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<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="2.0">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">JFR</journal-id>
      <journal-id journal-id-type="nlm-ta">JMIR Form Res</journal-id>
      <journal-title>JMIR Formative Research</journal-title>
      <issn pub-type="epub">2561-326X</issn>
      <publisher>
        <publisher-name>JMIR Publications</publisher-name>
        <publisher-loc>Toronto, Canada</publisher-loc>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">v5i10e32656</article-id>
      <article-id pub-id-type="pmid">34617905</article-id>
      <article-id pub-id-type="doi">10.2196/32656</article-id>
      <article-categories>
        <subj-group subj-group-type="heading">
          <subject>Original Paper</subject>
        </subj-group>
        <subj-group subj-group-type="article-type">
          <subject>Original Paper</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Detecting Subclinical Social Anxiety Using Physiological Data From a Wrist-Worn Wearable: Small-Scale Feasibility Study</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="editor">
          <name>
            <surname>Eysenbach</surname>
            <given-names>Gunther</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib contrib-type="reviewer">
          <name>
            <surname>Dechant</surname>
            <given-names>Martin</given-names>
          </name>
        </contrib>
      </contrib-group>
      <contrib-group>
        <contrib id="contrib1" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Shaukat-Jali</surname>
            <given-names>Ruksana</given-names>
          </name>
          <degrees>MEng</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-7282-6704</ext-link>
        </contrib>
        <contrib id="contrib2" contrib-type="author" corresp="yes" equal-contrib="yes">
          <name name-style="western">
            <surname>van Zalk</surname>
            <given-names>Nejra</given-names>
          </name>
          <degrees>BA, MSc, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <address>
            <institution>Dyson School of Design Engineering</institution>
            <institution>Imperial College London</institution>
            <addr-line>25 Exhibition Road</addr-line>
            <addr-line>London, SW7 2AZ</addr-line>
            <country>United Kingdom</country>
            <phone>44 2083318091</phone>
            <email>n.van-zalk@imperial.ac.uk</email>
          </address>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-3504-9037</ext-link>
        </contrib>
        <contrib id="contrib3" contrib-type="author" equal-contrib="yes">
          <name name-style="western">
            <surname>Boyle</surname>
            <given-names>David Edward</given-names>
          </name>
          <degrees>BEng, PhD</degrees>
          <xref rid="aff1" ref-type="aff">1</xref>
          <ext-link ext-link-type="orcid">https://orcid.org/0000-0002-1993-4482</ext-link>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label>
        <institution>Dyson School of Design Engineering</institution>
        <institution>Imperial College London</institution>
        <addr-line>London</addr-line>
        <country>United Kingdom</country>
      </aff>
      <author-notes>
        <corresp>Corresponding Author: Nejra van Zalk <email>n.van-zalk@imperial.ac.uk</email></corresp>
      </author-notes>
      <pub-date pub-type="collection">
        <month>10</month>
        <year>2021</year>
      </pub-date>
      <pub-date pub-type="epub">
        <day>7</day>
        <month>10</month>
        <year>2021</year>
      </pub-date>
      <volume>5</volume>
      <issue>10</issue>
      <elocation-id>e32656</elocation-id>
      <history>
        <date date-type="received">
          <day>5</day>
          <month>8</month>
          <year>2021</year>
        </date>
        <date date-type="rev-request">
          <day>26</day>
          <month>8</month>
          <year>2021</year>
        </date>
        <date date-type="rev-recd">
          <day>17</day>
          <month>9</month>
          <year>2021</year>
        </date>
        <date date-type="accepted">
          <day>20</day>
          <month>9</month>
          <year>2021</year>
        </date>
      </history>
      <copyright-statement>©Ruksana Shaukat-Jali, Nejra van Zalk, David Edward Boyle. Originally published in JMIR Formative Research (https://formative.jmir.org), 07.10.2021.</copyright-statement>
      <copyright-year>2021</copyright-year>
      <license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
        <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Formative Research, is properly cited. The complete bibliographic information, a link to the original publication on https://formative.jmir.org, as well as this copyright and license information must be included.</p>
      </license>
      <self-uri xlink:href="https://formative.jmir.org/2021/10/e32656" xlink:type="simple"/>
      <abstract>
        <sec sec-type="background">
          <title>Background</title>
          <p>Subclinical (ie, threshold) social anxiety can greatly affect young people’s lives, but existing solutions appear inadequate considering its rising prevalence. Wearable sensors may provide a novel way to detect social anxiety and result in new opportunities for monitoring and treatment, which would be greatly beneficial for persons with social anxiety, society, and health care services. Nevertheless, indicators such as skin temperature measured by wrist-worn sensors have not been used in prior work on physiological social anxiety detection.</p>
        </sec>
        <sec sec-type="objective">
          <title>Objective</title>
          <p>This study aimed to investigate whether subclinical social anxiety in young adults can be detected using physiological data obtained from wearable sensors, including heart rate, skin temperature, and electrodermal activity (EDA).</p>
        </sec>
        <sec sec-type="methods">
          <title>Methods</title>
          <p>Young adults (N=12) with self-reported subclinical social anxiety (measured using the widely used self-reported version of the Liebowitz Social Anxiety Scale) participated in an impromptu speech task. Physiological data were collected using an E4 Empatica wearable device. Using the preprocessed data and following a supervised machine learning approach, various classification algorithms such as Support Vector Machine, Decision Tree, Random Forest, and K-Nearest Neighbours (KNN) were used to develop models for 3 different contexts. Models were trained to differentiate (1) between baseline and socially anxious states, (2) among baseline, anticipation anxiety, and reactive anxiety states, and (3) social anxiety among individuals with social anxiety of differing severity. The predictive capability of the singular modalities was also explored in each of the 3 supervised learning experiments. The generalizability of the developed models was evaluated using 10-fold cross-validation as a performance index.</p>
        </sec>
        <sec sec-type="results">
          <title>Results</title>
          <p>With modalities combined, the developed models yielded accuracies between 97.54% and 99.48% when differentiating between baseline and socially anxious states. Models trained to differentiate among baseline, anticipation anxiety, and reactive anxiety states yielded accuracies between 95.18% and 98.10%. Furthermore, the models developed to differentiate between social anxiety experienced by individuals with anxiety of differing severity scores successfully classified with accuracies between 98.86% and 99.52%. Surprisingly, EDA was identified as the most effective singular modality when differentiating between baseline and social anxiety states, whereas ST was the most effective modality when differentiating anxiety among individuals with social anxiety of differing severity.</p>
        </sec>
        <sec sec-type="conclusions">
          <title>Conclusions</title>
          <p>The results indicate that it is possible to accurately detect social anxiety as well as distinguish between levels of severity in young adults by leveraging physiological data collected from wearable sensors.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>social anxiety</kwd>
        <kwd>wearable sensors</kwd>
        <kwd>physiological measurement</kwd>
        <kwd>machine learning</kwd>
        <kwd>young adults</kwd>
        <kwd>mental health</kwd>
        <kwd>mHealth</kwd>
        <kwd>new methods</kwd>
        <kwd>anxiety</kwd>
        <kwd>wearable</kwd>
        <kwd>sensor</kwd>
        <kwd>digital phenotyping</kwd>
        <kwd>digital biomarkers</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec sec-type="introduction">
      <title>Introduction</title>
      <sec>
        <title>Background</title>
        <p>Social anxiety is a fear of social situations in which the individual is exposed to possible scrutiny by others [<xref ref-type="bibr" rid="ref1">1</xref>], and high levels of social anxiety are associated with a low quality of life in various domains [<xref ref-type="bibr" rid="ref2">2</xref>,<xref ref-type="bibr" rid="ref3">3</xref>]. Even when not clinically diagnosable (ie, subclinical or threshold social anxiety), it can greatly affect young people’s lives. Fehm et al [<xref ref-type="bibr" rid="ref4">4</xref>] showed that young adults with social anxiety who do not receive treatment are at risk of developing social anxiety disorder (SAD) and comorbid mental health problems such as depression, both of which cause further adverse life impairments [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref5">5</xref>]. SAD is one of the most common anxiety disorders [<xref ref-type="bibr" rid="ref6">6</xref>]. One UK study in 2000 [<xref ref-type="bibr" rid="ref7">7</xref>] revealed that the annual health care cost per person with SAD was £609 (US $834.59), with annual productivity losses and social security benefits adding to £1920 (US $2631.22) per person with SAD, whereas those with SAD and a comorbidity incurred even higher costs. Nevertheless, many individuals do not receive treatment owing to limited availability or lack of awareness of social anxiety among health care professionals [<xref ref-type="bibr" rid="ref3">3</xref>,<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref8">8</xref>]. Some may not even seek treatment owing to a fear of being negatively evaluated by health care professionals [<xref ref-type="bibr" rid="ref8">8</xref>]. Thus, it is imperative to empower both individuals and health care professionals in early detection of social anxiety before it potentially escalates into SAD and other related problems.</p>
        <p>Common methods for assessing social anxiety involve using subjective measures, usually in a clinical setting. Owing to the rising prevalence of social anxiety, however, it is becoming evident that traditional approaches are inadequate and unsustainable for health care services [<xref ref-type="bibr" rid="ref4">4</xref>,<xref ref-type="bibr" rid="ref5">5</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. In recent years, increasing focus has been given to technological advances that might help in the early detection and subsequent intervention for anxiety-related problems. In terms of social anxiety, objective methods used to assess symptoms include monitoring physiological changes typically caused by anxiety such as an elevated heart rate (HR), increased electrodermal activity (EDA), variation in skin temperature (ST), and trembling [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref12">12</xref>].</p>
        <p>Nevertheless, despite extensive and promising research into stress and emotion detection based on physiological indices applicable to social anxiety collected from wearable sensors (<xref ref-type="table" rid="table1">Table 1</xref>), there has been little effort to predict social anxiety particularly using this approach. This might be ascribed to the recent shift in attention toward social anxiety reported by Heimberg and Butler [<xref ref-type="bibr" rid="ref13">13</xref>], owing to widening of the diagnostic criteria and leading to a rise in those who fit the criteria for social anxiety.</p>
        <p>Although not without its problems, detection via wearable sensors has the potential to underpin solutions addressing the growing needs of individuals with social anxiety and complement traditional therapeutic approaches. If subclinical social anxiety could reliably and validly be detected using wearable sensors, initial treatment could subsequently transition to digital self-help solutions to aid social anxiety at earlier stages when treatment is less extensive and costly [<xref ref-type="bibr" rid="ref7">7</xref>]. Furthermore, self-help solutions may be a more appropriate method of treatment as individuals with social anxiety often feel nervous to seek treatment in clinical settings [<xref ref-type="bibr" rid="ref8">8</xref>]. Detecting social anxiety using evidence-based objective methods could also complement current therapeutic approaches.</p>
      </sec>
      <sec>
        <title>Prior Work</title>
        <sec>
          <title>Emotion Detection Using Machine Learning</title>
          <p>A rise in wearable devices has further enabled researchers to investigate methods for the detection of emotion and stress states [<xref ref-type="bibr" rid="ref14">14</xref>,<xref ref-type="bibr" rid="ref15">15</xref>], with many studies reporting high-accuracy detection levels (<xref ref-type="table" rid="table1">Table 1</xref>). To detect emotional states using physiological data, researchers have executed data collection experiments that invoke the state to be detected, with tasks including hyperventilation and watching emotional films [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>].</p>
          <p>After data collection, a supervised machine learning (ML) approach is commonly used owing to the classification nature of the investigations [<xref ref-type="bibr" rid="ref16">16</xref>-<xref ref-type="bibr" rid="ref18">18</xref>]. In supervised ML, the training data are labeled in accordance with the correct class as the classification algorithms learn by example. <xref ref-type="table" rid="table1">Table 1</xref> shows an overview of ML approaches focusing on emotion and stress detection. The most dominant and successful algorithm in studies involving recognition of states using physiological data is Support Vector Machine (SVM). Classifiers such as Decision Tree, Random Forest, and K-Nearest Neighbours (KNN) have also been frequently used and are reportedly effective.</p>
          <table-wrap position="float" id="table1">
            <label>Table 1</label>
            <caption>
              <p>Studies on the recognition of emotion and stress states by using physiological indicators.</p>
            </caption>
            <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
              <col width="70"/>
              <col width="350"/>
              <col width="270"/>
              <col width="110"/>
              <col width="200"/>
              <thead>
                <tr valign="top">
                  <td>Study</td>
                  <td>Classification algorithms</td>
                  <td>Physiological data</td>
                  <td>Detection</td>
                  <td>Reported accuracy, %</td>
                </tr>
              </thead>
              <tbody>
                <tr valign="top">
                  <td>[<xref ref-type="bibr" rid="ref16">16</xref>]</td>
                  <td>SVM<sup>a</sup>, Decision Tree, KNN<sup>b</sup>, Naïve Bayes, Random Forest, Neural Network, Zero K</td>
                  <td>HR<sup>c</sup>, ST<sup>d</sup>, EDA<sup>e</sup></td>
                  <td>Stress</td>
                  <td>65.8-100%</td>
                </tr>
                <tr valign="top">
                  <td>[<xref ref-type="bibr" rid="ref18">18</xref>]</td>
                  <td>SVM</td>
                  <td>EDA, BVP<sup>f</sup>, PD<sup>g</sup></td>
                  <td>Stress</td>
                  <td>57.1-80%</td>
                </tr>
                <tr valign="top">
                  <td>[<xref ref-type="bibr" rid="ref19">19</xref>]</td>
                  <td>SVM, Decision Tree, KNN, Naïve Bayes</td>
                  <td>EDA, BVP, PZT<sup>h</sup>, EEG<sup>i</sup>, ECG<sup>j</sup>, EMG<sup>k</sup></td>
                  <td>Emotion</td>
                  <td>17-91.3%</td>
                </tr>
                <tr valign="top">
                  <td>[<xref ref-type="bibr" rid="ref20">20</xref>]</td>
                  <td>SVM</td>
                  <td>BVP, ST, EDA, PD</td>
                  <td>Stress</td>
                  <td>61.5-90.1%</td>
                </tr>
                <tr valign="top">
                  <td>[<xref ref-type="bibr" rid="ref21">21</xref>]</td>
                  <td>KNN</td>
                  <td>HRV<sup>l</sup></td>
                  <td>Stress</td>
                  <td>79.2-94.6%</td>
                </tr>
              </tbody>
            </table>
            <table-wrap-foot>
              <fn id="table1fn1">
                <p><sup>a</sup>SVM: Support Vector Machine.</p>
              </fn>
              <fn id="table1fn2">
                <p><sup>b</sup>KNN: K-Nearest Neighbours.</p>
              </fn>
              <fn id="table1fn3">
                <p><sup>c</sup>HR: heart rate.</p>
              </fn>
              <fn id="table1fn4">
                <p><sup>d</sup>ST: skin temperature.</p>
              </fn>
              <fn id="table1fn5">
                <p><sup>e</sup>EDA: electrodermal activity.</p>
              </fn>
              <fn id="table1fn6">
                <p><sup>f</sup>BVP: blood volume pulse.</p>
              </fn>
              <fn id="table1fn7">
                <p><sup>g</sup>PD: pupillary distance.</p>
              </fn>
              <fn id="table1fn8">
                <p><sup>h</sup>PZT: piezoelectric response.</p>
              </fn>
              <fn id="table1fn9">
                <p><sup>i</sup>EEG: electroencephalogram.</p>
              </fn>
              <fn id="table1fn10">
                <p><sup>j</sup>ECG: electrocardiogram.</p>
              </fn>
              <fn id="table1fn11">
                <p><sup>k</sup>EMG: electromyography.</p>
              </fn>
              <fn id="table1fn12">
                <p><sup>l</sup>HRV: heart rate variability.</p>
              </fn>
            </table-wrap-foot>
          </table-wrap>
        </sec>
        <sec>
          <title>Physiological Indicators of Social Anxiety</title>
          <p>Classical psychological experiments commonly use impromptu public speaking tasks to elicit a social anxiety response [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]. These experiments are often split into stages that measure three responses: <italic>baseline</italic>, <italic>anticipatory</italic>, and <italic>reactive</italic> anxiety (where the nature of the speaking task is announced beforehand to provoke an anticipatory anxiety response) [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]. In conjunction, respondents are typically asked about their anxiety levels through self-reports [<xref ref-type="bibr" rid="ref24">24</xref>]. Although self-reports are an important way of gauging individual perceptions of social anxiety, this approach is not without its problems, including a high level of subjectivity.</p>
          <p>A more objective way to measure social anxiety is using physiological indicators. Social anxiety activates the sympathetic nervous system (SNS) [<xref ref-type="bibr" rid="ref25">25</xref>]. HR and ST are modulated by both the parasympathetic nervous system (PNS) and SNS divisions of the autonomic nervous system (ANS), whereas EDA is modulated by the SNS alone. Therefore, EDA, HR, and ST are seen as markers of SNS activation and can be considered as potential indicators of social anxiety [<xref ref-type="bibr" rid="ref26">26</xref>-<xref ref-type="bibr" rid="ref29">29</xref>].</p>
          <p>Studies investigating physiological responses to social anxiety further illustrate the potential to use EDA, HR, and ST as indicators [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref12">12</xref>]. Despite the potential for these indicators, however, their responses are complex, and a few studies have indicated minor differences in SNS arousal for individuals with social anxiety compared to control groups [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref30">30</xref>]. Furthermore, although ST has been explored as a social anxiety marker [<xref ref-type="bibr" rid="ref12">12</xref>], wrist ST measurements have not been explored systematically. To our knowledge, this is the first study to explore wrist ST as an indicator of experimentally induced social anxiety.</p>
        </sec>
      </sec>
      <sec>
        <title>Research Aims and Objectives</title>
        <p>This study aimed to investigate whether social anxiety in young people with subclinical social anxiety can be detected using physiological data (based on HR, ST, and EDA) recorded from an existing multi-sensor wearable. The study aims to explore if models can be trained to differentiate (1) between baseline and socially anxious states, (2) among baseline, anticipation anxiety, and reactive anxiety states, and (3) between social anxiety among individuals with social anxiety of differing severity. This study also aims to explore the predictive capability of the singular modalities.</p>
      </sec>
    </sec>
    <sec sec-type="methods">
      <title>Methods</title>
      <sec>
        <title>Recruitment</title>
        <p>Young adult participants were recruited using posters around Imperial College London. The initial sample comprised 13 individuals who self-identified as shy or socially fearful. An exclusion criterion was created to ensure that only young adults with subclinical social anxiety were recruited, as described in <xref rid="figure1" ref-type="fig">Figure 1</xref>. To assess participants’ social anxiety levels, the self-reported version of the Liebowitz Social Anxiety Scale (LSAS-SR) was initially used (mean 64.33, SD 13.12, range 38-80). In total, 13 individuals attended the experiment. One participant who showed up for the experiment was known to the experimenter and had their data subsequently excluded owing to likely bias. The final study sample thus comprised 12 participants (58% female; mean age, 19.75 years, SD 1.76 years; 67% Asian, 25% White, and 8% Mixed race).</p>
        <fig id="figure1" position="float">
          <label>Figure 1</label>
          <caption>
            <p>Flow diagram explaining the study recruitment process. LSAS-SR: self-reported version of the Liebowitz Social Anxiety Scale, SAD: social anxiety disorder.</p>
          </caption>
          <graphic xlink:href="formative_v5i10e32656_fig1.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Measures</title>
        <sec>
          <title>LSAS-SR</title>
          <p>We used the self-report version of the LSAS-SR owing to its well-established validity and reliability in a large amount of previous literature [<xref ref-type="bibr" rid="ref24">24</xref>]. The LSAS-SR allows for the classification of individuals into differing severity groups, as a higher overall LSAS-SR score is seen to correspond with greater social anxiety severity [<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref31">31</xref>]. Furthermore, the LSAS-SR examines both affective aspects (ie, quantifying how anxious participants feel) using the fear subscale and behavioral aspects (ie, gauging to what extent they avoid various social situations) using the avoidance subscale. Each subscale consists of 24 items, with response items ranging on a 4-point scale from “none (0)” to “severe (3)” for the fear subscale, and “never (0)” to “usually (3)” for the Avoidance subscale. Prior studies indicate a high level of reliability of the LSAS-SR (Cronbach α=.95 [<xref ref-type="bibr" rid="ref24">24</xref>]). In this study, the Cronbach α values for the fear and avoidance subscales were .69 and .69, respectively, with an overall Cronbach α of .83.</p>
        </sec>
        <sec>
          <title>Social Phobia Screening Questionnaire</title>
          <p>To cross-validate the LSAS-SR, we also used the Social Phobia Screening Questionnaire (SPSQ), which comprises 8 questions about how much fear individuals feel in various social situations, including speaking in front of a group of people, going to a party, and being alone with someone unfamiliar [<xref ref-type="bibr" rid="ref32">32</xref>]. This measure has shown good validity in prior research [<xref ref-type="bibr" rid="ref32">32</xref>]. It can be used with or without additional questions that allow an estimation of whether individuals reach the clinical cut-off for SAD and has been used in previous research to indicate subclinical social anxiety levels [<xref ref-type="bibr" rid="ref33">33</xref>]. The response items ranged from “none (1)” and “some (2)” to “a lot (3)” (Cronbach α=.74).</p>
        </sec>
      </sec>
      <sec>
        <title>Ethics</title>
        <p>The University Ethics Committee approved all the procedures and measures used in the study. Throughout the procedure, participants were reminded that their participation was voluntary and that they could withdraw their data at any time until used for statistical analysis. The collected data were anonymized and stored in a password-protected folder.</p>
      </sec>
      <sec>
        <title>Data Collection</title>
        <p>The data were collected using the E4 Empatica research-grade multi-sensor wristband wearable. The device was selected as it simultaneously monitors various types of physiological data at predetermined sampling rates [<xref ref-type="bibr" rid="ref34">34</xref>]. However, only HR, EDA, and ST data were explored in this study as they could be considered social anxiety markers [<xref ref-type="bibr" rid="ref26">26</xref>-<xref ref-type="bibr" rid="ref29">29</xref>]. E4 Empatica has not yet been used in many studies of this nature, although other multi-sensor wrist-worn wearables have demonstrated effectiveness [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>].</p>
        <p>Using the default sampling rates of the E4 [<xref ref-type="bibr" rid="ref35">35</xref>], EDA was measured in microSiemens (μS) at 4 Hz using stainless steel electrodes positioned on the inner side of the wrist. HR was measured in beats per minute (BPM) at 1 Hz using data derived from a photoplethysmography sensor. ST was measured in °C at 4 Hz using an infrared thermophile [<xref ref-type="bibr" rid="ref35">35</xref>]. The data were collected throughout the duration of the experiment, an example of which is shown in <xref rid="figure2" ref-type="fig">Figure 2</xref>. The full data set and code needed to recreate the classification models and reproduce the results, as well as functions that enable further experimentation, is available in a designated GitHub repository (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>).</p>
        <fig id="figure2" position="float">
          <label>Figure 2</label>
          <caption>
            <p>A participant’s physiological data sample during the experimental stages. BPM: beats per minute.</p>
          </caption>
          <graphic xlink:href="formative_v5i10e32656_fig2.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Experimental Protocol</title>
        <p>The experiments had an approximate duration of 30 minutes. Similar to previous studies [<xref ref-type="bibr" rid="ref1">1</xref>,<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref23">23</xref>], the experiment was split into 3 stages involving relaxation (baseline), task preparation (anticipation anxiety), and performance (reactive anxiety), as responses might differ across these stages [<xref ref-type="bibr" rid="ref25">25</xref>]. <xref rid="figure3" ref-type="fig">Figure 3</xref> illustrates the experimental stages. The timestamps for the stages were also recorded for labeling purposes. The experimental protocol is listed below.</p>
        <fig id="figure3" position="float">
          <label>Figure 3</label>
          <caption>
            <p>The stages of the impromptu speech task.</p>
          </caption>
          <graphic xlink:href="formative_v5i10e32656_fig3.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>First, the wearable was attached to the participant’s wrist. The procedure commenced with a 10-minute baseline period. During this time, participants were offered magazines and ocean sounds were played to create a calming effect.</p>
        <p>Second, the nature of the task was then announced, and the participant was given 5 minutes to prepare a 3-minute speech on a selected subject from a choice of topics chosen on the basis of their anxiety-inducing potential. These included “<italic>Is Brexit good or bad, and why?</italic>,” “<italic>Intelligence is not enough</italic>,” and “<italic>The history of Western Europe until the 2000s</italic>.”</p>
        <p>Third, a “judging” panel comprising experimenter confederates entered the room, and the participant performed the speech while being timed.</p>
        <p>Finally, the participant was debriefed, and the wearable was removed.</p>
      </sec>
      <sec>
        <title>Data Preprocessing</title>
        <p>The HR data were first upsampled to 4 Hz, similar to ST and EDA. A Moving Average Filter (Equation 1) was then applied to the data to remove noise [<xref ref-type="bibr" rid="ref17">17</xref>] and reduce the risk of model overfitting [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref37">37</xref>].</p>
        <graphic xlink:href="formative_v5i10e32656_fig10.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        <p>Where <italic>w</italic> refers to window size, Input[<italic>i</italic>] refers to original time series signal and Output[<italic>i</italic>] refers to processed time series signal.</p>
        <p>An EDA range correction method (Equation 2) was applied to each participant’s EDA (<italic>E</italic>) data, see <xref rid="figure4" ref-type="fig">Figure 4</xref> [<xref ref-type="bibr" rid="ref38">38</xref>]. This removed inter-individual differences, particularly as physiological activation is believed to be better indicated by the variation within the EDA range rather than the range itself [<xref ref-type="bibr" rid="ref39">39</xref>].</p>
        <graphic xlink:href="formative_v5i10e32656_fig11.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        <fig id="figure4" position="float">
          <label>Figure 4</label>
          <caption>
            <p>Participants' data before and after range correction.</p>
          </caption>
          <graphic xlink:href="formative_v5i10e32656_fig4.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>Following this, the labels were allocated on the basis of the experiment timestamps, assuming the suspected states were invoked. Classification investigation (1) examined whether models can be trained to classify baseline and socially anxious states. Therefore, the participants’ data were split into the respective classes and labeled using the experiment timestamps (<xref rid="figure5" ref-type="fig">Figure 5</xref>).</p>
        <fig id="figure5" position="float">
          <label>Figure 5</label>
          <caption>
            <p>Labeling arrangement for classification investigation (1).</p>
          </caption>
          <graphic xlink:href="formative_v5i10e32656_fig5.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>Classification investigation (2) focused on whether models can be trained to differentiate among baseline, anticipation anxiety, and reactive anxiety states. Therefore, the data were divided into the 3 respective classes using the timestamps and labeled as shown in <xref rid="figure6" ref-type="fig">Figure 6</xref>.</p>
        <fig id="figure6" position="float">
          <label>Figure 6</label>
          <caption>
            <p>Labeling arrangement for classification investigation (2).</p>
          </caption>
          <graphic xlink:href="formative_v5i10e32656_fig6.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>Finally, classification investigation (3) examined whether models could be trained to differentiate between anxiety experienced by individuals with differing levels of social anxiety. Therefore, the data were collected from participants within differing ranges of LSAS-SR scores, including anxiety category 1 (LSAS-SR:50-64) and anxiety category 2 (LSAS-SR:65-80) and was subsequently labeled (<xref rid="figure7" ref-type="fig">Figure 7</xref>).</p>
        <fig id="figure7" position="float">
          <label>Figure 7</label>
          <caption>
            <p>Labeling arrangement for classification investigation (3).</p>
          </caption>
          <graphic xlink:href="formative_v5i10e32656_fig7.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
        <p>The first 2 minutes from the baseline period were disregarded to account for acclimatization, and the recording was discarded after the task as it was not needed. All participant data were then combined.</p>
        <p>The features were standardized to have zero mean and unit variance, which is a widely used scaling approach as algorithms such as Radial SVM assume features are centered around zero [<xref ref-type="bibr" rid="ref36">36</xref>,<xref ref-type="bibr" rid="ref40">40</xref>]. For each feature, the mean (µ) and the standard deviation (σ) were extracted from the raw training feature values. The training data were then standardized using equation (3), and the same transformation was applied to the test data [<xref ref-type="bibr" rid="ref37">37</xref>].</p>
        <graphic xlink:href="formative_v5i10e32656_fig12.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
      </sec>
      <sec>
        <title>Classification</title>
        <p>The investigations were framed as supervised learning tasks owing to their classification nature. Four classification algorithms were explored: SVM, Random Forest, Decision Tree, and KNN. Furthermore, for classification investigation (2), a “<italic>One Vs. Rest</italic>” strategy was utilized as the investigation involved a multi-class data set.</p>
        <p>The trained models were evaluated using 10-fold cross-validation. The method involves dividing the data set into k-folds with 1 fold for testing and the others for training. Confusion matrices were also utilized to calculate the average classification accuracy for each class.</p>
      </sec>
    </sec>
    <sec sec-type="results">
      <title>Results</title>
      <sec>
        <title>Study Descriptives</title>
        <p>All study descriptives are shown in <xref ref-type="table" rid="table2">Table 2</xref>. In this sample, women had higher mean levels for all study variables than men (though the differences were nonsignificant, which is likely owing to the small sample). This is uncharacteristic, as women typically have a higher risk to develop anxiety and higher mean levels of social anxiety than men [<xref ref-type="bibr" rid="ref41">41</xref>]. However, the self-reported LSAS scores were highly correlated with SPSQ scores (<italic>r</italic>=0.63; <italic>P</italic>=.05).</p>
        <table-wrap position="float" id="table2">
          <label>Table 2</label>
          <caption>
            <p>Descriptives for all study variables by gender.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="30"/>
            <col width="500"/>
            <col width="230"/>
            <col width="240"/>
            <thead>
              <tr valign="top">
                <td colspan="2">Gender</td>
                <td>Participants, n</td>
                <td>Score, mean (SD)</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="4">
                  <bold>Liebowitz Social Anxiety Scale fear subscale</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Women</td>
                <td>7</td>
                <td>1.3095 (0.33666)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Men</td>
                <td>5</td>
                <td>1.5917 (0.11562)</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>Liebowitz Social Anxiety Scale avoidance subscale</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Women</td>
                <td>7</td>
                <td>1.1845 (0.34766)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Men</td>
                <td>5</td>
                <td>1.3583 (0.25786)</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>Liebowitz Social Anxiety Scale avoidance subscale overall score</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Women</td>
                <td>7</td>
                <td>1.2470 (0.33190)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Men</td>
                <td>5</td>
                <td>1.4750 (0.15548)</td>
              </tr>
              <tr valign="top">
                <td colspan="4">
                  <bold>Social Phobia Screening Questionnaire</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Women</td>
                <td>7</td>
                <td>1.3469 (0.36288)</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Men</td>
                <td>5</td>
                <td>1.7429 (0.29277)</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
      </sec>
      <sec>
        <title>Combined Modalities</title>
        <p>For classification investigation (1), the yielded accuracies were between 97.54% and 99.48%, as shown in <xref ref-type="table" rid="table3">Table 3</xref>. For investigation (2), the accuracies were between 95.18% and 98.10%, as shown in <xref ref-type="table" rid="table4">Table 4</xref>. Additionally, for investigation (3) the yielded accuracies were between 98.86% and 99.52%, as shown in <xref ref-type="table" rid="table5">Table 5</xref>. In each classification investigation, Radial SVM outperformed other classifiers (<xref ref-type="table" rid="table3">Tables 3</xref>-<xref ref-type="table" rid="table5">5</xref>).</p>
        <table-wrap position="float" id="table3">
          <label>Table 3</label>
          <caption>
            <p>Cross-validation results for classification investigation (1).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="290"/>
            <col width="240"/>
            <col width="240"/>
            <col width="230"/>
            <thead>
              <tr valign="top">
                <td>Classifier</td>
                <td>Overall performance, %</td>
                <td>Baseline state accuracy, %</td>
                <td>Social anxiety state accuracy, %</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Radial Support Vector Machine</td>
                <td>99.48</td>
                <td>99.40</td>
                <td>99.52</td>
              </tr>
              <tr valign="top">
                <td>K-Nearest Neighbours</td>
                <td>99.08</td>
                <td>99.12</td>
                <td>99.05</td>
              </tr>
              <tr valign="top">
                <td>Decision Tree</td>
                <td>97.54</td>
                <td>99.04</td>
                <td>96.59</td>
              </tr>
              <tr valign="top">
                <td>Random Forest</td>
                <td>97.96</td>
                <td>99.38</td>
                <td>97.13</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <table-wrap position="float" id="table4">
          <label>Table 4</label>
          <caption>
            <p>Cross-validation results for classification investigation (2).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="250"/>
            <col width="180"/>
            <col width="200"/>
            <col width="190"/>
            <col width="180"/>
            <thead>
              <tr valign="top">
                <td>Classifier</td>
                <td>Overall performance, %</td>
                <td>Baseline state accuracy, %</td>
                <td>Anticipation anxiety state accuracy, %</td>
                <td>Reactive anxiety state accuracy, %</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Radial Support Vector Machine</td>
                <td>98.10</td>
                <td>99.30</td>
                <td>98.37</td>
                <td>95.52</td>
              </tr>
              <tr valign="top">
                <td>K-Nearest Neighbours</td>
                <td>97.61</td>
                <td>98.99</td>
                <td>97.28</td>
                <td>95.78</td>
              </tr>
              <tr valign="top">
                <td>Decision Tree</td>
                <td>96.63</td>
                <td>99.39</td>
                <td>96.86</td>
                <td>91.36</td>
              </tr>
              <tr valign="top">
                <td>Random Forest</td>
                <td>95.18</td>
                <td>99.27</td>
                <td>95.99</td>
                <td>85.99</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <table-wrap position="float" id="table5">
          <label>Table 5</label>
          <caption>
            <p>Cross-validation results for classification investigation (3).</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="280"/>
            <col width="220"/>
            <col width="250"/>
            <col width="250"/>
            <thead>
              <tr valign="top">
                <td>Classifier</td>
                <td>Overall performance, %</td>
                <td>Anxiety category 1 accuracy, %</td>
                <td>Anxiety category 2 accuracy, %</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td>Radial Support Vector Machine</td>
                <td>99.52</td>
                <td>100</td>
                <td>99.03</td>
              </tr>
              <tr valign="top">
                <td>K-Nearest Neighbours</td>
                <td>98.86</td>
                <td>99.35</td>
                <td>98.36</td>
              </tr>
              <tr valign="top">
                <td>Decision Tree</td>
                <td>99.04</td>
                <td>100</td>
                <td>98.09</td>
              </tr>
              <tr valign="top">
                <td>Random Forest</td>
                <td>99.34</td>
                <td>100</td>
                <td>98.70</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <p>There were common class misclassification patterns among all classifiers. For investigation (1), the models were less able to classify anxious states (<xref ref-type="table" rid="table3">Table 3</xref>). For investigation (2), reactive anxiety was misclassified the most and often mistaken for anticipation anxiety (<xref rid="figure8" ref-type="fig">Figure 8</xref>). Additionally, in investigation (2), the baseline class was most accurately classified, as shown in <xref ref-type="table" rid="table4">Table 4</xref>. For investigation (3), the models were not as effective at classifying anxiety category 2 (<xref ref-type="table" rid="table5">Table 5</xref>).</p>
        <fig id="figure8" position="float">
          <label>Figure 8</label>
          <caption>
            <p>Confusion matrix from classification investigation (2) using the Decision Tree.</p>
          </caption>
          <graphic xlink:href="formative_v5i10e32656_fig8.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
      <sec>
        <title>Singular Modalities</title>
        <p>The singular modality results are shown in <xref ref-type="table" rid="table6">Table 6</xref> and <xref rid="figure9" ref-type="fig">Figure 9</xref>. In classification investigation (1) EDA yielded 80.46% and was shown to have the highest predictive capability. EDA was also shown to have the highest classification accuracy of 70.02% for investigation (2), whereas ST was the most effective modality for investigation (3) with an accuracy of 89.47%. For each classification investigation, HR was observed to be the least effective modality. Furthermore, KNN generally outperformed other classifiers (<xref ref-type="table" rid="table6">Table 6</xref>).</p>
        <table-wrap position="float" id="table6">
          <label>Table 6</label>
          <caption>
            <p>Highest cross-validation results per single modality.</p>
          </caption>
          <table width="1000" cellpadding="5" cellspacing="0" border="1" rules="groups" frame="hsides">
            <col width="8"/>
            <col width="410"/>
            <col width="0"/>
            <col width="360"/>
            <col width="0"/>
            <col width="222"/>
            <thead>
              <tr valign="top">
                <td colspan="3">Modality</td>
                <td colspan="2">Classifier with the highest performance</td>
                <td>Overall performance, %</td>
              </tr>
            </thead>
            <tbody>
              <tr valign="top">
                <td colspan="6">
                  <bold>Classification investigation 1</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Heart rate</td>
                <td colspan="2">K-Nearest Neighbours</td>
                <td colspan="2">68.18</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Skin temperature</td>
                <td colspan="2">K-Nearest Neighbours</td>
                <td colspan="2">76.30</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Electrodermal activity</td>
                <td colspan="2">K-Nearest Neighbours</td>
                <td colspan="2">80.46</td>
              </tr>
              <tr valign="top">
                <td colspan="6">
                  <bold>Classification investigation 2</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Heart rate</td>
                <td colspan="2">K-Nearest Neighbours</td>
                <td colspan="2">53.91</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Skin temperature</td>
                <td colspan="2">K-Nearest Neighbours</td>
                <td colspan="2">68.32</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Electrodermal activity</td>
                <td colspan="2">K-Nearest Neighbours</td>
                <td colspan="2">70.02</td>
              </tr>
              <tr valign="top">
                <td colspan="6">
                  <bold>Classification investigation 3</bold>
                </td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Heart rate</td>
                <td colspan="2">K-Nearest Neighbours</td>
                <td colspan="2">72.00</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Skin temperature</td>
                <td colspan="2">K-Nearest Neighbours</td>
                <td colspan="2">89.47</td>
              </tr>
              <tr valign="top">
                <td>
                  <break/>
                </td>
                <td>Electrodermal activity</td>
                <td colspan="2">Random Forest and Decision Tree</td>
                <td colspan="2">75.66</td>
              </tr>
            </tbody>
          </table>
        </table-wrap>
        <fig id="figure9" position="float">
          <label>Figure 9</label>
          <caption>
            <p>Accuracies per modality. EDA: electrodermal activity, HR: heart reate, KNN:K-Nearest Neighbours, ST: skin temperature, SVM: Support Vector Machine.</p>
          </caption>
          <graphic xlink:href="formative_v5i10e32656_fig9.png" alt-version="no" mimetype="image" position="float" xlink:type="simple"/>
        </fig>
      </sec>
    </sec>
    <sec sec-type="discussion">
      <title>Discussion</title>
      <sec>
        <title>Principal Findings</title>
        <sec>
          <title>Combined Modalities</title>
          <p>This study aimed to determine if ML models could be trained to (1) classify baseline and socially anxious states, (2) differentiate among baseline, anticipation anxiety, and reactive anxiety states, and (3) classify social anxiety with differing severity levels of social anxiety. High accuracies were obtained when differentiating between baseline and socially anxious states, suggesting that it is possible to detect social anxiety using HR, ST, and EDA. These high accuracies are likely due to physiological differences between baseline and socially anxious states and have also been shown in previous research [<xref ref-type="bibr" rid="ref10">10</xref>-<xref ref-type="bibr" rid="ref12">12</xref>].</p>
          <p>The models also yielded high accuracies when classifying among baseline, anticipatory, and reactive states. The classifiers’ ability to differentiate between reactive and anticipatory anxiety might be due to the varying responses during these stages. It is, therefore, likely possible to detect the nature of social anxiety experienced on an individual basis.</p>
          <p>The models also yielded high accuracies when differentiating between marked and moderate social anxiety. This demonstrates the possibility to identify social anxiety levels using physiological indices, implying that individuals with differing severity levels of social anxiety exhibit diverse physiological responses. This is in line with prior research indicating that individuals with greater social anxiety exhibit responses consistent with greater threat [<xref ref-type="bibr" rid="ref10">10</xref>].</p>
          <p>The results also indicated that higher modeling accuracies were yielded when all modalities were combined [<xref ref-type="bibr" rid="ref42">42</xref>]. Research shows that models created using singular modalities may be underfit owing to lack of data [<xref ref-type="bibr" rid="ref37">37</xref>]. This is likely because each physiological index contains varying information that enables classifiers to differentiate among certain classes, thus providing measurement granularity. Furthermore, when modalities were combined, Radial SVM outperformed the other classifiers in all investigations, which is possibly owing to the classifier’s ability to formulate complex decision boundaries [<xref ref-type="bibr" rid="ref37">37</xref>,<xref ref-type="bibr" rid="ref43">43</xref>].</p>
          <p>Finally, certain classes were commonly misclassified, which could be explained by class imbalances owing to the different durations of each stage during the data collection sessions. Class imbalances can cause classifiers to bias toward larger classes [<xref ref-type="bibr" rid="ref44">44</xref>].</p>
        </sec>
        <sec>
          <title>Singular Modalities</title>
          <p>Each modality had varying predictive capabilities, despite the complexity of the physiological indicators used in the study. EDA was the most effective singular modality when differentiating between baseline and social anxiety states (including anticipatory and reactive states). This is possibly because EDA comprises the sum of phasic and tonic components that change following stimuli, which is likely because sweat glands responsible for EDA variation are entirely controlled by the SNS, whereas HR and ST are mediated by both the PNS and SNS [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. Thus, EDA represents an accumulation of information that could indicate social anxiety [<xref ref-type="bibr" rid="ref27">27</xref>].</p>
          <p>ST was the most effective modality when differentiating between anxiety experienced by individuals with differing severity levels of social anxiety. This might be because individuals with greater social anxiety exhibit differing amounts of blood flow to the skin. This surprising finding highlights the predictive capability of ST collected around the wrist and suggests that it could be viewed as a novel social anxiety marker.</p>
          <p>HR showed the lowest effectiveness in all investigations, which might be explained by HR being mediated by the PNS and SNS [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>]. The comparatively low recognition accuracies may also be a result of HR being sampled at the lowest rate.</p>
          <p>Furthermore, KNN was the most effective classifier when the modalities were singular, which is likely because KNN can formulate complex decision boundaries between classes.</p>
        </sec>
      </sec>
      <sec>
        <title>Limitations</title>
        <p>Despite these promising results, these findings are preliminary. The sample size was small, with the COVID-19 pandemic preventing further data collection. Prior to the COVID-19 pandemic, we intended to collect test data in “real-world” settings to evaluate the models’ ability to detect social anxiety in practice. Instead, the models were evaluated using a subset of data from the experiment. Although this approach is often used in ML studies [<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>], it does not offer a realistic indication of model generalizability. Therefore, given the small sample size, our results need to be interpreted cautiously.</p>
        <p>Additionally, classifiers may have been biased toward certain classes owing to the moderately differing class sizes (<xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>). This may have accounted for the high accuracies but reduced model generalizability [<xref ref-type="bibr" rid="ref44">44</xref>]. Like other studies of a similar nature (such as affect recognition studies using physiological data [<xref ref-type="bibr" rid="ref45">45</xref>]), it was difficult to establish the ground truth of the data with respect to the presence and nature of social anxiety. Therefore, labeling was assumed to be aligned with the experimental protocol.</p>
        <p>Furthermore, the physiological responses from the individuals could have been influenced by external factors such as caffeine and alcohol consumption [<xref ref-type="bibr" rid="ref46">46</xref>,<xref ref-type="bibr" rid="ref47">47</xref>], though this was not mitigated in the current study design. It is also important to note that EDA measurements can be affected by environmental conditions such as humidity and room temperature [<xref ref-type="bibr" rid="ref27">27</xref>]. Although the experiments took place in the same room, these variables were not monitored and controlled. In sum, all of these limitations remain challenges for future research.</p>
      </sec>
      <sec>
        <title>Comparison With Prior Work</title>
        <p>Despite its limitations, this study has extended previous work and applications focusing on supervised machine learning in the field of physiological anxiety detection. This experiment was informed by existing study protocols, such as using an impromptu speech task, which is a cornerstone of experimental work invoking social anxiety [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>]. Additionally, the study utilized the LSAS-SR measure, which is a widely used measure demonstrating good psychometric properties in previous research [<xref ref-type="bibr" rid="ref24">24</xref>], and the social anxiety self-reports were cross-validated using another well-known indicator of subclinical social anxiety (SPSQ [<xref ref-type="bibr" rid="ref32">32</xref>]). Overall, our findings also align with those of prior studies indicating that EDA is a “directed and undiluted” representation of the SNS [<xref ref-type="bibr" rid="ref27">27</xref>]. Although prior work has focused on EDA as an indicator, physiological measurement from the anatomical site of the wrist had not been explored in a social anxiety context.</p>
      </sec>
      <sec>
        <title>Conclusions</title>
        <p>This study examined whether social anxiety could be detected in young adults using physiological data (HR, ST, and EDA) from wrist-worn sensors. The findings indicate that it is possible to detect social anxiety and its severity using this approach. Future work in this area has the potential to identify novel methods of detecting and monitoring subclinical social anxiety in young adults, which could help counteract development into SAD. As mental health provision is transitioning toward digital interventions, it is crucial that they are evidence-based and can target individuals with subclinical levels of social anxiety. The ability for future interventions to detect social anxiety before it escalates further could have great social and economic benefits for health care, society and those who experience its consequences.</p>
      </sec>
    </sec>
  </body>
  <back>
    <app-group>
      <supplementary-material id="app1">
        <label>Multimedia Appendix 1</label>
        <p>A Github repository was created to accompany this work. The repository contains the full dataset and code needed to recreate the classification models and reproduce the results, as well as functions that enable further experimentation.</p>
        <media xlink:href="formative_v5i10e32656_app1.docx" xlink:title="DOCX File , 48 KB"/>
      </supplementary-material>
      <supplementary-material id="app2">
        <label>Multimedia Appendix 2</label>
        <p>The following tables illustrate the class data distributions for each classification investigation.</p>
        <media xlink:href="formative_v5i10e32656_app2.docx" xlink:title="DOCX File , 49 KB"/>
      </supplementary-material>
    </app-group>
    <glossary>
      <title>Abbreviations</title>
      <def-list>
        <def-item>
          <term id="abb1">ANS</term>
          <def>
            <p>autonomic nervous system</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb2">BPM</term>
          <def>
            <p>beats per minute</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb3">EDA</term>
          <def>
            <p>electrodermal activity</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb4">HR</term>
          <def>
            <p>heart rate</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb5">KNN</term>
          <def>
            <p>K-Nearest Neighbours</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb6">LSAS-SR</term>
          <def>
            <p>self-reported version of the Liebowitz Social Anxiety Scale</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb7">ML</term>
          <def>
            <p>machine learning</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb8">PNS</term>
          <def>
            <p>parasympathetic nervous system</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb9">SAD</term>
          <def>
            <p>social anxiety disorder</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb10">SNS</term>
          <def>
            <p>sympathetic nervous system</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb11">SPSQ</term>
          <def>
            <p>Social Phobia Screening Questionnaire</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb12">ST</term>
          <def>
            <p>skin temperature</p>
          </def>
        </def-item>
        <def-item>
          <term id="abb13">SVM</term>
          <def>
            <p>Support Vector Machine</p>
          </def>
        </def-item>
      </def-list>
    </glossary>
    <ack>
      <p>We would like to thank all the individuals who volunteered to take part in this study.</p>
    </ack>
    <fn-group>
      <fn fn-type="conflict">
        <p>None declared.</p>
      </fn>
    </fn-group>
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