their ability to withdraw from the interview at any time without consequences for future care (in accordance with the Helsinki Declaration).
The recruited patients—9 men and 3 women—were aged 56 to 75 years; their partners were aged 59 to 75 years. AHIs ranged from 16 to 64; 7 patients had moderate OSA with an AHI of 15 to 29, and 5 had severe OSA with an AHI of >30. The average number of years since type 2 diabetes mellitus diagnosis was 17 years (range 1-44 years), and all patients had elevated hemoglobin A1c levels (range 54-85 mmol/mol;
Patient characteristics (N=12).
Characteristics | Values |
Male, n | 9 |
Patient age (years), mean (range) | 67 (56-75) |
Partner age (years), mean (range) | 66 (59-75) |
Duration of diabetes (years), mean (range) | 17 (1-44) |
BMI (kg/m²), mean (range) | 33.9 (28.6-39.1) |
HbA1ca level (mmol/mol), mean (range) | 67 (54-85) |
Patients with retinopathy, n | 2 |
Patients experiencing elevated urinary albumin excretionb, n | 4 |
Vibrations perception threshold (V), mean (range) | 25 (10-50) |
Patients with cardiovascular diseasec, n | 4 |
Systolic blood pressure (mmHg), mean (range) | 142 (114-174) |
Diastolic blood pressure (mmHg), mean (range) | 79 (70-91) |
Apnea-hypopnea index (number of events per hour), mean (range) | 31 (16-64) |
aHbA1c: hemoglobin A1c.
bA urinary albumin excretion level of above 30 mg/g (albuminuria).
cCardiovascular diseases include myocardial infarction, stroke, and coronary artery bypass graft disease.
Semistructured interviews were conducted with 22 ethnic Danes—12 patients and 10 partners—before they started CPAP treatment. A total of 16 participants (representing both patients and partners) participated in follow-up interviews 3 months after CPAP treatment. Further, 1 patient died during the follow-up period, and 2 patients did not want to participate in the follow-up interviews.
There were large differences in how the participants experienced OSA. Of the 12 patients, 6 had been affected by symptoms of OSA in their everyday lives, while 6 had never anticipated that they would be diagnosed with OSA. Depending on how they experienced their sleep problems, there were differences in how they approached CPAP treatment. These differences had an impact on the structure of the themes for the thematic analysis. A total of 4 overall themes were identified; they are presented in the following sections:
All 9 follow-up patients were treated with CPAP. The time spent using the CPAP machine varied from 3 days to 3 months.
There was a clear lack of knowledge about OSA among patients with diabetes. When being diagnosed with OSA, all participants expressed surprise about their diagnosis. One patient said:
I did not think this sleep apnea was serious, but now I can see how serious it is and how many comorbidities that follow.
Both patients and partners frequently commented that they had never anticipated an OSA diagnosis. One patient said:
I had no idea that I had sleep apnea. I have never, ever thought about it.
Some participants thought that being tired was simply part of becoming older. One patient stated:
I have simply interpreted it as old age beginning to present itself.
Although they were told that they stopped breathing during the night, the patients had never taken it seriously or considered it to be a symptom of a disease.
A characteristic feature of OSA is constant sleepiness. Although some patients did not recognize a pattern of persistent sleepiness, it was prominently featured in the experiences of others. This was described by a female patient, as follows:
I’m tired when I get up and I’m tired when I go to bed, right, and I don’t really do anything, because I’m a senior citizen.
Many patients explained that when they are awake at night, they spend their time by using the computer while eating unhealthy snacks.
One of the major challenges of sleep apnea is a lack of consistent sleep; patients sleep in short intervals. One patient said:
If I sleep three hours straight, it’s a lot. But it's usually two hours.
Patients did not feel rested when they woke up in the morning after many short intervals of sleep during the night. This often resulted in napping during the day, and up to 4 naps were not uncommon among the study participants. The common belief among patients and partners was that napping was a natural part of becoming older. One partner stated:
When you are 67 years old, you have the right to take a nap, right?
None of the patients viewed napping as a burden. Some of the partners did express concern about their nightly situations and explained what they did to make the patient breathe again. A partner said:
Well, it is not so fun to know that he is lying there not breathing…what if he does not wake up again, right?
The patients who were motivated to continue CPAP treatment did not have more than 1 to 2 hours of continuous sleep for a long period before starting treatment. This had had a major impact on their quality of life. Thus, they were motivated to use the CPAP device. They used the CPAP device every night for 4 to 6 hours and experienced immediate beneficial effects. A patient stated:
Then in the months I've had CPAP I've been sleeping 5-6 hours every night. The first night I slept for seven hours, uninterrupted.
Another benefit that patients experienced was waking up less frequently, and if they did wake up, it was only for a short period. One patient said that before CPAP treatment, he was awake for 2 to 3 hours every night. However, after CPAP treatment, he was only awake for half an hour. Several patients indicated that after CPAP treatment, the quality of their sleep changed; they slept better, quieter, and deeper at night.
Despite the immediate benefit of CPAP treatment, most of the patients experienced technical challenges when using the CPAP mask and machine. The patients who were motivated to undergo CPAP treatment quickly became accustomed to using the CPAP device. One of the typical difficulties that patients experienced was finding the mask that best fit them. Patients who experienced persistent technical challenges typically used the CPAP device for 1 to 2 hours per night if they could make it work at all. Patient #12 had to try 4 different masks before he found one that worked. A small proportion of patients (2/12, 17%) opted to stop CPAP therapy because they could not make the device work properly. Furthermore, some of the patients only tried using the mask and machine a few times before stopping CPAP therapy. For example, one patient said:
Well, I had it one night and I took it off. I could not rest at all.
The main technical challenge was that the mask did not fit the shape of patients’ faces. The CPAP mask did not fit tightly; therefore, air blew into patients’ eyes, which made them very uncomfortable. Patients were also concerned about the hose, which can be too short or too long; they were worried that the hose would crack. Some of the partners felt annoyed by the sound of air and noise from the machine. Further, some patients found that they could not draw air and breathe freely and thus felt like they were being suffocated. One patient stated:
Yes, I did [panic], because I wasn't fully awake, and I couldn't get the mask off. It was awful.
When using the CPAP device, one must breathe with their mouth shut and exhale with resistance. This was a challenge for most patients, but some became accustomed to it. One patient said:
I feel I need to adjust my breathing to the machine, but I shouldn't, it does it for me. But I’m getting used to it and it's getting better and better. And then I learned how to slow down the blowing from the machine which helped.
All participants reported a decline in their memory over the previous few years. This decline in short-term memory was of great concern to all patients and their partners. As several couples were very worried about this, several patients underwent testing for dementia; all tests were negative.
As shown in
Participants reported consuming large amounts of candy and cake. Despite knowing that they should not eat sweets, many could not help themselves. For example, one partner said:
He feels like an addict if there is a cake.
Even though many participants reported that they ate many sweets, no one thought that this was related to OSA.
Several participants described being physically active during their youth. However, at the time of the baseline interviews, more than half of participating patients (9/12, 75%) did not exercise at all, and those who were still active had reduced their exercise intensity substantially. After initiating CPAP treatment, changes were observed in factors related to patients’ diabetes self-management. First, several of the patients felt well rested and healthier in the morning, and this feeling had a direct influence on their memory. They missed fewer appointments with their health care provider and could more easily recall when to take the right medicine. Some of the patients also described having the energy to eat healthier, exercise, and manage work tasks that they were not been able to perform for several years. One of the patients lost 10 kg during the 3-month test phase due to experiencing better sleep, which was the result of no longer eating during the night and being less hungry for snacks during the day. Several participants also explained how they started exercising again due to having more energy and being less tired. A combination of regular medicine intake, a well-regulated diet, and an increase in activity levels also improved several of the participants’ glucose levels. Due to improved sleep, patients needed fewer naps during the daytime, which improved their social relationships and had a positive impact on their partners.
Patients with OSA and diabetes and their partners did not consider OSA to be a serious disorder that affected daily living. Despite some patients’ experiences with excessive sleepiness during the day, they interpreted sleepiness and napping as natural components of aging and organized their daily activities accordingly. Since the symptoms of OSA were not familiar to participants, they did not associate these symptoms with a disease. The main outcome from the baseline interviews was that these patients performed limited amounts of daily physical activity, experienced challenges with short-term memory, and had a high intake of sweets. These factors had implications for their diabetes self-management. After using the CPAP device for 3 months, wide variations appeared among the patients. Many patients experienced technical difficulties with using the CPAP machine, which made them stop the treatment. This was often related to the fact that the mask did not fit their faces. Only the patients who were motivated to change their sleeping patterns overcame the technical difficulties. The patients who adhered to CPAP treatment after 3 months lost weight, improved their level of physical activity, improved their food intake, and had more energy in their lives. These improvements all correlated with their diabetes self-management.
The results show that a chronic condition can become a natural part of everyday routines. Study participants did not make conscious changes to their daily living due to a disease. Rather, their symptoms were integrated into their routines. This has been described in other studies of chronic illness [
Very few studies have analyzed partners’ perspectives on OSA, and most findings have indicated that partners are afraid and that many partners monitor patients’ breathing at night [
Several participants experienced challenges with short-term memory and developed corresponding strategies to overcome these challenges. Some even took a dementia test. A review found that patients with OSA and excessive daytime sleepiness may have cognitive impairments related to attention, concentration, learning, memory, and executive functions [
Patients who do not have symptoms of fatigue and a tendency to fall asleep during the day but experience many technical challenges in CPAP treatment are less likely to continue treatment. This may be related to the fact that they doubt their OSA diagnosis and the risk of complications, as they have no obvious symptoms [
In addition to sleeping better at night, many patients had higher energy levels during the day, resulting in the need for fewer and shorter naps as well as increased desires and energy for performing activities. These findings are supported by several studies that show that patients undergoing CPAP treatment report less snoring, longer coherent sleep, higher energy levels, fewer conflicts with family and others, better memory, and greater activity levels [
Some partners also experience the changes that patients exhibit, such as being in a better mood during the day as well as being awake for fewer and shorter periods at night. Studies that focus on couples' experiences with CPAP therapy have shown that partners can motivate and support patients both emotionally and practically in their use of a CPAP mask. Patients have shown consideration and do not interfere with their partners at night by using CPAP, thereby motivating patients to adhere to treatment [
Patients’ challenges with mask customization often resulted in adverse consequences in the form of eye inflammation and clogged and runny noses [
The dietary implications of OSA are highly relevant to patients with diabetes. Patients with OSA prefer more calorically dense food with a higher fat content [
In our study, some patients and partners benefitted from dietary changes and minor weight loss. This can be understood in the context that several of the patients undergoing CPAP treatment slept better at night and had higher levels of energy and activity during the day. In a study by Bakker et al [
One of the patients in our study lost 10 kg during the study period, and this had an immediate effect on his glucose levels. Consequently, dietary changes and weight reduction should be particularly emphasized in the treatment of both OSA and diabetes.
With regard to physical functions, OSA has implications for physical activity levels and the experience of subjective vigor [
The primary strength of this study lies in our use of qualitative methods. As there is a very high prevalence of undiagnosed OSA in the population [
There are some limitations to this study. Patients were recruited from a randomized controlled trial study and via self-selected participation. Therefore, they may differ from comparable patients with OSA and diabetes who chose not to participate. Additionally, only patients with moderate or severe OSA (an AHI of >15) were included; they were the most likely to exhibit daily symptoms and feel restricted by OSA. Further, our findings may not be generalizable to patients with an AHI of 5 to 15, about whom little is known in terms of treatment and how they live with OSA during their daily lives. Finally, the OSA diagnoses were made via polygraphy, which probably underestimated the AHI and subsequently misclassified patients with OSA.
In this study, we analyzed a group of older adults with comorbid OSA and diabetes and found that their lives were disrupted due to the two diseases and were characterized by poor sleep and frequent naps. Most often, patients are unaware of their OSA and do not seek treatment. The implications of reduced cognitive function, low levels of physical activity, and a high-calorie diet affect diabetes management and result in exacerbated diabetes. If used correctly, CPAP has the potential to significantly improve OSA, resulting in better sleep quality; improved physical activity; improved diet; and, in the end, better diabetes self-management. Nevertheless, there are many barriers to undergoing CPAP treatment, and only few patients manage to overcome these barriers and comply with correct treatment. Patients’ partners play a large role in promoting the correct use of the CPAP device, which can motivate patients to continue with the treatment. Patients who correctly use the CPAP device also exhibit improvements in their diabetes self-management. It is therefore important that CPAP-related barriers are prevented via thorough instruction and assistance from health care professionals.
It is also important that patients and their relatives acquire knowledge about the symptoms of and risk factors for OSA and understand the connection between OSA and diabetes. Patients and their relatives must be aware that changes in sleep patterns, increases in fatigue during the day, and the need for extra naps can be symptoms of OSA. Thus, there is also a great need for increasing OSA awareness among health care professionals, so that they can learn to identify affected individuals and develop skills for providing screening, education, and guidance based on the needs of patients and their partners. As a result, patients can gain an understanding of OSA and skills for managing symptoms in daily life.
apnea-hypopnea index
continuous positive airway pressure
Diabetes and Obstructive Sleep Apnoea
obstructive sleep apnea
The authors would like to thank all of the participants for taking the time to participate in this study.
None declared.